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United States Department of Agriculture

Agricultural Research Service

Related Topics

Thomas Ty Wang (Tom)
Diet, Genomics and Immunology Lab
Research Leader

Phone: (301) 504-8459 ext. 239
Fax: (304) 504-9062
Room 132
10300 BALTIMORE AVE
BLDG 307-C BARC-EAST
BELTSVILLE, MD, 20705-2350

Projects
Regulatory Mechanisms Induced by Health-Promoting Bioactive Food Components on Sex Steroid Hormone-Dependent Pathways, Cancer Cell-Stromal Cell Interactions, and the Gut Microbiome
Appropriated (D)
  Accession Number: 426494
Study of Nutrient Gene Interactions (Erx/AhR)2
Interagency Reimbursable Agreement (I)
  Accession Number: 427257
Research Partnership with Howard University
Nonfunded Cooperative Agreement (N)
  Accession Number: 427623
Research Partnership with the University of the District of Columbia
Nonfunded Cooperative Agreement (N)
  Accession Number: 427121
Research Partnership with Old Dominion University
Nonfunded Cooperative Agreement (N)
  Accession Number: 426389
Research Partnership with Konkuk University Division of Food and Bioscience (KKU)
Nonfunded Cooperative Agreement (N)
  Accession Number: 426462
Research Partnership with Shanghai Jiao Tong University
Nonfunded Cooperative Agreement (N)
  Accession Number: 426471
Study of Gene-nutrient Interactions in Cancer Cells
Reimbursable (R)
  Accession Number: 421834
DIET INDUCED CHANGES IN GENE INTERACTIONS IN CANCER CELLS
Specific Cooperative Agreement (S)
  Accession Number: 421966

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
The cellular uptake and transport of zein nanoparticles: Effect of sodium caseinate - (Peer Reviewed Journal)
Luo, Y., Teng, Z., Wang, T.T., Wang, Q. 2013. The cellular uptake and transport of zein nanoparticles: Effect of sodium caseinate. Journal of Agricultural and Food Chemistry. 61(31):7621-9.
Feeding probiotic Lactobacillus paracasei to Ossabaw pigs on a high fat diet prevents cholesteryl-ester accumulation and LPS modulation of the Liver X receptor and inflammatory axis in alveolar macrophages - (Peer Reviewed Journal)
Trasino, S.E., Dawson, H.D., Urban Jr, J.F., Wang, T.T., Solano Aguilar, G. 2013. Feeding probiotic Lactobacillus paracasei to Ossabaw pigs on a high fat diet prevents cholesteryl-ester accumulation and LPS modulation of the Liver X receptor and inflammatory axis in alveolar macrophages. Journal of Nutritional Biochemistry. 24(11):1931-1939.
Cholesterol-lowering activity of soy-derived glyceollins in the golden Syrian hamster model - (Peer Reviewed Journal)
Huang, H., Xie, Z., Boue, S.M., Bhatnagar, D., Yokoyama, W.H., Yu, L.L., Wang, T.T. 2013. Cholesterol-lowering activity of soy-derived glyceollins in the golden Syrian hamster model. Journal of Agricultural and Food Chemistry. 61(24):35772-5782.
Indole-3-carbinol and 3’, 3’-diindolylmethane modulate androgen effect up-regulation on C-C chemokine ligand 2 and monocyte attraction to prostate cancer cells - (Peer Reviewed Journal)
Kim, E.K., Kim, Y.S., Milner, J.A., Wang, T.T. 2013. Indole-3-carbinol and 3’, 3’-diindolylmethane modulate androgen effect up-regulation on C-C chemokine ligand 2 and monocyte attraction to prostate cancer cells. Cancer Prevention Research. 6(6):519-529.
Development and application of nanoparticles synthesized with folic acid-conjugated soy protein - (Peer Reviewed Journal)
Teng, Z., Luo, Y., Wang, T.T., Zanh, B., Wang, Q. 2013. Development and application of nanoparticles synthesized with folic acid-conjugated soy protein. Journal of Agricultural and Food Chemistry. 61(10):2556-64.
