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United States Department of Agriculture

Agricultural Research Service

Michael P. Heaton (Mike)

Research Microbiologist


Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Association of TMEM154 missense mutations with lentiviral infection and virus subtypes in sheep - (Proceedings) - (02-Apr-14)
SNPs for parentage testing and traceability in globally diverse breeds of sheep - (Peer Reviewed Journal)
Heaton, M.P., Leymaster, K.A., Kalbfleisch, T.S., Kijas, J.W., Clarke, S.M., McEwan, J., Maddox, J.F., Basnayake, V., Petrik, D.T., Simpson, B., Smith, T.P., Chitko-McKown, C.G. 2014. SNPs for parentage testing and traceability in globally diverse breeds of sheep. PLoS One. 9(4):e94851. DOI: 10.1371/JOURNAL.PONE.0094851.
Sequencing a North American yak genome - (Other)
Heaton, M.P. 2014. Sequencing a North American yak genome. International Yak Association. Online available. IYAK.org. http://0101.nccdn.net/1_5/11e/372/14c/HeatonIYAK2014_ARSapproved.pdf.
Worldwide patterns of ancestry, divergence, and admixture in domesticated cattle - (Peer Reviewed Journal)
Decker, J.E., Mckay, S.D., Rolf, M.M., Kim, J., Alcala, A., Sonstegard, T.S., Hanotte, O., Gotherstrom, A., Seabury, C.M., Praharani, L., Babar, M., Regitano, L. ., Yildiz, M., Heaton, M.P., Lui, W., Lei, C., Reecy, J.M., Saif-Ur-Rehman, M., Schnabel, R.D., Taylor, J.F. 2014. Worldwide patterns of ancestry, divergence, and admixture in domesticated cattle. PLoS Genetics. 10(3):e1004254.
Complete closed genome sequences of three Bibersteinia trehalosi nasopharyngeal isolates from cattle with shipping fever - (Peer Reviewed Journal)
Harhay, G.P., McVey, D.S., Koren, S., Phillippy, A.M., Bono, J.L., Harhay, D.M., Clawson, M.L., Heaton, M.P., Chitko-McKown, C.G., Korlach, J., Smith, T.P. 2014. Complete closed genome sequences of three Bibersteinia trehalosi nasopharyngeal isolates from cattle with shipping fever. Genome Announcements. 2(1):e00084-14.
Complete closed genome sequences of four Mannheimia varigena isolates from cattle with shipping fever - (Peer Reviewed Journal)
Harhay, G.P., Murray, R.W., Lubbers, B., Griffin, D., Koren, S., Phillippy, A.M., Harhay, D.M., Bono, J.L., Clawson, M.L., Heaton, M.P., Chitko McKown, C.G., Smith, T.P. 2014. Complete closed genome sequences of four Mannheimia varigena isolates from cattle with shipping fever. Genome Announcements. 2(1):e00088-14.
SNPs for parentage testing and traceability in globally diverse breeds of sheep - (Abstract Only)
Heaton, M.P., Leymaster, K.A., Kalbfleisch, T.S., Kijas, J.W., Clarke, S.M., McEwan, J., Maddox, J.F., Basnayake, V., Petrik, D.T., Simpson, B., Smith, T.P., Chitko McKown, C.G. 2014. SNPs for parentage testing and traceability in globally diverse breeds of sheep [Abstract]. Proceedings Plant and Animal Genome XXII Conference, January 11-15, 2014, San Diego, CA. Poster P614.
Mapping whole genome shotgun sequence and variant calling in mammalian species without their reference genomes - (Peer Reviewed Journal)
Kalbfleisch, T.S., Heaton, M.P. 2014. Mapping whole genome shotgun sequence and variant calling in mammalian species without their reference genomes. F1000 Research 2:244. doi: 10.12688/f1000research.2-244.v2.
Effects of TMEM154 haplotypes 1 and 3 on susceptibility to ovine progressive pneumonia virus following natural exposure in sheep - (Peer Reviewed Journal)
Leymaster, K.A., Chitko-McKown, C.G., Clawson, M.L., Harhay, G.P., Heaton, M.P. 2013. Effects of TMEM154 haplotypes 1 and 3 on susceptibility to ovine progressive pneumonia virus following natural exposure in sheep. Journal of Animal Science. 91(11):5114-5121.
Small ruminant lentivirus genetic subgroups associate with sheep TMEM154 genotypes - (Peer Reviewed Journal)
Sider, L.H., Heaton, M.P., Chitko-Mckown, C.G., Harhay, G.P., Smith, T.P.L., Leymaster, K.A., Laegreid, W.W., and Clawson, M.L. 2013. Small ruminant lentivirus genetic subgroups associate with sheep TMEM154 genotypes. Veterinary Research. 44:64. DOI: 10.1186/1297-9716-44-64.
Complete closed genome sequences of Mannheimia haemolytica serotypes A1 and A6 isolated from cattle - (Peer Reviewed Journal)
Harhay, G.P., Koren, S., Phillippy, A.M., McVey, D.S., Kuszak, J., Clawson, M.L., Harhay, D.M., Heaton, M.P., Chitko-McKown, C.G., Smith, T.P.L. 2013. Complete closed genome sequences of Mannheimia haemolytica serotypes A1 and A6 isolated from cattle. Genome Announcements. 1(3):e00188-13. DOI: 10.1128/GENOMEA.00188-13.
Characterization of ovine Nectin-4, a novel peste des petits ruminants virus (PPRV) receptor - (Peer Reviewed Journal)
Birch, J., Juleff, N., Heaton, M.P., Kalbfleisch, T., Kijas, J., Bailey, D. 2013. Characterization of ovine Nectin-4, a novel peste des petits ruminants virus (PPRV) receptor. Journal of Virology. 87(8):4756-4761.
