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Research Project:
NUTRITIONAL MODULATION OF BRAIN AGING AND COGNITIVE DECLINE
Location: Human Nutrition Research Center on Aging
Publications
(Clicking on the reprint icon
will take you to the publication reprint.)
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Fruits, Nuts, and Brain Aging: Nutritional Interventions Targeting Age-Related Neuronal and Behavioral Deficits
- (Book / Chapter)
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| Joseph, J.A., Shukitt Hale, B., Willis, L. 2009. Fruits, Nuts, and Brain Aging: Nutritional Interventions Targeting Age-Related Neuronal and Behavioral Deficits. In: Packer, L., Sies, H., Eggersdorfer, M., and Cadenas, E., editors. Micronutrients and Brain Health. Boca Raton, FL: CRC Press. p. 179-188. |
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Grape juice, berries and walnuts affect brain aging and behavior
- (Review Article)
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| Joseph, J.A., Shukitt Hale, B., Willis, L. 2009. Grape juice, berries and walnuts affect brain aging and behavior. Journal of Nutrition. 139:1813S-1817S. |
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Modulation of cognition and behavior in aged animals: role of antioxidant and essential fatty acid rich plant foods
- (Review Article)
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| Willis, L., Shukitt Hale, B., Joseph, J.A. 2009. Modulation of cognition and behavior in aged animals: role of antioxidant and essential fatty acid rich plant foods. American Journal of Clinical Nutrition. 89:1602S-1606S. |
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Effects of Blackberries on Motor and Cognitive Function in Aged Rats
- (Peer Reviewed Journal)
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| Shukitt Hale, B., Cheng, V., Joseph, J.A. 2009. Effects of Blackberries on Motor and Cognitive Function in Aged Rats. Nutritional Neuroscience.12:135-140. |
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Effects of heavy particle irradiation on diet on object recognition memory in rats
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| Rabin, B.M., Carrihill-Knoll, K., Hinchman, M., Shukitt Hale, B., Joseph, J.A., Foster, B.C. 2009. Effects of heavy particle irradiation on diet on object recognition memory in rats. Advances in Space Research. 43:1193-1199. |
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Plum Juice, but Not Dried Plum Powder, is Effective in Mitigating Cognitive Deficits in Aged Rats
- (Peer Reviewed Journal)
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| Shukitt Hale, B., Kalt, W., Carey, A., Vinqvist-Tymchuk, M., Mcdonald, J., Joseph, J.A. 2009. Plum Juice, but Not Dried Plum Powder, is Effective in Mitigating Cognitive Deficits in Aged Rats. Nutrition.25:567-573. |
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Recent Advances in Berry Supplementation and Age-Related Cognitive Decline
- (Review Article)
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| Willis, L., Shukitt Hale, B., Joseph, J.A. Recent Advances in Berry Supplementation and Age-Related Cognitive Decline. Current Opinion in Clinical Nutrition and Metabolic Care. 2009. 12:91-94. |
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Cellular and Behavioral Effects of Stilbene Resveratrol Analogs: Implications for Reducing the Deleterious Effects of Aging
- (Peer Reviewed Journal)
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| Joseph, J.A., Fisher, D.R., Cheng, V., Rimando, A.M., Shukitt Hale, B. 2008. Cellular and Behavioral Effects of Stilbene Resveratrol Analogs: Implications for Reducing the Deleterious Effects of Aging. Journal of Agriculture and Food Chemistry.56(22)10544-10551. |
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Dose-Dependent Effects of Walnuts on Motor and Cognitive Function in Aged Rats
- (Peer Reviewed Journal)
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| Willis, L., Shukitt Hale, B., Cheng, V., Joseph, J.A. 2009. Dose-Dependent Effects of Walnuts on Motor and Cognitive Function in Aged Rats. British Journal of Nutrition. 101:1140-1144. |
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Blueberry Antagonism of C-2 Ceramide Disruption of CA2+ Responses and Recovery in MAChR-Transfected COS-7 Cells
- (Peer Reviewed Journal)
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| Joseph, J.A., Neuman, A., Bielinski, D.F., Fisher, D.R. 2008. Blueberry Antagonism of C-2 Ceramide Disruption of CA2+ Responses and Recovery in MAChR-Transfected COS-7 Cells. Journal of Alzheimer's Disease.15:429-441. |