Encapsulation of indole-3-carbinol and 3'3'-diindolylmethane in zein/carboxymethyl chitosan nanoparticles with controlled release property and improved stability - (Peer Reviewed Journal)
Lou, Y., Wang, T.T., Teng, Z., Chen, P., Sun, J., Wang, Q. 2013. Encapsulation of indole-3-carbinol and 3'3'-diindolylmethane in zein/carboxymethyl chitosan nanoparticles with controlled release property and improved stability. Food Chemistry. 139(1-4):224-30.
Strong and weak plasma response to dietary carotenoids identified by cluster analysis and linked to beta-carotene 15,15'-monooxygenase 1 single nucleotide polymorphisms - (Peer Reviewed Journal)
Wang, T.T., Edwards, A.J., Clevidence, B.A. 2013. Strong and weak plasma response to dietary carotenoids identified by cluster analysis and linked to beta-carotene 15,15'-monooxygenase 1 single nucleotide polymorphisms. Journal of Nutritional Biochemistry. 24(8):1538-1546.
Characterization of lipopolysaccharide-stimulated cytokine expression in macrophages and monocytes - (Peer Reviewed Journal)
Huang, H., Fletcher, A., Niu, Y., Wang, T.T., Yu, L. 2012. Characterization of lipopolysaccharide-stimulated cytokine expression in macrophages and monocytes. Inflammation Research. 61(12):1329-1338.
Safflomide increases the expression of adiponectin in vitro and in vivo: Implication for hypoadiponectemia, visceral obesity, and insulin resistance - (Peer Reviewed Journal)
Park, J.B., Wang, T.T. 2012. Safflomide increases the expression of adiponectin in vitro and in vivo: Implication for hypoadiponectemia, visceral obesity, and insulin resistance. Journal of Agricultural and Food Chemistry. 25(60):4048-52.
Inhibition of soybean seeds in warm water results in the release of copious amounts of Bowman-Birk protease inhibitor, a putative anticarcinogenic agent - (Peer Reviewed Journal)
Palavalli, M.H., Natarajan, S.S., Wang, T.T., Krishnan, H.B. 2012. Inhibition of soybean seeds in warm water results in the release of copious amounts of Bowman-Birk protease inhibitor, a putative anticarcinogenic agent. Journal of Agricultural and Food Chemistry. 60:3135-3143.
Pleiotropic effects of the sirtuin inhibitor sirtinol involves concentration-dependent modulation of multiple nuclear receptor-mediated pathways in the androgen-responsive prostate cancer cell LNCaP - (Peer Reviewed Journal)
Wang, T.T., Schoene, N.W., Kim, E.K., Kim, Y.S. 2012. Pleiotropic effects of the sirtuin inhibitor sirtinol involves concentration-dependent modulation of multiple nuclear receptor-mediated pathways in the androgen-responsive prostate cancer cell LNCaP. Molecular Carcinogenesis. DOI:10.1002/mc.21906.
Transcriptomic alterations in human prostate cancer cell LNCaP tumor xenograft modulated by dietary phenethyl isothiocyanate - (Peer Reviewed Journal)
Li, R.W., Li, C., Wang, T.T. 2012. Transcriptomic alterations in human prostate cancer cell LNCaP tumor xenograft modulated by dietary phenethyl isothiocyanate. Molecular Carcinogenesis. DOI: 10.1002/mc.21873.
The protective effect of soybean phytochemicals on androgen responsive human prostate cancer cells LNCaP is likely mediated through modulation of hormone/cytokine-dependent pathways - (Peer Reviewed Journal)
Wang, T.T., Boue, S.M., Krishnan, H.B. 2011. The protective effect of soybean phytochemicals on androgen responsive human prostate cancer cells LNCaP is likely mediated through modulation of hormone/cytokine-dependent pathways. Functional Foods in Health and Disease. 1(11):457-471.
Chemical composition, and anti-proliferative and anti-inflammatory effects of the leaf and wholeplant samples of diploid and tetraploid gynostemma pentaphyllum - (Peer Reviewed Journal)
Xie, Z., Huang, H., Zhao, Y., Shi,, H., Wang, S., Wang, T.T., Chen, P., Yu, L. 2011. Chemical composition, and anti-proliferative and anti-inflammatory effects of the leaf and wholeplant samples of diploid and tetraploid gynostemma pentaphyllum. Food Chemistry. 132:125-133.