Rhodotorula minuta fungemia in a ewe lamb - (Peer Reviewed Journal)
Chitko-McKown, C.G., Leymaster, K.A., Heaton, M.P., Griffin, D.D., Veatch, J.K., Jones, S., Clawson, M.L. 2013. Rhodotorula minuta fungemia in a ewe lamb. Transboundary and Emerging Diseases. doi:10.1111/tbed.12062. [Epub ahead of print].
Genetic testing for TMEM154 mutations associated with lentivirus susceptibility in sheep - (Peer Reviewed Journal)
Heaton, M.P., Kalbfleisch, T.S., Petrik, D.T., Simpson, B., Kijas, J.W., Clawson, M.L., Chitko MckKown, C.G., Harhay, G.P., Leymaster, K.A. 2013. Genetic testing for TMEM154 mutations associated with lentivirus susceptibility in sheep. PLoS One. 8(2):e55490. doi:10.1371/journal.pone.0055490.
Application of SMRT genome sequencing to reveal the methylomes of bacteria associated with respiratory disease outbreaks in beef cattle - (Abstract Only)
Harhay, G.P., McVey, D.S., Korlach, J., Roberts, R., Chitko-McKown, C.G., Clawson, M.L., Heaton, M.P., Harhay, D.M., Smith, T.P.L., Anton, B.P. 2013. Application of SMRT genome sequencing to reveal the methylomes of bacteria associated with respiratory disease outbreaks in beef cattle [Abstract]. Advances in Genome Biology and Technology Conference, February 20-23, 2013, Marco Island, FL. Page 99.
Genetic testing for TMEM154 mutations associated with lentivirus susceptibility in sheep - (Abstract Only)
Heaton, M.P., Kalbfleisch, T., Petrik, D.T., Simpson, B., Kijas, J., Clawson, M.L., Chitko-McKown, C.G., Leymaster, K.A., Harhay, G.P. 2013. Genetic testing for TMEM154 mutations associated with lentivirus susceptibility in sheep [abstract]. International Plant & Animal Genome XXI Conference. No. P0625.
Mutations in ovine TMEM154 associated with reduced risk of ovine lentivirus infection are also associated with reduced proviral concentration - (Abstract Only)
Alshanbari, F., Mousel, M.R., Reynolds, J.O., Hermann-Hoesing, L.M., Heaton, M.P., Lewis, G.S., Knowles Jr, D.P., White, S.N. 2012. Mutations in ovine TMEM154 associated with reduced risk of ovine lentivirus infection are also associated with reduced proviral concentration . Annual International Plant & Animal Genome Conference. Plant & Animal Genomes Conference XXI, Abstract 0624. San Diego, CA. January 14, 2013..
Consistent divergence times and allele sharing measured from cross-species application of SNP chips developed for three domestic species - (Peer Reviewed Journal)
Miller, J.M., Kijas, J.W., Heaton, M.P., McEwan, J.C., Coltman, D.W. 2012. Consistent divergence times and allele sharing measured from cross-species application of SNP chips developed for three domestic species. Molecular Ecology Resources. 12(6):1145-1150. doi:10.1111/1755-0998.12017.
Phylogenetic clades of ovine progressive pneumonia virus (OPPV) associate with sheep TMEM154 genotypes - (Abstract Only)
Sider, L.H., Clawson, M.L., Heaton, M.P., Chitko Mckown, C.G., Harhay, G.P., Smith, T.P.L., Leymaster, K.A. 2012. Phylogenetic clades of ovine progressive pneumonia virus (OPPV) associate with sheep TMEM154 genotypes. The 58th Genomic Congress, September 11-14, 2012. Foz de Iguacu, Brazil. Poster No. GM001.
Reduced OPP susceptibility in naturally exposed lambs with homozygous TMEM154 K35 genotypes - (Abstract Only)
Chitko Mckown, C.G., Leymaster, K.A., Heaton, M.P., Clawson, M.L., Harhay, G.P. 2012. Reduced OPP susceptibility in naturally exposed lambs with homozygous TMEM154 K35 genotypes [abstract]. Immunology 2012. The 99th Annual Meeting of the American Association for Immunology, May 4-8, 2012, Boston, Massachusetts. Page 275. Abstract No. 170.3. Poster No. P1246.
Genome wide analysis of the world's sheep breeds reveals high levels of historic mixture and strong recent selection Reprint Icon - (Peer Reviewed Journal)
Kijas, J.W., Lenstra, J.A., Porto Neto, L., Mcculloch, R., Whan, V., Gietzen, K., Paiva, S., Gill, C., Barendse, W., Ciani, E., Raadsma, H., Mcewan, J., Dalrymple, B., Heaton, M.P., et al. 2012. Genome wide analysis of the world's sheep breeds reveals high levels of historic mixture and strong recent selection. PLoS Biology. 10(2): e1001258. DOI:10.1371/journal.pbio.1001258.
Development of a SNP panel for parentage assignment in sheep - (Abstract Only)
Kijas, J.W., Mcewan, J., Clarke, S.M., Maddox, J.F., Mcculloch, R., Driver, F., Ilic, K., Heaton, M.P. 2012. Development of a SNP panel for parentage assignment in sheep [abstract]. Plant & Animal Genome XX Conference, January 14-18, 2012, San Diego, California. Poster #P0577.
