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Timothy A Reinhardt (Tim)
Ruminant Diseases and Immunology Research Unit
Research Animal Scientist

Phone: (515) 337-7540
Fax: (515) 337-7149
Room 1135
1920 DAYTON AVE
AMES, IA, 50010

Projects
Molecular, Nutrient, and Endocrine Basis of Metabolic Diseases That Affect the Reproductive Health of the Dairy Cow
Appropriated (D)
  Accession Number: 410806
Identification of Factors Associated with Immune Suppression and Mastitis
Appropriated (D)
  Accession Number: 411875
Effect of Feeding Low and High Dietary Cation-Anion Difference Forages to Periparturient Dairy Cows
Specific Cooperative Agreement (S)
  Accession Number: 410812

Publications
Improvement of the Innate Immune Response of Bovine Monocytes Via an Intracrine Vitamin D Signaling Pathway - (Abstract) - (30-Sep-09)
Short Communication: The Preruminant Calf as a Model for Characterizing the Effects of Vitamin D Status in the Neonate - (Peer Reviewed Journal)
Nonnecke, B.J., Reinhardt, T.A., Waters, W.R. Short Communication: The Preruminant Calf as a Model for Characterizing the Effects of Vitamin D Status in the Neonate. Journal of Dairy Science. 92(11):5692-5696.
Expression of Inducible Nitric Oxide Synthase is Up-Regulated by Production of 1,25-Dihydroxyvitamin D3 in Bovine Monocytes in Response to Toll-Like Receptor Signaling - (Abstract)
Nelson, C.D., Beitz, D.C., Reinhardt, T.A., Lippolis, J.D. 2009. Expression of Inducible Nitric Oxide Synthase is Up-Regulated by Production of 1,25-Dihydroxyvitamin D3 in Bovine Monocytes in Response to Toll-Like Receptor Signaling [abstract]. American Dairy Science Association. Paper No. 84.
Proteomics of mastitis causing Escherichia coli - (Proceedings/Symposium)
Lippolis, J.D., Reinhardt, T.A., Kehrli Jr, M.E. 2009. Proteomics of mastitis causing Escherichia coli. Proceedings of National Mastitis Council. 48:236-237.
Mammary gland involution is associated with rapid down regulation of major mammary Ca**2+-ATPases - (Peer Reviewed Journal)
Reinhardt, T.A., Lippolis, J.D. 2009. Mammary gland involution is associated with rapid down regulation of major mammary Ca**2+-ATPases. Biochemical and Biophysical Research Communications. 378(1):99-102.
Vitamin D Status and Its Relationship to Body Fat, Final Height, and Peak Bone Mass in Young Women - (Peer Reviewed Journal)
Kremer, R., Campbell, P.P., Reinhardt, T.A., Gilsanz, V. 2009. Vitamin D Status and Its Relationship to Body Fat, Final Height, and Peak Bone Mass in Young Women. Journal of Clinical Endocrinology and Metabolism. 94(1):67-73.
Proteomic changes in Escherichia coli when grown in fresh milk versus laboratory media - (Peer Reviewed Journal)
Lippolis, J.D., Bayles, D.O., Reinhardt, T.A. 2009. Proteomic changes in Escherichia coli when grown in fresh milk versus laboratory media. Journal of Proteome Research. 8(1):149-158.
Vitamin D status in young women is strongly negatively related to body weight, body mass index and body fat, but is not associated to bone mass - (Abstract)
Kremer, R., Campbell, P., Reinhardt, T.A., Gilsanz, V. 2008. Vitamin D status in young women is strongly negatively related to body weight, body mass index and body fat, but is not associated to bone mass [abstract]. Journal of Bone and Mineral Research. 23(abstracts supplement):S290.
Vitamin D delays breast cancer progression in the PyVMT transgenic mouse model: local conversion of the precursor 25(OH)D3 into 1,25(OH)2D3 is safer and more effective than systemic administration of 1,25(OH)2D3 - (Abstract)
Rossdeutscher, L., Huang, D., Li, J., Reinhardt, T.A., Muller, W., Kremer, R. 2008. Vitamin D delays breast cancer progression in the PyVMT transgenic mouse model: local conversion of the precursor 25(OH)D3 into 1,25(OH)2D3 is safer and more effective than systemic administration of 1,25(OH)2D3 [abstract]. Journal of Bone and Mineral Research. 23(abstracts supplement):S53.
