This report serves to document research conducted under a Reimbursable Agreement between ARS and the U.S. Environmental Protection Agency. Additional details of research can be found in the report for the parent project 6408-13000-012-00D, Integrated Analysis of Landscape Processes for Management of Agricultural Watersheds. Analysis of historical flow and sediment data in combination with field evaluations of channel stability resulted in determination of “reference” or target values for sediment for ecoregions throughout the Mid South. Collaborative research with NSL ecologists is underway at two sites in Mississippi to attempt to link aquatic community structure with flow and sediment-transport conditions. Version 4.0 of the in house bank-stability model is being tested. An outline for a tiered approach to sediment TMDLs based on channel and watershed conditions, and available resources has been completed. Results are critical to action agencies to determine potential impacts of sediment on designated uses of Mid South water bodies.