Publications (Clicking on the reprint icon will take you to the publication reprint.)

Regulation of muscle growth in neonates - (Review Article)

Davis, T.A., Fiorotto, M.L. 2009. Regulation of muscle growth in neonates. Current Opinion in Clinical Nutrition and Metabolic Care. 12(1):78-85.

Nutritional regulation of mTOR signaling in skeletal muscle of neonates in vivo - (Abstract Only)

Davis, T.A., Fiorotto, M.L. 2008. Nutritional regulation of mTOR signaling in skeletal muscle of neonates in vivo [abstract]. The Federation of American Societies for Experimental Biology Summer Research Conferences, "Molecular Mechanisms Involved in the Nutrient Control of Cellular Function", Session 4, "Nutrient Control of Signal Transduction Pathways", July 20-25, 2008, Carefree, Arizona. p. 20.

Inadequate satellite cell replication compromises muscle regrowth following postnatal nutrient restriction - (Abstract Only)

Fiorotto, M.L., Lopez, R., Rosenberger, R., Davis, T.A., Gomez, A.J. Malphus, E.W. 2007. Inadequate satellite cell replication compromises muscle regrowth following postnatal nutrient restriction [abstract]. 5th International Congress on Developmental Origins of Health and Disease, November 6-10, 2007, Perth, Western Australia. 83(Suppl. 1):S58[Abstract #2E-6].

Postnatal ontogeny of skeletal muscle protein synthesis in pigs - (Peer Reviewed Journal)

Davis, T.A., Suryawan, A., Orellana, R.A., Nguyen, H.V., Fiorotto, M.L. 2008. Postnatal ontogeny of skeletal muscle protein synthesis in pigs. Journal of Animal Science. 86(14 Suppl):E13-E18.

Postnatal ontogeny of skeletal muscle protein synthesis in pigs - (Abstract Only)

Davis, T.A., Suryawan, A., Orellana, R.A., Fiorotto, M.L. 2007. Postnatal ontogeny of skeletal muscle protein synthesis in pigs [abstract]. Journal of Animal Science, Proceeding of the 2007 Annual Meeting of the American Society of Animal Science, July 8-12, 2007, San Antonio, Texas. 85(Suppl. 1):630, p. 445.

C57BL/6J male offspring exposed "in utero" and during weaning to a maternal low protein diet have reduced muscle weight by 12 months of age - (Abstract Only)

Fiorotto, M.L., Rosetta, R., Yu, Z., Oliver, W., Van den Veyver, I. 2007. C57BL/6J Male offspring exposed "in utero" and during weaning to a maternal low protein diet have reduced muscle weight by 12 months of age [abstract]. Reproductive Sciences. 14(1)[Suppl]:95A.

Stimulation of whole body protein synthesis by insulin in neonates is dependent on the pattern of amino acids available - (Abstract Only)

Orellana, R.A., Fiorotto, M.L., Jahoor, F., Burrin, D.G., Nguyen, H.V., Suryawan, A., Davis, T.A. 2007. Stimulation of whole body protein synthesis by insulin in neonates is dependent on the pattern of amino acids available [abstract]. The Federation of American Societies for Experimental Biology Journal. 21(5):A162.

Acute IGF-I infusion stimulates whole body protein synthesis but does not reduce proteolysis in neonates - (Abstract Only)

Wilson, F., Fiorotto, M.L., Burrin, D.G., Jahoor, F., Nguyen, H.V., Suryawan, A., Davis, T.A. 2007. Acute IGF-I infusion stimulates whole body protein synthesis but does not reduce proteolysis in neonates [abstract]. The Federation of American Societies for Experimental Biology Journal. 21(6):A1119.

Insulin and amino acids stimulate whole body protein synthesis in neonates - (Abstract Only)

Jeyapalan, A., Orellana, R.A., Burrin, D.G., Fiorotto, M.L., Jahoor, F., Nguyen, H.V., Suryawan, A., Davis, T.A. 2007. Insulin and amino acids stimulate whole body protein synthesis in neonates [abstract]. The Federation of American Societies for Experimental Biology Journal. 21(5):A334.

Transplacental transfer of a growth hormone-releasing hormone peptide from mother to fetus in the rat. - (Peer Reviewed Journal)

Fiorotto, M.L., Lopez, R., Oliver, W.T., Khan, A.S., Draghia-Akli, R. 2006. Transplacental transfer of a growth hormone-releasing hormone peptide from mother to fetus in the rat. DNA and Cell Biology. 25(8):429-437.

