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Agricultural Research Service United States Department of Agriculture
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David J Smith
Animal Metabolism-Agricultural Chemicals Research
Research Physiologist (Animals)

Phone: (701) 239-1238
Fax: (701) 239-1430
1605 ALBRECHT BLVD
BRL
BIOSCIENCES RESEARCH LABORATORY
FARGO, ND, 58105-5674

Projects
Metabolic Variables Affecting the Efficacy, Safety, and Fate of Agricultural Chemicals
Appropriated (D)
  Accession Number: 410345

Publications
The Fate and Transport of Reproductive Hormones and Their Conjugates in the Environment - (Abstract)
Casey, F., Shrestha, S., Hakk, H., Smith, D.J., Larsen, G.L., Padmanabhan, G. 2009. The Fate and Transport of Reproductive Hormones and Their Conjugates in the Environment. Eos Trans. AGU 90(52), Fall Meet. Suppl, Abstract H53A-0910.
Clorate Metabolism in Pure Cultures of E.Coli 0157:H7 Pretreated with Either Nitrate or Chlorate - (Peer Reviewed Journal)
Smith, D.J., Oliver, C.E., Shelver, W.L., Caesar, T., Anderson, R.C. 2009. Clorate Metabolism in Pure Cultures of Escherichia Coli 0157:H7 Pretreated with Either Nitrate or Chlorate. Journal of Agricultural and Food Chemistry. 57:10216-10224. DOI:10.1021/jf901513f
Residue and Food Safety Research at the USDA ARS Animal Metabolism Research Unit - (Abstract)
Smith, D.J., Huwe, J.K., Hakk, H., Shappell, N.W., Shelver, W.L. 2009. Residue and Food Safety Research at the USDA ARS Animal Metabolism Research Unit. In: Proceedings of 4th International Symposium on Recent Advances in Food Analysis, November 4-6, 2009, Prague, Czech Republic. Poster A-54, page 33.
Determination of Zilpaterol in Horse Urine from Withdrawal Day 0 to Day 21 by UPLC-MS/MS and ELISA - (Abstract)
Shelver, W.L., Thorson, J., Hammer, C., Smith, D.J. 2009. Determination of Zilpaterol in Horse Urine from Withdrawal Day 0 to Day 21 by UPLC-MS/MS and ELISA. In: Proceedings of Xth International Conference on Agri-Food Antibodies (ICAFA), September 7-10, 2009, Wageningen, The Netherlands. Presentation L-15, page 24.
Chlorate Concentration in the Jejunum and Cecum in Growing Pigs when Supplemented in Drinking Water - (Proceedings/Symposium)
Bahnson, P.B., Smith, D.J., Anderson, R.C., Borys, K.D. 2009. Chlorate Concentration in the Jejunum and Cecum in Growing Pigs when Supplemented in Drinking Water. In: Proceedings of International Symposium on the Epidemiology and Control of Foodborne Pathogens in Pork, September 30-2 October 2009, Quebec, Ontario, Canada.
Effect of chlorate, molybdate, and shikimic acid on Salmonella enterica serovar in aerobic anaerobic cultures - (Peer Reviewed Journal)
Oliver, C.E., Beier, R.C., Hume, M.E., Horrocks, S.M., Casey, T., Caton, J.S., Nisbet, D.J., Smith, D.J., Anderson, R.C. 2009. Effect of chlorate, molybdate, and shikimic acid on Salmonella enterica serovar in aerobic anaerobic cultures. Anaerobe. DOI: 10.1016/j.anaerobe.2009.05.006.
Analytical Method for the Determination of Chlorate in Animal Matrices - (Abstract)
Smith, D.J., Taylor, J.B., Bahnson, P. 2009. Analytical Method for the Determination of Chlorate in Animal Matrices. In: Program of American Chemical Society National Meeting and Exposition, August 16-20, 2009, Washington, D.C. Program Vol. 77, Abstract #42, page 96-97.
