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United States Department of Agriculture

Agricultural Research Service

Jay J. Cao

Nutritionist


Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Role of glucocorticoid-induced leucine zipper (GILZ) in bone acquisition - (Peer Reviewed Journal) - (04-Jun-14)
Dietary protein level and source differentially affect bone metabolism, strength, and intestinal calcium transporter expression during ad libitum and food-restricted conditions in male rats - (Peer Reviewed Journal)
Gaffney-Stomberg, E., Cao, J.J., Lin, G.G., Wulff, C.R., Murphy, N.E., Young, A.J., Mcclung, J.P., Pasiakos, S.M. 2014. Dietary protein level and source differentially affect bone metabolism, strength, and intestinal calcium transporter expression during ad libitum and food-restricted conditions in male rats. Journal of Nutrition. 144(6):821-829.
N-acetylcysteine supplementation decreases osteoclast differentiation and increases bone mass in mice fed a high-fat diet Reprint Icon - (Peer Reviewed Journal)
Cao, J.J., Picklo, M.J. 2014. N-acetylcysteine supplementation decreases osteoclast differentiation and increases bone mass in mice fed a high-fat diet. Journal of Nutrition. 144:289-296.
Calcium homeostasis and bone metabolic responses to high-protein diets during energy deficit in healthy young adults: a randomized control trial Reprint Icon - (Peer Reviewed Journal)
Cao, J.J., Pasiakos, S.M., Margolis, L.M., Sauter, E.R., Whigham Grendell, L.D., Mcclung, J.P., Young, A.J., Combs, G.F. 2014. Calcium homeostasis and bone metabolic responses to high-protein diets during energy deficit in healthy young adults: a randomized control trial. American Journal of Clinical Nutrition. 99:400-407.
Whole-body protein turnover response to short-term high-protein diets during weight loss: a randomized controlled trial - (Peer Reviewed Journal)
Pasiokos, S.M., Margolis, L.M., Mcclung, J.P., Cao, J.J., Whigham Grendell, L.D., Combs, G.F., Young, A.J. 2014. Whole-body protein turnover response to short-term high-protein diets during weight loss: a randomized controlled trial. International Journal of Obesity. 38(7):1015-1018.
Effects of energy deficit, dietary protein, and feeding on intracellular regulators of skeletal muscle proteolysis Reprint Icon - (Peer Reviewed Journal)
Carbone, J.W., Margolis, L.M., Mcclung, J.P., Cao, J.J., Murphy, N.E., Sauter, E.R., Combs, G.F., Young, A.J., Pasiakos, S.M. 2013. Effects of energy deficit, dietary protein, and feeding on intracellular regulators of skeletal muscle proteolysis. Journal of Federation of American Societies for Experimental Biology. (12):5104-11.
Curcumin reduces trabecular and cortical bone in naive and Lewis lung carcinoma-bearing mice Reprint Icon - (Peer Reviewed Journal)
Yan, L., Yee, J.A., Cao, J.J. 2013. Curcumin reduces trabecular and cortical bone in naive and Lewis lung carcinoma-bearing mice. Anticancer Research. 33:3153-3162.
Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of CYP1 enzymes Reprint Icon - (Peer Reviewed Journal)
Iqbal, J., Sun, L., Cao, J.J., Yuen, T., Bab, I., Leu, N., Wagage, S., Hunter, C., Nebert, D.W., Zaidi, M. 2013. Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of CYP1 enzymes. Proceedings of the National Academy of Sciences. 110(27):1115-11120.
Effects of high protein diets on fat-free mass and muscle protein synthesis following weight loss: a randomized controlled trial Reprint Icon - (Peer Reviewed Journal)
Pasiakos, S.M., Cao, J.J., Margolis, L.M., Sauter, E.R., Whigham Grendell, L.D., Mcclung, J.P., Rood, J.C., Carbone, J.W., Combs, G.F., Young, A.J. 2013. Effects of high protein diets on fat-free mass and muscle protein synthesis following weight loss: a randomized controlled trial. Journal of Federation of American Societies for Experimental Biology. doi: 10.1096/fj.13-230227.