Application of combined SMRT and long-read pyrosequencing to produce reference genome sequences of bacteria associated with respiratory disease outbreaks in beef cattle - (Abstract Only)
Harhay, G.P., Mcvey, D.S., Kitzmiller, A., Clamp, M., Osborne, B., Dwan, C., Zhang, J., Sisneros, N., Wang, S., Peluso, P., Bono, J.L., Chitko Mckown, C.G., Clawson, M.L., Heaton, M.P., Harhay, D.M., Smith, T.P.L. [abstract]. 2012. Application of combined SMRT and long-read pyrosequencing to produce reference genome sequences of bacteria associated with respiratory disease outbreaks in beef cattle. Advances in Genome Biology and Technology, February 15-18, 2012, Marco Island, Florida. Poster No. 129.
Reduced lentivirus susceptibility in sheep with TMEM154 mutations - (Peer Reviewed Journal)
Heaton, M.P., Clawson, M.L., Chitko-Mckown, C.G., Leymaster, K.A., Smith, T.P.L., Harhay, G.P., White, S.N., Herrmann-Hoesing, L.M., Mousel, M.R., Lewis, G.S., Kalbfleisch, T.S., Keen, J.E., Laegreid, W.W. 2012. Reduced lentivirus susceptibility in sheep with TMEM154 mutations. PLoS Genetics. 8(1): e1002467. DOI: 10.1371/journal.pgen.1002467.
A case report describing detection of Rhodoturola minuta fungemia in an ewe lamb - (Abstract Only)
Chitko Mckown, C.G., Leymaster, K.A., Heaton, M.P., Griffin, D.D., Veatch, J.K., Jones, S.A., Clawson, M.L. 2011. A case report describing detection of Rhodoturola minuta fungemia in an ewe lamb [Abstract]. Proceeding of the 2011 Conference of Research Workers in Animal Diseases, December 4-6, 2011, Chicago, Illinois. p. 95.
Discovery of a lentivirus susceptibility gene in sheep - (Abstract Only)
Heaton, M.P. 2011. Discovery of a lentivirus susceptibility gene in sheep. Queenstown Molecular Biology 2011 Meeting Abstracts.
Ovine Reference Materials and Assays for Prion Genetic Testing Reprint Icon - (Peer Reviewed Journal)
Heaton, M.P., Leymaster, K.A., Kalbfleisch, T.S., Freking, B.A., Smith, T.P., Clawson, M.L., Laegreid, W.W. 2010. Ovine Reference Materials and Assays for Prion Genetic Testing. BioMed Central (BMC) Veterinary Research [serial online]. 6:23. Available: http://www.biomedcentral.com/1746-6148/6/23.
Ovine Reference Materials and Assays for Prion Genetic Testing - (Abstract Only)
Heaton, M.P., Leymaster, K.A., Kalbfleisch, T.S., Freking, B.A., Smith, T.P., Clawson, M.L., Laegreid, W.W. 2009. Ovine Reference Materials and Assays for Prion Genetic Testing [abstract]. Plant and Animal Genomes XVIII Conference. Abstract No. P577. Available: http://www.intl-pag.org/18/abstracts/
Discovery, Validation and Characterization of 1039 Cattle Single Nucleotide Polymorphisms Reprint Icon - (Peer Reviewed Journal)
Donthu, R., Larkin, D.M., Heaton, M.P., Lewin, H.A. 2010. Discovery, Validation and Characterization of 1039 Cattle Single Nucleotide Polymorphisms. Animal Genetics. 41(4):421-423.
Resolving the Evolution of Extant and Extinct Ruminants With High-Throughput Phylogenomics Reprint Icon - (Peer Reviewed Journal)
Decker, J.E., Pires, J.C., Conant, G.C., McKay, S.D., Heaton, M.P., Chen, K., Cooper, A., Vilkki, J., Seabury, C.M., Caetano, A.R., Johnson, G.S., Brenneman, R.A., Hanotte, O., Eggert, L.S., Wiener, P., Kim, J.J., Kim, K.S., Sonstegard, T.S., Van Tassell, C.P., Neibergs, H.L., McEwan, J.C., Brauning, R., Coutinho, L.L., Babar, M.E., Wilson, G.A., McClure, M.C., Rolf, M.M., Kim, J., Schnabel, R.D., Taylor, J.F. 2009. Resolving the Evolution of Extant and Extinct Ruminants With High-Throughput Phylogenomics. Proceedings of the National Academy of Sciences. 106(44):18644-18649.
Frequent Missense and Insertion/Deletion Polymorphisms in the Ovine Shadoo Gene Parallel Species-Specific Variation in PrP Reprint Icon - (Peer Reviewed Journal)
Daude, N., Wohlgemuth, S., Rogaeva, E., Farid, A.H., Heaton, M.P., Westaway, D. 2009. Frequent Missense and Insertion/Deletion Polymorphisms in the Ovine Shadoo Gene Parallel Species-Specific Variation in PrP. PLoS One [serial online]. 4(8):e6538.
High-Throughput Phylogenomics: from Ancient DNA to Signatures of Human Animal Husbandry - (Abstract Only)
Decker, J.E., Pires, J.C., Conant, G.C., Mckay, S.D., Heaton, M.P., Vilkki, J., Seabury, C.M., Caetano, A.R., Johnson, G.S., Brenneman, R.A., Hanotte, O., Eggert, L.S., Wiener, P., Kim, J., Kim, K.S., Sonstegard, T.S., Van Tassell, C.P., Neibergs, H.L., Chen, K., Cooper, A., Mcewan, J.C., Brauning, R., Coutinho, L.L., Babar, M.E., Wilson, G.A., Mcclure, M.C., Rolf, M.M., Kim, J., Schnabel, R.D., Taylor, J.F. 2009. HIGH-THROUGHPUT PHYLOGENOMICS: FROM ANCIENT DNA TO SIGNATURES OF HUMAN ANIMAL HUSBANDRY. Cold Spring Harbor Meeting.
