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United States Department of Agriculture

Agricultural Research Service

Title: Method to Control Insect Reproduction
See also: US Patent Office Full Record

Midwest Area

Patent Number: 7129226
Docket Number: 16603
Serial Number: 10659509
Date Patented: 10/31/2006

Technology Description:

The invention relates to novel pseudopeptide analogs of the insect allatostatin neuropeptide family, which possess biological activity mimicking that of the naturally occurring neuropeptides. By addition of a hydrophobic moiety to an active portion of the allatostatin peptides, analogs are produced which exhibit an overall amphiphilic nature and which are capable of penetrating the insect cuticle while still retaining biological activity. By substituting sterically hindered amino acids or aromatic acids for any or all of the second, third, or fifth amino acid residues of the allatostatic C-terminal pentapeptide, analogs have been produced which are resistant to degradation by insect peptidases while still retaining biological activity. The analogs may be used for insect control by disrupting critical reproductive and/or developmental processes normally regulated by allatostatins in insects.


Please refer to USPN 7,129,226 (Docket #0166.03), "Mimetic Insect Allatostatin Analogs for Insect Control," issued on October 31, 2006, which is a cip of S.N. 10/659,233 (Docket #0165.03), filed on September 10, 2003, and a divisional of S.N. 10/385,317 (Docket #0062.03), filed on March 10, 2003, and a divisional of USPN 6,664,371 (Docket #0239.00), issued on December 17, 2003, and a divisional of USPN 6,207,643 (Docket #0047.99), issued on March 27, 2001.  Foreign rights are not available.


Ronald J. Nachman 
Areawide Pest Management Research 
2881 F&B Road
College Station, TX 77845
(979) 260-9315 / Fax: (979) 260-9377
Peter E. A. Teal 
Chemistry Research
1600-1700 S.W. 23rd Drive
Gainesville, FL 32604
(352) 374-5788 / Fax: (352) 374-5707
Christopher S. Garside 
University of Toronto
Toronto, Canada
(416) 978-3517 / Fax: (416) 978-3522


Stephen S. Tobe
University of Toronto
Toronto, Canada
(416) 978-3517 / Fax: (416) 978-3522










Last Modified: 10/1/2015
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