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Research Project:
IMPACT OF NUTRITIONAL STATUS ON IMMUNE-INDUCED CHANGES IN GUT FUNCTION
Location: Diet, Genomics and Immunology Lab
Publications
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Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function
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| Morales-Tirado, V., Sojka, D.K., Katzman, S.D., Lazarski, C.A., Finkelman, L.D., Urban Jr, J.F., Fowell, D.J. 2010. Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function. Blood. 115(17):3498-3507. |
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Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection
- (Peer Reviewed Journal)
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| Herbert, D.R., Yang, J.Q., Hogan, S.P., Groschwitz, K., Khodoun, M., Munitz, A., Orekov, T., Perkins, C., Wang, Q., Brombacher, F., Urban Jr, J.F., Rothenberg, M.E., Finkelman, F.D. 2009. Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection. Journal of Experimental Medicine. 206(13):2947-2957. |
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IL-13 receptor alpha-2 regulates the immune and functional response to Nippostrongylus brasiliensis infection
- (Peer Reviewed Journal)
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| Morimoto, M., Zhao, A., Sun, R., Stiltz, J., Madden, K.B., Mentink-Kane, M., Ramalingam, T., Wynn, T.A., Urban Jr, J.F., Shea-Donohue, T. 2009. IL-13 receptor alpha-2 regulates the immune and functional response to Nippostrongylus brasiliensis infection. Journal of Immunology. 183(3):1934-1999. |
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Quantitative evaluation of his-tag purification and immunoprecipitation of tristetraprolin and its mutant proteins from transfected human cells
- (Peer Reviewed Journal)
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| Cao, H., Lin, R. 2009. Quantitative evaluation of his-tag purification and immunoprecipitation of tristetraprolin and its mutant proteins from transfected human cells. Biotechnology Progress. 25:461-467. |
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Anti-inflammatory Mechanisms of Enteric Heligmosomoides polygyrus Infection on TNBS-Induced Colitis in a Murine Model
- (Peer Reviewed Journal)
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| Sutton, T.L., Zhao, A., Madden, K.B., Elfrey, J.E., Tuft, B.A., Sullivan, C.A., Urban Jr, J.F., Shea-Donohue, T. 2008. Anti-inflammatory mechanisms of enteric Heligmosomoides polygyrus infection on TNBS-induced colitis in a murine model. Infection and Immunity 76(10):4772-82. |
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Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages
- (Peer Reviewed Journal)
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| Zhao, A., Urban Jr, J.F., Anthony, R.M., Sun, R., Stiltz, J., van Rooijen, N., Wynn, T.A., Gause, W.C., Shea-Donohue, T. 2008. Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages. Gastroenterology. 135(1):217-225. |
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Production and characterization of ZFP36L1 antiserum against recombinant protein from Escherichia coli
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| Cao, H., Lin, R., Ghosh, S., Anderson, R.A., Urban Jr, J.F. 2008. Production and characterization of ZFP36L1 antiserum against recombinant protein from Escherichia coli. Biotechnology Progress. 24(2)326-333. |
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Production and Characterization of ZFP36L1 Antiserum Against Recombinant Protein From Escherichia coli
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| Cao, H., Lin, R., Ghosh, S., Anderson, R.A., Urban Jr, J.F. 2008. Production and Characterization of ZFP36L1 Antiserum Against Recombinant Protein From Escherichia coli. [abstract]. Journal of Federation of American Societies for Experimental Biology. 22:1003.7. |
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Heligmosomoides polygyrus promotes T regulatory cytokine production in the normal distal murine intestine.
- (Peer Reviewed Journal)
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| Setiawan, T., Metwali, A., Blum, A., Urban Jr, J.F., Elliott, D., Weinstock, J. 2007. Heligmosomoides polygyrus promotes T regulatory cytokine production in the normal distal murine intestine. Infection and Immunity. |
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Amphiregulin-a Th2 cytokine enhancing resistance to nematodes
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| Zaiss, D.M., Yang, L., Shah, P.R., Kobie, J.J., Urban, J.F., Mosmann, T.R. 2006. Amphiregulin-a TH2 cytokine enhancing resistance to nematodes. Science. 314(5806):1746. |
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Il-4producing memory T-cells induce alternatively activated macrophages to mediate protection against nematode parasites.