Soy protein isolates prevent loss of bone quantity associated with obesity in rats through regulation of insulin signaling in osteoblasts Reprint Icon - (Peer Reviewed Journal)
Chen, J., Zhang, J., Laranko, O.P., Cao, J.J., Blackburn, M.L., Badger, T.M., Ronis, M.J. 2013. Soy protein isolates prevent loss of bone quantity associated with obesity in rats through regulation of insulin signaling in osteoblasts. Federation of American Societies for Experimental Biology Conference. 27(9):3514-3523.
Mx1-cre mediated Rgs12 conditional knockout mice exhibit increased bone mass phenotype Reprint Icon - (Peer Reviewed Journal)
Yang, S., Li, Y., Liu, T., He, X., Yuan, X., Li, C., Cao, J.J., Kim, Y. 2013. Mx1-cre mediated Rgs12 conditional knockout mice exhibit increased bone mass phenotype. Genesis. 51:201-209.
Selenium in bone health: roles in antioxidant protection and cell proliferation Reprint Icon - (Peer Reviewed Journal)
Zeng, H., Cao, J.J., Combs, G.F. 2013. Selenium in bone health: roles in antioxidant protection and cell proliferation. Nutrients. 5:97-110.
Dietary protein intake, energy deficit, and nitrogen balance in normal-weight adults: a randomized controlled - (Abstract Only)
Margolis, L.M., Cao, J.J., Whigham Grendell, L.D., Mcclung, J.P., Combs, G.F., Young, A.J., Pasiakos, S.M. 2013. Dietary protein intake, energy deficit, and nitrogen balance in normal-weight adults: a randomized controlled. Federation of American Societies for Experimental Biology Conference. 27:1075.11.
Calcium homeostasis and bone metabolic responses to protein diets and energy restriction: a randomized control trial - (Abstract Only)
Cao, J.J., Pasiakos, S.M., Margolis, L.M., Whigham Grendell, L.D., Mcclung, J.P., Young, A.Y., Combs, G.F. 2013. Calcium homeostasis and bone metabolic responses to high protein diets and energy restriction: a randomized control trial. Federation of American Societies for Experimental Biology Conference. 27:249.1.
Influences of fiber, methionine and form of selenium on selenium hindgut targeting and tissue accumulation - (Abstract Only)
Jackson, M.I., Padmanaban, K., Cao, J.J. 2013. Influences of fiber, methionine and form of selenium on selenium hindgut targeting and tissue accumulation. Federation of American Societies for Experimental Biology Conference. 27:860.16.
Vitamin C reverses hypogonadal bone loss Reprint Icon - (Peer Reviewed Journal)
Zhu, L., Cao, J.J., Sun, M., Yuen, T., Zhou, R., Li, J., Peng, Y., Moonga, S.S., Guo, L., Mechanick, J.I., Iqbal, J., Peng, L., Blair, H.C., Biam, Z., Zaidi, M. 2012. Vitamin C reverses hypogonadal bone loss. PLoS One. 7(10):1-6.
S-Adenosylmethionine-dependent protein methylation Is required for expression of selenoprotein P and gluconeogenic enzymes in HepG2 human hepatocytes Reprint Icon - (Peer Reviewed Journal)
Jackson, M.I., Cao, J.J., Zeng, H., Uthus, E.O., Combs, G.F. 2012. S-Adenosylmethionine-dependent protein methylation Is required for expression of selenoprotein P and gluconeogenic enzymes in HepG2 human hepatocytes. Journal of Biological Chemistry. 287(43):36455-36464.
Hyperthyroid-associated osteoporosis is exacerbated by the loss of TSH signaling Reprint Icon - (Peer Reviewed Journal)
Baliram, R., Sun, L., Cao, J.J., Li, J., Latif, R., Huber, A.K., Yuen, T., Blair, H.C., Zaidi, M., Davies, T.F. 2012. Hyperthyroid-associated osteoporosis is exacerbated by the loss of TSH signaling. Journal of Clinical Investigation. 122(10):3737-3741.