Serum 25-Hydroxvitamin D Concentrations in Captive and Free-Ranging, White-Tailed Deer (Odocoileus virginianus) - (Peer Reviewed Journal) - (04-Jul-08)
Vitamin D status in young women and its relationship to body fat, final height and peak bone mass - (Abstract) - (15-Jun-08)
Metabolic alkalosis transition in renal proximal tubule cells facilitates an increase in CYP27B1, while blunting responsiveness to PTH - (Abstract)
Forster, M.A., Masilamani, S., Reinhardt, T.A., Beckman, M.J. 2008. Metabolic alkalosis transition in renal proximal tubule cells facilitates an increase in CYP27B1, while blunting responsiveness to PTH [abstract]. Journal of Bone and Mineral Research. 23(abstracts supplement):S422.
The promise of proteomics in animal science - (Abstract)
Lippolis, J.D., Reinhardt, T.A. 2008. The promise of proteomics in animal science [abstract]. 2008 Joint Annual Meeting of the American Dairy Science Association/American Society of Animal Science, July 7-11, 2008, Indianapolis, Indiana. 2008 CD-ROM.
Centennial Paper: Proteomics in animal science - (Peer Reviewed Journal)
Lippolis, J.D., Reinhardt, T.A. 2008. Centennial Paper: Proteomics in animal science. Journal of Animal Science. 86(9):2430-2441.
Developmental changes in the milk fat globule membrane proteome during the transition from colostrum to milk - (Peer Reviewed Journal)
Reinhardt, T.A., Lippolis, J.D. 2008. Developmental changes in the milk fat globule membrane proteome during the transition from colostrum to milk. Journal of Dairy Science. 91(6):2307-2318.
Toll-like receptor signaling increases production of 1,25-dihydroxyvitamin D3 in bovine macrophages - (Abstract)
Nelson, C.D., Beitz, D.C., Reinhardt, T.A., Lippolis, J.D. 2008. Toll-like receptor signaling increases production of 1,25-dihydroxyvitamin D3 in bovine macrophages [abstract). Experimental Biology 2008. p. 188.
Autocrine signaling mechanism of vitamin D in the bovine innate immune response - (Abstract)
Nelson, C.D., Beitz, D.C., Reinhardt, T.A., Lippolis, J.D. 2008. Autocrine signaling mechanism of vitamin D in the bovine innate immune response [abstract]. 2008 American Dairy Science Association, American Society of Animal Science, Midwestern Section, Annual Meeting. p. 37.
Adaptive changes in protein expression in Escherichia coli as a consequence of growth in milk - (Abstract)
Lippolis, J.D., Reinhardt, T.A. 2007. Adaptive changes in protein expression in Escherichia coli as a consequence of growth in milk [abstract]. Conference of Research Workers in Animal Diseases. p. 123.
Developmental changes in the milk fat globule membrane proteome during the transition from colostrum to milk - (Abstract)
Reinhardt, T.A. 2007. Developmental changes in the milk fat globule membrane proteome during the transition from colostrum to milk [abstract]. International Symposium on Milk Genomics and Human Health. p. 15-16.
Developmental changes in milk fat globule membrane proteome expression during the transition from colostrum to milk - (Abstract)
Reinhardt, T.A., Lippolis, J.D. 2007. Developmental changes in milk fat globule membrane proteome expression during the transition from colostrum to milk [abstract]. 2007 Joint Meeting-American Dairy Science Association, Poultry Science Association, Asociacion Mexicana de Produccion Animal, American Society of Animal Sciences. p. 58.
Changes in protein expression in Escherichia coli as a consequence of growth in milk whey - (Abstract)
Lippolis, J.D., Reinhardt, T.A. 2007. Changes in protein expression in Escherichia coli as a consequence of growth in milk whey [abstract]. 2007 Joint Meeting-American Dairy Science Association, Poultry Science Association, Asociacion Mexicana de Produccion Animal, American Society of Animal Sciences. p. 8.