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Effects of Berry Fruits on Neurocognitive Deficits Produced by Exposure to Space Radiation
- (Book / Chapter)
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| Rabin, B.M., Joseph, J.A., Shukitt Hale, B. 2008. Effects of Berry Fruits on Neurocognitive Deficits Produced by Exposure to Space Radiation. In: Arora, R. Herbal Radiomodulators Applications in Medicine, Homeland Defence and Space. Wallingford, UK: Institute of Nuclear Medicine and Allied Sciences. p.151-161. |
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Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus
- (Peer Reviewed Journal)
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| Shukitt Hale, B., Lau, F.C., Carey, A.N., Galli, R.L., Spangler, E.L., Ingram, D.K., Joseph, J.A. 2008. Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus. Nutritional Neuroscience. 11(4):172-182. |
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"Brainberries" and Aging
- (Other)
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| Joseph, J.A., Shukitt Hale, B. 2008. "Brainberries" and Aging. Clinical Nutrition Insight.34:1-4. |
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Berry Fruit Supplementation in the Aging Brain
- (Review Article)
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| Shukitt Hale, B., Lau, F.C., Joseph, J.A. 2008. Berry Fruit Supplementation in the Aging Brain. Journal of Agriculture and Food Chemistry. 56:636-641. |
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Polyphenols and Polyunsaturate Fatty Acids: The Pollyanna's of Age-Related Cognitive Decline, Neurodegenerative Disease
- (Book / Chapter)
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| Joseph, J.A., Smith, M.A., Perry, G., Shukitt Hale, B. 2008. Polyphenols and Polyunsaturate Fatty Acids: The Pollyanna's of Age-Related Cognitive Decline, Neurodegenerative Disease. In Coulston, A.M. and Boushey, C.J., editors. Nutrition in the Prevention and Treatment of Disease. 2nd edition. San Diego: Elsevier. p. 269-287. |
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Blueberries and Human Health: A Review of Current Research
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| Kalt, W., Joseph, J.A., Shukitt Hale, B. 2007. Blueberries and Human Health: A Review of Current Research. Journal of American Pomological Society. 61:151-160. |
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Dietary modulation of the effects of exposure to 56FE particles
- (Peer Reviewed Journal)
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| Rabin, B.M., Joseph, J.A., Shukitt Hale, B., Carey, A.N. 2007. Dietary modulation of the effects of exposure to 56FE particles. Advances in Space Research. 40(4):576-580. |
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A blueberry-enriched diet provides cellular protection against oxidative stress and attenuates a kainate-induced learning impairment in rats
- (Peer Reviewed Journal)
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| Duffy, K.B., Spangler, E.L., Devan, B.D., Guo, Z., Bowker, J.L., Janas, A.M., Hagapanos, A., Minor, R.K., Decabo, R., Mouton, P.R., Shukitt Hale, B., Joseph, J.A., Ingram, D.K. 2008. A blueberry-enriched diet provides cellular protection against oxidative stress and attenuates a kainate-induced learning impairment in rats. Neurobiology of Aging. 29:1680-1689. |
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Amphetamine-Induced Taste Aversion Learning in Young and Old F-344 Rats Following Exposure to 56Fe Particles
- (Peer Reviewed Journal)
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| Carrihill-Knoll, K.L., Rabin, B.M., Shukitt Hale, B., Joseph, J.A., Carey, A. 2007. Amphetamine-Induced Taste Aversion Learning in Young and Old F-344 Rats Following Exposure to 56Fe Particles. Pharmacology, Biochemistry and Behavior. 29(2):69-76. |
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Cytoprotective effects of anthocyanins and other phenolic fractions of Boysenberry and blackcurrant on dopamine and amyloid Beta induced oxidative stress in transfected COS-7 cells
- (Peer Reviewed Journal)
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| Ghosh, D., Mcghie, T.K., Fisher, D.R., Joseph, J.A. 2007. Cytoprotective effects of anthocyanins and other phenolic fractions of Boysenberry and blackcurrant on dopamine and amyloid Beta induced oxidative stress in transfected COS-7 cells. Journal of the Science of Food and Agriculture. 87:2061-2067. |
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Fruit Polyphenols and their effects on Neuronal Signaling and Behavior in Senescence.