A role for p53 in selenium-induced senescence - (Peer Reviewed Journal)
Wu, M., Wu, R., Wang, T.T., Cheng, W. 2011. A role for p53 in selenium-induced senescence. Journal of Agricultural and Food Chemistry. 591:1182-1187.
Dietary phenethyl isothiocyanate inhibition of androgen-responsive LNCaP prostate cancer cell tumor growth correlates with decreased angiogenesis - (Peer Reviewed Journal)
Hudson, T., Perkins, S., Hursting, S., Young, H., Kim, Y., Wang, T., Wang, T.T. 2011. Dietary phenethyl isothiocyanate inhibition of androgen-responsive LNCaP prostate cancer cell tumor growth correlates with decreased angiogenesis. International Journal of Oncology. 40:1113-1121.
Isolation and characterization of two flavonoids, engeletin and astilbin, from the leaves of Engelhardia roxburghiana, and their potential anti-inflammatory properties - (Peer Reviewed Journal)
Huang, H., Cheng, Z., Shi, H., Xin, W., Wang, T.T., Yu, L. 2011. Isolation and characterization of two flavonoids, engeletin and astilbin, from the leaves of Engelhardia roxburghiana, and their potential anti-inflammatory properties. Journal of Agricultural & Food Chemistry. 59(9):4562-9.
Broccoli-derived phytochemicals indole-3-carbinol and 3,3’-diindolylmethane exert concentration-dependent pleiotropic effects on prostate cancer cells: Comparison with other cancer preventive phytochemicals - (Peer Reviewed Journal)
Wang, T.T., Schoene, N.W., Milner, J.A., Kim, Y.S. 2011. Broccoli-derived phytochemicals indole-3-carbinol and 3,3’-diindolylmethane exert concentration-dependent pleiotropic effects on prostate cancer cells: Comparison with other cancer preventive phytochemicals. Molecular Carcinogenesis. DOI: 10.1002/mc.20774.
Chemical composition of five commercial gynostemma pentaphyllum samples and their radical scavenging, antiproliferative, and anti-inflammatory properties - (Peer Reviewed Journal)
Xie, Z., Liu, W., Huang, H., Slavin, M., Zhao, Y., Whent, M., Blackford, J., Lutterodt, H., Zhou, H., Chen, P., Wang, T.T., Liangli, Y. 2010. Chemical composition of five commercial gynostemma pentaphyllum samples and their radical scavenging, antiproliferative, and anti-inflammatory properties. Journal of Agricultural and Food Chemistry. 58(21):11243-11249.
Effect of resveratrol and zinc on intracellular zinc status in normal human prostate epithelial cells - (Peer Reviewed Journal)
Zhang, J., Wu, M., Schoene, N.W., Cheng, W., Wang, T.T., Alshatwi, A.A., Alsaif, M., Lei, K.Y. 2009. Effect of resveratrol and zinc on intracellular zinc status in normal human prostate epithelial cells. American Journal of Physiology - Cell Physiology. 297(3):C632-644.
Differential effects of resveratrol and its methylether analogs on cell cycle and apoptosis in human androgen-responsive LNCaP cancer cells - (Peer Reviewed Journal)
Wang, T.T., Schoene, N.W., Kim, Y.S., Mizuno, C.S., Rimando, A.M. 2010. Differential effects of resveratrol and its methylether analogs on cell cycle and apoptosis in human androgen-responsive LNCaP cancer cells. Molecular Nutrition and Food Research. 54(3):335-344.
Ligand, receptor, and cell type-dependent regulation of ABCA1 and ABCG1 mRNA in prostate cancer epithelial cells - (Peer Reviewed Journal)
Trasino, S.E., Kim, Y.S., Wang, T.T. 2009. Ligand, receptor, and cell type-dependent regulation of ABCA1 and ABCG1 mRNA in prostate cancer epithelial cells. Molecular Cancer Therapeutics. 8(7):1934-1945.
Selenoprotein W Modulates Control of Cell Cycle Entry Reprint Icon - (Peer Reviewed Journal)
Hawkes, W.C., Wang, T.T., Alkan, Z., Richter, D., Dawson, K. 2009. Selenoprotein W Modulates Control of Cell Cycle Entry. Humana Press Inc, Biological Trace Element Research. 131:229-244.
