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United States Department of Agriculture

Agricultural Research Service

WILLIAM T.. JOHNSON (THOMAS)

Collaborator


Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
High fructose feeding induces copper deficiency in Sprague-Dawley rats: A novel mechanism for obesity related fatty liver Reprint Icon - (Peer Reviewed Journal)
Song, M., Schuschke, D.A., Zhou, Z., Chen, T., Wang, R., Johnson, W.T., Mcclain, C.J. 2012. High fructose feeding induces copper deficiency in Sprague-Dawley rats: A novel mechanism for obesity related fatty liver. Hepatology. 56:433-440.
Expression of oxidative phosphorylation components in mitochondria of long-living Ames dwarf mice Reprint Icon - (Peer Reviewed Journal)
Brown-Borg, H.M., Johnson, W.T., Rakoczy, S.G. 2012. Expression of oxidative phosphorylation components in mitochondria of long-living Ames dwarf mice. Age. 34:43-57.
The hepatic Igf2/H19 locus is not altered in 1-day old pups born to obese-prone Sprague-Dawley rats fed a low protein diet containing adequate folic acid - (Abstract Only)
Uthus, E.O., Claycombe, K.J., Johnson, W.T. 2011. The hepatic Igf2/H19 locus is not altered in 1-day old pups born to obese-prone Sprague-Dawley rats fed a low protein diet containing adequate folic acid. Federation of American Societies for Experimental Biology Conference. 25:990.16.
Marginal Copper Deficiency Increases Liver Neutrophil Accumulation After Ischemia/Reperfusion in Rats - (Peer Reviewed Journal)
Sakai, N., Shin, T., Schuster, R., Blanchard, J., Lentsch, A.B., Johnson, W.T., Schuschke, D.A. 2010. Marginal Copper Deficiency Increases Liver Neutrophil Accumulation After Ischemia/Reperfusion in Rats. Biological Trace Element Research. Available: www.doi.org. 10.1007/s12011-010-8743-9.
Maternal Copper Deficiency Perpetuates Altered Vascular Function in Sprague-Dawley Rat Offspring Reprint Icon - (Peer Reviewed Journal)
Anderson, C.M., Johnson, W.T. 2010. Maternal Copper Deficiency Perpetuates Altered Vascular Function in Sprague-Dawley Rat Offspring. Journal of Developmental Origins of Health and Disease. 1(2):131-140.
The Influence of Copper (Cu) Deficiency in a Cardiomyocyte Cell Model (HL-1 Cell) of Ischemia/Reperfusion Injury Reprint Icon - (Abstract Only)
Johnson, W.T., Briske Anderson, M.J., Curtis, S.A., Asher, E.T. 2010. The Influence of Copper (Cu) Deficiency in a Cardiomyocyte Cell Model (HL-1 Cell) of Ischemia/Reperfusion Injury. Journal of Federation of American Societies for Experimental Biology. 24:719.1.
Placenta Copper Transport Proteins in Preeclampsia Reprint Icon - (Abstract Only)
Iseminger, C.V., Anderson, C.M., Johnson, W.T. 2010. Placenta Copper Transport Proteins in Preeclampsia. Journal of Federation of American Societies for Experimental Biology. 24:609.5.
Maternal Copper Deficiency Perpetuates Altered Vascular Function Across Two Generations of Sprague-Dawley Rat Offspring - (Abstract Only)
Anderson, C.M., Johnson, W.T. 2009. Maternal Copper Deficiency Perpetuates Altered Vascular Function Across Two Generations of Sprague-Dawley Rat Offspring. [Meeting Abstract]. Journal of Developmental Origins of Health and Disease (Vol. 1 Suppl 1).
Cyclooxygenase-2 is Upregulated in Copper-Deficient Rats - (Peer Reviewed Journal)
Schuschke, D.A., Adeagbo, A.S., Patibandla, P.K., Fernandez-Botran, R., Johnson, W.T. 2009. Cyclooxygenase-2 is Upregulated in Copper-Deficient Rats. Inflammation. 32(5):333-339.
