Projects

IDENTIFICATION AND ENHANCEMENT OF SEED-BASED BIOCHEMICAL RESISTANCE IN CROPS TO AFLATOXIN PRODUCING PATHOGENS Appropriated (D)   Accession Number: 409782

AFLATOXIN CONTROL THROUGH TARGETING MECHANISMS GOVERNING AFLATOXIN BIOSYNTHESIS IN CORN AND COTTONSEED Appropriated (D)   Accession Number: 409790

ECOLOGICAL BASIS FOR AFLATOXIN REDUCTION THROUGH CROP MANAGEMENT AND BIOLOGICAL CONTROL Appropriated (D)   Accession Number: 409880

DISCOVERY OF ANTIFUNGAL COMPOUNDS FROM LOW VALUE/UNDERUTILIZED CROPS AND CROP CO-PRODUCTS Appropriated (D)   Accession Number: 418510

PHYTOESTROGENIC EFFECTS OF FUNGALLY INDUCED ISOFLAVONOIDS IN LEGUMES Appropriated (D)   Accession Number: 410552

DEVELOPMENT OF A REAL-TIME ELECTRONIC SENSOR TO DETECT ASPERGILLUS FLAVUS GROWTH ON STORED CORN Nonfunded Cooperative Agreement (N)   Accession Number: 418344

DETERMINE NATURAL PRODUCT INDUCTION IN LEGUMES AND THE PHARMACOLOGIC CONSEQUENCES IN HUMAN MODEL SYSTEMS Specific Cooperative Agreement (S)   Accession Number: 413440

REGULATION OF AFLATOXIN PRODUCTION IN ASPERGILLUS PARASITICUS Specific Cooperative Agreement (S)   Accession Number: 409964

PHYTOESTROGENIC EFFECTS OF FUNGALLY INDUCED ISOFLAVONOIDS IN LEGUMES Specific Cooperative Agreement (S)   Accession Number: 413335

TOTAL ECONOMIC IMPACT OF AFLATOXIN: MODELS OF ECONOMIC LOSS AND INDUSTRY LEARNING Specific Cooperative Agreement (S)   Accession Number: 411182

DEVELOPMENT OF RAPID, NON-DESTRUCTIVE HYPERSPECTRAL IMAGING METHODOLOGY TO MEASURE FUNGAL GROWTH AND AFLATOXIN CONTAMINATION Specific Cooperative Agreement (S)   Accession Number: 417999

Publications

Transgenic approaches for pre-harvest control of mycotoxin contamination in crop plants - (Review Article)

Cary, J.W., Rajasekaran, K., Yu, J., Brown, R.L., Bhatnagar, D., Cleveland, T.E. 2009. Transgenic approaches for pre-harvest control of mycotoxin contamination in crop plants. World Mycotoxin Journal. 2(2):203-214.

Phytoalexin-Enriched Functional Foods - (Review Article)

Boue, S.M., Cleveland, T.E., Carter Wientjes, C.H., Shih, B.Y., Bhatnagar, D., Mclachlan, J.M., Burow, M. 2009. Phytoalexin-Enriched Functional Foods. Journal of Agricultural and Food Chemistry. 57(7):2614-2622.

Potential of Aspergillus flavus Genomics for Applications in Biotechnology - (Peer Reviewed Journal)

Cleveland, T.E., Yu, J., Fedorova, N., Bhatnagar, D., Payne, G.A., Nierman, W.C., Bennett, J.W. 2009. Potential of Aspergillus flavus Genomics for Applications in Biotechnology. Trends in Biotechnology. 27(3):151-157.

Cost-Effectiveness of Aflatoxin Control Methods: Economic Incentives - (Peer Reviewed Journal)

Wu, F., Liu, Y., Bhatnagar, D. 2008. Cost-Effectiveness of Aflatoxin Control Methods: Economic Incentives. Toxins Reviews. 27:223-235.

The MYCOGLOBE Project: A European Union Funded Successful Experiment in Enhancing Cooperation and Coordination Amongst Mycotoxin Researchers Worldwide - (Review Article)

Bhatnagar, D., Perrone, G., Visconti, A. 2008. The MYCOGLOBE Project: A European Union Funded Successful Experiment in Enhancing Cooperation and Coordination Amongst Mycotoxin Researchers Worldwide. World Mycotoxin Journal. 1(4):493-500.

The "omics" Tools: Genomics, Proteomics, Metabolomics for Solving the Aflatoxin Contamination Problem - (Review Article)

Bhatnagar, D., Rajasekaran, K., Payne, G.A., Brown, R.L., Yu, J., Cleveland, T.E. 2008. The "omics" Tools: Genomics, Proteomics, Metabolomics for Solving the Aflatoxin Contamination Problem. World Mycotoxin Journal. 1(1):3-12.

Genetics and Genomics of Aspergillus flavus - (Review Article) - (20-Dec-07)

Molecular Approaches to Development of Resistance to Preharvest Aflatoxin Contamination - (Book/Chapter)

Bhatnagar, D., Rajasekaran, K., Cary, J.W., Brown, R.L., Yu, J., Cleveland, T.E. 2007. Molecular Approaches to Development of Resistance to Preharvest Aflatoxin Contamination. In: Leslie, J.F., Bandyopadhyay, R., and Visconti, A. (eds.) Mycotoxins: Detection Methods, Management, Public Health, and Agricultural Trade. Wallingford, Oxfordshire, UK:CABI Publishing. p. 259-279.

Elucidation of the functional genomics of antioxidant-based inhibition of aflatoxin biosynthesis - (Peer Reviewed Journal)

Kim, J.H., Yu, J., Mahoney, N.E., Chan, K.L., Molyneux, R.J., Varga, J., Bhatnagar, D., Cleveland, T.E., Campbell, B.C. 2008. Elucidation of the functional genomics of antioxidant-based inhibition of aflatoxin biosynthesis. International Journal of Food Microbiology.122(1-2):49-60.

