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United States Department of Agriculture

Agricultural Research Service

Title: Method to Control Insect Reproduction for Insect Control
See also: US Patent Office Full Record

Plains Area

Patent Number: 7078384
Docket Number: 6203
Serial Number: 10385317
Date Patented: 07/18/2006

Technology Description:


The invention relates to novel pseudopeptide analogs from the insect allatostatin neuropeptide family, which possess biological activity that mimic naturally occurring neuropeptides.  By adding a hydrophobic moiety to an active portion of the allatostatin peptides, analogs are produced which exhibit an overall amphiphilic nature and which are capable of penetrating the insect cuticle while still retaining biological activity.  By substituting sterically hindered amino acids or aromatic acids for any or all of the second, third, or fifth amino acid residues of the allatostatic C-terminal pentapeptide, analogs have been produced which are resistant to degradation by insect peptidases while still retaining biological activity.   The analogs may be used for insect control by disrupting critical reproductive and/or developmental processes normally regulated by allatostatins in insects.




Please refer to USPN 7,078,384 (Docket #0062.03). AMimetic Insect Allatostatin Analogs for Insect Control,@ which issued on July 18, 2006, and is a divisional of USPN 6,664,371 (Docket #0239.00), which issued on December 16, 2003, and is a divisional of USPN 6,207,643 (Docket #0047.99), which issued on March 27, 2001.

Foreign rights are not available.




Ronald J. Nachman
Areawide Pest Management Research
2771 F&B Road
College Station, TX  77845
Phone: (979)260-9315
    Fax: (979)260-9386

Christopher S. Garside
University of Toronto
Toronto, Ontario, Canada
Phone: (416)978-3517
    Fax: (416)978-3522

Peter E. A. Teal
Chemistry Research
1600-1700 S.W. 23rd Drive
Gainesville, FL  32608

Phone: (352)374-5730
    Fax: (352)374-5707

Stephen S. Tobe
University of Toronto
Toronto, Ontario, Canada
Phone: (416)978-3517
   Fax: (416)978-3522


Last Modified: 10/1/2015
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