Nitroethane, 2-nitro-methyl-propionate and dimethyl-2-nitroglutarate markedly reduce ruminal methane production without adversely affecting ruminal fermentation - (Abstract)
Anderson, R.C., Huwe, J.K., Smith, D.J., Stanton, T.B., Krueger, N.A., Callaway, T.R., Edrington, T.S., Harvey, R.B., Nisbet, D.J. 2009. Nitroethane, 2-nitro-methyl-propionate and dimethyl-2-nitroglutarate markedly reduce ruminal methane production without adversely affecting ruminal fermentation [abstract]. In: Proceedings of the 2009 Conference on Gastrointestinal Function, April 20-22, 2009, Chicago, IL. p. 562.
Fate of glucuronide conjugated estradiol in the environment - (Abstract)
Shrestha, S.L., Casey, F.X., Hakk, H., Larsen, G.L., Smith, D.J., Padmanabhan, G. 2009. Fate of Glucuronide Conjugated Estradiol in the Environment [Abstract]. In: Proceedings of American Society of Civil Engineers - Environmental and Water Resources Institute Conference, January 5-7, 2009, Bangkok, Thailand.
Fate of glucuronide conjugated estradiol in soil - (Abstract)
Shrestha , S. L., Casey, F. X. M., Smith, D. J., Hakk, H.,Larsen, G., and Padmanabhan, G.,2008, Fate of Glucuronide Conjugated Estradiol in Soil.Annual meeting of the Geol. Soc. Am. Agron. Soc. Am., Crop Sci. Soc. Am., and Soil Sci. Soc. Am., Houston, October 5-9, 2008.
Fate of chlorate present in cattle wastes and its impact on Salmonella typhimurium and E. coli 0157:H7 - (Peer Reviewed Journal)
Oliver, C.E., Magelky, B.K., Bauer, M., Cheng, F., Caton, J.S., Hakk, H., Larsen, G.L., Anderson, R.C., Smith, D.J. 2008. Fate of chlorate present in cattle wastes and its impact on Salmonella typhimurium and E. coli 0157:H7. Journal of Agricultural Chemistry 56:6573-6583.
Depletion of zilpaterol hydrochloride residues from the urine of orally treated horses - (Abstract)
Smith, D.J., Hammer, C.J., Mostrom, M.S., Thorson, J.F., Shelver, W.L. 2008. Depletion of Zilpaterol Hydrochloride Residues from the Urine of Orally Treated Horses [Abstract]. In: Program of 236th American Chemical Society National Meeting, Agrochemicals Division, August 17-21, 2008, Philadelph, PA. Vol. 75, Abstract #27, Page 76.
Absorption, tissue distribution, and elimination of residues after 2,4,6-trinitro[14C]toluene administration to sheep - (Peer Reviewed Journal)
Smith, D.J., Craig, A.M., Duringer, J.M., Chaney, R.L. 2008. Absorption, tissue distribution, and elimination of residues after 2,4,6-trinitro[14C]toluene administration to sheep. Environmental Science and Technology 42(7):2563-2569.
Comparative absorption and bioaccumulation of polybrominated diphenyl ethers following ingestion via dust and oil in male rats - (Peer Reviewed Journal)
Huwe, J.K., Hakk, H., Smith, D.J., Diliberto, J.J., Richardson, V., Birnbaum, L.S., Stapleton, H.M. 2008. Comparative absorption and bioaccumulation of polybrominated diphenyl ethers following ingestion via dust and oil in male rats. Environmental Science and Technology 42:2694-2700.
Adverse effects of zilpaterol administration in horses: three cases - (Peer Reviewed Journal)
Wagner, S.A., Mostrum, M.S., Hammer, C.J., Thorson, J.S., Smith, D.J. 2008. Adverse effects of zilpaterol administration in horses: three cases. Journal of Equine Veterinary Science 28(4):238-243.
Distribution and residues of orally administered 2,4,6-trinitro[14C]toluene in ruminating sheep. - (Abstract)
Smith, D.J., Craig, A.M., Duringer, J., Chaney, R.L. 2007. Distribution and residues of orally administered 2,4,6-trinitro[14C]toluene in ruminating sheep. Meeting Abstract. 234th meeting of the American Chemical Society, Aug. 19-23, 2007, Boston, MA.
