Dr. Campbell has a broad spectrum of research experience involving biochemistry, evolutionary biology and molecular biology. Dr. Campbell is currently involved in chemogenomic and chemosensitization research. The chemogenomic research is being done in collaboration with Drs. Russell Molyneux and Jong H. Kim, of PMR, and Dr. Jiujiang Yu, ARS Food and Feed Safety Research Unit, New Orleans, and William Nierman, at the J. Craig Venter Institute. The chemogenomic research involves the use of chemical probes to elucidate the functional genomics of mycotoxin biosynthesis. This work has led to the discovery of targeting the oxidative stress response system of fungi to inhibit mycotoxin production. The chemosensitization work is being done in collaboration with Dr. Kim, of PMR, Dr. Greg May, MD Anderson Cancer Center, Univ. of Texas, Natália Faria and Dr. Maria de Luz Martins, Institute of Hygiene and Tropical Medicine, New Univ. of Lisbon, Portugal, Drs. Larisa Scherbakova and Vitaly Dzhavakhiya, Russian Research Institute of Phytopathology (RRIP), Moscow, and Dr. Chang-Lin Xiao, Washington State Univ. This work uses safe, natural products to target fungal genes that control stress response. This targeting results in greatly heightened sensitivity to commercial fungicides and antifungal drugs.
Earlier research in Dr. Campbell's career originated the concept of tri-trophic interactions. This concept brought to light possible negative consequences in the interaction between biological control and host-plant resistance in that the chemical bases of insect-plant interactions involves other trophic levels, namely insect parasitoids or symbiotic bacteria. Later, with Dr. David Dreyer (ARS retired), he discovered structural differences in plant matrix heteropolysaccharides (e.g., pectins) affect host-plant recognition and feeding behavior by aphids. Dr. Campbell was also in the forefront of using molecular phylogenetic tools, based on DNA and RNA secondary structure, to infer evolutionary relationships among insects; including Hemiptera, with Drs. Thierry Bourgoin and David Ouvrard at the Museum national d'Histoire naturelle (MNHN), Paris, France, and Chalcidoidea, with Dr. John Heraty, University of California, Riverside.
Dr. Campbell has supervised the research of nine post-doctoral research associates, two Ph.D. students from the University of California, Berkeley, Masters students from Northeastern Univ. and the New Univ. of Lisbon, and a Diplôme d'Etudes Approfondies and Ph. D. student from MNHN. In his lab, he has hosted visiting scholars from the Chinese Academy of Sciences, Univ. of Oulu, Finland, RRIP and MNHN. Dr. Campbell was Adjunct Professor to the Univ. of California, Berkeley and Scientific Officer for the Office of Scientific Quality Review in charge of peer-review of all ARS research projects. He is a Fellow of the American Association for the Advancement of Science and currently has >100 senior and co-authored publications as peer-reviewed journal papers and book chapters.
2009
Molyneux, R. J., Mahoney, N., Kim, J. H., and Campbell, B. C. Health aspects and antiaflatoxigenic activity of phytochemicals in tree nuts. In: Alasalvar, C. and Shahidi, F. (eds.). Tree Nuts: Composition, Phytochemicals, and Health Effects. pp. 95-107. CRC Press, Boca Raton, FL.
2008
Campbell, B. C., Kim, J. H., Yu, J., Molyneux, R. J., Mahoney, N. Palumbo, J. D., Chan, K. L., Bhatnagar, D. Cleveland, T. E. and Nierman, W. C. Natural products as tools for chemogenomic analysis of mycotoxin biosynthesis and fungal stress-response systems. In: Siantar, D. P., Trucksess, M., Scott, P. M. and Herman, E. M. (eds.). Food Contaminants: Mycotoxins and Food Allergies. Proceedings of the 232nd National Meeting of the American Chemical Society, Symposium Series No. 1001. Chapter 1. ISBN 978-0-8412-6954-5.
Yu, J., Nierman, W. C., Bennett, J. W., Campbell, B. C.,Bhatnagar, D., Cleveland, T. E. and Payne, G. A. Genetics and Genomics of Aspergillus flavus. In: Rai, M. K. (ed). Current Advances in Mycology. Springer Verlag. In press.
