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United States Department of Agriculture

Agricultural Research Service

Title: Bovine Tumor Necrosis Factor Recepton-1 and Methods of Use
See also: US Patent Office Full Record

Midwest Area
  Ames, Iowa

Patent Number: 6406907
Docket Number: 32299
Serial Number: 9513007
Date Patented: 06/18/2002

Technology Description:

The invention relates to nucleic acid sequences encoding a bovine tumor necrosis factor (TNF) receptor-I. Also, within theinvention is a soluble bovine TNF-RI which is a potent inhibitor of bovine tumor necrosis factor-a (TNF-a). TNF-a is apleiotropic cytokine, and is produced by activated macrophages/monocytes and lymphocytes. It is also a potent mediator ininflammatory and immune responses including the recruitment of leukocytes to injured tissues during bacterial and othermicrobial infections, and following stimulation with inflammatory substances. The invention demonstrates that solublebovine TNF-RI has therapeutic value as an inhibitor of TNF in cattle suffering from coliform mastitis, or other inflammatorydisease. The invention features a pharmaceutical composition, including one or more soluble, functional polypeptidefragments of bovine TNF-RI and a pharmaceutically acceptable carrier. It also provides a kit which includes at least one unitdose of the described pharmaceutical composition.


Please refer to USPN 6,406,907 (Docket #0322.99), which issued opn June 18, 2002.  Foreign rights are not available.

Marcus E. Kherli, Jr.
National Animal Disease Center
Ames, IA 50010
(515) 663-7201
Michael J. Taylor
Iowa State University
Ames, IA 50010
(515) 294-4740
Eun-Kyung Lee
(Same address & phone as first inventor)

* Based on Provisional Patent Application 60/122,156, filed February 26, 1999.
Last Modified: 10/1/2015
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