LOCAL IGF-I ENHANCES THE SENSITIVITY OF MUSCLE PROTEIN SYNTHESIS TO INSULIN - (Abstract Only)

Oliver, W.T., Rosenberger, J., Lopez, R., Fiorotto, M.L. 2006. The local IGF-I enhances the sensitivity of muscle protein synthesis to insulin [abstract]. The 88th Annual Meeting of The Endocrine Society, June 24-27, 2006, Boston, Massachusetts. Abstract #OR40-6, p. 134.

REGULATION OF ERK EXPRESSION BY MUSCLE IGF-I "IN VIVO" DETERMINES THE CAPACITY FOR MYONUCLEAR PROLIFERATION - (Abstract Only)

Oliver, W.T., Lopez, R., Yorks, K.A., Fiorotto, M.L. 2006. Regulation of ERK expression by muscle IGF-I "in vivo" determines the capacity for myonuclear proliferation [abstract]. The Federation of American Societies for Experimental Biology Conference: Advancing the Biomedical Frontier, April 1-5, 2006, San Francisco, California. 20(5):Part II, p. A1046.

MODULATION OF MUSCLE PROTEIN SYNTHESIS BY INSULIN IS MAINTAINED DURING NEONATAL ENDOTOXEMIA - (Peer Reviewed Journal)

Orellana, R.A., O'Connor, P.M.J., Bush, J.A., Suryawan, A., Thivierge, M.C. Nguyen, H.V., Fiorotto, M.L., Davis, T.A. 2006. Modulation of muscle protein synthesis by insulin is maintained during neonatal endotoxemia. American Journal Physiology - Endocrinology and Metabolism. 291(1):E159-E166.

THE LOCAL EXPRESSION AND ABUNDANCE OF INSULIN-LIKE GROWTH FACTOR (IGF) BINDING PROTEINS IN SKELETAL MUSCLE ARE REGULATED BY AGE AND GENDER BUT NOT LOCAL IGF-I "IN VIVO" - (Peer Reviewed Journal)

Oliver, W.T., Rosenberger, J., Lopez, R., Gomez, A., Cummings, K.K. Fiorotto, M.L. 2005. The local expression and abundance of insulin-like growth factor (IGF) binding proteins in skeletal muscle are regulated by age and gender but not local IGF-I "in vivo". Endocrinology. 146(12):5455-5462.

LOCAL IGF-I ENHANCES THE SENSITIVITY OF MUSCLE PROTEIN SYNTHESIS TO INSULIN - (Abstract Only)

Oliver, W.T., Rosenberger, J., Lopez, R., Fiorotto, M.L. 2006. Local IGF-I enhances the sensitivity of muscle protein synthesis to insulin [abstract]. The Federation of American Societies for Experimental Biology Conference: Advancing the Biomedical Frontier, April 1-5, 2006, San Francisco, California. 20(5):Part II, p. A821.

IN VIVO, SKELETAL MUSCLE IGF-I ACTIVATES AKT DIRECTLY VIA THE IGF-1R AND INDIRECTLY BY ENHANCING INSULIN RECEPTOR PHOSPHORYLATION - (Abstract Only)

Oliver, W.T., Cummings, K.K., Rosenberger, J., Lopez, R., Gomez, A., Fiorotto, M.L. 2005. In vivo, skeletal muscle IGF-I activates Akt directly via the IGF-1R and indirectly by enhancing insulin receptor phosphorylation [abstract]. The Endocrine Society's 87th Annual Meeting "Shaping the Future of Endocrinology: Today's Research...Tomorrow's Care". Abstract P3-715, p. 721.

Overexpression of des(1-3)hIGF-I in the mammary gland during prolonged lactation enhances milk yield and elevates prolactin secretion - (Abstract Only)

Hadsell, D.L., Torres, D., George, J., Shelton, G.S., Parlow, A.F., Fiorotto, M.L. 2005. Overexpression of des(1-3)hIGF-I in the mammary gland during prolonged lactation enhances milk yield and elevates prolactin secretion [abstract]. In: The 87th Annual Meeting of the Endocrine Society, June 4-7, 2005, San Diego, California. p. 531.

FUNCTIONAL SIGNIFICANCE OF DEVELOPMENTAL CHANGES IN MUSCLE IGFBPS FOR IGF-I SIGNALING - (Abstract Only)

Oliver, W.T., Lopez, R., Cummings, K.K., Rosenberger, J., Fiorotto, M.L. 2005. Functional significance of developmental changes in muscle IGFBPs for IGF-I signaling [abstract]. The Federation of American Societies for Experimental Biology Conference. Part II(abstract 579.3):A985.