- (Book / Chapter)
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| Joseph, J.A., Shukitt Hale, B., Lau, F.C. 2007. Fruit Polyphenols and their effects on Neuronal Signaling and Behavior in Senescence. Annals of the New York Academy of Sciences. 1100:470-485. |
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Dopamine and ABeta-induced Stress Signaling and Decrements in CA2+ Buffering in Primary Neonatal Hippocampal Cells are Antagonized by Blueberry Extract
- (Peer Reviewed Journal)
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| Joseph, J.A., Carey, A.N., Brewer, G.J., Lau, F.C., Fisher, D.R. 2007. Dopamine and ABeta-induced Stress Signaling and Decrements in CA2+ Buffering in Primary Neonatal Hippocampal Cells are Antagonized by Blueberry Extract. Journal of Alzheimer's Disease. 11:433-446. |
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Inhibitory effects of Blueberry Extract on the Production of Inflammatory Mediators in LPS-activated BV2 Microglia
- (Peer Reviewed Journal)
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| Lau, F.C., Bielinski, D., Joseph, J.A. 2007. Inhibitory effects of Blueberry Extract on the Production of Inflammatory Mediators in LPS-activated BV2 Microglia. Journal of Neuroscience Research. 85:1010-1017. |
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Elevated plus-maze performance of Fischer-344 rats as a function of age and of exposure to 56Fe particles
- (Peer Reviewed Journal)
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| Rabin, B.M., Carrihill-Knoll, K.L., Carey, A.N., Shukitt Hale, B., Joseph, J.A., Foster, B.C. 2007. Elevated plus-maze performance of Fischer-344 rats as a function of age and of exposure to 56Fe particles. Advances in Space Research. 39:981-986. |
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Interaction between age and exposure to 56Fe particles on behavior and neurochemistry
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| Carey, A.N., Shukitt Hale, B., Rabin, B.M., Joseph, J.A. 2007. Interaction between age and exposure to 56Fe particles on behavior and neurochemistry. Advances in Space Research. 39:987-993. |
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Exposure to 56Fe irradiation accelerates normal brain aging and produces deficits in spatial learning and memory
- (Review Article)
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| Shukitt Hale, B., Casadesus, G., Carey, A.N., Rabin, B.M., Joseph, J.A. 2007. Exposure to 56Fe irradiation accelerates normal brain aging and produces deficits in spatial learning and memory. Advances in Space Research. 39:1087-1092. |
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Nutritional Intervention in Brain Aging: Reducing the Effects of Inflammation and Oxidative Stress
- (Book / Chapter)
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| Lau, F.C., Shukitt Hale, B., Joseph, J.A. 2007. Nutritional Intervention in Brain Aging: Reducing the Effects of Inflammation and Oxidative Stress. Inflammation in the Pathogenesis of Chronic Diseases:The COX-2 controversy. Subcellular Biochemistry. Volume 42. New York, NY:Springer Publication. p.299-318. |
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Nutritional Interventions in Aging and Age-Associated Diseases
- (Proceedings)
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| Roth, G.S., Ingram, D.K., Joseph, J.A. 2007. Nutritional Interventions in Aging and Age-Associated Diseases. 3rd International Conference on Healthy Ageing and Longevity. Annals of the New York Academy of Sciences. 1114:369-371. |
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Beneficial effects of berryfruit polyphenols on neuronal behavioral aging
- (Review Article)
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| Lau, F.C., Shukitt Hale, B., Joseph, J.A. 2006. Beneficial effects of berryfruit polyphenols on neuronal behavioral aging. Journal of the Science of Food and Agriculture.86:2251-2255. |
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DIETARY SUPPLEMENTATION WITH BLUEBERRY EXTRACT IMPROVES SURVIVAL OF TRANSPLANTED DOPAMINE NEURONS
- (Peer Reviewed Journal)
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| Mcguire, S.O., Sortwell, C.E., Shukitt Hale, B., Joseph, J.A., Hejna, M.J., Collier, T.J. 2006. Dietary supplementation with blueberry extract improves survival of transplanted dopamine neurons. Nutritional Neuroscience. 9(5/6): 251-258. |