Molecular effects of soy phytoalexin glyceollins in human prostate cancer cells LNCaP Reprint Icon - (Peer Reviewed Journal)
Payton-Stewart, F., Schoene, N.W., Kim, Y.S., Burrow, M.E., Cleveland, T.E., Boue, S.M., Wang, T.T. 2009. Molecular effects of soy phytoalexin glyceollins in human prostate cancer cells LNCaP. Molecular Carcinogenesis. 48(9):862-871.
Differential effects of resveratrol on androgen-responsive LNCaP human prostrate cancer cells in vitro and in vivo. - (Peer Reviewed Journal)
Wang, T.T., Hudson, T.S., Wang, T.C., Remsberg, C.M., Davies, N.M., Takahashi, Y., Kim, Y.S., Seifried, H., Vinyard, B.T., Perkins, S.N., Hursting, S.D. 2008. Differential effects of resveratrol on androgen-responsive LNCaP human prostrate cancer cells in vitro and in vivo. Carcinogenesis. 29(10):2001-2010.
Concentration-dependent effects of genistein on global gene expression in MCF-7 breast cancer cells: an oligo microarray study. - (Peer Reviewed Journal)
Lavigne, J.A., Takahashi, Y., Chandramouli, G.V., Liu, H., Shih, J., Perkins, S.N., Hursting, S.D., Barrett, J., Wang, T.T. 2007. Concentration-dependent effects of genistein on global gene expression in MCF-7 breast cancer cells: an oligo microarray study. Breast Cancer Research and Treatment. [DOI 10.1007/s10549-007-9705-6].
Inhibition of prostate cancer growth by muscadine grapeskin extract and resveratrol through distinct mechanisms - (Peer Reviewed Journal)
Hudson, T.S., Hartle, D.K., Hursting, S.D., Nunez, N.P., Wang, T.T., Young, H.A., Arany, P., Green, J.E. 2007. Inhibition of prostate cancer growth by muscadine grapeskin extract and resveratrol through distinct mechanisms. Cancer Research. 67(17):8396-8405.
Androgen regulation of aldehyde dehydrogenase 1A3 (ALDH1A3) in androgen responsive human prostate cancer cell LNCaP. - (Peer Reviewed Journal)
Trasino, S.E., Harrison, E.H., Wang, T.T. 2007. Androgen regulation of aldehyde dehydrogenase 1A3 (ALDH1A3) in androgen responsive human prostate cancer cell LNCaP. Experimental Biology and Medicine (Maywood). 232(6):762-771.
Molecular Signatures of Soy-Derived Phytochemicals in Androgen-Responsive Prostate Cancer Cells: a Comparison Study Using DNA Microarray - (Peer Reviewed Journal)
Takahashi, Y., Lavigne, J.A., Hursting, S.D., Chandramouli, G.V., Perkins, S.N., Kim, Y.S., Wang, T.T. 2006. Molecular signatures of soy-derived phytochemicals in androgen-responsive prostate cancer cells: a comparison study using dna microarray. Molecular Carcinogenesis. 12:943-956.
Enhanced Estrogenic Responses and Sensitivity to Azosymethane Following Dietary Soy Isoflavone Supplementation in Older Female Rats - (Peer Reviewed Journal)
Daly, K.T., Tracy, A.C., Malik, M., Wang, T.T., Francke-Carroll, S., Magnuson, B.A. 2007. Enhanced estrogenic responses and sensitivity to azosymethane following dietary soy isoflavone supplementation in older female rats. Food and Chemical Toxicology. 45(4):628-637.
17beta-Estradiol Differentially Regulates Androgen-Responsive Genes Through An Estrogen Receptor-Beta-Dependent Pathway in Lncap Human Prostate Cancer Cells - (Peer Reviewed Journal)
Takahashi, Y., Hursting, S.D., Perkins, S.N., Wang, T.T. 2007. 17beta-estradiol differentially regulates androgen-responsive genes through an estrogen receptor-beta-dependent pathway in lncap human prostate cancer cells. Molecular Carcinogenesis. E-publication. 46(2):117-129.