Total radioactive residues and residues of [36Cl]chlorate in market size broilers. - (Peer Reviewed Journal)
Smith, D.J., Byrd, J.A., Anderson, R.C. 2007. Total radioactive residues and residues of [36Cl]chlorate in market size broilers. Journal of Agricultural and Food Chemistry 55:5898-5903.
The in vitro reduction of sodium [36Cl]-chlorate in bovine ruminal fluid - (Peer Reviewed Journal)
Oliver, C.E., Bauer, M.L., Caton, J.S., Anderson, R.C., Smith, D.J. 2007. The in vitro reduction of sodium [36Cl]-chlorate in bovine ruminal fluid. Journal of Animal Science 85:2059-2068.
Pharmacokinetics of ruminally-dosed sodium chlorate in beef cattle - (Peer Reviewed Journal)
Oliver, C.E., Craigmill, A.L., Caton, J.S., Anderson, R.C., Smith, D.J. 2007. Pharmacokinetics of ruminally-dosed sodium chlorate in beef cattle. Journal of Veterinary Pharmacology and Therapeutics 30:358-365.
Efficacy of chlorate against E. coli O157:H7 and Salmonella Typhimurium in bovine feedlot soil mixture. - (Abstract)
Oliver, C.E., Magelky, B.K., Bauer, M.L., Caton, J.S., Hakk, H., Larsen, G.L., Anderson, R.C., Smith, D.J. 2007. Efficacy of chlorate against E. coli O157:H7 and Salmonella Typhimurium in bovine feedlot soil mixture. Meeting Abstract. American Society of Animal Science Meetings, July 8-12, 2007, San Antonio, TX.
Accumulation, Whole-body Depletion, and Debromination of Decabromodiphenyl Ether (BDE-209) in Male Sprague-Dawley Rats Following Dietary Exposure - (Peer Reviewed Journal)
Huwe, J.K., Smith, D.J. 2007. Accumulation, Whole-body Depletion, and Debromination of Decabromodiphenyl Ether (BDE-209) in Male Sprague-Dawley Rats Following Dietary Exposure. Environmental Science and Technology 41:2371-2377.
Fate of chlorate salts excreted from animals. - (Abstract)
Smith, D.J., Oliver, C.E., Hakk, H., Anderson, R.C., Larsen, G.L. 2007. Fate of chlorate salts excreted from animals. Meeting Abstract. American Chemical Society Abstracts, March 25-29, 2007, Chicago, IL.
The in vitro reduction of sodium [36Cl]-chlorate in bovine ruminal fluid. - (Abstract)
Oliver, C.E., Bauer, M.L., Caton, J.S., Anderson, R.C., Smith, D.J. 2007. The in vitro reduction of sodium [36Cl]-chlorate in bovine ruminal fluid. American Chemical Society Spring Meetings, March 25-29, 2007, Chicago, IL
Tissue Residues, Metabolism, and Excretion of Na[36cl]o3 in Rats - (Peer Reviewed Journal)
Hakk, H., Smith, D.J., Shappell, N.W. 2007. Tissue residues, metabolism, and excretion of Na[36Cl]O3 in rats. Journal of Agricultural and Food Chemistry 55:2034-2042.
Absorption, Distribution, Metabolism, and Elimination of [14C]-2,4,6-Trinitrotoluene in Sheep After a 30-Day Exposure to Dietary Unlabeled 2,4,6-Trinitrotoluene - (Abstract)
Craig, A.M., Duringer, J.M., Smith, D.J., Delorme, M.M., Chaney, R.L. 2006. Absorption, Distribution, Metabolism, and Elimination of [14C]-2,4,6-Trinitrotoluene in Sheep After a 30-Day Exposure to Dietary Unlabeled 2,4,6-Trinitrotoluene. Meeting Abstract. p. E109.
Tissue Distribution, Elimination, and Metabolism of Sodium [36cl]perchlorate in Lactating Goats - (Peer Reviewed Journal)
Smith, D.J., Hakk, H., Larsen, G.L. 2006. Tissue distribution, elimination, and metabolism of sodium [36cl]perchlorate in lactating goats. Journal of Agriculture and Food Chemistry 54:8829-8835.
