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United States Department of Agriculture

Agricultural Research Service

DANIEL HWANG

Research Molecular Biologist


Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Acylcarnitines activate pro-inflammatory signaling pathways - (Peer Reviewed Journal)
Rutkowsky, J.M., Knotts, T.A., Ono-Moore, K.D., Mc Coin, C.S., Huang, S., Schneider, D.A., Singh, S., Adams, S.H., Hwang, D.H. 2014. Acylcarnitines activate pro-inflammatory signaling pathways. Molecular and Cellular Biology. DOI: 10.1152/ajpendo.00656.2013.
Influence of reactive oxygen species on the sterilization of microbes - (Peer Reviewed Journal)
Uhm, H.S., Choi, E.H., Cho, G.S., Hwang, D.H. 2013. Influence of reactive oxygen species on the sterilization of microbes. Current Applied Physics. 13:S30-S35.
Toll-like receptor 2 mediates high-fat diet-induced impairment of vasodilator actions of insulin - (Peer Reviewed Journal)
Jang, H., Ridgeway, S.D., Vashista, P., Hwang, D.H., Quon, M.J., Kim, J. 2013. Toll-like receptor 2 mediates high-fat diet-induced impairment of vasodilator actions of insulin. American Journal of Physiology - Endocrinology and Metabolism. 304(10):E1077-E1088. First e-published 03/26/2013. DOI:10.1152/ajpendo.00578.2012.
Dietary strawberries increase proliferative response of CD3/CD28-activated CD8+ T cells and production of TNF-alpha in lipopolysaccharide-stimulated monocytes from obese human subjects - (Peer Reviewed Journal)
Zunino, S.J., Storms, D.H., Freytag, T.L., Mackey, B.E., Zhao, L., Gouffon, J.S., Hwang, D.H. 2013. Dietary strawberries increase proliferative response of CD3/CD28-activated CD8+ T cells and production of TNF-alpha in lipopolysaccharide-stimulated monocytes from obese human subjects. British Journal of Nutrition. 110:2011-2019. DOI: 10.1017/S0007114513000937. Epub ahead of print.
Saturated fatty acids activate TLR-mediated pro-inflammatory signaling pathways - (Peer Reviewed Journal)
Huang, S., Rutkowsky, J.M., Snodgrass, R.G., Ono-Moore, K., Schneider, D.A., Newman, J.W., Adams, S.H., Hwang, D.H. 2012. Saturated fatty acids activate TLR-mediated pro-inflammatory signaling pathways. Journal of Lipid Research. Epublished. DOI: 10.1194/jlr.D029546.
Nod1 Activation Induces Proinflammatory Gene Expression and Insulin Resistance in 3t3-L1 Adipocytes Reprint Icon - (Peer Reviewed Journal)
Zhao, L., Hu, P., Zhou, Y., Purohit, J., Hwang, D.H. 2011. NOD1 activation induces proinflammatory gene expression and insulin resistance in 3T3-L1 adipocytes. American Journal of Physiology. Available: http://ajpendo.physiology.org/content/early/2011/06/15/ajpendo.00709.2010.reprint
Dietary modulation of inflammation - (Book / Chapter) - (03-Jun-11)
Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals Reprint Icon - (Review Article)
Ling, Z., Lee, J., Hwang, D.H. 2011. Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals. Nutrition Reviews. 69:6(310-320).
Modulation of blood cell gene expression by DHA supplementation in hypertriglyceridemic men Reprint Icon - (Peer Reviewed Journal)
Dawson, K., Zhao, L., Adkins, Y.C., Rodriguez, R.L., Kelley, D.S., Hwang, D.H. 2011. Modulation of blood cell gene expression by DHA supplementation in hypertriglyceridemic men. Journal of Nutritional Biochemistry. Available: http://www.sciencedirect.com/science/article/pii/S0955286311000933
Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals - (Review Article)
Zhao, L., Lee, J.Y., Hwang, D.H. 2011. Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals. Nutrition Reviews. 69(6):310-320, DOI: 10.1111/j.1753-4887.2011.00394.x.