Yu, J., Payne, G. A., Nierman, W. C., Machida, M., Bennett, J. W., Campbell, B. C., Robens, J. F., Bhatnagar, D., Dean, R. A. and Cleveland, T. E. 2008. Aspergillus flavusgenomics as a tool for studying the mechanism of aflatoxin formation. Food Addit. Contamin. 25(9): 1152-1157. [PDF reprint]
Kim, J. H., Campbell, B. C.*, Mahoney, N., Chan, K. L., Molyneux, R. J. and May, G. S. 2008. Chemosensitization prevents tolerance of Aspergillus fumigatusto antimycotic drugs. Biochem. Biophys. Res. Comm.372: 266-271. [PDF reprint]
Kim, J. H., Mahoney, N., Chan, K. L,. Molyneux, R. J. , May, G. S. and Campbell, B. C.* 2008. Chemosensitization of fungal pathogens to antimicrobial agents using benzo analogs. FEMS Microbiol. Lett. 281(1): 64-72. [PDF reprint]
Kim, J. H., Yu, J., Mahoney, N., Chan, K. L., Molyneux, R. J., Varga, J., Bhatnagar, D., Cleveland, T. E., Nierman, W. C. and Campbell, B. C.* 2008. Elucidation of the functional genomics of antioxidant-based inhibition of aflatoxin biosynthesis. Int. J. Food Microbiol.122: 49-60. [PDF reprint]
Molyneux, R. J., Mahoney, N., Kim, J. H. and Campbell, B. C.2008. Bioassay-directed isolation and identification of anti-aflatoxigenic constituents of walnuts. In: Colegate, S. M. and Molyneux, R. J. (eds). Bioactive Natural Products: Detection, Isolation and Structural Identification. pp. 421-437. CRC Press, Boca Raton, FL. [PDF reprint]
Yu, J., Payne, G. A., Campbell, B. C., Guo, B. Z., Cleveland, T. E., Robens, J. F., Keller, N. P., Bennett, J. W. and Nierman, W. C. 2008. Mycotoxin production and prevention of aflatoxin contamination in food and feed. In: Osmani, S. and Goldman, G. (eds). The ASPERGILLI: Genomics, Medical Aspects, Biotechnology, and Research Methods. pp. 457-472. CRC Press, Boca Raton, FL. [PDF reprint]
2007
Beck, J. J., Kim, J. H., Campbell, B. C.and Chou, S.-C. 2007. Fungicidal activities of dihydroferulic acid alkyl ester analogues. J. Nat. Prod. 70(5): 779-782. [PDF reprint]
Kim, J. H., Campbell, B. C.*, Mahoney, N., Chan, K. L., Molyneux, R. J. and May. G. S. 2007. Enhanced activity of strobilurin and fludioxonil by using berberine and phenolic compounds to target fungal antioxidative stress response. Lett. Appl. Microbiol. 45(2):134-141. [PDF reprint]
Kim, J. H., Campbell, B. C.*, Mahoney, N., Chan, K. L., Molyneux, R. J. and May, G. S. 2007. Enhancement of fludioxonil fungicidal activity by disrupting cellular glutathione homeostasis with 2,5-dihydroxybenzoic acid. FEMS Microbiol. Lett. 270(2): 284-290. [PDF reprint]
Lee, S.-E., Park, B. S., Bayman, P., Baker, J. L., Choi, W. S. and Campbell, B. C. 2007. Suppression of ochratoxin biosynthesis by naturally occurring alkaloids. Food Addit. Contamin. 24(4): 391-397. [PDF reprint]
Molyneux, R. J., Mahoney, N., Kim, J. H. and Campbell, B. C.2007. Mycotoxins in edible tree nuts. Int. J. Food Microbiol.119: 72-78. [PDF reprint]
Molyneux, R. J., Mahoney, N., Kim, J. H. and Campbell, B. C.2007. Inhibition of aflatoxin biosynthesis in Aspergillus flavusby phenolic natural products. pp. 231-251 In: Natural Products: Essential Resources for Human Survival (Zhu, Y.-Z, Tan, B. K.-H., Bay, B.-H. and Liu, C.-H., eds.) World Scientific Publishing Co., Singapore. [PDF reprint]
Yu, J., Ronning, C. M., Wilkinson, J. R., Campbell, B. C., Payne, G. A., Bhatnagar, D., Cleveland, T. E. and Nierman, W. C. 2007. Gene profiling for studying the mechanism of aflatoxin biosynthesis inAspergillus flavusandA. parasiticus. Food Addit. Contamin.24(10): 1035-1042. [PDF reprint]
2006
Kim, J. H., Mahoney, N., Chan, K. L., Molyneux. R. J. and Campbell, B. C.*. 2006. Controlling food-contaminating fungi by targeting their antioxidative stress-response system with natural phenolic compounds. Appl. Microbiol. Biotechnol. 70(6): 735-739. [PDF reprint]
Kim, J. H., Campbell, B. C.*, Yu, J., Mahoney, N., Chan, K. L., Molyneux, R. J., Bhatnagar, D. and Cleveland, T. E. 2006. High throughput genetic tool for examining effects of natural products in fungi. pp. 27-33. In: EBA 2005 Proc. 1st Intl. Conf. Plant Microbe Interactions: Endophytes and Biocontrol Agents. (Sovari, S. and Toldi, O., eds.). SaariselkŠ, Finland, 18-22 April 2005. Karhukopio OY, Turku, Finland. 176 pp.
Kim, J. H., Campbell, B. C.*, Mahoney, N., Chan, K. L. and May, G. S. 2006. Targeting antioxidative signal transduction and stress response system: Control of pathogenic Aspergillus with phenolics that inhibit mitochondrial function. J. Appl. Microbiol. 101(1): 181-189. [PDF reprint]
Kim, J. H., Campbell, B. C.*, Molyneux, R. J., Mahoney, N., Yu, J., Wilkinson, J. R., Cary, J. W., Bhatnagar, D. and Cleveland., T. E. 2006. Gene targets for fungal and mycotoxin control. Mycotoxin Research22(1): 3-8.
Yu, J., Cleveland, T. E., Wilkinson, J., Campbell, B. C., Kim, J. H., Kim, H. S., Bhatnagar, D., Payne, G. A. and Nierman, W. C. 2006. Aspergillus flavus expressed sequence tags and microarray as tools in understanding aflatoxin biosynthesis. Mycotoxin Research22(1): 16-21.
* corresponding author
Printable Version
E-mail this page