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Dopamine-Induced Stress Signaling in COS-7 Cells Transfected With Selectively Vulnerable Muscarinic Receptor Subtypes is Partially Mediated Via the i3 Loop and Antagonized By Blueberry Extract
- (Peer Reviewed Journal)
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| Joseph, J.A., Fisher, D.R., Carey, A.N., Bielinski, D.F. 2006. Dopamine-Induced Stress Signaling in COS-7 Cells Transfected With Selectively Vulnerable Muscarinic Receptor Subtypes is Partially Mediated Via the i3 Loop and Antagonized By Blueberry Extract. Journal of Alzheimer's Disease. 10:423-437. |
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BHT blocks NfkB activation and Ethanol-Induced Brain Damage
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| Crews, F.T., Nixon, K., Kim, D., Joseph, J.A., Shukitt Hale, B., Qin, L., Zou, J. 2006. Bht blocks nfkb activation and ethanol-induced brain damage. Alcoholism: Clinical and Experimental.30(11):1938-1949. |
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A blueberry-enriched antioxidant diet reduces an age-related deficit in one trial per day discriminative reward learning
- (Abstract Only)
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| Goyarzu, P., Malin, D.H., Moon, W.D., Moy, E., Moy, D., Jennings, R., Lippold, S., Shukitt Hale, B., Joseph, J.A. 2006. A blueberry-enriched antioxidant diet reduces an age-related deficit in one trial per day discriminative reward learning. Society for Neuroscience Abstracts and Proceedings. |
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COUPLING OF NEURONAL FUNCTION TO OXYGEN AND GLUCOSE METABOLISM THROUGH CHANGES IN NEUROTRANSMITTER DYNAMICS AS REVEALED WITH AGING, HYPOGLYCEMIA AND HYPOXIA
- (Book / Chapter)
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| Joseph, J.A., and Gibson, G.E. 2007. Coupling of neuronal function to oxygen and glucose metabolism through changes in neurotransmitter dynamics as revealed with aging, hypoglycemia and hypoxia. In Gibson, G.E. and Dienel, G., editors. Handbook of Neurochemistry and Molecular Biology. 3rd edition. Volume 5. New York, NY: Springer. p.297-320. |
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BLUEBERRY EXTRACT ALTERS OXIDATIVE STRESS-MEDIATED SIGNALING IN COS-7 CELLS TRANSFECTED WITH SELECTIVELY VULNERABLE MUSCARINIC RECEPTOR SUBTYPES
- (Peer Reviewed Journal)
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| Joseph, J.A., Fisher, D.R., Bielinski, D. 2006. Blueberry extract alters oxidative stress-mediated signaling in cos-7 cells transfected with selectively vulnerable muscarinic receptor subtypes. Journal of Alzheimer's Disease. 9(1):35-42. |
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Blueberries and the Aging Brain: Beyond Antioxidants
- (Trade Journal)
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| Mark, D.A., Shukitt Hale, B., Joseph, J.A. 2006. Blueberries and the Aging Brain: Beyond Antioxidants. The Food Journal.49(2):50-55. |
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BLUEBERRY POLYPHENOLS INCREASE CAENORHABDITIS ELEGANS SURVIVAL DURING AGING AND THERMAL STRESS
- (Peer Reviewed Journal)
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| Wilson, M.A., Shukitt Hale, B., Kalt, W., Ingram, D.K., Joseph, J.A., Wolkow, C.A. 2006. Blueberry polyphenols increase caenorhabditis elegans survival during aging and thermal stress. Aging Cell. (5):55-68 |
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AGE RELATED NEURONAL AND BEHAVIORAL DEFICITS ARE IMPROVED BY POLYPHENOL RICH BLUEBERRY SUPPLEMENTATION
- (Book / Chapter)
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| Lau, F.C., Shukitt Hale, B., Joseph, J.A. 2005. Age related neuronal and behavioral deficits are improved by polyphenol rich blueberry supplementation. CRC Press. p. 499. |
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THE BENEFICIAL EFFECTS OF FRUIT POLYPHENOLS ON BRAIN AGING
- (Review Article)
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| Lau, F.C., Shukitt Hale, B., Joseph, J.A. 2005. The beneficial effects of fruit polyphenols on brain aging. Neurobiology of Aging. 26S:S128-S132. |