Proteome and Differential Expression Analysis of Membrane and Cytosolic Proteins from Mycobacterium avium subsp. paratuberculosis Strains K-10 and 187. - (Peer Reviewed Journal)
Radosevich, T.J., Reinhardt, T.A., Lippolis, J.D., Bannantine, J.P., Stabel, J.R. 2007. Proteome and Differential Expression Analysis of Membrane and Cytosolic Proteins from Mycobacterium avium subsp. paratuberculosis Strains K-10 and 187. Journal of Bacteriology. 189(3):1109-1117.
Characterization of a Factor from Bovine Intestine That Protects Against Cryptosporidium Parvum Infection - (Peer Reviewed Journal)
Akili, D., Heidari, M., Welter, L.M., Reinhardt, T.A., Harp, J.A. 2006. Characterization of a factor from bovine intestine that protects against Cryptosporidium parvum infection. Veterinary Parasitology. 142(1-2):168-172.
Proteome and Differential Expression Analysis of Membrane and Cytosolic Protein from Mycobacterium Avium Subs Paratuberculosis Strains K10 and 187 - (Abstract)
Radosevich, T.J., Stabel, J.R., Bannantine, J.P., Lippolis, J.D., Reinhardt, T.A. 2006. Proteome and Differential Expression Analysis of Membrane and Cytosolic Protein from Mycobacterium avium subs paratuberculosis Strains k10 and 187 [abstract]. American Society for Microbiology. p. 112.
Neutrophil Extracellular Trap Formation by Bovine Neutrophils Is Not Inhibited by Milk - (Peer Reviewed Journal)
Lippolis, J.D., Reinhardt, T.A., Goff, J.P., Horst, R.L. 2006. Neutrophil extracellular trap formation by bovine neutrophils is not inhibited by milk. Veterinary Immunology and Immunopathology. 113(1-2):248-255.
Bovine Milk Fat Globule Membrane Proteome - (Peer Reviewed Journal)
Reinhardt, T.A., Lippolis, J.D. 2006. Bovine milk fat globule membrane proteome. Journal of Dairy Research. 73(4):406-416.
Bovine Milk Fat Globule Membrane Proteome - (Peer Reviewed Journal)
Reinhardt, T.A., Lippolis, J.D. 2006. Bovine milk fat globule membrane proteome. Journal of Dairy Research. 73(4):406-416.
Neutrophil Extracellular Trap Formation: An Important Neutrophil Killing Mechanism That Is Not Inhibited in Milk - (Abstract)
Lippolis, J.D., Reinhardt, T.A., Goff, J.P., Horst, R.L. 2006. Neutrophil extracellular trap formation: an important neutrophil killing mechanism that is not inhibited in milk [abstract]. American Dairy Science Association-American Society of Animal Science 2006 Joint Annual Meeting. p. 94.
Parturition and Hypocalcemia Blunts Calcium Signals in Immune Cells of Dairy Cattle - (Peer Reviewed Journal)
Kimura, K., Reinhardt, T.A., Goff, J.P. 2006. Parturition and hypocalcemia blunts calcium signals in immune cells of dairy cattle. Journal of Dairy Science. 89(7):2588-2595.
Differential Expression Analysis of Proteins from Neutrophils in the Periparturient Period and Neutrophils from Dexamethasone-Treated Dairy Cows - (Peer Reviewed Journal)
Lippolis, J.D., Peterson-Burch, B.D., Reinhardt, T.A. 2006. Differential expression analysis of proteins from neutrophils in the periparturient period and neutrophils from dexamethasone-treated dairy cows. Veterinary Immunology and Immunopathology. 111(3-4):149-164.
Expression Library Immunization Confers Protection Against Mycobacterium Avium Subsp. Paratuberculosis Infection - (Peer Reviewed Journal)
Huntley, J.F., Stabel, J.R., Paustian, M., Reinhardt, T.A., Bannantine, J.P. 2005. Expression Library Immunization Confers Protection against Mycobacterium avium subsp. paratuberculosis Infection. Infection and Immunity. 73(10):6877-6884.