Development and Characterization of a High Density SNP Genotyping Assay for Cattle Reprint Icon - (Peer Reviewed Journal)
Matukumalli, L.K., Lawley, C.T., Schnabel, R.D., Taylor, J.F., Allan, M.F., Heaton, M.P., O'Connell, J., Moore, S.S., Smith, T.P., Sonstegard, T.S., Van Tassell, C.P. 2009. Development and Characterization of a High Density SNP Genotyping Assay for Cattle. PLoS One. 4(4):e5350. Available: http://dx.doi.org/10.1371/journal.pone.0005350.
A Genome Wide Survey of SNP Variation Reveals the Genetic Structure of Sheep Breeds Reprint Icon - (Peer Reviewed Journal)
Kijas, J.W., Townley, D., Dalrymple, B.P., Heaton, M.P., Maddox, J.F., McGrath, A., Wilson, P., Ingersoll, R.G., McCulloch, R., McWilliam, S., Tang, D., McEwan, J., Cockett, N., Oddy, V.H., Nicholas, F.W., Raadsma, H. 2009. A Genome Wide Survey of SNP Variation Reveals the Genetic Structure of Sheep Breeds. PLoS One [serial online]. 4(3):e4668. Available: http://www.plosone.org.
A web-based genome browser for 'SNP-aware' assay design - (Abstract Only)
Morris, J.P., Heaton, M.P., Kalbfleisch, T.S. 2009. A web-based genome browser for 'SNP-aware' assay design [abstract]. Plant and Animal Genomes XVII Conference. Abstract No. CP843. Available: http://www.intl-pag.org/17/abstracts/
Prevalence of the prion gene E211K variant in U.S. cattle - (Peer Reviewed Journal)
Heaton, M.P., Keele, J.W., Harhay, G.P., Richt, J., Koohmaraie, M., Wheeler, T.L., Shackelford, S.D., Casas, E., King, D.A., Sonstegard, T.S., Van Tassell, C.P., Neibergs, H.L., Chase, C.C., Kalbfleisch, T.S., Smith, T.P., Clawson, M.L., Laegreid, W.W. 2008. Prevalence of the prion gene E211K variant in U.S. cattle. BioMed Central (BMC) Veterinary Research [journal online]. 4:25. Available: (http://www.biomedcentral.com/1746-6148/4/25).
Scrapie resistance in ARQ sheep - (Peer Reviewed Journal)
Laegreid, W.W., Clawson, M.L., Heaton, M.P., Green, B.T., Orourke, K.I., Knowles Jr, D.P. 2008. Scrapie resistance in ARQ sheep. Journal of Virology. 82(20):10318-10320. Available: DOI:10.1128/JVI.00710-08.
A sequencing strategy for identifying variation throughout the prion gene of BSE-affected cattle - (Peer Reviewed Journal)
Clawson, M.L., Heaton, M.P., Keele, J.W., Smith, T.P., Harhay, G.P., Richt, J., Laegreid, W.W. 2008. A sequencing strategy for identifying variation throughout the prion gene of BSE-affected cattle. BMC Research Notes [journal online]. 1:32. Available: http://www.biomedcentral.com/1756-0500/1/32.
Association of a bovine prion gene haplotype with atypical BSE - (Peer Reviewed Journal)
Clawson, M.L., Richt, J., Baron, T., Biacabe, A., Czub, S., Heaton, M.P., Smith, T.P., Laegreid, W.W. 2008. Association of a bovine prion gene haplotype with atypical BSE. PLoS One [serial online]. 3(3):e1830. Available: http://www.plosone.org.
Prevalence of the prion gene E211K variant in U.S. cattle - (Abstract Only)
Heaton, M.P., Keele, J.W., Harhay, G.P., Richt, J., Koohmaraie, M., Wheeler, T.L., Shackelford, S.D., Casas, E., King, D.A., Sonstegard, T.S., Van Tassell, C.P., Neibergs, H.L., Chase, C.C., Kalbfleisch, T.S., Smith, T.P., Clawson, M.L., Laegreid, W.W. 2008. Prevalence of the prion gene E211K variant in U.S. cattle (abstract). Plant and Animal Genome XVI Conference. Poster No. P538.
Scrapie resistance in ARQ sheep - (Abstract Only)
Laegreid, W.W., Clawson, M.L., Heaton, M.P., Green, B.T., Orourke, K.I., Knowles Jr, D.P. 2008. Scrapie resistance in ARQ sheep (abstract). Plant and Animal Genome XVI Conference. Poster No. P550.
Association of Escherichia coli O157:H7 tir polymorphisms in human infection Reprint Icon - (Peer Reviewed Journal)
Bono, J.L., Keen, J.E., Clawson, M.L., Durso, L.M., Heaton, M.P., Laegreid, W.W. 2007. Association of Escherichia coli O157:H7 tir polymorphisms with human infection. BMC Infectious Diseases. 7:98.
Genome scan for BSE susceptibility and/or resistance in European Holstein cattle - (Abstract Only)
Murdoch, B., Mckay, S., Prasad, A., Marques, E., Kolbehdari, D., Wang, Z., Stella, A., Clawson, M.L., Heaton, M.P., Laegreid, W.W., Moore, S., Williams, J. 2007. Genome scan for BSE susceptibility and/or resistance in European Holstein cattle [abstract]. Prion 2007 Conference. Abstract No. P03.126.
Prion gene haplotypes of U.S. cattle Reprint Icon - (Peer Reviewed Journal)
Clawson, M.L., Heaton, M.P., Keele, J.W., Smith, T.P., Harhay, G.P., Laegreid, W.W. 2006. Prion gene haplotypes of U.S. cattle. BioMed Central (BMC) Genetics. 7:51.