Application of biotechnology towards the enhancement of maize resistance to aflatoxin contamination by Aspergillus flavus - (Review Article)

Brown, R.L., Chen, Z., Menkir, A., Cleveland, T.E., Bhatnagar, D. 2008. Application of Biotechnology Towards the Enhancement of Maize Resistance to Aflatoxin Contamination by Aspergillus flavus. In: Thangadurai, D., editor. Crop Improvement and Biotechnology. India: Bioscience Publications. p. 57-67.

Strategies for the Prevention of Preharvest Aflatoxin Contamination of Maize - (Review Article)

Brown, R.L., Chen, Z., Menkir, A., Cleveland, T.E., Bhatnagar, D. 2008. Strategies for the Prevention of Preharvest Aflatoxin Contamination of Maize. In: Stevens, C., editor. Recent Advancement in Agriculture. Kerala, India: Research Signpost. p. 131-150.

Genes Differentially Expressed by Aspergillus flavus Strains After Loss of Aflatoxin Production by Serial Transfers - (Abstract)

Chang, P., Wilkinson, J.R., Horn, B.W., Yu, J., Bhatnagar, D., Cleveland, T.E. 2007. Genes Differentially Expressed by Aspergillus flavus Strains After Loss of Aflatoxin Production by Serial Transfers. Multicrop Aflatoxin and Fumonisin Elimination and Fungal Genomics Workshop-The Peanut Foundation, Atlanta, GA. p. 34.

Genes Differentially Expressed by Aspergillus flavus Strains After Loss of Aflatoxin Production by Serial Transfers - (Peer Reviewed Journal)

Chang, P., Wilkinson, J.R., Horn, B.W., Yu, J., Bhatnagar, D., Cleveland, T.E. 2007. Genes differentially expressed by Aspergillus flavus strains after loss of aflatoxin production by serial transfers. Applied Microbiology and Biotechnology. 77:917-925.

Aspergillus flavus Genomics as a Tool for Studying the Mechanism of Aflatoxin Formation - (Peer Reviewed Journal)

Yu, J., Payne, G.A., Nierman, W.C., Machida, M., Bennett, J.W., Campbell, B.C., Robens, J.F., Bhatnagar, D., Dean, R.A., Cleveland, T.E. 2008. Aspergillus flavus Genomics as a Tool for Studying the Mechanism of Aflatoxin Formation. Journal of Food Additives & Contaminants. 25(9):1152-1157.

Aflatoxin Formation and Gene Expression in Response to Carbon Source Media Shift in Aspergillus Parasiticus - (Peer Reviewed Journal)

Wilkinson, J.R., Yu, J., Abbas, H.K., Scheffler, B.E., Kim, H.S., Nierman, W.C., Bhatnagar, D., Cleveland, T.E. 2007. Aflatoxin formation and gene expression in response to carbon source media shift in Aspergillus parasiticus. Journal of Food Additives & Contaminants. 24(10):1051-1060.

Analysis of aflatoxin regulatory factors in serial transfer-induced non-aflatoxigenic Aspergillus parasiticus - (Peer Reviewed Journal)

Kale, S.P., Cary, J.W., Hollis, N., Wilkinson, J.R., Bhatnagar, D., Yu, J., Cleveland, T.E., Bennett, J.W. 2007. Analysis of aflatoxin regulatory factors in serial transfer-induced non-aflatoxigenic Aspergillus parasiticus. Journal of Food Additives & Contaminants. 24(10):1061-1069.

Understanding Nonaflatoxigenicity of Aspergillus sojae: A Windfall of Aflatoxin Biosynthesis Research - (Review Article)

Chang, P.-K., Matsushima, K., Takahashi, T., Yu, J., Abe, K., Bhatnagar, D., Yuan, G., Koyama, Y., Cleveland, T.E. 2007. Understanding nonaflatoxigenicity of Aspergillus sojae: a windfall of aflatoxin biosynthesis research. Applied Microbiology and Biotechnology. 76:977-984.

Gene Profiling for Studying the Mechanism of Aflatoxin Biosynthesis in Aspergillus flavus and A. parasiticus - (Peer Reviewed Journal)

Yu, J., Ronning, C.M., Wilkinson, J.R., Campbell, B.C., Payne, G.A., Bhatnagar, D., Cleveland, T.E., Nierman, W.C. 2007. Gene profiling for studying the mechanism of aflatoxin biosynthesis in Aspergillus flavus and A. parasiticus. Journal of Food Additives & Contaminants. 24(10):1035-1042.

Elucidation of veA Dependent Genes Associated with Aflatoxin and Sclerotial Production in Aspergillus flavus by Functional Genomics - (Peer Reviewed Journal)

Cary, J.W., OBrian, G.R., Nielsen, D.M., Nierman, W., Harris-Coward, P.Y., Yu, J., Bhatnagar, D., Cleveland, T.E., Payne, G.A., Calvo, A.M. 2007. Elucidation of veA-dependent genes associated with aflatoxin and sclerotial production in Aspergillus flavus by functional genomics. Applied Microbiology and Biotechnology. 76:1107-1118.

What Can Comparative Genomics Tell Us About Species Concepts in the Genus Aspergillus? - (Peer Reviewed Journal)

Rokas, A., Payne, G., Fedorova, N.D., Baker, S.E., Machida, M., Yu, J., Georgianna, D.R., Dean, R.A., Bhatnagar, D., Cleveland, T.E., Wortman, J.R., Maiti, R., Joardar, V., Amedeo, P., Denning, D.W., Nierman, W.C. 2007. What Can Comparative Genomics Tell Us About Species Concepts in the Genus Aspergillus?. Studies in Mycology. 59:11-17.

