2007 Annual Report
Objective 2: Develop new technology for preparation of fabrics having insect controlling and/or repelling properties. Repellent compounds will be covalently bonded to fabric polymers, and the resulting polymers will be tested to determine if repellent activity against mosquitoes is retained; if these derivatized polymers are repellent, then research will continue to optimize conditions required to produce insect repellent fabrics. Objective 3: Identify the mechanisms underlying the activity of key mosquito repellents and attractants, and develop ways to exploit the mechanisms for commercial use. This objective will focus on state-of-the-art application of odorant binding protein (OBP) research by covalently bonding cloned mosquito OBPs to HPLC columns for use in screening natural product and synthetic chemical libraries for binding activity. Bound compounds will be identified and tested in conventional behavioral bioassays for activity against mosquitoes. Also, the mechanisms of action for selected compounds will be investigated electrophysiologically, including single cell recording experimentation to pinpoint the sites of receptors involved in the perception of bioactive compounds.
Develop new technology for preparation of fabrics having insect controlling and/or repelling properties.
Identify the mechanisms underlying the activity of key mosquito repellents and attractants, and develop ways to exploit the mechanisms for commercial use.
Klun, J.A., Khrimian, A., Rowton, E., Kramer, M.H., Debboun, M. 2006. Biting-deterrent activity of a deet analog, two depa analogs and ss220 applied topically to human volunteers compared with deet against three species of blood-feeding flies. Journal of Medical Entomology. 43:1248-1251.
Tran, K., Chauhan, K.R. 2007. Structural activity of bovidic acid and related compounds as feeding deterrents against Aedes aegypti. Biopestic. Int. 3(1):53-57.
Chauhan, K.R., Raina, A. 2007. Effect of catnip oil and its major components on the Formosan subterranean termites. Biopesticides International 2(2):137-143.
Zhu, J., Zeng, X., Ma, Y., Liu, T., Qian, K., Han, Y., Xue, S., Tucker, B., Schultz, G., Coats, J. 2006. Comparisons of adult repellency and larvicidal activity of plant essential oils against mosquitoes. Journal of the Mosquito Control Association. 35:249-257
Carroll, J.F., Cantrell, C.L., Klun, J.A., Kramer, M.H. 2007. Repellency of two terpenoid compounds isolated from Callicarpa americana (Lamiaceae) against Ixodes scapularis and Amblyomma americanum ticks. Experimental and Applied Acarology. 41:215-224.