A marker set for parentage-based DNA traceback in beef and dairy cattle - (Abstract Only)
Heaton, M.P., Snelling, W.M., Smith, T.P., Keele, J.W., Harhay, G.P., Wiedmann, R.T., Bennett, G.L., Freking, B.A., Van Tassell, C.P., Sonstegard, T.S., Gasbarre, L.C., Moore, S.S., Murdoch, B., Mckay, S.D., Kalbfleisch, T., Laegreid, W.W. 2007. A marker set for parentage-based DNA traceback in beef and dairy cattle [abstract]. Plant and Animal Genome XV Conference. Poster No. P516.
Development of a web services based system for dissemination of single nucleotide polymorphism data - (Abstract Only)
Heaton, M.P., Morris, J., Eltonsy, N., Rouchka, E., Kalbfleisch, T. 2007. Development of a web services based system for dissemination of single nucleotide polymorphism data [abstract]. Plant and Animal Genome XV Conference. Poster No. P517.
Genome adaptations of a tripartite motif protein for retroviral defense in cattle and sheep - (Abstract Only)
Smith, T.P., Heaton, M.P., Snelling, W.M., Ylinen, L., Keckesova, Z., Webb, B.L., Towers, G.J. 2007. Genome adaptations of a tripartite motif protein for retroviral defense in cattle and sheep [abstract]. Plant and Animal Genome XV Conference. Poster No. P540.
A rapid sequence-based method for comprehensive polymorphism identification within a 25.2-kb region of the bovine prion gene in BSE-affected cattle - (Abstract Only)
Clawson, M.L., Heaton, M.P., Keele, J.W., Smith, T.P., Harhay, G.P., Laegreid, W.W. 2007. A rapid sequence-based method for comprehensive polymorphism identification within a 25.2-kb region of the bovine prion gene in BSE-affected cattle [abstract]. Plant and Animal Genome XV Conference. Poster No. P533.
Polymorphisms and haplotype structure of bovine PRND (doppel) and PRNT - (Abstract Only)
Laegreid, W.W., Clawson, M.L., Smith, T.P., Harhay, G.P., Keele, J.W., Heaton, M.P. 2007. Polymorphisms and haplotype structure of bovine PRND (doppel) and PRNT [abstract]. Plant and Animal Genome XV Conference. Poster No. P535.
Linkage Disequilibrium Across Six Prion Gene Regions Spanning 20 Kbp in U.S. Sheep - (Peer Reviewed Journal)
Green, B.T., Heaton, M.P., Clawson, M.L., Laegreid, W.W. 2006. Linkage disequilibrium across six prion gene regions spanning 20 kbp in U.S. sheep. Mammalian Genome. 17(11):1121.1129.
Characterization of 954 Bovine Full-Cds Cdna Sequences - (Peer Reviewed Journal)
Harhay, G.P., Sonstegard, T.S., Keele, J.W., Heaton, M.P., Clawson, M.L., Snelling, W.M., Wiedmann, R.T., Van Tassell, C.P., Smith, T.P. 2005. Characterization of 954 bovine full-CDS cDNA sequences. Biomed Central (BMC) Genomics 6:166 (11 pp).
Evaluation of Associations Between Prion Haplotypes and Growth, Carcass, and Meat Quality Traits in a Dorset X Romanov Sheep Population - (Peer Reviewed Journal)
Isler, B.J., Freking, B.A., Thallman, R.M., Heaton, M.P., Leymaster, K.A. 2006. Evaluation of associations between prion haplotypes and growth, carcass, and meat quality traits in a Dorset x Romanov sheep population. Journal of Animal Science. 84:783-788.
A Freely-Available Set of Reference Dnas for Genotyping the Major Scrapie Susceptibility Alleles in Sheep - (Abstract Only)
Heaton, M.P., Leymaster, K.A., Clawson, M.L., Freking, B.A., Laegreid, W.W. 2006. A freely-available set of reference DNAs for genotyping the major scrapie susceptibility alleles in sheep [abstract]. Plant and Animal Genome Conference Proceedings. p. 239.
Linkage Disequilibrium and Haplotype Structure in the Prion Gene of U.S. Beef and Dairy Cattle - (Abstract Only)
Clawson, M.L., Heaton, M.P., Keele, J.W., Smith, T.P., Laegreid, W.W. 2006. Linkage disequilibrium and haplotype structure in the prion gene of U.S. beef and dairy cattle (abstract). Plant and Animal Genome Conference Proceedings. p. 145.
Use of Bovine Single Nucleotide Polymorphism Markers for Confirmation of Identity and Parentage - (Abstract Only)
Laegreid, W.W., Clawson, M.L., Heaton, M.P. 2005. Use of bovine single nucleotide polymorphism markers for confirmation of identity and parentage [abstract]. United States Animal Health Association. p. 710.
In Silico Discovery, Mapping, and Genotyping of 1,039 Cattle Snps on a Panel of Eighteen Breeds - (Abstract Only)
Donthu, R., Larkin, D.M., Heaton, M.P., Lewin, H.A. 2006. In silico discovery, mapping, and genotyping of 1,039 cattle SNPs on a panel of eighteen breeds [abstract]. Plant and Animal Genome Conference Proceedings. p. 235.
Discrimintion of Escherichia Coli O157:h7 Isolates by Genotyping Single Nucleotide Polymorphisms - (Abstract Only)
Bono, J.L., Keen, J.E., Clawson, M.L., Heaton, M.P., Chitko Mckown, C.G., Miller, L.C., Laegreid, W.W. 2005. Discrimintion of Escherichia coli O157:H7 isolates by genotyping single nucleotide polymorphisms. [abstract] American Society of Microbiologists. p. 318.