Oxidative Stress in Cardiac Mitochondria Caused by Copper Deficiency May Be Insufficient to Damage Mitochondrial Proteins Reprint Icon - (Abstract Only)
Johnson, W.T. 2009. Oxidative Stress in Cardiac Mitochondria Caused by Copper Deficiency May Be Insufficient to Damage Mitochondrial Proteins. Journal of Federation of American Societies for Experimental Biology. 23:727.1.
Tempol Normalizes Aortic Relaxation But Not Elevated Isoprostanes or PGE2 in Copper-Deficient Rats Reprint Icon - (Abstract Only)
Schuschke, D.A., Johnson, W.T., Adeagbo, A.S. 2009. Tempol Normalizes Aortic Relaxation But Not Elevated Isoprostanes or PGE2 in Copper-Deficient Rats. Journal of Federation of American Societies for Experimental Biology. 23:727.3.
Endothelial Cell-Derived Nitric Oxide Mobilization is Attenuated in Copper-Deficient Rats - (Peer Reviewed Journal) - (18-Jul-08)
Endothelial Cell-Derived Nitric Oxide Mobilization is Attenuated in Copper-Deficient Rats Reprint Icon - (Peer Reviewed Journal)
Falcone, J.C., Lominadze, D., Johnson, W.T., Schuschke, D.A. 2008. Endothelial Cell-Derived Nitric Oxide Mobilization is Attenuated in Copper-Deficient Rats. Applied Physiology, Nutrition & Metabolism. 33:1073-1078.
Regression of Copper-Deficient Heart Hypertrophy: Reduction in the Size of Hypertrophic Cardiomyocytes Reprint Icon - (Peer Reviewed Journal)
Zhou, Z., Johnson, W.T., Kang, Y.J. 2009. Regression of Copper-Deficient Heart Hypertrophy: Reduction in the Size of Hypertrophic Cardiomyocytes. Journal of Nutritional Biochemistry. 20(8):621-628.
Cardiac Cytochrome c Oxidase Activity and Contents of Submits 1 and 4 are Altered in Offspring by Low Prenatal Intake by Rat Dams Reprint Icon - (Peer Reviewed Journal)
Johnson, W.T., Anderson, C.M. 2008. Cardiac Cytochrome c Oxidase Activity and Contents of Submits 1 and 4 are Altered in Offspring by Low Prenatal Intake by Rat Dams. Journal of Nutrition. 138:1269-1273
Copper Deficiency Inhibits CA2+-Induced Swelling in Rat Cardiac Mitochondria Reprint Icon - (Peer Reviewed Journal)
Johnson, W.T., Johnson, L.K. 2008. Copper Deficiency Inhibits CA2+-Induced Swelling in rat Cardiac Mitochondria. Journal of Nutritional Biochemistry.doi.10.1016/j.jnutbio.2008.02.009
Prenatal copper deficiency in rat dams causes persistent reduction in nuclear-encoded cytochrome c oxidase subunits in cardiac mitochrondria of the first generation Reprint Icon - (Abstract Only)
Johnson, W.T., Anderson, C. 2008. Prenatal copper deficiency in rat dams causes persistent reduction in nuclear-encoded cytochrome c oxidase subunits in cardiac mitochrondria of the first generation [Abstract]. Journal of Federation of American Societies for Experimental Biology. 22:443.2.
Marginal copper deficiency impairs endothelium-dependent relaxation responses across two generations Reprint Icon - (Abstract Only)
Anderson, C.M., Johnson, W.T. 2008. Marginal copper deficiency impairs endothelium-dependent relaxation responses across two generations [Abstract]. Journal of Federation of American Societies for Experimental Biology. 22:695.1.