Aspergillus flavus Genomics for Development of Strategies to Interrupt Aflatoxin Formation and Discovery of Fungal Enzymes for Biofuel Production - (Abstract)

Cleveland, T.E., Yu, J., Bhatnagar, D., Nierman, W.C., Payne, G.A. 2007. Aspergillus flavus Genomics for Development of Strategies to Interrupt Aflatoxin Formation and Discovery of Fungal Enzymes for Biofuel Production. Society of Industrial Microbiology Annual Meeting, July 29-August 2, 2007, Denver, CO. Abstract #S87. p. 102.

Genetic and Biochemical Control of Aflatoxigenic Fungi - (Book/Chapter)

Bhatnagar, D., Rajasekaran, K., Brown, R.L., Cary, J.W., Yu, J., Cleveland, T.E. 2007. Genetic and Biochemical Control of Aflatoxigenic Fungi. In: Wilson, C.L. (editor). Microbial Food Contamination. CRC Press. 17:395-426.

Aspergillus flavus Genomics for Controlling Aflatoxin Contamination - (Abstract) - (01-Apr-07)

Comparative Genomics in Identifying Aflatoxin Biosynthetic Genes - (Abstract) - (01-Apr-07)

Comparative Genomics of Aspergillus flavus and A. oryzae: An Early View - (Abstract) - (30-Mar-07)

Natural Products as Tools for Chemogenomic Analysis of Mycotoxin Biosynthesis and Fungal Stress-Response Systems - (Proceedings/Symposium)

Campbell, B.C., Kim, J.H., Yu, J., Molyneux, R.J., Mahoney, N.E., Palumbo, J.D., Chan, K.L., Bhatnagar, D., Cleveland, T.E., Nierman, W.C. 2008. Natural Products as Tools for Chemogenomic Analysis of Mycotoxin Biosynthesis and Fungal Stress-Response Systems. p. 1-12. In: Food Contaminants: Mycotoxins and Food Allergens. American Chemical Society Symposium Series 1001. p. 543.

Natural Products as Tools for Chemogenomic Analysis of Mycotoxin Biosynthesis and Fungal Stress-Response Systems - (Book/Chapter)

Campbell, B.C., Kim, J.H., Yu, J., Molyneux, R.J., Mahoney, N.E., Palumbo, J.D., Chan, K.L., Bhatnagar, D., Cleveland, T.E., Nierman, W.C. 2008. Natural Products as Tools for Chemogenomic Analysis of Mycotoxin Biosynthesis and Fungal Stress-Response Systems. American Chemical Society Symposium Series. In: Siantar, D.P. Trucksess, M., Scott, P.M., Herman, E.M. editors, Food Contaminants: Mycotoxins and Food Allergens. Oxford University Press. p. 2-11.

Comparative and Functional Genomics in Identifying Aflatoxin Biosynthetic Genes - (Abstract)

Yu, J., Wilkinson, J., Payne, G., Machida, M., Campbell, B.C., Bennett, J., Bhatnagar, D., Cleveland, T.E., Nierman, W. 2007. Comparative and Functional Genomics in Identifying Aflatoxin Biosynthetic Genes. In: Proceedings of the 24th Fungal Genetics Conference and the 4th International Aspergillus Meeting, March 18-25, 2007, Asilomar, CA. p. 82.

Aspergillus flavus Genomic Data Mining Provides Clues for Its Use in Producing Biobased Products - (Abstract)

Yu, J., Nierman, W.C., Bhatnagar, D., Cleveland, T.E. 2007. Aspergillus flavus Genomic Data Mining Provides Clues for Its Use in Producing Biobased Products. In: Proceedings of the American Chemical Society National Meeting, March 25-29, 2007, Chicago, IL. p. 108.

A First Glance into the Genome Sequence of Aspergillus flavus - (Book/Chapter)

Payne, G.A., Yu, J., Nierman, W.C., Machida, M., Bhatnagar, D., Cleveland, T.E., Dean, R.A. 2007. A first glance into the genome sequence of aspergillus flavus, pp. 15-23. In: Osmani, S. and Goldman, G. (eds). The Aspergilli: Genomics, Medical Aspects, Biotechnology, and Research Methods, CRC Press, Boca Raton, FL.

The Use of Crop Proteomics and Fungal Genomics in Elucidating Fungus-Crop Interactions - (Abstract)

Cleveland, T.E., Yu, J., Chen, Z., Brown, R.L., Cary, J.W., Rajasekaran, K., Bhatnagar, D., Campbell, B.C., Nierman, W.C., Payne, G.A. 2006. The Use of Crop Proteomics and Fungal Genomics in Elucidating Fungus-Crop Interactions. In: Proceedings of the Myco-Globe Conference, September 26-30, 2006, Bari, Italy. p. 32.

The Effect of Elevated Temperature on Gene Transcription and Aflatoxin Biosynthesis - (Peer Reviewed Journal)

OBrian, G.R., Georgianna, D.R., Wilkinson, J.R., Yu, J., Abbas, H.K., Bhatnagar, D., Cleveland, T.E., Nierman, W.C., Payne, G.A. 2007. The Effect of Elevated Temperature on Gene Transcription and Aflatoxin Biosynthesis. Mycologia. 99(2):232-239.

Amino Acid Supplementation Reveals Differential Regulation of Aflatoxin Biosynthesis in Aspergillus Flavus Nrrl 3357 and Aspergillus Parasiticus Srrc 143 - (Peer Reviewed Journal)

Wilkinson, J.R., Yu, J., Bland, J.M., Nierman, W.C., Bhatnagar, D., Cleveland, T.E. 2007. Amino acid supplementation reveals differential regulation of aflatoxin biosynthesis in Aspergillus flavus NRRL 3357 and Aspergillus parasiticus SRRC 143. Applied Microbiology and Biotechnology. 74:1308-1319.