Blocking antibody to the beta-subunit of FSH prevents bone loss by inhibiting bone resorption and stimulating bone synthesis Reprint Icon - (Peer Reviewed Journal)
Zhu, L., Blair, H.C., Cao, J.J., Yuen, T., Latif, R., Guo, L., Tourkova, I.L., Li, J., Davies, T.F., Sun, L., Bian, Z., Rosen, C., Zallone, A., New, M.I., Zaidi, M. 2012. Blocking antibody to the beta-subunit of FSH prevents bone loss by inhibiting bone resorption and stimulating bone synthesis. Proceedings of the National Academy of Sciences. 109(36):14574-14579.
Critical role for CCAAT/Enhancer-binding protein beta in immune complex-induced acute lung injury Reprint Icon - (Peer Reviewed Journal)
Yan, C., Wu, M., Cao, J.J., Tang, H., Zhu, M., Johnson, P.E., Gao, H. 2012. Critical role for CCAAT/Enhancer-binding protein beta in immune complex-induced acute lung injury. Journal of Immunology. 189(3):1480-90.
Bone marrow oxytocin mediates the anabolic action of estrogen on the skeleton Reprint Icon - (Peer Reviewed Journal)
Colaianni, G., Sun, L., Di Benedetto, A., Tamma, R., Zhu, L., Cao, J.J., Grano, M., Yuan, T., Colucci, S., Cuscito, C., Mancini, L., Li, J., Nishimori, K., Bab, I., Lee, H., Iqbal, J., Young, W., Rosen, C., Zallone, A., Zaidi, M. 2012. Bone marrow oxytocin mediates the anabolic action of estrogen on the skeleton. Proceedings of the National Academy of Sciences. 287(34):29159-29167.
CCAAT/enhancer-binding protein ¿ is a critical regulator of IL-1ß-induced IL-6 production in alveolar epithelial cells Reprint Icon - (Peer Reviewed Journal)
Yan, C., Wang, X., Cao, J.J., Wu, M., Gao, H. 2012. CCAAT/enhancer-binding protein ¿ is a critical regulator of IL-1ß-induced IL-6 production in alveolar epithelial cells. Proceedings of the National Academy of Sciences. 7(4):e35492. doi:10.1371/journal.pone.0035492.
Selenium deficiency decreases antioxidative capacity and is detrimental to bone microarchitecture in mice Reprint Icon - (Peer Reviewed Journal)
Cao, J.J., Gregoire, B.R., Zeng, H. 2012. Selenium deficiency decreases antioxidative capacity and is detrimental to bone microarchitecture in mice. Journal of Nutrition. 142:1526-1531.
Green tea polyphenols benefits body composition and improves bone quality in long-term high-fat diet-induced obese rats Reprint Icon - (Peer Reviewed Journal)
Shen, C., Cao, J.J., Dagda, R., Chanjaplammootil, S., Lu, C., Chyu, M., Gao, W., Wang, J., Yeh, J.K. 2012. Green tea polyphenols benefits body composition and improves bone quality in long-term high-fat diet-induced obese rats. Nutrition Research. 32:448-457.
Alpha-1 antitrypsin reduces ovariectomy-induced bone loss in mice Reprint Icon - (Peer Reviewed Journal)
Cao, J.J., Gregoire, B.R., Song, S. 2012. Alpha-1 antitrypsin reduces ovariectomy-induced bone loss in mice. Annals of the New York Academy of Sciences. doi: 10.111/j.1749-6632.2011.06370.x.
A high protein diet upregulated whole-body protein turnover during energy deficit - (Abstract Only)
Margolis, L.M., Cao, J.J., Sauter, E.R., Whigham Grendell, L.D., Mcclung, J.P., Combs, G.F., Young, A.J., Pasiakos, S.M. 2012. A high protein diet upregulated whole-body protein turnover during energy deficit. Federation of American Societies for Experimental Biology Conference. 26:1013.3.