Marginal copper deficiency in pregnancy: Vascular responses in dams and progeny - (Abstract Only)
Anderson, C.M., Johnson, W.T. 2007. Marginal copper deficiency in pregnancy: Vascular responses in dams and progeny. [abstract] Presented at Aspen Perinatal Biology Symposium, August 25-28, 2007, Aspen, CO. Abstracts were not published.
Dietary interaction of high fat and marginal copper deficiency on cardiac contractile function Reprint Icon - (Peer Reviewed Journal)
Relling, D.P., Esberg, L.B., Johnson, W.T., Murphy, E.J., Carlson, E.C., Lukaski, H.C., Saari, J.T., Ren, J. 2007. Dietary interaction of high fat and marginal copper deficiency on cardiac contractile function. Obesity. 15(5):1242-1257.
Prenatal Cu intake by rat dams is the principle determinant of cardiac cytochrome c oxidase activity in their offspring Reprint Icon - (Abstract Only)
Johnson, W.T., Anderson, C.M. 2007. Prenatal Cu intake by rat dams is the principle determinant of cardiac cytochrome c oxidase activity in their offspring [abstract]. Journal of Federation of American Societies for Experimental Biology. 21(5):A722.
Copper deficiency attenuates endothelial nitric oxide release Reprint Icon - (Abstract Only)
Schuschke, D.A., Johnson, W.T., Falcone, J.C. 2007. Copper deficiency attenuates endothelial nitric oxide release [abstract]. Journal of Federation of American Societies for Experimental Biology.21(5):A721.
Copper deficiency decreases the protein expression of Complex IV but not Complex I, II, III and V in mitochondrial respiratory chain in rat heart Reprint Icon - (Abstract Only)
Zeng, H., Saari, J.T., Johnson, W.T. 2007. Copper deficiency decreases the protein expression of Complex IV but not Complex I, II, III and V in mitochondrial respiratory chain in rat heart [abstract]. Journal of Federation of American Societies for Experimental Biology. 21(5):A722.
Copper deficiency decreases the protein expression of Complex IV but not Complex I, II, III, or V in mitochondrial respiratory chain in rat heart Reprint Icon - (Peer Reviewed Journal)
Zeng, H., Saari, J.T., Johnson, W.T. 2007. Copper deficiency decreases complex IV but not complex I, II, III, or V in the mitochondrial respiratory chain in rat heart. Journal of Nutrition. 137:14-18.
Pinto beans are a source of highly bioavailable copper Reprint Icon - (Peer Reviewed Journal)
Saari, J.T., Reeves, P.G., Johnson, W.T., Johnson, L.K. 2006. Pinto beans are a source of highly bioavailable copper. Journal of Nutrition. 136:2999-3004.
Rhoa Signal Transduction: Effects of Maternal Copper Deficiency on Progeny Reprint Icon - (Abstract Only)
Anderson, C.A., Brown-Borg, H.M., Johnson, W.T. 2006. Rhoa signal transduction: Effects of maternal copper deficiency on progeny [abstract]. Presented by Cindy A. Anderson at the 4th International Congress on Developmental Origins of Health and Disease (DOHaD). University of Utrecht, The Netherlands. September 12-16, 2006.
Hearts in adult offspring of copper-deficient dams exhibit decreased cytochrome c oxidase activity, increased mitochondrial hydrogen peroxide generation and enhanced formation of intracellular residual bodies Reprint Icon - (Peer Reviewed Journal)
Johnson, W.T., Newman Jr, S.M. 2007. Hearts in adult offspring of copper-deficient dams exhibit decreased cytochrome c oxidase activity, increased mitochondrial hydrogen peroxide generation and enhanced formation of intracellular residual bodies. Journal of Nutritional Biochemistry. 18:97-104.