Genomics of Mycotoxigenic Fungi - (Book/Chapter)

Bhatnagar, D., Proctor, R., Payne, G.A., Wilkinson, J.R., Yu, J., Cleveland, T.E., Nierman, W.C. 2006. Genomics of Mycotoxigenic Fungi. In: Barug, D., Bhatnagar, D., van Egmond, H.P., van der Kamp, J.W., van Osenbruggen, W.A. Visconti, A., editors. The Mycotoxin Factbook. The Netherlands: Wageningen Academic Publishers. 400 p.

Global Perspectives of Fungal Secondary Metabolite Research - (Abstract)

Bhatnagar, D., Cary, J.W. 2006. Preface: Global Perspectives of Fungal Secondary Metabolite Research. Mycopathologia. 162:141-142.

Understanding the Genetics of Regulation of Aflatoxin Production and Aspergillus flavus Development - (Review Article)

Bhatnagar, D., Cary, J.W., Ehrlich, K., Yu, J., Cleveland, T.E. 2006. Understanding the Genetics of Regulation of Aflatoxin Production and Aspergillus flavus Development. Mycopathologia. 162:155-166.

Est Profiling for Elucidation of Molecular Regulation of Aflatoxin Bbiosynthesis in Aspergillus Flavus - (Abstract)

Yu, J., Wilkinson, J.R., Cleveland, T.E., Campbell, B.C., Bhatnagar, D., Payne, G.A., Nierman, W.C. 2006. EST profiling for elucidation of molecular regulation of aflatoxin biosynthesis in Aspergillus flavus. In: Proceedings of the Myco-Globe Conference: Advances on Genomics, Biodiversity and Rapid Systems for Detection of Toxigenic Fungi and Mycotoxins, September 26-30, 2006, Bari, Italy. p. 29.

Temperature Dependent Molecular Regulation of Aflatoxin Biosynthesis - (Abstract)

Obrian, G.R., Georgiana, D.R., Wilkinson, J.R., Yu, J., Bhatnagar, D., Cleveland, T.E., Payne, G.A. 2006. Temperature dependent molecular regulation of aflatoxin biosynthesis. In: Proceedings of the American Society for Microbiology Annual Meeting, May 21-26, 2006, Orlando, FL. Abstract #O-063, p. 433.

Media Shift of Aspergillus Parasiticus Cultures for Studying the Molecular Regulation of Aflatoxin - (Abstract)

Wilkinson, J.R., Yu, J., Abbas, H.K., Scheffler, B.E., Kim, H.S., Nierman, W.C., Bhatnagar, D., Cleveland, T.E. 2006. Media shift of Aspergillus parasiticus cultures for studying the molecular regulation of aflatoxin. In: Proceedings of the American Society for Microbiology Annual Meeting, May 21-26, 2006, Orlando, FL. Abstract #O-064, p. 433.

Whole Genome Comparison of Aspergillus Flavus and A. Oryzae - (Review Article)

Payne, G.A., Nierman, W.C., Wortman, J.R., Pritchard, B.L., Brown, D., Dean, R.A., Bhatnagar, D., Cleveland, T.E., Machida, M., Yu, J. 2006. Whole genome comparison of Aspergillus flavus and A. oryzae. Medical Mycology. 44:9-11.

The Sec Mutant of Aspergillus Parasiticus Is Altered in Its Profile of Secondary Metabolites - (Abstract)

Glassbrook, N.J., Kale, S.P., Bhatnagar, D., Wilkinson, J.R., Yu, J., Cary, J.W., Cleveland, T.E., Payne, G.A. 2006. The sec- mutant of Aspergillus parasiticus is altered in its profile of secondary metabolites. In: Proceedings of the American Society for Microbiology Annual Meeting, May 21-26, 2006, Orlando, FL. Abstract #O-040, p. 428.

Regulatory Elements in Aflatoxin Biosynthesis - (Review Article)

Cary, J.W., Ehrlich, K., Kale, S.P., Calvo, A.M., Bhatnagar, D., Cleveland, T.E. 2006. Regulatory Elements in Aflatoxin Biosynthesis. Mycotoxin Research. 22(2):105-109.

Aspergillus Flavus Expressed Sequence Tags and Microarray As Tools in Understanding Aflatoxin Biosynthesis - (Peer Reviewed Journal)

Yu, J., Cleveland, T.E., Wilkinson, J.R., Campbell, B.C., Kim, J.H., Kim, H.S., Bhatnagar, D., Payne, G.A., Nierman, W.C. 2006. Aspergillus flavus expressed sequence tags and microarray as tools in understanding aflatoxin biosynthesis. Mycotoxin Research. 22(1):16-21.

Gene Targets for Fungal and Mycotoxin Control - (Peer Reviewed Journal)

Campbell, B.C., Kim, J.H., Molyneux, R.J., Mahoney, N.E., Chan, K.L, Yu, J., Wilkinson, J.R., Cary, J.W., Bhatnagar, D., Cleveland, T.E. 2006. Gene targets for fungal and mycotoxin control. Mycotoxin Research. 22(1):3-8.

The Aflatoxin Pathway Regulator AFLR Induces Gene Transcription Inside and Outside of the Aflatoxin Biosynthetic Cluster - (Peer Reviewed Journal)

Price, M.S., Yu, J., Nierman, W.C., Kim, H.S., Pritchard, B., Jacobus, C.A., Bhatnagar, D., Cleveland, T.E., Payne, G.A. 2006. The aflatoxin pathway regulator AflR induces gene transcription inside and outside of the aflatoxin biosynthetic cluster. Federation of European Microbiological Societies Microbiology Letters. 255:275-279.

