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United States Department of Agriculture

Agricultural Research Service

Title: Methods for Detection of Prion Protein as an Indication of Transmissible Spongiform Encephalopathies
See also: US Patent Office Full Record

Pacific West Area


Patent Number: 6514707
Docket Number: 22800
Serial Number: 9687672
Date Patented: 02/04/2003

Methods for Detection of Prion Protein as an Indication of Transmissible Spongiform Encephalopathies

Technology Description:

The invention involves a non-invasive method of detecting a specific protein that indicates the presence of transmissible spongiform encephalopathies (TSE) in ruminant animals. The invention uses monoclonal antibodies that bind to a prion protein in animal tissue from sheep, cattle, mule, deer and elk. The invention comprises a non-invasive diagnostic assay using third eyelid lymphoid tissue to detect prion protein in sheep. The invention is a specific, reliable and flexible tool to accurately diagnose TSE. This method is a practical and inexpensive way to test for presence of this potentially fatal neurological disease.

Reference:

Please refer to USPN 6,514,707, which issued on February 4, 2003, and is a division of USPN 6,165,784, "Antibodies for the Detection of Prion Protein as an Indication of Transmissible Spongiform Encephalopathies," which issued on December 26, 2000.

Inventors:

Katherine I. O’Rourke
Animal Diseases Research
Pullman, WA 99164-6630
(509) 335-6020 / Fax: (509) 335-8328
korourke@vetmed.wsu.edu
Donald P. Knowles, Jr.
(Same as first inventor)
(509) 335-6022 / Fax: (509) 335-8328

dknowles@vetmed.wsu.edu


T. V. Baszler
Washington State University
Pullman, WA 99164
(510) 335-6047

Steven M. Parish
Washington State University
Pullman, WA 99164

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Last Modified: 2/24/2014