Cardiac Mitochondrial Function Is Altered in the Adult Offspring of Copper-Deficient Dams - (Abstract Only)
Johnson, W.T., Newman, Jr., S.M. 2006. Cardiac mitochondrial function is altered in the adult offspring of copper-deficient dams [abstract]. Journal of Federation of American Societies for Experimental Biology. 20(5):A1065.
High-Fat Diet-Induced Juvenile Obesity Leads to Cardiomyocyte Dysfunction and Upregulation of Foxo3a Transcription Factor Independent of Lipotoxicity and Apoptosis Reprint Icon - (Peer Reviewed Journal)
Relling, D.P., Esberg, L.B., Fang, C.X., Johnson, W.T., Murphy, E.J., Carlson, E.C., Saari, J.T., Ren, J. 2006. High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis. Journal of Hypertension. 24:549-561.
Cardiac Cytochrome-C Oxidase Deficiency Occurs During Late Postnatal Development in Progeny of Copper-Deficient Rats Reprint Icon - (Peer Reviewed Journal)
Johnson, W.T., Brown-Borg, H.M. 2006. Cardiac cytochrome-c oxidase deficiency occurs during late postnatal development in progeny of copper-deficient rats. Experimental Biology and Medicine. 231:172-180.
Copper - (Book / Chapter)
Reeves, P.G., Johnson, W.T. 2006. Copper. In: Driskell, J.A., Wolinsky, I., editors. Sports Nutrition: Vitamins and Trace Elements, 2nd Edition. Boca Raton, FL:CRC Taylor & Francis Group. p. 235-252.
Serum Superoxide Dismutase 3 (Extracellular Superoxide Dismutase)activity Is a Sensitive Indicator of Cu Status in Rats Reprint Icon - (Peer Reviewed Journal)
Johnson, W.T., Johnson, L.K., Lukaski, H.C. 2005. Serum superoxide dismutase 3 (extracellular superoxide dismutase) activity is a sensitive indicator of Cu status in rats. Journal of Nutritional Biochemistry. 16:682-692.
Serum Superoxide Dismutase (Sod) Activity Is An Index of Copper Status - (Abstract Only)
Johnson, W.T., Lukaski, H.C. 2005. Serum superoxide dismutase (SOD) activity is an index of copper status [abstract]. The Federation of American Societies for Experimental Biology Journal. 19(5):A1485.
Dietary Copper Deficieny Reduces Iron Absorption and Duodenal Enterocyte Hephaestin Protein in Male and Female Rats Reprint Icon - (Peer Reviewed Journal)
Reeves, P.G., DeMars, L.C.S., Johnson, W.T., Lukaski, H.C. 2005. Dietary copper deficiency reduces iron absorption and duodenal enterocyte hephaestin protein in male and female rats. Journal of Nutrition. 135:92-98.
Supplemental Ascorbate Or Alpha-Tocopherol Induces Cell Death in Cu-Deficient Hl-60 Cells - (Peer Reviewed Journal)
Raymond, L.J., Johnson, W.T. 2004. Supplemental ascorbate or alpha-tocopherol induces cell death in Cu-deficient HL-60 cells. Experimental Biology and Medicine. 229:885-894.
Increased Heme Oxygenase-1 Expression During Copper Deficiency in Rats Results from Increased Mitochondrial Generation of Hydrogen Peroxide - (Peer Reviewed Journal)
Johnson, W.T., Demars, L.C. 2004. Increased heme oxygenase-1 expression during copper deficiency in rats results from increased mitochondrial generation of hydrogen peroxide. Journal of Nutrition. 134:1328-1333.
Copper Deficiency Induces Heme Oxygenase-1 in Rat Heart and Liver - (Abstract Only)
Johnson, W.T., Demars, L.C. 2004. Copper deficiency induces heme oxygenase-1 in rat heart and liver [abstract]. The Federation of American Societies for Experimental Biology Journal. 18:A914-A915.
