Publications (Clicking on the reprint icon will take you to the publication reprint.)

FATTY ACIDS MODULATE TOLL-LIKE RECEPTOR 4 ACTIVATION THROUGH REGULATION OF RECEPTOR DIMERIZATION AND RECRUITMENT INTO LIPID RAFTS - (Peer Reviewed Journal)

(01-Aug-09)

Suppression of the TRIF-dependent signaling pathway of Toll-like receptors by luteolin     - (Peer Reviewed Journal)

Lee, J., Kim, S., Kim, Y., Lee, W., Hwang, D.H., Lee, J. 2009. Suppression of the TRIF-dependent signaling pathway of Toll-like receptors by luteolin. Biochemical Pharmacology. Vol.77:1391-1400.

DHA Supplementation Decreases Serum C - Reactive Protein and Other Markers of Inflammation in Hypertriglyceridemic Men1-3     - (Peer Reviewed Journal)

Kelley, D.S., Siegel, D., Fedor, D.M., Adkins, Y.C., Mackey, B.E. 2009. Docosahexaenoic Acid Supplementation Decreases Serum C - Reactive Protein and Other Markers of Inflammation in Hypertriglyceridemic Men1-3. Journal of Nutrition. 138: 30-35, 2008.

HIGH GLUCOSE INDUCES TOLL-LIKE RECEPTOR EXPRESSION IN HUMAN MONOCYTES: MECHANISM OF ACTIVATION     - (Peer Reviewed Journal)

Dasu, M.R., Devaraj, S., Ling, Z., Hwang, D.H., Jialal, I. 2008. HIGH GLUCOSE INDUCES TOLL-LIKE RECEPTOR EXPRESSION IN HUMAN MONOCYTES: MECHANISM OF ACTIVATION. Diabetes 57(11):3090-3098, 2008.

Inhibition of Nod2 signaling and target gene expression by curcumin     - (Peer Reviewed Journal)

Huang, S., Zhao, L., Kim, K., Lee, D., Hwang, D.H. 2008. Inhibition of Nod2 signaling and target gene expression by curcumin. Molecular Pharmacology 74(1):274-281, 2008.

Vitamin A deficiency decreases and high dietary vitamin A increases disease severity in the mouse model of asthma - (Peer Reviewed Journal)

Schuster, G.U., Kenyon, N.J., Stephensen, C.B. 2008. Vitamin A deficiency decreases and high dietary vitamin A increases disease severity in the mouse model of asthma. Journal of Immunology, 180:1834-1842.

Garlic (Allium sativum) Extracts Inhibits Lipopolysaccharide-Induced Toll-Like Receptor 4 Dimerization     - (Peer Reviewed Journal)

Youn, H., Lim, H., Lee, H., Hwang, D.H., Yang, M., Jeon, R., Ryu, J. 2008. Garlic (Allium sativum) Extracts Inhibits Lipopolysaccharide-Induced Toll-Like Receptor 4 Dimerization. Bioscience Biotechnology and Biochemistry 72(2):368-375, 2008.

Acrolein with an alpha, beta-unsaturated Carbonyl Group Inhibits LPS-induced Homodimerization of Toll-like Receptor 4 - (Peer Reviewed Journal)

Lee, J., Lee, J., Lee, M., Hwang, D.H., Youn, H. 2007. Acrolein with an alpha, beta-unsaturated Carbonyl Group Inhibits LPS-induced Homodimerization of Toll-like Receptor 4. Molecules and Cells. Vol.25, No2, 253-257.

Docosahexaenoic acid supplementation decreases remnant-like particle-cholesterol and increases omega-3 index in hypertriglyceridemic men1-3.     - (Peer Reviewed Journal)

Kelley, D.S., Siegel, D., Vemuri, M., Chung, G.H., Mackey, B.E. 2007. Docosahexaenoic acid supplementation decreases remnant-like particle-cholesterol and improves omega-3 index in hypertriglyceridemic men1-3.. Journal of Nutrition. 2007. Journal Nutrition 138:30-35, 2008.

Docosahexaenoic Acid (DHA) But Not Eicosapentaenoic Acid (EPA) Reverses Trans-10, Cis-12 Conjugated Linoleic Acid Induced Insulin Resistance in Mice1 - (Peer Reviewed Journal)

Vemuri, M., Kelley, D.S., Mackey, B.E., Rasooly, R., Bartolini, G.L. Docosahexaenoic Acid (DHA) But Not Eicosapentaenoic Acid (EPA) Reverses Trans-10, Cis-12 Conjugated Linoleic Acid Induced Insulin Resistance in Mice. Metabolic Syndrome and Related Disorders, 2007 Vol.5, No.4:315-322.