Fatty Acids Modulate Toll-Like Receptor 4 Activation Through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts - (Peer Reviewed Journal) - (01-Aug-09)
Toll-like receptors in the pathogenesis of inflammatory diseases Reprint Icon - (Peer Reviewed Journal)
Lee, J.K., Hwang, D.H., Lee, J.Y. 2009. Toll-like receptors in the pathogenesis of inflammatory diseases. Journal of Organ Dysfuntion. 5:2,119-128, 2009.
Plasma Acylcarnitine Profiles Suggest Incomplete Fatty Acid ß-Oxidation and Altered Tricarboxylic Cycle Activity in Type 2 Diabetic African-American Women Reprint Icon - (Peer Reviewed Journal)
Adams, S.H., Hoppel, C.L., Lok, K.H., Zhao, L., Wong, S.W., Minkler, P.E., Hwang, D.H., Newman, J.W., Garvey, W.T. 2009. Plasma Acylcarnitine Profiles Suggest Incomplete Fatty Acid ß-Oxidation and Altered Tricarboxylic Cycle Activity in Type 2 Diabetic African-American Women. Journal of Nutrition, 139:1073-1081.
Suppression of the TRIF-dependent signaling pathway of Toll-like receptors by luteolin Reprint Icon - (Peer Reviewed Journal)
Lee, J., Kim, S., Kim, Y., Lee, W., Hwang, D.H., Lee, J. 2009. Suppression of the TRIF-dependent signaling pathway of Toll-like receptors by luteolin. Biochemical Pharmacology. Vol.77:1391-1400.
High Glucose Induces Toll-Like Receptor Expression in Human Monocytes: Mechanism of Activation Reprint Icon - (Peer Reviewed Journal)
Dasu, M.R., Devaraj, S., Ling, Z., Hwang, D.H., Jialal, I. 2008. HIGH GLUCOSE INDUCES TOLL-LIKE RECEPTOR EXPRESSION IN HUMAN MONOCYTES: MECHANISM OF ACTIVATION. Diabetes 57(11):3090-3098, 2008.
Inhibition of Nod2 signaling and target gene expression by curcumin Reprint Icon - (Peer Reviewed Journal)
Huang, S., Zhao, L., Kim, K., Lee, D., Hwang, D.H. 2008. Inhibition of Nod2 signaling and target gene expression by curcumin. Molecular Pharmacology 74(1):274-281, 2008.
The Phosphatidylinositol 3-Kinase/Akt Pathway Negatively Regulates Nod2-Mediated NF-kB Pathway Reprint Icon - (Peer Reviewed Journal)
Zhao, L., Lee, J.Y., Hwang, D.H. The Phosphatidylinositol 3-Kinase/Akt Pathway Negatively Regulates Nod2-Mediated NF-kB Pathway. 2008. Biochemical Pharmacology. 75:1515-1525, 2008.
Garlic (Allium sativum) Extracts Inhibits Lipopolysaccharide-Induced Toll-Like Receptor 4 Dimerization Reprint Icon - (Peer Reviewed Journal)
Youn, H., Lim, H., Lee, H., Hwang, D.H., Yang, M., Jeon, R., Ryu, J. 2008. Garlic (Allium sativum) Extracts Inhibits Lipopolysaccharide-Induced Toll-Like Receptor 4 Dimerization. Bioscience Biotechnology and Biochemistry 72(2):368-375, 2008.
Acrolein with an alpha, beta-unsaturated Carbonyl Group Inhibits LPS-induced Homodimerization of Toll-like Receptor 4 - (Peer Reviewed Journal)
Lee, J., Lee, J., Lee, M., Hwang, D.H., Youn, H. 2007. Acrolein with an alpha, beta-unsaturated Carbonyl Group Inhibits LPS-induced Homodimerization of Toll-like Receptor 4. Molecules and Cells. Vol.25, No2, 253-257.