Copper Deficiency: a Potential Model for Determining the Role of Mitochondria in Cardiac Aging - (Peer Reviewed Journal)
Johnson, W.T., Newman, S.M., Jr. 2003. Copper deficiency: A potential model for determining the role of mitochondria in cardiac aging. Journal of the American Aging Association. 26:29-38.
Changes in Respiratory Complex Activities of Heart Mitochondria Caused by Copper Deficiency During Development in Rats Are Resistant to Copper Supplementation - (Abstract Only)
Johnson, W.T. 2003. Changes in respiratory complex activities of heart mitochondria caused by copper deficiency during development in rats are resistant to copper supplementation [abstract]. The Federation of American Societies for Experimental Biology Journal. 17:A378.
Copper and Brain Function - (Book / Chapter)
Johnson, W.T. 2005. Copper and brain function. In: Lieberman, H.R., Kanarek, R.B., Prasad, C., editors. Nutritional Neuroscience. Boca Raton, FL:CRC Press/Taylor & Francis Group. p. 289-305.
Oxidative Stress Resulting from Inhibition of the Mitochondrial Electron Transport Chain Contributes to the Induction of Hepatic Heme Oxygenase-1 Incopper-Deficient Rats - (Abstract Only)
Johnson, W.T. 2003. Oxidative stress resulting from inhibition of the mitochondrial electron transport chain contributes to the induction of hepatic heme oxygenase-1 in copper deficient rats [abstract]. Journal of Nutrition. 133(5S-1):203E.
Dietary Copper But Not Dietary Zinc Decreases Protein Kinase C Alpha Expression and Dimethylhydrazine-Induced Aberrant Crypt Foci Formation in the Rat Colon - (Abstract Only)
Fox, E., Davis, C.D., Johnson, W.T. 2002. Dietary copper but not dietary zinc decreases protein kinase C alpha expression and dimethylhydrazine-induced aberrant crypt foci formation in the rat colon [abstract]. Proceedings of the North Dakota Academy of Science. 56:45.
Dietary Copper Affects Azoxymethane-Induced Intestinal Tumor Formation and Protein Kinase C Isozyme Protein and Mrna Expression in Colon of Rats - (Peer Reviewed Journal)
Davis, C.D., Johnson, W.T. 2002. Dietary copper affects azoxymethane-induced intestinal tumor formation and protein kinase C isozyme protein and MRNA expression in colon of rats. Journal of Nutrition. 132:1018-1025.
Mitochondrial Oxidant Generation and Oxidative Damage in Ames Dwarf and Gh Transgenic Mice - (Peer Reviewed Journal)
Brown-Borg, H., Johnson, W.T., Rakoczy, S., Romanick, M. 2001. Mitochondrial oxidant generation and oxidative damage in Ames dwarf and GH transgenic mice. Journal of American Aging Association. 24:85-96.
Low Dietary Copper (Cu) But Not Low Dietary Zinc (Zn) Affects Protein Kinase C and Alpha (Pkc) Expression in Rat Colon and Dimethylhydrazine Induced Aberrant Crypt Foci (Acf) Formation - (Abstract Only)
Davis, C.D., Johnson, W.T. 2002. Low dietary copper (Cu) but not low dietary zinc (Zn) affects protein kinase C and alpha (PKC) expression in rat colon and dimethylhydrazine-induced aberrant crypt foci (ACF) formation [abstract]. The Federation of American Societies of Experimental Biology Journal. 16:A374-A375.
Copper Deficiency in Hl-60 Cells Increases Their Susceptibility to Apoptosis When Treated with Antioxidants - (Abstract Only)
Sumner, L.J., Johnson, W.T. 2001. Copper deficiency in HL-60 cells increases their susceptibility to apoptosis when treated with antioxidants [abstract]. Presented at Frank Low Research Day, University of North Dakota, Grand Forks, ND, April 19, 2001.