Health Effects of Foods Rich in Polyphenols - (Book / Chapter)

Vermuri, M., Kelley, D.S., Erickson, K. 2008. Health Effects of Foods Rich in Polyphenols. Book Chapter, "Wild-Type Food in Health Promotion and Disease Prevention, The Columbus Concept. De Meester, Fabien; Watson, Ronald R. (Eds.) Humana Press, Chapter 27;pp.393-412.

Cinnamaldehyde suppresses Toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization     - (Peer Reviewed Journal)

Youn, H.S., Lee, J.K., Choi, Y.J., Saitoh, S.I., Miyake, K., Hwang, D.H., Lee, J.Y. 2008. Cinnamaldehyde suppresses Toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization. 2007. Biochemical Pharmacology. Vol.75(2), p.494-502, 2008.

Docosahexaenoic acid supplementation improves fasting and postprandial plasma lipid profiles in hypertriglyceridemic men.     - (Peer Reviewed Journal)

Kelley, D.S., Siegel, D., Vemuri, M., Mackey, B.E. 2007. Docosahexaenoic acid supplementation improves fasting and postprandial plasma lipid profiles in hypertriglyceridemic men. American Journal of Clinical Nutrition. 86:324-333, 2007.

THE MODULATION OF INFLAMMATORY GENE EXPRESSION BY LIPIDS: MEDIATION THROUGH TOLL-LIKE RECEPTORS - (Review Article)

Lee, J., Hwang, D.H. The modulation of inflammatory gene expression by lipids: mediation through toll-like receptors. Review Article. 2006. Molecules and Cells, Vol.21,No.2,pp.174-185.

Differential Modulation of Nods Signaling Pathways by Fatty Acids in Human Colonic Epithelial HCT116 cells     - (Peer Reviewed Journal)

Zhao, L., Kwon, M., Lee, J.Y., Fukase, K., Inohara, N., Hwang, D.H. 2007. Differential Modulation of Nods Signaling Pathways by Fatty Acids in Human Colonic Epithelial HCT116 cells. Journal of Biological Chemistry. Vol.282, No.16,pp.11618-11628.

The Effects of Dietary Fatty Acids on Lipid Metabolism - (Book / Chapter)

Vemuri, M., Kelley, D.S. 2007. The Effects of Dietary Fatty Acids on Lipid Metabolism. Book Chapter in, "Fatty Acids in Foods and their Health Implications, third edition". CRC Press Taylor & Francis Group pp.591-630.

AURANOFIN, AS AN ANTI-RHEUMATIC GOLD COMPOUND SUPPRESSES LPS-INDUCED HOMODIMERIZATION OF TLR4     - (Peer Reviewed Journal)

Youn, H.S., Lee, J.Y., Saitoh, S.I., Miyake, K., Hwang, D.H. 2006. AURANOFIN, AS AN ANTI-RHEUMATIC GOLD COMPOUND SUPPRESSES LPS-INDUCED HOMODIMERIZATION OF TLR4. Biochemistry and Biophysics Research Communication. 350 (2006) 866-871.

DIETARY T10, C-12-CONJUGATED LINOLEIC ACID REDUCES THE EXPRESSION OF FATTY ACID OXIDATION AND DRUG DETOXIFICATION ENZYMES IN MOUSE LIVER     - (Peer Reviewed Journal)

Rasooly, R., Kelley, D.S., Greg, J., Mackey, B.E. Dietary t10, c-12-conjugated linoleic acid reduces the expression of fatty acid oxidation and drug detoxification enzymes in mouse liver. Journal of Nutrition. 97:58-66, 2007.

SUPPRESSION OF MYD88- AND TRIF-DEPENDENT SIGNALING PATHWAYS OF TOLL-LIKE RECEPTOR BY (-)-EPIGALLOCATECHIN-3-GALLATE, A POLYPHENOL COMPONENT OF GREEN TEA     - (Peer Reviewed Journal)

Youn, H.S., Lee, J.Y., Saotoh, S.I., Miyake, K., Kang, K.W., Choi, Y., Hwang, D.H. 2006. Suppression of myd88- and trif-dependent signaling pathways of toll-like receptor by (-)-epigallocatechin-3-gallate, a polyphenol component of green tea. Biochemical Pharmacology; Elsevier 72 (2006) 850-859.

GENOME-WIDE IDENTIFICATION OF PEROXISOME PROLIFERATOR RESPONSE ELEMENTS USING INTEGRATED COMPUTATIONAL GENOMICS     - (Peer Reviewed Journal)

Lemay, D.G., Hwang, D.H. Genome-wide identification of peroxisome proliferator response elements using integrated computational genomics. Journal of Lipid Research. 47:1583-1587, 2006.

INHIBITION OF HOMODIMERIZATION OF TOLL-LIKE RECEPTOR 4 BY CURCUMIN     - (Peer Reviewed Journal)

Youn, H.S., Saitoh, S.I., Miyake, K., Hwang, D.H. 2006. INHIBITION OF HOMODIMERIZATION OF TOLL-LIKE RECEPTOR 4 BY CURCUMIN. Biochemical Pharmacology. 72(2006):62-69.