Enhancing Food Safety: Prevention of Preharvest Aflatoxin Contamination - (Review Article)

Rajasekaran, K., Bhatnagar, D., Brown, R.L., Chen, Z., Cary, J.W., Cleveland, T.E. 2005. Enhancing food safety: Prevention of preharvest aflatoxin contamination. In: Ramasamy, C., Ramanathan, S. and Dhakshinamoorthy, M., editors. Perspectives of Agricultural Research and Development. India: Tamil Nadu Agricultural University. p. 434-467.

The Aflatoxin Biosynthesis Cluster Gene Hypa Is Required for Conversion of Versicolorin a to Sterigmatocystin - (Peer Reviewed Journal)

Ehrlich, K., Montalbano, B.G., Boue, S.M., Bhatnagar, D. 2005. An aflatoxin biosynthesis cluster gene encodes a novel oxidase required for conversion of versicolorin a to sterigmatocystin. Applied and Environmental Microbiology. 71:8963-8965.

Genome Sequencing and Analysis of Aspergillus Oryzae - (Peer Reviewed Journal)

Machida, M., Asai, K., Sano, M., Tanaka, T., Kumagai, T., Terai, G., Kusumoto, K., Arima, T., Akita, O., Kashiwagi, Y., Abe, K., Gomi, K., Horiuchi, H., Kitamoto, K., Kobayashi, T., Takeuchi, M., Denning, D.W., Galagan, J.E., Nierman, W.C., Yu, J., Archer, D., Bhatnagar, D., Cleveland, T.E., Gotoh, O., Horikawa, H., Hosoyama, A., Ichinomiya, M., Igarashi, R., Iwashita, K., Juvvadi, P., Kato, M., Kato, Y., Kin, T., Kokubun, A., Maeda, H., Maeyama, N., Maruyama, J., Nagasaki, H., Nakajima, T., Oda, K., Okada, K., Paulsen, I., Sakamoto, K., Sawano, T., Takahashi, M., Takase, K., Terabayashi, T., Wortman, J., Yamada, O., Yamagata, O., Anazawa, H., Hata, Y., Koide, Y., Komori, T., Koyama, Y., Minetoki, T., Suharnan, S., Tanaka, A., Isono, K., Kuhara, S., Ogasawara, N., Kikuchi, H. 2005. Genome sequencing and analysis of Aspergillus oryzae. Nature. 438(7071):1157-1161.

Batch Submission and Release of 19,618 Aspergillus flavus Expressed Sequence Tags (ESTs) - (Other)

Yu, J., Nierman, W.C., Bhatnagar, D., Cleveland, T.E. 2006. Batch Submission and Release of 19,618 Aspergillus flavus Expressed Sequence Tags (EST). National Center for Biotechnology Information (NCBI). (NCBI, http://www.ncbi.nlm.nih.gov/), CO133039-CO152656.

Classification, Analysis, and Release of Aspergillus flavus Gene Index Consisting of 7,218 Expressed Unique Genes - (Other)

Yu, J., Cleveland, T.E., Bhatnagar, D., Nierman, W.C. 2006. Classification, Analysis, and Release of Aspergillus flavus Gene Index Consisting of 7,218 Expressed Unique Genes. In: The Institute for Genomic Research and The Dana Farber Cancer Institute ().

Aspergillus Flavus Genomics for Studying the Mechanism of Aflatoxin Biosynthesis - (Abstract)

Yu, J., Wilkinson, J.R., Kim, H.S., Nierman, W.C., Kim, J.H., Campbell, B.C., Bhatnagar, D., Cleveland, T.E. 2005. Aspergillus flavus genomics for studying the mechanism of aflatoxin biosynthesis. International Union of Microbiological Societies (IUMS) Proceedings/Abstracts, July 23-28, 2005, San Francisco, CA. p. 6.

The Aflatoxin Pathway Regulatory Gene aflR Regulates Genes Outside of the Aflatoxin Biosynthetic Cluster - (Other)

Price, M.S., Yu, J., Bhatnagar, D., Cleveland, T.E., Nierman, W.C., Pritchard, B., Payne, G.A. 2005. The Aflatoxin Pathway Regulatory Gene aflR Regulates Genes Outside of the Aflatoxin Biosynthetic Cluster [Ph D Dissertation]. Raleigh, NC: North Carolina State University. 80 p.

Profiling of Genes Putatively Involved on Aflatoxin Biosynthesis Using Aspergillus Flavus Microarrays - (Abstract)

Yu, J., Wilkinson, J.R., Kim, H., Nierman, W.C., Payne, G.A., Bennett, J.W., Kim, J.H., Campbell, B.C., Bhatnagar, D., Cleveland, T.E. 2005. Profiling of genes putatively involved on aflatoxin biosynthesis using Aspergillus flavus microarrays. American Society for Microbiology Meeting, June 6-9, 2005, Atlanta, GA. p. 426.

Isolation and Partial Characterization of 5-Azacytidine-Induced Non-Aflatoxigenic Aspergillus Parasiticus Mutants - (Abstract) - (01-Mar-05)

Aspergillus Flavus Genome Sequence: Initial Analysis - (Abstract)

Payne, G.A., Pritchard, B.L., Yu, J., Nierman, W.C., Dean, R.A., Bhatnagar, D., Cleveland, T.E. 2005. Aspergillus flavus genome sequence: Initial analysis. 23rd Fungal Genetic Conference and 2nd Aspergillus Meeting, Asilomar Conference Center, March 13-20, 2005, Pacific Grove, CA. p. 96.