Dietary Copper and Dimethylhydrazine (Dmh) Affect Protein Kinase C (Pkc) Isozyme Protein and Mrna Expression and the Formation of Aberrant Crypts in Colon of Rats - (Peer Reviewed Journal)
Davis, C.D., Johnson, W.T. 2001. Dietary copper and dimethylhydrazine (DMH) affect protein kinase C (PKC) isozyme protein and MRNA expression and the formation of aberrant crypts in colon of rats. Biofactors. 15:11-26.
Mitochondrial Oxidative Stress May Contribute to the Induction of Hepatic Heme Oxygenase-1 in Copper Deficient Rats - (Abstract Only)
Johnson, W.T. 2001. Mitochondrial oxidative stress may contribute to the induction of hepatic heme oxygenase-1 in copper deficient rats [astract]. The Federation of American Societies for Experimental Biology Journal. 15:A271.
Copper Deficiency in Hl-60 Cells Increases Their Susceptibility to Apoptosis When Treated with Antioxidants - (Abstract Only)
Sumner, L.J. 2001. Copper deficiency in HL-60 cells increases their susceptibility to apoptosis when treated with antioxidants [abstract]. The Federation of American Societies for Experimental Biology Journal. 15:A271.
Gender Influences the Effect of Perinatal Copper Deficiency on Cerebellar Pkc Gamma Content - (Peer Reviewed Journal)
Johnson, W.T., Prohaska, J.R. 2000. Gender influences the effect of perinatal copper deficiency on cerebellar PKC gamma content. Biofactors. 11:163-169.
Copper Deficiency Does Not Increase Hepatic Mitochondrial Hydrogen Peroxide Production - (Abstract Only)
Johnson, W.T. 2000. Copper deficiency does not increase hepatic mitochondrial hydrogen peroxide production [abstract]. The Federation of American Societies for Experimental Biology Journal. 14:A773.
Dietary Copper and Dimethylhydrazine (Dmh) Affect Protein Kinase C (Pkc) Isozyme Expression in Rat Colon - (Abstract Only)
Davis, C.D., Johnson, W.T. 2000. Dietary copper and dimethylhydrazine (DMH) affect protein kinase C (PKC) isozyme expression in rat colon [abstract]. The Federation of American Societies for Experimental Biology Journal. 14:A169.
Effects of Copper Deficiency and Food Restriction on Cytochrome C Oxidase, Manganese Superoxide Dismutase, Glutathione Peroxidase and Protein Oxidation in Liver and Heart Mitochondria - (Abstract Only) - (17-Apr-99)
Copper and Signal Transduction: Platelets As a Model to Determine the Role of Copper in Stimulus-Response Coupling - (Review Article) - (24-Feb-99)
Copper Deprivation Potentiates Oxidative Stress in Hl-60 Cell Mitochondria - (Peer Reviewed Journal) - (03-Feb-99)
Maternal Copper Deficiency Alters the Distribution of Protein Kinase C Isoforms in Neonatal Rat Brain - (Abstract Only) - (18-Apr-98)
Platelet Cytochrome C Oxidase As An Indicator of Copper Status - (Abstract Only) - (10-Sep-97)
Evidence of Oxidative Stress in Hl60 Cells Deprived of Copper - (Abstract Only) - (06-Apr-97)
Copper Deficiency Causes in Vivo Oxidative Modification of Erythrocyte Membrane Proteins in Rats - (Peer Reviewed Journal) - (07-Aug-96)
Copper Deficiency Causes in Vivo Oxidative Modification of Erythrocyte Membrane Proteins in Rats - (Proceedings) - (19-May-96)
Dietary Copper (Cu) Influences the Postnatal Expression of Protein Kinase C(pkc) Isoforms in Rat Brain - (Abstract Only) - (14-Apr-96)
In Vivo Oxidative Modification of Erythrocyte Membrane Proteins in Copper Deficiency - (Abstract Only) - (16-Nov-95)
Last Modified: 10/18/2013
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