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Summary: Methods and compositions for rapidly identifying CGEPs required for viral infection of mammalian cells are provided. Also provided are methods of inhibiting viral infection of mammalian cells by inhibiting the activity of one or more CGEPs (e.g., as identified in accordance with methods of the invention) in the cells. Aspects of the invention further include specifically identified CGEPs implicated in mammalian cell infection of specific viruses, e.g., African Swine Fever Virus and Foot and Mouth Virus, and methods of modulating their activity to achieve viral resistance.
Patent Status: Patent Application Filed on August 2, 2007. Link at USPTO filed under patent title “Methods and compositions for identifying cellular genes exploited by viral pathogens.”
Inventors:
Laszlo Zsak
Endemic Poultry Viral Diseases Research Unit
USDA,ARS,SAA, SPRL
934 COLLEGE STATION ROAD
ATHENS, GA, 30605
Phone: (706) 546-3654
Fax: (706) 546-3161
Laszlo.Zsak@ars.usda.gov
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Docket Number: 16108