Effect of Sodium [36cl]chlorate Dose on Total Radioactive Residues and Residues of Parent Chlorate in Growing Swine - (Peer Reviewed Journal)
Smith, D.J., Anderson, R.C., Huwe, J.K. Effect of sodium [36cl]chlorate dose on total radioactive residues and residues of parent chlorate in growing swine. Journal of Agriculture and Food Chemistry 54:8648-8653.
Effect of chlorate, molybdate, and shikimic acid on Salmonella Typhimurium in aerobic and anaerobic cultures - (Abstract)
Oliver, C.E., Smith, D.J., Casey, T., Horrocks, S.M., Anderson, R.C., Nisbet, D.J. 2006. Effect of chlorate, molybdate, and shikimic acid on Salmonella Typhimurium in aerobic and anaerobic cultures. American Society of Microbiology National Meetings Victoria, British Columbia, Sept. 10-12, 2006. Abstract No. 85.
Tissue Distribution, Elimination, and Metabolism of Sodium 36cl-Perchlorate in Lactating Goats. - (Abstract)
Smith, D.J., Hakk, H., Larsen, G.L. 2006. Tissue distribution, elimination, and metabolism of sodium 36cl-perchlorate in lactating goats. American Chemical Society Abstracts. San Francisco, CA, Sept. 10-14, 2006.
Effect of Dose on Residues and Disposition of An Experimental 36cl-Chlorate Product in Broilers. - (Abstract)
Smith, D.J., Byrd Ii, J.A., Anderson, R.C. 2006. Effect of dose on residues and disposition of an experimental 36cl-chlorate product in broilers. American Chemistry Society Abstracts. San Francisco, CA, Sept. 10-14, 2006.
Stabilization of a Ractopamine Enzyme Conjugate in Aqueous Solution, a Rapid and Convenient Immunoassay Method for the Detection of Ractopamine. - (Abstract)
Wang, G., Rodrigues, W., Agrawal, A., Philips, H., Abolencia, E., Nuguyen, M., Smith, D.J., Shelver, W.L. 2006. Stabilization of a ractopamine enzyme conjugate in aqueous solution, a rapid and convenient immunoassay method for the detection of ractopamine. American Chemical Society Abstracts. San Francisco, CA, Sept. 10-14, 2006.
Tissue Residues and Urinary Excretion of Zilpaterol in Sheep Treated for 10-Days with Dietary Zilpaterol. - (Peer Reviewed Journal)
Shelver, W.L., Smith, D.J. 2006. Tissue residues and urinary excretion of zilpaterol in sheep treated for 10-days with dietary zilpaterol. Journal of Agricultural and Food Chemistry 54:4155-4161.
Tissue Residue and Urinary Excretion of Zilpaterol in Sheep Treated for 10 Days with Dietary Zilpaterol. - (Abstract)
Shelver, W.L., Smith, D.J. 2006. Tissue residue and urinary excretion of zilpaterol in sheep treated for 10 days with dietary zilpaterol. Meeting Abstract. Fifth International Symposium on Hormone and Veterinary Drug Residue Analysis Meeting, Antwerp, Belgium, May 16-19, 2006.
Effect of Ractopamine on E. Coli O157:h7 and Salmonella in Vitro and on Intestinal Populations and Fecal Shedding in Experimentally Infected Sheep and Pigs - (Peer Reviewed Journal)
Edrington, T.S., Callaway, T.R., Smith, D.J., Genovese, K.J., Anderson, R.C., Nisbet, D.J. 2006. Effects of ractopamine HCl on Escherichia coli O157:H7 and Salmonella in vitro and on intestinal populations and fecal shedding in experimentally infected sheep and pigs. Current Microbiology. 53:82-88.
Effect of Sodium [36cl]chlorate Dose on Total Radioactive Residues and Residues of Parent Chlorate in Beef Cattle. - (Peer Reviewed Journal)
Smith, D.J., Oliver, C.E., Caton, J.S., Anderson, R.C. 2005. Effect of sodium [36Cl]chlorate dose on total radioactive residues and residues of parent chlorate in beef cattle. Journal of Agricultural and Food Chemistry 53:7352-7360.