Functional Genomics Studies for Identifying Genes Involved in Aflatoxin Formation in Aspergillus Flavus - (Abstract)

Yu, J., Wilkinson, J.R., Kim, H., Nierman, W.C., Payne, G.A., Bennett, J.W., Kim, J.H., Campbell, B.C., Bhatnagar, D., Cleveland, T.E. 2005. Functional genomics studies for identifying genes involved in aflatoxin formation in Aspergillus flavus. 23rd Fungal Genetic Conference and 2nd Aspergillus Meeting, Asilomar Conference Center, March 13-20, 2005, Pacific Grove, CA. p. 203.

Examination of Fungal Stress Response Genes Using Saccharomyces Cerevisiae As a Model System: Targeting Genes Affecting Aflatoxin Biosynthesis by Aspergillus Flavus Link. - (Peer Reviewed Journal)

Kim, J.H., Campbell, B.C., Molyneux, R.J., Mahoney, N.E., Chan, K.L., Yu, J., Wilkinson, J.R., Cary, J.W., Bhatnagar, D., Cleveland, T.E. 2005. Examination of fungal stress response genes using saccharomyces cerevisiae as a model system: targeting genes affecting aflatoxin biosynthesis by Aspergillus Flavus Link. Applied Microbiology and Biotechnology. 67(6):807-815.

Secondary Metabolite Biosynthetic Gene Clusters in Filamentous Fungi - (Abstract)

Nierman, W.C., Fedorova, N., Ronning, C.M., Kulkarni, R., Denning, D., Anderson, M., Machida, M., Kitamoto, K., Asai, K., Bennett, J., Payne, G.A., Yu, J., Bhatnagar, D., Cleveland, T.E., Wortman, J., Ravel, J. 2005. Secondary metabolite biosynthetic gene clusters in filamentous fungi. 23rd Fungal Genetic Conference and 2nd Aspergillus Meeting, Asilomar Conference Center, March 13-20, 2005, Pacific Grove, CA. p. 95.

Removal of Aflatoxins from Food and Feed Crops - (Book/Chapter)

Chen, Z.-Y., Rajasekaran, K., Brown, R.L., Bhatnagar, D., Cleveland, T.E. 2005. Removal of aflatoxins from food and feed crops. In: Jaiwal, P.K., Singh, R.P., editors. Plant Genetic Engineering, Metabolic Engineering and Molecular Farming II. Houston, TX: Studium Press LLC. 8:73-110.

Molecular Aspects of Corn Resistance Mechanisms Against Aflatoxigenic Fungi - (Book/Chapter)

Brown, R.L., Chen, Z.-Y., Cleveland, T.E., Bhatnagar, D. 2005. Molecular aspects of corn resistance mechanisms against aflatoxigenic fungi. In: Thangdunai, D., Pullaiah, T., Balatti, P.A., editors. Genetic Resources and Biotechnology. v. 2. New Delhi, India: Regency Publications. p. 281-294.

Profiling of Genes Related to Aflatoxin Formation Using Aspergillus Flavus Microarray - (Abstract)

Yu, J., Bhatnagar, D., Cleveland, T.E. 2004. Profiling of genes related to aflatoxin formation using Aspergillus flavus microarray. Great Lakes Regional American Chemical Society Symposium, October 17-20, Peoria, IL. p. 60.

Aspergillus Flavus Expressed Sequence Tags for Identification of Genes with Putative Roles in Aflatoxin Contamination of Crops - (Peer Reviewed Journal)

Yu, J., Whitelaw, C.A., Nierman, W.C., Bhatnagar, D., Cleveland, T.E. 2004. Aspergillus flavus expressed sequence tags for identification of genes with putative roles in aflatoxin contamination of crops. Federation of European Microbiological Societies Microbiol Letters. 237:333-340.

Aspergillus Flavus Genomics for Solving Aflatoxin Contamination in Crops - (Abstract)

Yu, J., Nierman, W.C., Payne, G.A., Bhatnagar, D., Cleveland, T.E. 2004. Aspergillus flavus genomics for solving aflatoxin contamination in crops. Annual Conference of the U.S.-Japan Cooperative Program in Natural Resources (UJNR), October 7-13, 2004, Atlanta, GA. p. 14.

Genomics of Aspergillus Spp for Controlling Harmful Toxins and Harnessing Beneficial Metabolites - (Abstract)

Bhatnagar, D., Yu, J., Cleveland, T.E. Genomics of Sspergillus species for controlling harmful toxins and harnessing beneficial metabolites [abstract]. Society of Industrial Microbiology Annual Meeting, July 25-29, 2004, Anaheim, California.

Profiling of Genes Involved in Aflatoxin Production in Aspergillus Flavus by Expressed Sequence Tags and Microarray - (Abstract)

Yu, J., Kim, H., Wilkinson, J.R., Nierman, W.C., Bhatnagar, D., Cleveland, T.E. 2004. Profiling of genes involved in aflatoxin production in Aspergillus flavus by expressed sequence tags and microarray [abstract]. Society of Industrial Microbiology Annual Meeting, July 25-29, 2004, Anaheim, California.

Aspergillus Genomics: Understanding Fungal Ecology and Aflatoxin Production - (Abstract)

Bhatnagar, D., Yu, J., Ehrlich, K., Cleveland, T.E. Aspergillus genomics: Understanding fungal ecology and aflatoxin production [abstract]. International Union of Pure and Applied Chemistry (IUPAC) Symposium on Mycotoxins and Phycotoxins, May 17-21, 2004, Bethesda, Maryland.

Identification of Natural Resistance in Corn Against Mycotoxin-Producing Fungi - (Review Article)

Brown, R.L., Chen, Z., Gembeh, S.V., Cleveland, T.E., Bhatnagar, D., Howard, K. 2004. Identification of natural resistance in corn against mycotoxin-producing fungi. In: Research Advances in Food Science. Kerala, India: Global Research Network. p. 85-96.

