Page Banner

United States Department of Agriculture

Agricultural Research Service

Brian Brunelle
brian.brunelle@ars.usda.gov
Research Microbiologist

Brian W. Brunelle

National Animal Disease Center        

Research Microbiologist

E-mail:  brian.brunelle@ars.usda.gov

Phone (515) 337-7612

P.O. Box 70

1920 Dayton Ave.

Ames, IA  50010

 

Degrees:

B.S. Rensselaer Polytechnic Institute, Biochemistry and Biophysics, 1997

Ph.D. University of California, Berkeley, Infectious Diseases and Immunity, 2005

Postdoctoral Researcher, National Animal Disease Center, Virus and Prions Unit, 2008

 

Research Interests:

My research objectives are to identify factors that influence Salmonella Typhimurium virulence (invasion, colonization, and shedding), with an emphasis on the impact antibiotics have on multidrug-resistant (MDR) isolates.  With my collaborators, I have:

·        Discovered particular antibiotics commonly used in livestock can induce the invasiveness of MDR Salmonella.

·        Identified antibiotics that can promote attachment and decrease flagella in MDR Salmonella.

·        Determined antibiotic exposure to MDR Salmonella can stimulate phage-mediated horizontal gene transfer to naïve bacteria.

 

Laboratory Personnel:

Briony Atkinson, Biological Science Laboratory Technician

Devin Holman, Postdoctoral Researcher

 

Recent Publications:   Complete list of published work:

http://www.ncbi.nlm.nih.gov/pubmed/?term=brunelle+bw+[au]

 

1.     Brunelle BW, Bearson BL, Bearson SMD (2015). Chloramphenicol and tetracycline decrease motility and increase invasion and attachment gene expression in multidrug-resistant Salmonella enterica serovar Typhimurium.  Front Microbiol 5:801.

2.     Bearson BL, Brunelle BW (2015). Fluoroquinolone induction of phage-mediated gene transfer in multidrug-resistant Salmonella.  Int J Antimicrob Agents 46: 201-204.

3.     Lippolis JD, Brunelle BW, Reinhardt TA, Sacco RE, Nonnecke BJ, Dogan B, Simpson K, and Schukken Y  (2014). Proteomic analysis reveals protein expression differences in Escherichia coli strains associated with persistent versus transient mastitis.  J Proteomics 108: 373-381.

4.     Bearson BL, Allen HK, Brunelle BW, Lee I, Casjens SR, Stanton TB (2014). The agricultural antibiotic carbadox induces phage-mediated gene transfer in Salmonella. Front Microbiol 5: 52.

5.     Brunelle BW, Bearson SMD, Bearson BL (2013). Tetracycline accelerates the temporally-regulated invasion response in specific isolates of multidrug-resistant Salmonella enterica serovar Typhimurium. BMC Microbiology 13: 202.

 


Last Modified: 4/26/2016
Footer Content Back to Top of Page