An essential role for the Stat3 in regulating IgG immune complex-induced pulmonary inflammation Reprint Icon - (Peer Reviewed Journal)
Tang, H., Yan, C., Cao, J.J., Sarma, J.V., Haura, E.B., Wu, M., Gao, H. 2011. An essential role for the Stat3 in regulating IgG immune complex-induced pulmonary inflammation. Journal of Federation of American Societies for Experimental Biology. 25:4292-4300.
Effects of obesity on bone metabolism Reprint Icon - (Review Article)
Cao, J.J. 2011. Effects of obesity on bone metabolism. Journal of Orthopaedic Surgery and Research. doi:10.1186/1749-799X-6-30.
Green tea and bone health Reprint Icon - (Book / Chapter)
Shen, C., Yeh, J.K., Cao, J.J., Chyu, M., Wang, J. 2012. Green tea and bone health. Pharmacological Research. 64(2):155-161.
Supplementation with green tea polyphenols improves bone microstructure and quality in aged, orchidectomized rats Reprint Icon - (Peer Reviewed Journal)
Shen, C., Cao, J.J., Dagda, R.Y., Tenner, T.E., Chyu, M., Yeh, J.K. 2011. Supplementation of green tea polyphenols improves bone microstructure and quality in aged, orchidectomized rats. Calcified Tissue International. 88(6):455-463.
Green tea polyphenols avert chronic inflammation-induced myocardial fibrosis of female rats Reprint Icon - (Peer Reviewed Journal)
Shen, C., Samathanam, C., Tatum, O.L., Graham, S., Tubb, C., Cao, J.J., Dunn, D.M., Wang, J. 2011. Green tea polyphenols avert chronic inflammation-induced myocardial fibrosis of female rats. Inflammation Research. 60(7):665-672.
A diet high in meat protein and potential renal acid load increases fractional Ca absorption and urinary Ca excretion, without affecting markers of bone resorption or formation in postmenopausal women Reprint Icon - (Peer Reviewed Journal)
Cao, J.J., Johnson, L.K., Hunt, J.R. 2011. A diet high in meat protein and potential renal acid load increases fractional Ca absorption and urinary Ca excretion, without affecting markers of bone resorption or formation in postmenopausal women. Journal of Nutrition. 141(3):391-397.
Zinc deficiency increases miR-34a expression in mice - (Abstract Only)
Liuzzi, J.P., Valencia, K., Cao, J.J., Gonzales, A. 2011. Zinc deficiency increases miR-34a expression in mice. Federation of American Societies for Experimental Biology Conference. 25:977.1.
Dietary protein, calcium metabolism and bone health in humans - (Abstract Only)
Cao, J.J. 2010. Dietary protein, calcium metabolism and bone health in humans. International Conference on Osteoporosis. Abstract No. HT6. p.75.
Suppressor of cytokine signaling 3 inhibits LPS-induced IL-6 expression in osteoblasts by suppressing CCAAT/enhancer-binding protein ß activity Reprint Icon - (Peer Reviewed Journal)
Yan, C., Cao, J.J., Wu, M., Jiang, T., Yoshimura, A., Gao, H., Zhang, W. 2010. Suppressor of cytokine signaling 3 inhibits LPS-induced IL-6 expression in osteoblasts by suppressing CCAAT/enhancer-binding protein ß activity. Journal of Biological Chemistry. 285(48):37227-37239.
Acid diet (high meat protein) effects on calcium metabolism and bone health Reprint Icon - (Review Article)
Cao, J.J., Nielsen, F.H. 2010. Acid diet (high meat protein) effects on calcium metabolism and bone health. Current Opinion in Clinical Nutrition and Metabolic Care. 13(6):698-702.
Pinto beans as a course of bioavailable selenium to support bone structure in mice - (Abstract Only)
Cao, J.J., Gregoire, B.R., Zeng, H. 2010. Pinto beans as a course of bioavailable selenium to support bone structure in mice [abstract]. Journal of Bone and Mineral Research. 25(Supplement 1).