Targeting Stress-Response Genes for Control of Mycotoxin Biosynthesis in Aspergillus - (Abstract)

Kim, J.H., Yu, J., Bhatnagar, D., Cleveland, T.E., Campbell, B.C. 2004. Targeting stress-response genes for control of mycotoxin biosynthesis in Aspergillus [abstract]. 7th European Conference on Fungal Genetics and 1st Aspergillus Workshop, April 17-21, 2004, Copenhagen, Denmark.

Completed Sequence of Aflatoxin Pathway Gene Cluster in Aspergillus Parasiticus - (Peer Reviewed Journal)

Yu, J., Bhatnagar, D., Cleveland, T.E. 2004. Completed sequence of aflatoxin pathway gene cluster in aspergillus parasiticus. Federation of European Biochemical Societies Letters. 564:126-130.

Genetic and Biochemical Studies on the Mechanisms of Aflatoxin Biosynthesis - (Abstract)

Yu, J., Cleveland, T.E., Bhatnagar, D. 2004. Genetic and biochemical studies on the mechanisms of aflatoxin biosynthesis [abstract]. 7th European Conference on Fungal Genetics and 1st Aspergillus Workshop, April 17-21, 2004, Copenhagen, Denmark.

Progress in Elucidating the Molecular Basis of the Host Plant-Aspergillus flavus Interaction: A Basis for Devising Strategies to Reduce Aflatoxin Contamination in Crops - (Book/Chapter)

Cleveland, T.E., Yu, J., Bhatnagar, D., Chen, Z.-Y., Brown, R.L., Chang, P., Cary, J.W. 2005. Progress in Elucidating the Molecular Basis of the Host Plant-Aspergillus flavus Interaction: A Basis for Devising Strategies to Reduce Aflatoxin Contamination in Crops. In: Abbas, H.K., editor. Aflatoxin and Food Safety. Boca Raton, FL: Taylor & Francis. p. 167-193.

Aflatoxin Biosynthetic Gene Profiling in Aspergillus Flavus by Est and Microarray - (Abstract)

Yu, J., Kim, H., Cleveland, T.E., Bhatnagar, D., Nierman, W.C. 2004. Aflatoxin biosynthetic gene profiling in Aspergillus flavus by EST and microarray [abstract]. American Society for Microbiology Annual Meeting, New Orleans, Louisiana.

Gene Profiling by Est and Microarray in Aspergillus Flavus for Controlling Aflatoxin Contamination in Crops - (Abstract)

Yu, J., Kim, H., Whitelaw, C.A., Nierman, W.C., Bhatnagar, D., Cleveland, T.E. 2004. Gene profiling by EST and microarray in Aspergillus flavus for controlling aflatoxin contamination in crops [abstract]. 7th European Conference on Fungal Genetics and 1st Aspergillus Workshop, April 17-21, 2004, Copenhagen, Denmark.

Aspergillus Genome Project - (Abstract)

Bhatnagar, D., Yu, J., Cleveland, T.E. Aspergillus genome project [abstract]. International Symposium on Mycotoxins and Phytotoxins, May 17-21, 2004, Bethesda, Maryland.

Genetics and Biochemistry of Aflatoxin Formation and Genomics Approach for Eliminating Aflatoxin Contamination - (Review Article)

Yu, J., Bhatnagar, D., Cleveland, T.E. 2004. Genetics and biochemistry of aflatoxin formation and genomics approach for eliminating aflatoxin contamination. In: Romeo, J.T., editor. Recent Advances in Phytochemistry: Secondary Metabolism in Model Systems. Elsevier. 38:224-242.

The Clustered Pathway Genes in Aflatoxin Biosynthesis - (Review Article)

Yu, J., Chang, P.-K., Ehrlich, K., Cary, J.W., Bhatnagar, D., Cleveland, T.E., Payne, G.A., Linz, J.E., Woloshuk, C.P., Bennett, J.W. 2004. The clustered pathway genes in aflatoxin biosynthesis. Applied And Environmental Microbiology. 70(3):1253-1262.

Elucidation of the Molecular Basis of the Host Plant-Aspergillus flavus Interaction, a Basis for Devising Strategies to Reduce Aflatoxin Contamination in Crops - (Review Article)

Cleveland, T.E., Yu, J., Bhatnagar, D., Chen, Z.-Y., Brown, R.L., Chang, P.-K., Cary, J.W. 2004. Elucidation of the molecular basis of the host plant-Aspergillus flavus interaction, a basis for devising strategies to reduce aflatoxin contamination in crops. In: Shier, W.T., Tu, A.T., Yu, C., Abbas, H.K., editors. Journal of Toxicology - Toxin Reviews. New York, NY: Marcel Dekker, Inc. 23(2,3):345-380.

Aspergillus Flavus Est and Microarray in Identifying Target Genes for Controlling Aflatoxin Contamination - (Abstract)

Yu, J., Whitelaw, C.A., Cleveland, T.E., Bhatnagar, D., Nierman, W.C. 2003. Aspergillus flavus EST and microarray in identifying target genes for controlling aflatoxin contamination [abstract]. Multicrop Aflatoxin and Fumonisin Elimination and Fungal Genomics Workshop, The Peanut Foundation, October 13-15, 2003, Savannah, Georgia.

Characterization of the Complete Aflatoxin Pathway Gene Cluster in Aspergillus Parasiticus - (Abstract)

Yu, J., Chang, P.-K., Ehrlich, K., Cary, J.W., Bhatnagar, D., Cleveland, T.E. 2003. Characterization of the complete aflatoxin pathway gene cluster in Aspergillus parasiticus. Proceedings of USDA-ARS Aflatoxin/Fumonisin Elimination and Fungal Genomics Workshop, October 13-15, 2003, Savannah, Georgia.