Effect of Sodium [36cl]chlorate Dose on Total Radioactive Residues and Residues of Parent Chlorate in Swine. - (Proceedings/Symposium)
Smith, D.J., Anderson, R.C. 2005. Effect of sodium [36Cl]chlorate dose on total radioactive residues and residues of parent chlorate in swine. Proceedings of the 6th International Symposium on the Epidemiology & Control of Foodborne Pathogens in Pork (SafePork 2005), Sept. 6-9, 2005, Rohnert Park, CA, pp. 142-144.
Ergovaline Movement Across Caco-2 Cells. - (Peer Reviewed Journal)
Shappell, N.W., Smith, D.J. 2005. Ergovaline movement across CACO-2 cells. In Vitro Cellular and Developmental Biology - Animals 41:245-251.
Tissue Distribution, Elimination, and Metabolism of Dietary Sodium [36cl]chlorate in Beef Cattle - (Peer Reviewed Journal)
Smith, D.J., Anderson, R.C., Ellig, D.A., Larsen, G.L. 2005. Tissue distribution, elimination, and metabolism of dietary sodium [36Cl]chlorate in beef cattle. Journal of Agricultural and Food Chemistry 53:4272-4280.
Laboratory and on-Farm Studies on the Bioavailability of Dioxins from a Contaminated Mineral Supplement Fed to Dairy Cows - (Peer Reviewed Journal)
Huwe, J.K., Smith, D.J. 2005. Laboratory and on-farm studies on the bioavailability of dioxins from a contaminated mineral supplement fed to dairy cows. Journal of Agriculture and Food Chemistry 53:2362-2370.
Residues and Metabolism of 36cl-Labeled Sodium Chlorate in Cattle. - (Abstract)
Smith, D.J., Oliver, C.E., Anderson, R.C., Caton, J.S. 2005. Residues and metabolism of 36cl-labeled sodium chlorate in cattle. [abstract] American Chemical Society (ACS) Spring Meeting, San Diego, CA, March 13-17, 2005, Picogram No. 68, Abstract No. 106.
Pharmacokinetics of Intraruminally-Dosed 36cl-Labeled Sodium Chlorate in Cattle - (Abstract)
Oliver, C.E., Smith, D.J., Anderson, R.C., Caton, J.S. 2005. Pharmacokinetics of intraruminally-dosed 36cl-labeled sodium chlorate in cattle. [abstract] American Chemical Society (ACS) Spring Meetings. March 14-17, 2005, San Diego, CA, Picogram No. 68, Abstract No. 105.
Biotransformation of [14c]-Phenylbutazone after Oral Or Intravenous Administration to Cattle - (Abstract)
Smith, D.J., Huwe, J.K., Lorentzsen, M.K., Harrington, G.E. 2004. Biotransformation of [14c]-phenylbutazone after oral or intravenous administration to cattle. [abstract] American Chemical Society National Meeting, Philadelphia, PA, 8/22-26/2004, Picogram No. 67, Abstract No. 124.
Ergovaline Transport Across Human Gastrointestinal Cells (Caco-2). - (Abstract)
Shappell, N.W., Smith, D.J. 2004. Ergovaline transport across human gastrointestinal cells (caco-2). [abstract] Joint Meeting of American Society of Animal Science, American Dairy Science Association, and Poultry Science Association, St. Louis, MO, July 25-29, 2004, Journal of Animal Science 82(Suppl 1):181, Abstract T71.
Development of An Enzyme Linked Immunosorbent Assay for the Beta-Adrenergic Agonist Zilpaterol. - (Proceedings/Symposium)
Shelver, W.L., Smith, D.J. 2004. Development of an enzyme linked immunosorbent assay for the beta-adrenergic agonist zilpaterol. EuroResidue V Conference Proceedings, May 10-12, 2004, Noordwijkerhout, The Netherlands.
Tissue Distribution, Elimination, and Metabolism of Dietary Sodium [36cl]chlorate in Beef Cattle - (Abstract)
Smith, D.J., Anderson, R.C., Ellig, D.A., Larsen, G.L. 2004. Tissue distribution, elimination, and metabolism of dietary sodium [36cl]chlorate in beef cattle. [abstract] International Association for Food Protection 91st Annual Meeting, August 8-11, 2004, Phoenix, AZ. Abstract #T35.