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EFFECTS OF CONCORD GRAPE JUICE ON COGNITIVE AND MOTOR DEFICITS IN AGING
- (Peer Reviewed Journal)
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| Shukitt Hale, B., Carey, A.N., Simon, L.E., Mark, D.A., Joseph, J.A. 2006. Effects of Concord Grape Juice on Cognitive and Motor Deficits in Aging. Nutrition. 22:295-302. |
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MICROARRAY ANALYSIS REVEALS UPREGULATION OF NUCLEAR RECEPTOR SUBFAMILY 4, MEMBER 2 (NR4A2) BY NICOTINE IN VENTRAL TEGMENTAL AREA AND STRIATUM OF RAT
- (Abstract Only)
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| Gutala, R., Kim, J.M., Wang, J., Hwang, Y., Lau, F.C., Goyarzu, P., Malin, D.H., Li, M.D. 2005. Microarray analysis reveals upregulation of nuclear receptor subfamily 4, member 2 (nr4a2) by nicotine in ventral tegmental area and striatum of rat. Society for Neuroscience Abstracts and Proceedings. Abstract No. 1028.5. |
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BLUEBERRY EXTRACT INHIBITS DA-OR AB-INDUCED DECREMENTS IN CALCIUM FLUX IN PRIMARY HIPPOCAMPAL CELLS
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| Joseph, J.A., Fisher, D.R. 2005. Blueberry extract inhibits da-or ab-induced decrements in calcium flux in primary hippocampal cells. Society for Neuroscience Abstracts and Proceedings. Abstract No. 93.6. |
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INHIBITORY EFFECTS OF BLUEBERRY POLYPHENOLS ON THE PRODUCTION OF PROINFLAMMATORY MEDIATORS IN ACTIVATED MICROGLIAL CELLS
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| Lau, F.C., Bielinski, D.F., Joseph, J.A. 2005. Inhibitory effects of blueberry polyphenols on the production of proinflammatory mediators in activated microglial cells. Society for Neuroscience Abstracts and Proceedings. Abstract No. 337.17 |
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BLUEBERRY EXTRACT PREVENTS C-2 CERAMIDE DISRUPTION OF CA2+ BUFFERING IN MACHR-TRANSFECTED COS-7 CELLS
- (Abstract Only)
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| Fisher, D.R., Bielinski, D.F., Joseph, J.A. 2005. Blueberry extract prevents c-2 ceramide disruption of ca2+ buffering in machr-transfected cos-7 cells. Society for Neuroscience Abstracts and Proceedings. Abstract No. 93.7 |
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EFFECTS OF AGE AND EXPOSURE TO GOUND-BASED MODELS OF COSMIC RAYS ON ELEVATED PLUS MAZE PERFORMANCE IN RATS
- (Abstract Only)
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| Carrihill-Knoll, K.L., Maloney, B.K., Rabin, B.M., Shukitt Hale, B., Joseph, J.A., Carey, A.N. 2005. Effects of age and exposure to gound-based models of cosmic rays on elevated plus maze performance in rats. Society for Neuroscience Abstracts and Proceedings. Abstract No. 656.10. |
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DIFFERENTIAL EFFECTS OF BLUEBERRY EXTRACT PREPARATIONS ON COGNTIVE AND MOTOR FUNCTION IN AGING: THE ROLE OF PHENOLICS
- (Abstract Only)
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| Shukitt Hale, B., Carey, A.N., Kalt, W., Mcdonald, J., Vinqvist, M., Joseph, J.A. 2005. Differential effects of blueberry extract preparations on cogntive and motor function in aging: the role of phenolics. Society for Neuroscience Abstracts and Proceedings. Abstract No. 93.5. |
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OXIDATIVE STRESS AND INFLAMMATION IN BRAIN AGING: NUTRITIONAL CONSIDERATIONS
- (Review Article)
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| Joseph, J.A., Shukitt Hale, B., Casadesus, G., Fisher, D.R. 2005. Oxidative stress and inflammation in brain aging: nutritional considerations. Neurochemical Research. Volume(30):927-935 |
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THE EFFECTS OF ANTIOXIDANTS IN THE SENESCENT AUDITORY CORTEX
- (Peer Reviewed Journal)
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| De Rivera, C., Shukitt Hale, B., Joseph, J.A., Mendelson, J.R. 2006. The effects of antioxidants in the senescent auditory cortex. Neurobiology of Aging. 27(7):1035-1044. |
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DIETARY SUPPLEMENTATION WITH FRUIT POLYPHENOLICS AMELIORATES AGE-RELATED DEFICITS IN BEHAVIOR AND NEURONAL MARKERS OF INFLAMMATION AND OXIDATIVE STRESS
