ARRA - Robert W. Holley Center for Agriculture and Health, Ithaca, New
The Robert W. Holley Center for Agriculture and
Health developed a simple, inexpensive cellular model that simulates digestion
and nutrient absorption to allow for better understanding of how nutrients are
absorbed by people.
Robert W. Holley Center for Agriculture and Health, Ithaca, New York
- Scope of work under Recovery Act
Repair of critical deferred maintenance including replacing
windows to prevent water infiltration damaging structure and contents.
September 2010 - Construction contract awarded for $264,212 to replace windows.
Research at the Robert W. Holley Center for Agriculture and Health
Scientists at the Robert W. Holley Center for Agriculture and Health do
research at the interface of human nutrition and agriculture to improve the
nutritional quality and health promoting properties of food crops. For example,
they are using specific genes linked to Vitamin E synthesis in corn are being
used to develop more nutritious corn and other cereal varieties. The Holley
Center has also developed a simple, inexpensive cellular model that simulates
digestion and nutrient absorption that allows researcher to better understand
how people actually absorb nutrients.
They also create innovative pest and disease management methods that reduce
the need for synthetic chemical pesticides while still providing long-term
control. Researchers at the Holley Center have discovered a fungus that is more
highly virulent against a broad range of caterpillar pests than any now on the
In addition, the center maintains an extensive collection of fungal
pathogens and insect and nematode pests, which is a unique resource that
supports research at the center as well as helping other researchers.
Plant, Soil and Nutrition Research Unit
Conduct research at the interface of human nutrition and agriculture to
improve the nutritional quality and health promoting properties of food crops.
- Improving crop mineral nutrition and plant tolerance to mineral and
metal-related stresses in the soil.
- Use of genomics, proteomics, molecular genetics and computational biology
to dissect complex traits in plants and identify the genes and mechanisms
- Integrating computational biology and bioinformatics with genomic and
genetic-based methodologies to model and better understand gene regulatory
circuitry at the cellular level.
Biological Integrated Pest Management Research Unit
Provide innovative pest and disease management methods that reduce the use
of synthetic chemical pesticides while still providing long-term control.
Research includes both basic and applied areas in order to understand how best
to interfere with pest/pathogen life cycles and/or host-pest/pathogen
interactions. Targets include insects, nematodes, diseases, and viruses
attacking field and greenhouse crops and invasive weed species in semi-natural
and natural settings.
Approaches include genomics, genetic resistance, development of
biopesticides and biological control agents, risk analysis and post-release
monitoring, secondary metabolism, and genetic manipulation in host and control
agent or pathogen populations. An extensive culture collection of fungal
pathogens of insect and nematode pests is a unique resource that supports many
of our research efforts. Key commodities are potato, small grains, greenhouse
and nursery crops, and natural ecosystems, but results are applicable to many
crops and agroecosystems in general.
Plant-Microbe Interaction Research Unit
This research unit focuses on the model plant pathogen Pseudomonas
syringae pv tomato DC3000, which causes speck disease on tomatoes and the
model laboratory plant Arabidopsis. Close relatives to this bacteria cause
disease on virtually every major vegetable crop.
The molecular processes inside the plant host and bacterial pathogen cells,
as well as the "chemical communication" between these cells, can all
be monitored using powerful, state-of- the-art technologies. These processes
are governed by proteins that are, in turn, encoded by genes defined by the DNA
sequence - the genome. This group focuses on using a combination of
computational and laboratory methods to identify genes in the P. syringae
genome and determine how the expression of these genes is controlled.
Roughly speaking, they "reverse engineer" the genetic
"circuits" in the bacterial cell related to interactions with its
environment, including interactions with plant cells and plant-associated
compounds. The end results of the research are used by other groups as starting
points for detailed studies of plant defense mechanisms.
Project Photographs Before Construction