Substrate-induced Lipase Gene Expression and Aflatoxin Production in Aspergillus parasiticus and Aspergillus flavus - (Peer Reviewed Journal)

Yu, J., Mohawed, S.M., Bhatnagar, D., Cleveland, T.E. 2003. Substrate-induced Lipase Gene Expression and Aflatoxin Production in Aspergillus parasiticus and Aspergillus flavus. Journal of Applied Microbiology. 95(6):1334-1342.

Genomics of Economically Significant Aspergillus and Fusarium Species - (Book/Chapter)

Yu, J., Proctor, R.H., Brown, D.W., Abe, K., Gomi, K., Machida, M., Hasegawa, F., Nierman, W.C., Bhatnagar, D., Cleveland, T.E. 2004. Genomics of economically significant aspergillus and fusarium species. In: Arora, D.K., Khachatourians, G.G.. Applied Mycology and Biotechnology: Fungal Genomics. v. 4. Elsevier Science B.V. p. 249-283.

Mycotoxins - (Review Article)

Chu, F.S., Bhatnagar, D. Mycotoxins, p. 325-342. In Arora, D. K. (ed.) Fungal Biotechnology in Agricultural, Food, and Environmental Applications, Marcel Dekker, Inc., New York. 2004.

Genetic Analysis of Morphological Variants of Aspergillus Parasiticus Deficient in Secondary Metabolite Production - (Peer Reviewed Journal)

KALE, S.P., CARY, J.W., BAKER, C., WALKER, D., BHATNAGAR, D., BENNETT, J.W. GENETIC ANALYSIS OF MORPHOLOGICAL VARIANTS OF ASPERGILLUS PARASITICUS DEFICIENT IN SECONDARY METABOLITE PRODUCTION. MYCOLOGICAL RESEARCH. 2003. V. 107. P. 831-840.

Fungal Genomics: An Overview - (Review Article)

DESJARDINS, A.E., BHATNAGAR, D. FUNGAL GENOMICS: AN OVERVIEW. APPLIED MYCOLOGY AND BIOTECHNOLOGY. 2003. V. 3. P. 1-13.

Pre-Harvest Prevention of Mycotoxins and Mycotoxigenic Fungi in U.S. Crops - (Review Article)

Cleveland, T.E., Dowd, P.F., Desjardins, A.E., Bhatnagar, D., Cotty, P.J. 2003. Pre-harvest prevention of mycotoxins and mycotoxigenic fungi in U.S. crops. Pest Management Science ARS Special Issue. 59:629-642.

Mycotoxins: Current Issues in U.S.A. - (Review Article)

Bhatnagar, D., Payne, G.A., Cleveland, T.E., Robens, J.F. Mycotoxins: Current issues in U.S.A. [abstract]. Proceedings of the 2nd Second World Mycotoxin Forum, February 17-18, 2003, Noordwijk, The Netherlands.

Protoplast Isolation, Regeneration and Fusion in Filamentous Fungi - (Review Article)

Kale, S.P., Bhatnagar, D. 2004. Protoplast isolation, regeneration, and fusion in filamentous fungi. In: Aurora, D.K., editor. Handbook of Fungal Biotechnology. New York NY: Marcel Dekker, Inc. p. 9-24.

Fungal Genomics: An Overview - (Book/Chapter)

DESJARDINS, A.E., BHATNAGAR, D. FUNGAL GENOMICS: AN OVERVIEW. ARORA, D.K., KHACHATOURIANS, G.G., EDITORS. ELSEVIER, AMSTERDAM. APPLIED MYCOLOGY BIOTECHNOLOGY: AN INTERNATIONAL SERIES. VOLUME 3. FUNGAL GENOMICS. CHAPTER 1. 2003. P. 1-13.

Molecular Genetic Analysis of Aflatoxin Biosynthesis and Its Application to Understanding the Biological Role of Aflatoxin - (Review Article)

Bhatnagar, D., Ehrlich, K., Cleveland, T.E. 2003. Molecular genetic analysis of aflatoxin biosynthesis and its application to understanding the biological role of aflatoxin. Applied Microbiology and Biotechnology. 61:83-93.

Aflatoxin Biosynthesis - (Review Article)

Yu, J., Bhatnagar, D., Ehrlich, K. 2002. Aflatoxin biosynthesis. Revista Iberoamericana De Micologia. 19:191-200.

Molecular Biology for Control of Mycotoxigenic Fungi - (Book/Chapter)

Brown, R.L., Chen, Z.-Y., Bhatnagar, D., Cleveland, T.E. 2004. Molecular biology for control of mycotoxigenic fungi. In: Arora, D., Bridge, P., Bhatnagar, D., editors. Fungal Biotechnology in Agricultural, Food, and Environmental Applications. New York, NY: Marcel Dekker, Inc. p. 69-77.

Balancing the Benefits and Potential Risks of Using Biotechnology to Enhance Resistance in Crops to Aspergillus Flavus Infection and Aflatoxin Contamination - (Proceedings/Symposium)

Cleveland, T.E., Rajasekaran, K., Cary, J.W., Chen, Z.-Y., Brown, R.L., Bhatnagar, D., Radin, J.W. 2002. Balancing the possible risks and benefits of using biotechnology to enhance resistance in crops to Aspergillus flavus infection and aflatoxin contamination. In: Pathogenic Microorganisms and Their Toxins: A Global Perspective of Their Risk (Book Chapter). IXth International Symposium, U.S.- Japan Natural Resources Panel on Toxic Microorganisms (UJNR). p. 268-301.