Bovine Single Nucleotide Polymorphisms (Snps) and Their Use in Animal Identification, Parentage Testing, and Traceback - (Abstract Only)
Heaton, M.P. 2005. Bovine single nucleotide polymorphisms (SNPs) and their use in animal identification, parentage testing, and traceback [abstract]. Midwestern Section of the American Society of Animal Science. p.8.
Effects of Prion Haplotype on Growth and Carcass Traits in Sheep - (Peer Reviewed Journal)
Isler, B.J., Freking, B.A., Heaton, M.P., Thallman, R.M., Leymaster, K.A. 2005. Effects of prion haplotype on growth and carcass traits in sheep [abstract]. Midwestern Section of the American Society of Animal Science. 83(Suppl. 2):44-45
Identification of Polymorphisms in Non-Coding Regions of the Ovine Prnp Gene - (Abstract Only)
Green, B.T., Clawson, M.L., Heaton, M.P., Chitko Mckown, C.G., Fox, J.M., Laegreid, W.W. 2004. Identification of polymorphisms in non-coding regions of the ovine PRNP gene [abstract]. Research Workers in Animal Diseases Conference. p. 90.
Use of Bovine Snp Markers to Verify Sample Tracking in Beef Processing - (Abstract Only)
Heaton, M.P., Keen, J.E., Clawson, M.L., Harhay, G.P., Bauer, N., Shultz, C., Green, B.T., Durso, L.M., Chitko Mckown, C.G., Laegreid, W.W. Use of bovine SNP markers to verify sample tracking in beef processing [abstract]. Plant and Animal Genome Conference Proceedings. p. 124.
Use of Bovine Single Nucleotide Polymorphism Markers to Verify Sample Tracking in Beef Processing - (Peer Reviewed Journal)
Heaton, M.P., Keen, J.E., Clawson, M.L., Harhay, G.P., Bauer, N., Schultz, C., Green, B.T., Durso, L.M., Chitko Mckown, C.G., Laegreid, W.W. 2005. Use of bovine single nucleotide polymorphism markers to verify sample tracking in beef processing. Journal of the American Veterinary Medical Association 226(8):1311-1314.
Discrimination of Escherichia Coli O157:h7 from Other Bacteria by Genotyping Single Nucleotide Polymorphisms - (Abstract Only)
Bono, J.L., Keen, J.E., Clawson, M.L., Heaton, M.P., Fox, J.M., Chitko McKown, C.G., Laegreid, W.W. 2004. Discrimination of Escherichia coli O157:H7 from other bacteria by genotyping single nucleotide polymorphisms [abstract]. American Society for Microbiology. Paper No. C-311.
Prion Gene Sequence Variation Within Diverse Groups of U.S. Sheep, Beef Cattle, and Deer - (Abstract Only)
HEATON, M.P., LEYMASTER, K.A., FREKING, B.A., HAWK, D.A., KEELE, J.W., LAEGREID, W.W. PRION GENE SEQUENCE VARIATION WITHIN DIVERSE GROUPS OF U.S. SHEEP, BEEF CATTLE, AND DEER. PLANT AND ANIMAL GENOME CONFERENCE PROCEEDINGS. 2004. ABSTRACT NO. P311.
Accurate Determination of Prnp Haplotypes in U.S. Sheep - (Abstract Only)
HEATON, M.P., LEYMASTER, K.A., FREKING, B.A., LAEGREID, W.W. ACCURATE DETERMINATION OF PRNP HAPLOTYPES IN U.S. SHEEP. PLANT AND ANIMAL GENOME CONFERENCE PROCEEDINGS. 2004. ABSTRACT NO. P312.
Correlation of Sry and Zfy Alleles of the Y Chromosome in U.S. Beef Cattle - (Abstract Only)
CLAWSON, M.L., HEATON, M.P., FOX, J.M., CHITKO MCKOWN, C.G., SMITH, T.P., LAEGREID, W.W. CORRELATION OF SRY AND ZFY ALLELES OF THE Y CHROMOSOME IN U.S. BEEF CATTLE. PLANT AND ANIMAL GENOME CONFERENCE PROCEEDINGS. 2004. ABSTRACT NO. P310.
Genetic Risk Factors for Failure of Passive Transfer in the Bovine Neonatal Fc Receptor - (Abstract Only)
LAEGREID, W.W., CLAWSON, M.L., HEATON, M.P., KEEN, J.E., CHITKO MCKOWN, C.G., FOX, J.M., SMITH, T.P., SNELLING, W.M., KEELE, J.W. GENETIC RISK FACTORS FOR FAILURE OF PASSIVE TRANSFER IN THE BOVINE NEONATAL FC RECEPTOR. PLANT AND ANIMAL GENOME CONFERENCE PROCEEDINGS. ABSTRACT NO. P642.
Male-Specific Sry and Zfy Haplotypes in U.S. Beef Cattle - (Peer Reviewed Journal)
Clawson, M.L., Heaton, M.P., Fox, J.M., Chitko Mckown, C.G., Smith, T.P., Laegreid, W.W. 2004. Male-specific SRY and ZFY haplotypes in U.S. beef cattle. Animal Genetics. 35(3):246-249.
Evaluation of a Real-Time Pcr Kit for Detecting Escherichia Coli O157 in Bovine Fecal Samples - (Peer Reviewed Journal)
BONO, J.L., KEEN, J.E., MILLER, L.C., FOX, J.M., CHITKO MCKOWN, C.G., HEATON, M.P., LAEGREID, W.W. EVALUATION OF A REAL-TIME PCR KIT FOR DETECTING ESCHERICHIA COLI O157 IN BOVINE FECAL SAMPLES. APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 2004. V. 70. P. 1855-1857.