Cinnamaldehyde suppresses Toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization Reprint Icon - (Peer Reviewed Journal)
Youn, H.S., Lee, J.K., Choi, Y.J., Saitoh, S.I., Miyake, K., Hwang, D.H., Lee, J.Y. 2008. Cinnamaldehyde suppresses Toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization. 2007. Biochemical Pharmacology. Vol.75(2), p.494-502, 2008.
The Modulation of Inflammatory Gene Expression by Lipids: Mediation Through Toll-Like Receptors - (Review Article)
Lee, J., Hwang, D.H. The modulation of inflammatory gene expression by lipids: mediation through toll-like receptors. Review Article. 2006. Molecules and Cells, Vol.21,No.2,pp.174-185.
Differential Modulation of Nods Signaling Pathways by Fatty Acids in Human Colonic Epithelial HCT116 cells Reprint Icon - (Peer Reviewed Journal)
Zhao, L., Kwon, M., Lee, J.Y., Fukase, K., Inohara, N., Hwang, D.H. 2007. Differential Modulation of Nods Signaling Pathways by Fatty Acids in Human Colonic Epithelial HCT116 cells. Journal of Biological Chemistry. Vol.282, No.16,pp.11618-11628.
Auranofin, As An Anti-Rheumatic Gold Compound Suppresses Lps-Induced Homodimerization of Tlr4 Reprint Icon - (Peer Reviewed Journal)
Youn, H.S., Lee, J.Y., Saitoh, S.I., Miyake, K., Hwang, D.H. 2006. AURANOFIN, AS AN ANTI-RHEUMATIC GOLD COMPOUND SUPPRESSES LPS-INDUCED HOMODIMERIZATION OF TLR4. Biochemistry and Biophysics Research Communication. 350 (2006) 866-871.
Suppression of Myd88 and Trif-Dependent Signaling Pathways of Toll-Like Receptor by (-)-Epigallocatechin-3-Gallate, a Polyphenol Component of Green Tea Reprint Icon - (Peer Reviewed Journal)
Youn, H.S., Lee, J.Y., Saotoh, S.I., Miyake, K., Kang, K.W., Choi, Y., Hwang, D.H. 2006. Suppression of myd88- and trif-dependent signaling pathways of toll-like receptor by (-)-epigallocatechin-3-gallate, a polyphenol component of green tea. Biochemical Pharmacology; Elsevier 72 (2006) 850-859.
Genome-Wide Identification of Peroxisome Proliferator Response Elements Using Integrated Computational Genomics Reprint Icon - (Peer Reviewed Journal)
Lemay, D.G., Hwang, D.H. Genome-wide identification of peroxisome proliferator response elements using integrated computational genomics. Journal of Lipid Research. 47:1583-1587, 2006.
Inhibition of Homodimerization of Toll-Like Receptor 4 by Curcumin Reprint Icon - (Peer Reviewed Journal)
Youn, H.S., Saitoh, S.I., Miyake, K., Hwang, D.H. 2006. INHIBITION OF HOMODIMERIZATION OF TOLL-LIKE RECEPTOR 4 BY CURCUMIN. Biochemical Pharmacology. 72(2006):62-69.
Overexpression of the Prostaglandin E2 Receptor Ep2 Results in Enhanced Skin Tumor Development Reprint Icon - (Peer Reviewed Journal)
Sung, Y., He, G., Hwang, D.H., Fishcher, S.M. Overexpression of the prostaglandin e2 receptor ep2 results in enhanced skin tumor development. Oncogene (2006) 25, 5507-5516.