Deciphering Molecular Signatures of Phytochemicals in Cells - (Proceedings)
Wang, T.T., Kim, Y.S., Hursting, S.D., Perkins, S.N., Gadisetti, C.R., Lavigne, J.A., Takahashi, Y. 2005. Deciphering molecular signatures of phytochemicals in cells. UJNR Food & Agricultural Panel Proceedings.
Genistein Affects Androgen-Responsive Genes Through Both Androgen Receptor and Estrogen Receptor-Mediated Pathways - (Peer Reviewed Journal)
Takahashi, Y., Hursting, S.D., Perkins, S.N., Wang, T.T. 2006. Genistein affects androgen-responsive genes through both androgen receptor- and estrogen receptor-mediated pathways. Molecular Carcinogenesis. 45:18-25.
Phytochemicals As Modulator of Apoptosis Pathways - (Proceedings)
Wang, T.T., Wang, T., Kim, Y.S., Hursting, S.D., Perkins, S.N., Lavigne, J.A., Leh, Y., Takahashi, Y. 2004. Phytochemicals as modulator of apoptosis pathways. United Stats/Japan Nutrition Research (UJNR) Food and Agricultural Panel Proceedings. p.149-152.
Using DNA Microarray Analyses to Elucidate the Effects of Genistein in Androgen-Dependent Prostate Cancer Cells: Identification of Novel Targets for Cancer Prevention - (Peer Reviewed Journal)
Takahashi, Y., Lavigne, J.A., Hursting, S.D., Chandramouli, G.V., Perkins, S.N., Barrett, C., Wang, T.T. 2004. Using dna microarray analyses to elucidate the effects of genistein in androgen-dependent prostate cancer cells: identification of novel targets for cancer prevention. Molecular Carcinogenesis, Vol. 1 (2), pp. 108-119.
Numerical Deconvolution of Cdna Microarray Signal - (Peer Reviewed Journal)
Rosenfeld, S., Wang, T.T.Y., Young, K., and Milner, J. Numerical deconvolution of cDNA microarray signal, Ann. N.Y. Acad. Sci., 1020:110-123, 2004.
Utiity of Microarray Technology in Studies of Cancer Preventive Phytochemicals (Abstract, Us-Japan Natural Resources Panel Meeting, Tsukuba, Japan, November 7-15, 2003) - (Abstract Only)
Wang, T.T., Lavigne, J.A., Hursting, D.S., Chandramouli, G.V.R., Takahashi, Y. 2003. Utillity of microarray technology in studies of cancer preventive phytochemicals. Proceedings of the 32nd Annual Meeting of the United States-Japan Natural Resources Food and Agriculture Panel Members Meeting, Tsukuba, Japan. 304-307.
Soy Isoflavone Genistein Modulates Expression of An Androgen-Responsive Gene Spak in Human Prostate Cancer (Us-Japan Natural Resources Panel Meeting, Tsukuba, Japan, November 7-15, 2003) - (Abstract Only)
Takahashi, Y., Hursting, D.S., Wang, T.T. 2003. Soy isoflavone genistein modulates expression of an androgen-respnsive gene SPAK in human prostate cancer cells. Proceedings of the 32nd Annual Meeting of the United States-Japan Natural Resources Food and Agriculture Panel Members, Tsukuba, Japan. 313-315.
Genistein-Induced Apoptosis in Mcf-7 Cells Involves Changes in Bak and Bel-X Without Evidence of Anti-Oestrogenic Effects - (Peer Reviewed Journal) - (18-Jun-02)
Beta-Naphthoflavone, An Inducer of Xenobiotic Metabolizing Enzymes, I Luciferase Activity - (Peer Reviewed Journal)
Wang, T.T. 2002. Beta-naphthoflavone, an inducer of xenobiotic metabolizing enzymes,inhibits luciferase activity. Analytical Biochemistry. 304:122-126.
Modulation of Cyclophilin Gene Expression by N-4-(Hydroxyphenyl) Retinamideassociation with Reactive Oxygen Species Generation and Apoptosis - (Peer Reviewed Journal) - (01-Oct-01)
Low Dose Genistein Induces Cyclin-Dependent Kinase Inhibitors and G1 Cell Cycle Arrest in Human Prostate Cancer Cells - (Peer Reviewed Journal) - (01-Oct-01)
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Last Modified: 10/23/2014