Determination of 14c Residue in Eggs of Laying Hens Administered Orally with [14c]sulfaquinoxaline. - (Peer Reviewed Journal)
Shaikh, B., Rummel, N., Smith, D.J. 2004. Determination of 14C residue in eggs of laying hens administered orally with [14C]sulfaquinoxaline. Journal of Food Additives & Contaminants. 21:545-554.
Enzyme-Linked Immunosorbent Assay Development for the Beta-Adrenergic Agonist Zilpaterol. - (Peer Reviewed Journal)
Shelver, Weilin L. and Smith, David J. 2004. Enzyme-linked immunosorbent assay development for the beta-adrenergic agonist zilpaterol. Journal of Agricultural and Food Chemistry. 52:2159-2166.
Development of An Enzyme-Linked Immunosorbent Assay for Beta-Agonist Zilpaterol. - (Abstract)
Shelver, W.L., Smith, D.J. 2004. Development of an enzyme-linked immunosorbent assay for beta-agonist zilpaterol. EuroResidue V, May 10-12, 2004, Noordwijkerhout, The Netherlands.
The Effect of Ractopamine Stereoisomers on Lipolysis of Bovine Subcutaneous and Intramuscular Adipose Tissue. - (Abstract)
Shields, T.H., Smith, T.R., Althen, T., Smith, D.J. The effect of ractopamine stereoisomers on lipolysis of bovine subcutaneous and intramuscular adipose tissue. [abstract]. Federation of American Societies for Experimental Biology Annual Meeting, April 17-24, 2004, Washington, DC. Abstract #8086.
Determination of Ractopamine in Cattle and Sheep Urine Samples Using An Optical Biosensor Analysis:comparative Study with Hplc and Elisa. - (Peer Reviewed Journal)
Shelver, W.L., Smith, D.J. 2003. Determination of ractopamine in cattle and sheep urine samples using an optical biosensor analysis:comparative study with HPLC and ELISA. Journal of Agricultural and Food Chemistry 51(13):3715-3721.
Determination of Ractopamine in Cattle and Sheep Urine Using Biosensor - (Abstract)
Shelver, W.L., Smith, D.J. 2003. Determination of ractopamine in cattle and sheep urine using biosensor. VII International Conference on Agri-Food Antibodies, September 10-13, 2003, Uppsala, Sweden.
Uptake and Excretion of Pcdd/fs from a Magnesium Mineral Supplement Fed to Dairy Cows. - (Peer Reviewed Journal)
Huwe, J.K., Smith, D.J. 2003. Uptake and excretion of pcdd/fs from a magnesium mineral supplement fed to dairy cows. Organohalogen Compounds. 64:419-422.
Beta-Adrenergic Receptor Subtypes That Mediate Ractopamine Stimulation of Lipolysis. - (Peer Reviewed Journal)
Mills, S.E., Spurlock, M.E., Smith, D.J. 2002. Beta-adrenergic receptor subtypes that mediate ractopamine stimulation of lipolysis. Journal of Animal Science 81:662-668.
Stereoselectivity of Porcine Beta-Adrenergic Receptors for Ractopamine Stereoisomers. - (Peer Reviewed Journal)
Mills, S.E., Kissel, J., Bidwell, C.A., Smith, D.J. 2002. Stereoselectivity of porcine beta-adrenergic receptors for ractopamine stereoisomers. Journal of Animal Science 81:122-129.
Liquid Chromatography/electrospray Tandem Mass Spectrometric Analysis of Incurred Ractopamine Residues in Livestock. - (Peer Reviewed Journal)
Churchwell, M.I., Holder, C.L., Little, D., Preece, S., Smith, D.J., Doerge, D.R. 2002. Liquid chromatography/electrospray tandem mass spectrometric analysis of incurred ractopamine residues in livestock. Rapid Communications in Mass Spectrometry 16:1261-1265.

   
 
Last Modified: 02/09/2010
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