Ca2+-Adenosine Triphosphatase Protein Expression in the Mammary Gland of Periparturient Cows - (Peer Reviewed Journal)
Prapong, S., Reinhardt, T.A., Goff, J.P., Horst, R.L. 2005. Ca2+-adenosine triphosphatase protein expression in the mammary gland of periparturient cows. Journal of Dairy Science. 88(5):1741-1744.
Differential Expression Analysis of Immunosuppressed Versus Normal Neutrophil Proteome - (Abstract)
Lippolis, J.D., Reinhardt, T.A. 2005. Differential expression analysis of immunosuppressed versus normal neutrophil proteome [abstract]. American Society for Mass Spectrometry. p. 73.
Adapting to the Transition Between Gestation and Lactation: Differences Between Rat, Human and Dairy Cow - (Peer Reviewed Journal)
Horst, R.L., Goff, J.P., Reinhardt, T.A. 2005. Adapting to the transition between gestation and lactation: differences between rat, human and dairy cow. Journal of Mammary Gland Biology and Neoplasia. 10(2):141-156.
Energy and Protein Effects on the Immune System - (Book/Chapter)
Kehrli, Jr., M.E., Neill, J.D., Burvenich, C., Goff, J.P., Lippolis, J.D., Reinhardt, T.A., Nonnecke, B.J. 2006. Energy and protein effects on the immune system. In: Sejrsen, K., Hvelplund, T., Nielsen, M.O., editors. Ruminant Physiology. Wageningen, The Netherlands: Wageningen Academic Publishers. p. 455-471.
Energy and Protein Effects on the Immune System - (Proceedings/Symposium) - (30-Aug-04)
Proteomic Survey of Bovine Neutrophils - (Peer Reviewed Journal)
Lippolis, J.D., Reinhardt, T.A. 2005. Proteomic survey of bovine neutrophils. Veterinary Immunology and Immunopathology. 103(1-2):53-65.
Null Mutation in the Gene Encoding Plasma Membrane Ca2+-Atpase Isoform 2 Impairs Calcium Transport into Milk - (Peer Reviewed Journal)
Reinhardt, T.A., Lippolis, J.D., Shull, G.E., Horst, R.L. 2004. Null mutation in the gene encoding plasma membrane CA2+-ATPase isoform 2 impairs calcium transport into milk. Journal of Biological Chemistry. 279(41):42369-42373.
Vitamin D Metabolism - (Book/Chapter)
Horst, R.L., Reinhardt, T.A., Reddy, G.S. 2005. Vitamin D metabolism. In: Feldman, D., Pike, J.W., Glorieux, F.H., editors. Vitamin D. 2nd edition, Vol. I. London, UK: Elsevier Academic Press. p. 15-36.
Calcium Pumps and Calcium Transport in the Mammary Gland - (Abstract)
Reinhardt, T.A. 2004. Calcium pumps and calcium transport in the mammary gland. Meeting Abstract.
Comparative Proteomic Analysis of Normal and Periparturient Bovine Neutrophils Demonstrating a Reduction of Myeloperoxidase During Transition - (Abstract)
Lippolis, J.D., Goff, J.P., Reinhardt, T.A. 2004. Comparative proteomic analysis of normal and periparturient bovine neutrophils demonstrating a reduction of myeloperoxidase during transition [abstract]. Experimental Biology Meeting. Paper No. 776.3.
Decreased Neutrophil Function As a Cause of Retained Placenta in Dairy Cattle - (Abstract)
Kimura, K., Goff, J.P., Kehrli Jr., M.E., Reinhardt, T.A. 2003. Decreased neutrophil function as a cause of retained placenta in dairy cattle [abstract]. ARS Immunology Research Workshop. p. 58.
Use of Micro Assay Technology to Compare Gene Expression of Mice Infected Or Not Infected with Cryptosporidium Parvum - (Abstract) - (12-Nov-02)

   
 
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