- (Peer Reviewed Journal)
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| Shukitt Hale, B., Meterko, V., Carey, A.N., Bielinski, D., Mcguie, T., Galli, R., Joseph, J.A. 2005. Dietary supplementation with fruit polyphenolics ameliorates age-related deficits in behavior and neuronal markers of inflammation and oxidative stress. Age. 2005, 27, 49-57. |
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REVERSING THE DELETERIOUS EFFECTS OF AGING ON NEURONAL COMMUNICATION AND BEHAVIOR: THE BENEFICIAL PROPERTIES OF FRUIT POLYPHENOLICS
- (Peer Reviewed Journal)
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| Joseph, J.A., Shukitt Hale, B., Casadesus, G. 2005. Reversing the deleterious effects of aging on neuronal communication and behavior: the beneficial properties of fruit polyphenolics. American Journal of Clinical Nutrition 2005, 81 (Suppl.) 313S-316S |
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EFFECT OF DIET ON THE DISRUPTION OF OPERANT RESPONDING AT DIFFERENT AGES FOLLOWING EXPOSURE TO FE56 PARTICLES
- (Peer Reviewed Journal)
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| Rabin, B.M., Carrihill-Knoll, K.L., Carey, A.N., Shukitt Hale, B., Joseph, J.A. 2005. Effect of diet on the disruption of operant responding at different ages following exposure to fe56 particles. Age. 205, 27, 69-73. |
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DIET AS A FACTOR IN BEHAVIORAL RADIATION PROTECTION FOLLOWING EXPOSURE TO HEAVY PARTICLES
- (Peer Reviewed Journal)
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| Rabin, B.M., Shukitt Hale, B., Joseph, J.A., Tood, P. 2005. Diet as a factor in behavioral radiation protection following exposure to heavy particles. American Society for Gravitation and Space Biology 18(2)June 2005. |
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ANTHOCYANINS IN AGED BLUEBERRY-FED RATS ARE FOUND CENTRALLY AND MAY ENHANCE MEMORY
- (Peer Reviewed Journal)
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| Andres-Lacueva, C., Shukitt Hale, B., Galli, R.L., Jaurengui, O., Lamuela-Raventos, R.M., Joseph, J.A. 2005. Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutritional Neuroscience, April 2005:8(2): 111-120. |
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EFFECTS OF AGE AND DIET ON THE HEAVY PARTICLE-INDUCED DISRUPTIONS OF OPERANT RESPONDING PRODUCED BY A GROUND-BASED MODEL FOR EXPOSURE TO COSMIC RAYS
- (Peer Reviewed Journal)
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| Rabin, B.M., Joseph, J.A., Shukitt Hale, B., 2005. Effects of age and diet on the heavy particle-induced disruptions of operant responding produced by a ground-based model for exposure to cosmic rays. Brain Research 1036(2005) 122-129. |
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A LONGITUDINAL STUDY OF OPERANT RESPONDING IN RATS IRRADIATED AT TWO MONTHS OF AGE
- (Peer Reviewed Journal)
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| Rabin, B.M., Joseph, J.A., Shukitt Hale, B. 2005. A longitudinal study of operant responding in rats irradiated at two months of age. Radiation Research. 164:552-555. |
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MODULATION OF HIPPOCAMPAL PLASTICITY AND COGNITIVE BEHAVIOR BY SHORT-TERM BLUEBERRY SUPPLEMENTATION IN AGED RATS
- (Peer Reviewed Journal)
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| Casadesus, G., Shukitt Hale, B., Stellwagen, H.M., Zhu, X., Lee, H., Smith, M.A., Joseph, J.A. 2004. Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats. Nutritional Neuroscience, Volume 7 Number 5/6 (October/December 2004), pp.309-316 |
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FLAVONOIDS AND THE BRAIN: INTERACTIONS AT THE BLOOD BRAIN BARRIER AND THEIR PHYSIOLOGICAL EFFECT ON THE CNS
- (Review Article)
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| Youdim, K.A., Shukitt Hale, B., Joseph, J.A. 2004. Flavonoids and the brain: interactions at the blood brain barrier and their physiological effect on the cns. Free Radical Biology and Medicine, VOL 37, NO11 PP. 1683-1693. |
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THE BENEFICIAL EFFECTS OF FRUIT AND VEGETABLE SUPPLEMENTATION ON NEURONAL SIGNALING AND BEHAVIOR IN AGING: BEYOND ANTIOXIDANTS
- (Book / Chapter)