The Regulation of the Expression of Inducible Nitric Oxide Synthase by Src-Family Tyrosine Kinase Mediated Through Myd88-Independent Signaling Payways of Toll-Like Receptor 4 - (Peer Reviewed Journal)
Lee, J.Y., Lowell, C.A., Lemay, D.G., Youn, H.S., Rhee, S.H., Sohn, K.H., Jang, B., Ye, J., Chung, J.H., Hwang, D.H. 2005. THE REGULATION OF THE EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE BY SRC-FAMILY TYROSINE KINASE MEDIATED THROUGH MYD88-INDEPENDENT SIGNALING PAYWAYS OF TOLL-LIKE RECEPTOR 4. Biochemical Pharmacology, 70:1231-1240.
Specific Inhibition of Myd88-Independent Signaling Pathways of Toll-Like Receptor 3 and 4 by Resveratrol: Molecular Targets Are Tbk1 in Trif Complex* Reprint Icon - (Peer Reviewed Journal)
Youn, H.S., Lee, J.Y., Fitzgerald, K.A., Young, H., Akira, S., Hwang, D.H. 2005. SPECIFIC INHIBITION OF MYD88-INDEPENDENT SIGNALING PATHWAYS OF TOLL-LIKE RECEPTOR 3 AND 4 BY RESVERATROL: MOLECULAR TARGETS ARE TBK1 IN TRIF COMPLEX. Journal of Immunology. 175:3339-3346, 2005.
Src-Family Tyrosine Kinase Inhibitor (Pp1) Suppresses Lps-Induced Expression of Inducible Nitric Oxide Synthase Mediated Through the Inhibition of Interferon B Expression in Macrophages - (Abstract Only)
Lee, J., Youn, H.S., Lemay, D., Lowell, C.A., Hwang, D.H. Src-family tyrosine kinase inhibitor (pp1) suppresses lps-induced expression of inducible nitric oxide synthase mediated through the inhibition of interferon b expression in macrophages. Experimental Biology. Abstract 829.7 (pge A1453)
Saturated and Polyunsaturated Fatty Acids Reciprocally Modulate Dendritic Cell Functions Mediated Through Tlr4 Reprint Icon - (Peer Reviewed Journal)
Weatherill, A., Lee, J., Zhao, L., Lemay, D., Youn, H.S., Hwang, D.H. Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through tlr4. Journal of Immunology. 174:5390-5397, 2005.
Inhibition of Insulin Sensitivity by Free Fatty Acids Requires Activation of Multiple Serine Kinases in 3t3-L1 Adipocytes - (Peer Reviewed Journal)
Gao, Z., Zhang, X., Zuberi, A., Hwang, D.H., Quon, M.J., Lefevre, M., Ye, J. Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3t3-l1 adipocytes. Molecular Endocrinology 18:2024-2034, (2004).
Saturated Fatty Acid Activates But Polyunsaturated Fatty Acid Inhibits Toll-Like Receptor 2 Dimerized with Toll-Like Receptor 6 Or 1 - (Peer Reviewed Journal)
Lee, J.Y., Zhao, L., Young, H., Weatherill, A., Tapping, R., Feng, L., Lee, W.H., Fitzgerald, K., Hwang, D.H. Saturated fatty acid activates but polyunsaturated fatty acid inhibits toll-like receptor 2 dimerized with toll-like receptor 6 or 1. Journal of Biological Chemistry 279(17) 16971-16979, 2004.
Reciprocal Modulation of Toll-Like Receptor-4 Signaling Pathways Involving Myd88 and Phosphatidylinositol 3-Kinase/akt by Saturated and Polyunsaturated Fatty Acids - (Peer Reviewed Journal)
Lee, J., Ye, J., Gao, Z., Youn, H., Lee, W., Zhao, L., Sizemore, N., Hwang, D.H. 2003. RECIPROCAL MODULATION OF TOLL-LIKE RECEPTOR-4 SIGNALING PATHWAYS INVOLVING MYD88 AND PHOSPHATIDYLINOSITOL 3-KINASE/AKT BY SATURATED AND POLYUNSATURATED FATTY ACIDS. Journal of Biological Chemistry 278 (39) 37041-37051, 2003.
Last Modified: 11/17/2011
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