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United States Department of Agriculture

Agricultural Research Service

Research Project: TRANSMISSION OF CATTLE TME INTO PRION DEFICIENT CATTLE Project Number: 3625-32000-086-09
Project Type: Contract

Start Date: Oct 01, 2005
End Date: Sep 30, 2010

To evaluate whether PrP knock-out cattle are susceptible or resistant to prion diseases.

Evaluation of the resistance of PrP knock-out cattle to prion disease will involve in vivo studies conducted individually and jointly by ARS and cooperator. The studies will involve the preparation of PrP knock-out cattle and normal controls, inoculation of knock-out and normal cattle with Transmissible Mink Encephalopathy (TME); housing of cattle in biocontainment facilities; observation, euthanasia, and necropsy of cattle; collection and testing of samples from cattle for the presence of PrP**SC; and analysis of data.

Last Modified: 8/27/2015
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