Green tea polyphenols supplementation improves bone microstructure in orchidectomized middle-Aged rats - (Abstract Only)
Shen, C., Yeh, J.K., Cao, J.J., Tenner, T., Wang, J. 2010. Green tea polyphenols supplementation improves bone microstructure in orchidectomized middle-Aged rats [abstract]. Journal of Bone and Mineral Research. 25(Supplement1).
Protective actions of green tea polyphenols and alfacalcidol on bone microstructure in female rats with chronic inflammation Reprint Icon - (Peer Reviewed Journal)
Shen, C., Yeh, J.K., Samathanam, C.A., Cao, J.J., Stoecker, B.J., Dagda, R.Y., Chyu, M., Wang, J. 2011. Protective actions of green tea polyphenols and alfacalcidol on bone microstructure in female rats with chronic inflammation. Journal of Nutritional Biochemistry. 22(7):673-680.
Osteoprotective Effect of Alfacalcidol in Female Rats with Systemic Chronic Inflammation - (Abstract Only)
Shen, C., Cao, J.J., Yeh, J.K. 2010. Osteoprotective Effect of Alfacalcidol in Female Rats with Systemic Chronic Inflammation. [abstract] Endocrine Society Meeting. 31(3):S1065.
Green tea polyphenols attenuate deterioration of bone microarchitecture in female rats with systemic chronic inflammation Reprint Icon - (Peer Reviewed Journal)
Shen, C., Yeh, J.K., Samathanam, C., Cao, J.J., Stoecker, B.J., Dagda, R.Y., Chyu, M., Dunn, D.M., Wang, J. 2011. Green tea polyphenols attenuate deterioration of bone microarchitecture in female rats with systemic chronic inflammation. Osteoporosis International. 22:327-337.
Selenium from Pinto Beans is Bioavailable to Support Bone Structure in Mice Reprint Icon - (Abstract Only)
Cao, J.J., Gregoire, B.R. 2010. Selenium from Pinto Beans is Bioavailable to Support Bone Structure in Mice. Journal of Federation of American Societies for Experimental Biology. 24:726.1.
Synergistic effects of green tea polyphenols and alphacalcidol on chronic inflammation-induced bone loss in female rats Reprint Icon - (Peer Reviewed Journal)
Shen, C., Yeh, J.K., Cao, J.J., Tatum, O.L., Dagda, R.Y., Wang, J. 2010. Synergistic effects of green tea polyphenols and alphacalcidol on chronic inflammation-induced bone loss in female rats. Osteoporosis International. 21(11):1841-1852.
Diet-induced Obesity Alters Bone Remodeling Leading to Decreased Femoral Trabecular Bone Mass in Mice Reprint Icon - (Peer Reviewed Journal)
Cao, J.J., Sun, L., Gao, H. 2010. Diet-induced Obesity Alters Bone Remodeling Leading to Decreased Femoral Trabecular Bone Mass in Mice. Annals of the New York Academy of Sciences. 1192:292-297.
Green tea polyphenols mitigate bone loss of female rats in a chronic inflammation-induced bone loss model Reprint Icon - (Peer Reviewed Journal)
Shen, C., Yeh, J.K., Cao, J.J., Tatum, O.L., Dagda, R.Y., Wang, J. 2010. Green tea polyphenols mitigate bone loss of female rats in a chronic inflammation-induced bone loss model. Journal of Nutritional Biochemistry. 21(10):968-974.
Pinto Bean Hull Extract Supplementation Favorably Affects Markers of Bone Metabolism and Bone Structure in Mice - (Abstract Only)
Cao, J.J., Gregoire, B.R., Gao, H. 2009. Pinto Bean Hull Extract Supplementation Favorably Affects Markers of Bone Metabolism and Bone Structure in Mice. American Society for Bone and Mineral Research. 24S1:263.