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| Joseph, J.A., Shukitt Hale, B., Casadesus, G. 2006. The beneficial effects of fruit and vegetable supplementation on neuronal signaling and behavior in aging: beyond antioxidants. In: Stagg, J.J. and Foster, J. G. Editors. Nutrients, Stress and Medical Disorders. Totowa, MJ:Humana Press. p. 67-82 |
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FRUIT POLYPHENOLS PREVENT INFLAMMATORY MEDIATED DECREMENTS IN COGNITION
- (Proceedings)
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| Shukitt Hale, B., Carey, A.N., Belinski, D., Lau, F.C., Galli, R.L., Spangler, E.L., Ingram, D.K., Joseph, J.A. 2004. Fruit polyphenols prevent inflammatory mediated decrements in cognition. Soc. Neurosci. Abs. 2004, 30,565.5. |
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BLUEBERRY EXTRACT INHIBITS DA-INDUCED INCREASES IN MAPK SIGNALING IN MUSCARINIC M1 AND M3-TRANSFECTED COS-7 CELLS
- (Proceedings)
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| Joseph, J.A., Bielinski, D., Fisher, D.R. 2004. Blueberry extract inhibits DA-induced increases in MAPK signaling in Muscarinic M1 and M3-transfected COS-7 cells. Soc.Neurosci. Abs. 2004, 30, 1017.17. |
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THE BENEFICIAL PROPERTIES OF FRUIT POLYPHENOLS ON NEURONAL COMMUNICATION AND BEHAVIOR IN AGING
- (Book / Chapter)
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| Joseph, J.A., Shukitt Hale, B., Casadesus, G. 2004. The beneficial properties of fruit polyphenols on neuronal communication and behavior in aging. In: Stagg, J.J., Foster, J.G. editors. Medicinal and Aromatic Plants: Production, Business and Applications. West Virginia: Mountain State University Press. p.18-30. |
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DIETARY SUPPLEMENTATION WITH BLUEBERRY EXTRACT DECREASES INFLAMMATION AFTER BRAIN INJURY IN RATS: IMPLICATIONS FOR NEURAL TRANSPLANTATION
- (Proceedings)
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| Mcguire, S.O., Hejna, M.J., Shukitt Hale, B., Joseph, J.A., Collier, T.J., Lorens, S.A. Dietary supplementation with blueberry extract decreases inflammation after brain injury in rats: implications for neural transplantation. 2004 Society for Neuroscience Abstracts and Proceedings. |
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FRUIT POLYPHENOLICS AND SIGNALING IN THE AGED BRAIN:ALTERING MOTOR AND COGNITIVE DEFICITS
- (Book / Chapter)
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| Joseph, J.A., Shukitt Hale, B. 2004. Fruit polyphenolics and signaling in the aged brain:altering motor and cognitive deficits. In: Ozben, T., Chevion. M., editors. Frontiers in Aging and Neurodegenerative Disorders: Fundamental Aspects, Clinical Perspectives and New Insights. Amsterdam, The Netherlands:IOS Press. p. 170-181. |
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NUTRITIONAL ANTIOXIDANTS, VITAMINS, COGNITION AND NEURODEGENERATIVE DISEASE
- (Book / Chapter)
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| Martin, A., Smith, M.A., Perry, G., Joseph, J.A. 2004. Nutritional antioxidants, vitamins, cognition and neurodegenerative disease. Principles of Gender Specific Medicine, Volume 2. Elsevier: San Diego, 2004, 813-823. |
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ALZHEIMER DISEASE: CAUSES, CONSEQUENCES AND SURPRISES
- (Other)
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| Smith, M.A., Zhu, X., Casadesus, G., Aliev, G., Ogawa, O., Nunomura, A., Takeda, A., Joseph, J.A., Peterson, R.B., Perry, G., 2003. Alzheimer disease: causes, consequences and surprises. Biogerontology 2003, 4 (Suppl 1): 88-89. |
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EAT LESS, EAT BETTER, AND LIVE LONGER: DOES IT WORK AND IS IT WORTH IT? THE ROLE OF DIET IN AGING AND DISEASE
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| Casadesus, G., Perry, G., Joseph, J.A., Smith, M.A. 2004. Eat less, eat better, and live longer: does it work and is it worth it? the role of diet in aging and disease. In: edited by Post, S.G. and Binstock, R.H. The Fountain of Youth: Cultural, Scientific and Ethical Perspectives on a Biomedical Goal. New York:Oxford University Press. p. 463. |
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