Start Date: Dec 14, 2004
End Date: Dec 13, 2009
Quantitative molecular and solution characteristics of methyl-substituted celluloses will be used to select a range of properties including but not be limited to viscosity. Polymers representing a range of characteristics will be fed to test animals to determine their plasma lipid and glucose modifying ability. A model based on molecular and solution characteristics that improves plasma markers will be developed. The hyperlipidemic hamster model will be used as the test animal. Plasma lipoprotein cholesterol, glucose and triglycerides; fecal bile acids; liver cholesterol and triglycerides will be used as markers of disease risk. Documents CRADA. Log 27709.