Beta-2-Microglobulin Haplotypes in U.S. Beef Cattle and Association with Failure of Passive Transfer in Newborn Calves - (Peer Reviewed Journal)
Clawson, M.L., Heaton, M.P., Chitko Mckown, C.G., Fox, J.M., Smith, T.P., Snelling, W.M., Keele, J.W., Laegreid, W.W. 2004. Beta-2-microglobulin haplotypes in u.s. beef cattle and association with failure of passive transfer in newborn calves. Mammalian Genome. 2004. V. 15. P. 227-236.
Gene Expression Profiling of Bovine Macrophages in Response to Escherichia Coli O157:h7 Lipopolysaccharide - (Abstract Only)
CHITKO MCKOWN, C.G., FOX, J.M., MILLER, L.C., HEATON, M.P., BONO, J.L., KEEN, J.E., GROSSE, W.M., LAEGREID, W.W. GENE EXPRESSION PROFILING OF BOVINE MACROPHAGES IN RESPONSE TO ESCHERICHIA COLI O157:H7 LIPOPOLYSACCHARIDE. IMMUNOLOGY RESEARCH WORKSHOP. 2003. ABSTRACT NO. 23.
Gene Expression Profiling of Bovine Macrophages in Response to Escherichia Coli O157:h7 Lipopolysaccharide - (Peer Reviewed Journal)
CHITKO MCKOWN, C.G., FOX, J.M., MILLER, L.C., HEATON, M.P., BONO, J.L., KEEN, J.E., GROSSE, W.M., LAEGREID, W.W. GENE EXPRESSION PROFILING OF BOVINE MACROPHAGES IN RESPONSE TO ESCHERICHIA COLI O157:H7 LIPOPOLYSACCHARIDE. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY. 2004. V. 28. P. 635-645.
Effect of Exogenous Glucocorticoids and Dietary Change on Winter and Summer Stec O157 Fecal Shedding in Naturally-Infected Beef Cattle - (Abstract Only)
KEEN, J.E., LAEGREID, W.W., CHITKO MCKOWN, C.G., BONO, J.L., FOX, J.M., CLAWSON, M.L., HEATON, M.P. EFFECT OF EXOGENOUS GLUCOCORTICOIDS AND DIETARY CHANGE ON WINTER AND SUMMER STEC O157 FECAL SHEDDING IN NATURALLY-INFECTED BEEF CATTLE. RESEARCH WORKERS IN ANIMAL DISEASES CONFERENCE PROCEEDINGS. 2003. ABSTRACT NO. 83.
Prion Gene Sequence Variation Within Diverse Groups of U.S. Sheep, Beef Cattle, and Deer - (Peer Reviewed Journal)
HEATON, M.P., LEYMASTER, K.A., FREKING, B.A., HAWK, D.A., SMITH, T.P., KEELE, J.W., SNELLING, W.M., FOX, J.M., CHITKO MCKOWN, C.G., LAEGREID, W.W. PRION GENE SEQUENCE VARIATION WITHIN DIVERSE GROUPS OF U.S. SHEEP, BEEF CATTLE, AND DEER. MAMMALIAN GENOME. 2003. V. 14. P. 765-777.
Association of Nos2a Haplotypes and Bactericidal Activity of Bovine Monocyte-Derived Macrophages - (Abstract Only)
CHITKO MCKOWN, C.G., HEATON, M.P., GROSSE, W.M., KEEN, J.E., BONO, J.L., CLAWSON, M.L., FOX, J.M., MILLER, L.C., LAEGREID, W.W. ASSOCIATION OF NOS2A HAPLOTYPES AND BACTERICIDAL ACTIVITY OF BOVINE MONOCYTE-DERIVED MACROPHAGES. AMERICAN ASSOCIATION OF IMMUNOLOGISTS PROCEEDINGS. 2003. Abstract No. 150.1.
Beta2-Microglobulin Haplotype Structure in U.S. Beef Cattle and Correlation with Serum Igg Concentration in Newborn Calves - (Abstract Only)
CLAWSON, M.L., HEATON, M.P., LAEGREID, W.W. BETA2-MICROGLOBULIN HAPLOTYPE STRUCTURE IN U.S. BEEF CATTLE AND CORRELATION WITH SERUM IGG CONCENTRATION IN NEWBORN CALVES. PLANT AND ANIMAL GENOME CONFERENCE PROCEEDINGS. 2003. Abstract No. P261.
Association of Bovine Neonatal Fc Receptor Gene (Fcgrt) Haplotypes with Serum Igg Concentration in Newborn Calves - (Peer Reviewed Journal)
LAEGREID, W.W., HEATON, M.P., KEEN, J.E., GROSSE, W.M., CHITKO MCKOWN, C.G., SMITH, T.P., KEELE, J.W., BENNETT, G.L., BESSER, T.E. ASSOCIATION OF BOVINE NEONATAL FC RECEPTOR GENE ALPHA-CHAIN GENE (FCGRT) HAPLOTYPES WITH SERUM IgG CONCENTRATION IN NEWBORN CALVES. MAMMALIAN GENOME. 2002. v. 13. p. 704-710.
Evaluation of Single Nucleotide Polymorphisms in Capn1 for Association with Meat Tenderness in Cattle. - (Peer Reviewed Journal)
Page, B.T., Casas, E., Heation, M.P., Cullen, N.G., Hyndman, D.L., Morris, C.A., Crawford, A.M., Wheeler, T.L., Koohmaraie, M., Keele, J.W., Smith, T.P.L. Journal Animal Science. 2002. v. 80. p. 3077-3085.
Selection and Use of Snp Markers for Animal Identification and Paternity Analysis in U.S. Beef Cattle - (Peer Reviewed Journal)
Mammalian Genome. 2002. v. 13. p. 272-281.