Green Tea Polyphenols and Vitamin D3 Protect Bone Microarchitecture in Female Rats with Chronic Inflammation - (Abstract Only)
Shen, C., Yeh, J., Cao, J.J., Stoecker, B.J., Samathanam, C., Graham, S., Tatum, O., Dagda, R., Tubb, C., Wang, J. 2009. Green Tea Polyphenols and Vitamin D3 Protect Bone Microarchitecture in Female Rats with Chronic Inflammation. American Society for Bone and Mineral Research. 24S1:227.
Pinto Bean Hull Extract Supplementation Favorably Affects Markers of Bone Metabolism and Bone Structure in Mice Reprint Icon - (Peer Reviewed Journal)
Cao, J.J., Gregoire, B.R., Sheng, X., Liuzzi, J.P. 2010. Pinto Bean Hull Extract Supplementation Favorably Affects Markers of Bone Metabolism and Bone Structure in Mice. Food Research International. 43(2):560-566.
Green Tea and Bone Metabolism Reprint Icon - (Peer Reviewed Journal)
Shen, C., Yeh, J.K., Cao, J.J., Wang, J. 2009. Green Tea and Bone Metabolism. Nutrition Research. 29(7):437-56.
Serum Cytokine Levels and Bone Structure in the Femur Are Affected By High-Fat Diet in Mice - (Abstract Only)
Cao, J.J., Gao, H. 2009. Serum Cytokine Levels and Bone Structure in the Femur Are Affected By High-Fat Diet in Mice. 3rd New York Skeletal biology and Medicine Conference. Abstract will not be published.
High-fat Diet Decreases Cancellous Bone Mass But Has No Effect on Cortical Bone Mass in the Tibia in Mice Reprint Icon - (Peer Reviewed Journal)
Cao, J.J., Gregoire, B.R., Gao, H. 2009. High-fat Diet Decreases Cancellous Bone Mass But Has No Effect on Cortical Bone Mass in the Tibia in Mice. Bone. 44:1097-1104.
A Diet High in Meat Protein and Potential Renal Acid Load Increases Absorption and Urinary Excretion of Calcium, As Well As Serum IGF-I in Postmenopausal Women Reprint Icon - (Abstract Only)
Cao, J.J., Johnson, L.K., Hunt, J.R. A Diet High in Meat Protein and Potential Renal Acid Load Increases Absorption and Urinary Excretion of Calcium, As Well As Serum IGF-I in Postmenopausal Women. Journal of Federation of American Societies for Experimental Biology. 23:108.7.
Synergistic Effect of Green Tea Polyphenols and Vitamin D on Chronic Inflammation-Induced Bone Loss in Female Rats Reprint Icon - (Abstract Only)
Shen, C., Yeh, J.K., Dunn, D.M., Cao, J.J., Wang, J. 2009. Synergistic Effect of Green Tea Polyphenols and Vitamin D on Chronic Inflammation-Induced Bone Loss in Female Rats. Journal of Federation of American Societies for Experimental Biology. 23:220.2.
Obesity induced by high dietary fat leads to increased bone resorption marker, TRAP, and decreased bone mass in mice - (Abstract Only)
Cao, J.J., Gregoire, B.R., Gao, H. 2008. Obesity induced by high dietary fat leads to increased bone resorption marker, TRAP, and decreased bone mass in mice [Abstract]. 23S1:432.
Relative bone mass decreased in mice fed high dietary fat despite an increase in body mass and bone formation markers Reprint Icon - (Abstract Only)
Cao, J.J. 2008. Relative bone mass decreased in mice fed high dietary fat despite an increase in body mass and bone formation markers [Abstract]. Journal of Federation of American Societies for Experimental Biology. 22:314.1.
Aging impairs IGF-1 receptor activation and induces skeletal resistance to IGF-1 Reprint Icon - (Peer Reviewed Journal)
Cao, J.J., Kurimoto, P., Boudignon, B., Rosen, C., Lima, F., Halloran, B.P. 2007. Aging impairs IGF-1 receptor activation and induces skeletal resistance to IGF-1. Journal of Bone and Mineral Research. 22(8):1271-1279.
Last Modified: 8/27/2014