- (Peer Reviewed Journal)
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| Anthony, R.M., Urban Jr, J.F., Alem, F., Hamed, H.A., Boucher, J., Van Rooijen, N., Gauge, W.C. 2006. IL-4-producing memory T cells induce alternatively activated macrophages to mediate protection against nematode parasites. Nature (Medicine). 12(8):955-960. |
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IL-18 STIMULATES IL-13 MEDIATED IFN-GAMMA SENSITIVE HOST RESISTANCE IN VIVO
- (Peer Reviewed Journal)
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| Liu, Q., Liu, Z., Whitmire, J., Alem, F., Hamed, H., Pesce, J., Urban Jr, J.F., Gause, W. 2006. IL-18 stimulates IL-13 mediated INF-gamma sensitive host resistance in vivo. European Journal of Immunology. 36(5):1187-1198. |
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CONTRIBUTION OF 5-HT2A RECEPTOR IN NEMATODE INFECTION-INDUCED MURINE INTESTINAL SMOOTH MUSCLE HYPER CONTRACTILITY
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| Zhao, A., Urban, Jr, J.F., Morimoto, M., Elfrey, J., Madden, K., Finkelman, F., Shea-Donohue, T. 2006. Contribution of 5-HT2A receptor in nematode infection-induced murine intestinal smooth muscle hyper contractility. Gastroenterology. 131(2):568-578 |
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FUNCTIONAL IMPORTANCE OF REGIONAL DIFFERENCES IN LOCALIZED GENE EXPRESSION OF RECEPTORS FOR IL-13 IN MURINE GUT
- (Peer Reviewed Journal)
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| Morimoto, M., Morimoto, M., Zhao, A., Madden, K., Dawson, H., Finkleman, F., Mentink-Kane, M., Urban Jr., J.F., Wynn, T., and Shea-Donohue, T. 2006. Functional importance of regional differences in localized gene expression of receptors for IL-13 in murine gut. Journal of Immunology. 176(1):491-495. |
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ALTERNATIVELY ACTIVATED MACROPHAGES ACCUMULATE AT THE HOST PARASITE INTERFACE AND CONTRIBUTE TO PROTECTION AGAINST A NEMATODE PARASITE.
- (Abstract Only)
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| Anthony, R., Urban Jr, J.F., Alem, F., Hamed, H., Van Rooijen, N., Gause, W. 2005. Alternatively activated macrophages accumulate at the host parasite interface and contribute to protection against a nematode parasite.. Meeting Abstract. |
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IMMUNE REGULATION OF PROTEASE-ACTIVATED RECEPTOR-1 EXPRESSION IN MURINE SMALL INTESTINE DURING NIPPOSTRONGYLUS BRASILIENSIS INFECTION
- (Peer Reviewed Journal)
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| Zao, A., Morimoto, M., Dawson, H., Elfrey, J.E., Madden, K.B., Gause, W.C., Min, B., Finkelman, F.D., Urban, J.F. Jr., Shea-Donohue, T. 2005. Immune regulation of protease-activated receptor-1 expression in murine small intestine during nippostrongylus brasiliensis infection. Journal of Immunology. 175(4):2563-2569. |
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THE IL-21 RECEPTOR AUGUMENTS TH2 EFFECTOR FUNCTION AND ALTERNATIVE MACROPHAGE ACTIVATION.
- (Peer Reviewed Journal)
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| Pesce, J., Kaviratne, M., Ramalingam, T., Thompson, R.W., Urban Jr, J.F., Cheever, A., Young, D., Collins, M., Grusby, M., Wynn, T. 2006. The IL-21 receptor auguments Th2 effector function and alternative macrophage activation. Journal of Clinical Investigation. 116(7):2044-2055. |
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CONDITIONAL DELETION OF GATA-3 REVEALS ITS CRITICAL ROLE IN TH1/TH2 RESPONSES
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| Zhu, J., Min, B., Hu-Li, J., Watson, C., Grinberg, A., Wang, Q., Killeen, N., Urban Jr, J.F., Guo, L., Paul, W. 2004. Conditional deletion of gata-3 reveals its critical role in th1/th2 responses. Nature Immunology. 5(11):1157-1165. |
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HELIGMOSOMOIDES POLYGYRUS INHIBITS ESTABLISHED COLITIS IN IL-10 DEFICIENT MICE
- (Peer Reviewed Journal)
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| Elliott, D.E., Setiawan T., Metwali, A., Blum, A., Urban, Jr., J.F., Weinstock, J.V. 2004. Heligmosomoides polygyrus inhibites established colitis in IL-10 deficient mice. European Journal of Immunology. 34:2690-2696. |
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DEPENDENCE OF I1-4, IL-13, AND NEMATODE-INDUCED ALTERATIONS IN MURINE SMALL INTESTINAL SMOOTH MUSCLE CONTRACTILITY ON STAT6 AND ENTERIC NERVES
- (Peer Reviewed Journal)
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| Zhao, A., Mcdermott, J., Urban Jr, J.F., Gause, W., Madden, K., Auyeung, K., Morris, S., Finkelman, F., Shea-Donohue, T. 2004. Dependence of i1-4, il-13, and nematode-induced alterations in murine small intestinal smooth muscle contractility on stat6 and enteric nerves. Journal of Immunology. 171:948-954 (2003). |
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