FATTY ACID PROFILES OF LIVER, ADIPOSE TISSUE, SPLEEN, AND HEART OF MICE FED DIETS CONTAINING T10, C-12-, AND C9, T11-CONJUGATED LINOLEIC ADIC     - (Peer Reviewed Journal)

Kelley, D.S., Bartolini, G.L., Newman, J.W., Vemuri, M., Mackey, B.E. 2006. FATTY ACID PROFILES OF LIVER, ADIPOSE TISSUE, SPLEEN, AND HEART OF MICE FED DIETS CONTAINING T10, C-12-, AND C9, T11-CONJUGATED LINOLEIC ADIC. Prostaglandins Leukotrienes and Essential Fatty Acids. 74:331-338.

THE INNATE IMMUNE SYSTEM - FRIEND AND FOE     - (Peer Reviewed Journal)

Kelley, D.S., Stephensen, C.B. 2006. THE INNATE IMMUNE SYSTEM - FRIEND AND FOE. American Journal of Clinical Nutrition. 83:187-188, 2006.

CONSUMPTION OF BING SWEET CHERRIES LOWERS CIRCULATING CONCENTRATIONS OF INFLAMMATION MARKERS IN HEALTHY MEN AND WOMEN     - (Peer Reviewed Journal)

Kelley, D.S., Rasooly, R., Jacob, R.A., Kader, A.A., Mackey, B.E. 2006. CONSUMPTION OF BING SWEET CHERRIES LOWERS CIRCULATING CONCENTRATIONS OF INFLAMMATION MARKERS IN HEALTHY MEN AND WOMEN. Journal of Nutrition. 136:981-986, 2006.

THE REGULATION OF THE EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE BY SRC-FAMILY TYROSINE KINASE MEDIATED THROUGH MYD88-INDEPENDENT SIGNALING PAYWAYS OF TOLL-LIKE RECEPTOR 4 - (Peer Reviewed Journal)

Lee, J.Y., Lowell, C.A., Lemay, D.G., Youn, H.S., Rhee, S.H., Sohn, K.H., Jang, B., Ye, J., Chung, J.H., Hwang, D.H. 2005. THE REGULATION OF THE EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE BY SRC-FAMILY TYROSINE KINASE MEDIATED THROUGH MYD88-INDEPENDENT SIGNALING PAYWAYS OF TOLL-LIKE RECEPTOR 4. Biochemical Pharmacology, 70:1231-1240.

SPECIFIC INHIBITION OF MYD88-INDEPENDENT SIGNALING PATHWAYS OF TOLL-LIKE RECEPTOR 3 AND 4 BY RESVERATROL: MOLECULAR TARGETS ARE TBK1 IN TRIF COMPLEX*     - (Peer Reviewed Journal)

Youn, H.S., Lee, J.Y., Fitzgerald, K.A., Young, H., Akira, S., Hwang, D.H. 2005. SPECIFIC INHIBITION OF MYD88-INDEPENDENT SIGNALING PATHWAYS OF TOLL-LIKE RECEPTOR 3 AND 4 BY RESVERATROL: MOLECULAR TARGETS ARE TBK1 IN TRIF COMPLEX. Journal of Immunology. 175:3339-3346, 2005.

SRC-FAMILY TYROSINE KINASE INHIBITOR (PP1) SUPPRESSES LPS-INDUCED EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE MEDIATED THROUGH THE INHIBITION OF INTERFERON B EXPRESSION IN MACROPHAGES - (Abstract Only)

Lee, J., Youn, H.S., Lemay, D., Lowell, C.A., Hwang, D.H. Src-family tyrosine kinase inhibitor (pp1) suppresses lps-induced expression of inducible nitric oxide synthase mediated through the inhibition of interferon b expression in macrophages. Experimental Biology. Abstract 829.7 (pge A1453)

SATURATED AND POLYUNSATURATED FATTY ACIDS RECIPROCALLY MODULATE DENDRITIC CELL FUNCTIONS MEDIATED THROUGH TLR4     - (Peer Reviewed Journal)

Weatherill, A., Lee, J., Zhao, L., Lemay, D., Youn, H.S., Hwang, D.H. Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through tlr4. Journal of Immunology. 174:5390-5397, 2005.

INHIBITION OF INSULIN SENSITIVITY BY FREE FATTY ACIDS REQUIRES ACTIVATION OF MULTIPLE SERINE KINASES IN 3T3-L1 ADIPOCYTES     - (Peer Reviewed Journal)

Gao, Z., Zhang, X., Zuberi, A., Hwang, D.H., Quon, M.J., Lefevre, M., Ye, J. Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3t3-l1 adipocytes. Molecular Endocrinology 18:2024-2034, (2004).