Selection and Use of Single Nucleotide Polymorphism (Snp) Markers for Animal Identification and Paternity Analysis in U.S. Beef Cattle - (Abstract Only) - (06-Dec-01)
Haplotype Structure of the Bovine Neonatal Fc Receptor (Bfcrn) Gene in U.S.BEEF Cattle and Association with Serum Igg Concentration in Newborn Calves - (Abstract Only) - (06-Dec-01)
Distribution of Inducible Nitric Oxide Synthase (Nos2) Haplotypes in U.S. Beef Cattle - (Abstract Only) - (14-Sep-01)
DNA Sequence Diversity and Haplotype Relationships at Gene Loci in U.S. Beef Cattle Populations - (Abstract Only) - (14-Jun-01)
Interleukin-8 Haplotype Structure from Nucleotide Sequence Variation in Commercial Populations of U.S. Beef Cattle - (Peer Reviewed Journal)
Heaton, M.P., Chitko Mckown, C.G., Grosse, W.M., Keele, J.W., Keen, J.E., Laegreid, W.W. 2001. Interleukin-8 haplotype structure from nucleotide sequence variation in commercial populations of U.S. beef cattle. Mammalian Genome. 12:219-226.
Allelic Variation in Both Coding and Non-Coding Regions of the Bovine Interleukin-13 Gene - (Abstract Only) - (11-Oct-00)
Estimation of DNA Sequence Diversity in Bovine Cytokine Genes - (Peer Reviewed Journal)
Heaton, M.P., Grosse, W.M., Kappes, S.M., Keele, J.W., Chitko Mckown, C.G., Cundiff, L.V., Braun, A., Little, D.P., Laegreid, W.W. 2001. Estimation of DNA sequence diversity in bovine cytokine genes. Mammalian Genome. 12:32-37.
Identification of Allelic Variation Within the Bovine Interleukin-13 Gene - (Abstract Only) - (02-Aug-00)
Allelic Variation in the Bovine Interleukin-10 Gene - (Abstract Only) - (02-Aug-00)
Structure of the Genes for Porcine Endometrial Secreted and Membrane Folate Binding Proteins - (Peer Reviewed Journal)
Vallet, J.L., Smith, T.P., Sonstegard, T.S., Heaton, M.P., Fahrenkrug, S.C. 2001. Structure of the genes for porcine endometrial secreted and membrane folate binding proteins. Domestic Animal Endocrinology. 21(1):55-72.
Interleukin-8 Haplotype Structure from Nucleotide Sequence Variation in Commercial Populations of U.S. Beef Cattle - (Abstract Only) - (14-Mar-00)
Characterization of the Gene for Porcine Endometrial/placental Membrane Folate Binding Protein (Mfbp) - (Abstract Only)
Vallet, J.L., Smith, T.P., Sonstegard, T.S., Heaton, M.P., Fahrenkrug, S.C. 2000. Characterization of the gene for porcine endometrial/placental membrane folate binding protein (mFBP) [abstract]. Journal of Animal Science. 78(Supplement 2):77. (Abstract No. 231)
Single Nucleotide Polymorphisms (Snps) in the Bovine Inducible Nitric Oxide Synthase (Bnos2) Gene - (Abstract Only) - (07-Oct-99)
Development of Single Nucleotide Polymorphism (Snp) Markers for Bovine Neonatal Fc Receptor - (Abstract Only) - (07-Oct-99)
Snp Frequency and Haplotype Diversity in Beef Cattle Cytokine Genes - (Abstract Only) - (19-Aug-99)
Single Nucleotide Polymorphism (Snp) Discovery and Linkage Mapping of Bovine Cytokine Genes - (Peer Reviewed Journal)
Grosse, W.M., Kappes, S.M., Laegreid, W.W., Keele, J.W., Chitko Mckown, C.G., Heaton, M.P. 1999. Single nucleotide polymorphism (SNP) discovery and linkage mapping of bovine cytokine genes. Mammalian Genome. 10:1062-1069.
Identification, Single Nucleotide Polymorphism (Snp) Discovery, and Linkage Mapping of Bovine Immune Response Genes - (Abstract Only) - (21-Jun-99)
Genetic Variation in Beef Cattle Cytokine Genes: Frequency of Snps in the Marc Reference Family - (Abstract Only) - (30-Oct-98)
Development of Single Nucleotide Polymorphism (Snp) Markers for Bovine C-X-C Chemokine Genes - (Abstract Only) - (01-Oct-98)
Identification and Genetic Mapping of Bovine Chemokine Genes Expressed in Epithelial Cells - (Peer Reviewed Journal) - (02-Sep-98)
Mapping Bovine and Ovine Genes with Intronic Single Nucleotide Polymorphisms - (Abstract Only) - (01-Jul-98)
Structure of the Gene for Porcine Endometrial Folate Binding Protein - (Abstract Only) - (29-Jun-98)
Expression-Based Gene Identification and Single Nucleotide Polymorphism (Snp) Mapping in Cattle - (Abstract Only) - (01-May-98)
Estimation of Genomic Coverage and Genetic Length of the Bovine Genome - (Proceedings) - (01-Jan-98)
Gene Expression in Bovine Epithelial Cells: Identification of Chemokine Genes Induced by Escherichia Coli O157:h7 Lipopolysaccharide - (Abstract Only) - (07-Oct-97)
Cattle Gene Mapping: Estimation of Chromosome Coverage by Fluorescence in Situ Hybridization of Microsatellites at the Ends of the Linkage Groups for Bta1, 3, 15, 16, 17, 20, 22, 28 and 29 - (Proceedings) - (30-May-97)
Directed Cosmid Isolation for Physical Assignment by Fish: Pcr-Based Iterative Screening of Random Genomic Libraries - (Peer Reviewed Journal) - (17-Apr-97)
Last Modified: 4/1/2013