LOCAL IGF-I ENHANCES ACTIVATION OF THE MUSCLE IGF-I RECEPTOR (IGF-1R) BUT NOT OF ERK 1/2 IN VIVO - (Abstract Only)

Oliver, W.T., Cummings, K.K., Rosenberger, J., Lopez, R., Fiorotto, M.L. 2005. Local IGF-I enhances activation of the muscle IGF-I receptor (IGF-1R) but not of ERK 1/2 "in vivo" [abstract]. The Federation of American Societies for Experimental Biology Conference. Part I (abstract 348.7):A571.

NONPLACENTAL GROWTH HORMONE-RELEASING HORMONE (GHRH) IS TRANSPORTED FROM THE MOTHER TO THE FETUS IN THE RAT - (Abstract Only)

Fiorotto, M.L., Lopez, R., Oliver, W.T., Rosenberger, J., Draghia-Akli, R. 2004. Nonplacental growth hormone-releasing hormone (GHRH) is transported from the mother to the fetus in the rat [abstract]. The Endocrine Society's 86th Annual Meeting, June 16-19, 2004, New Orleans, Louisiana. Abstract P3-96, p. 488.

MUSCLE-DERIVED IGF-I DOES NOT REGULATE THE LOCAL ABUNDANCE OF IGF BINDING PROTEINS (IGFBP)-3 AND -5 IN VIVO - (Abstract Only)

Oliver, W.T., Rosenberger, J., Fiorotto, M.L. 2004. Muscle-derived IGF-I does not regulate the local abundance of IGF binding proteins (IGFBP)-3 and -5 in vivo [abstract]. Federation of American Societies for Experimental Biology Conference. 18(5):A896.

OVEREXPRESSION OF THE REPRESSOR PROTEIN ID-I IN SKELETAL MUSCLE IMPAIRS MYOFIBRILLAR GENE EXPRESSION BUT NOT MYOFIBRILLAR PROTEIN SYNTHESIS - (Abstract Only)

Fiorotto, M.L., Rosenberger, J., Donovan, M. 2004. Overexpression of the repressor protein Id-I in skeletal muscle impairs myofibrillar gene expression but not myofibrillar protein synthesis [abstract]. Federation of American Societies for Experimental Biology Conference. 18(4):A356.

MECHANICAL STIMULI REGULATE RAPAMYCIN-SENSITIVE SIGNALLING BY A PHOSPHOINOSITIDE 3-KINASE-, PROTEIN KINASE B- AND GROWTH FACTOR-INDEPENDENT MECHANISM - (Peer Reviewed Journal)

Hornberger, T.A., Stuppard, R., Conley, K.E., Fedele, M.J., Fiorotto, M.L., Chin, E.R., Esser, K.A. 2004. Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism. Biochemical Journal. 380(Pt 3):795-804.

MUSCLE-SPECIFIC OVEREXPRESSION OF ID-1 IMPAIRS THE DEVELOPMENTAL ACCRETION OF MYOFIBRILLAR PROTEINS - (Abstract Only)

Fiorotto, M.L., Davis, T.A., Rosenberger, J., DeBurin, C., Donovan, M. 2002. Muscle-specific overexpression of Id-1 impairs the developmental accretion of myofibrillar proteins [abstract]. Federation of American Societies for Experimental Biology Journal, Part II. 16(5):A773.

PROTEINS - (Book / Chapter)

Fiorotto, M.L. 2003. Proteins. In: Kleinman, R.E. editor. Pediatric Nutrition Handbook. 5th Edition. Elk Grove Village, IL:American Academy of Pediatrics. P.229-240.

A NEW PLASMID-MEDIATED APPROACH TO SUPPLEMENT SOMATOTROPIN PRODUCTION IN PIGS - (Peer Reviewed Journal)

Draghia-Akli, R., Fiorotto, M.L. 2004. A new plasmid-mediated approach to supplement somatotropin production in pigs. Journal of Animal Science. 82(8)[E. Suppl.]:E264-E269.

REGULATION OF SKELETAL MUSCLE PROTEIN METABOLISM IN GROWING ANIMALS - (Book / Chapter)

Davis, T.A., Fiorotto, M.L. 2005. Regulation of skeletal muscle protein metabolism in growing animals. In: Burrin, D.G., Mersmann, H.J., Salek, E., editors. Biology of Metabolism in Growing Animals. Biology of Growing Animals Series, Volume 3. London, United Kingdom:Elsevier Limited. Part II: Protein Metabolism, Chapter 2, p. 37-68.

MATERNAL GHRH PLASMID ADMINISTRATION CHANGES PITUITARY CELL LINEAGE AND IMPROVES PROGENY GROWTH OF PIGS - (Abstract Only)

Khan, A.S., Fiorotto, M.L., Cummings, K.K., Pope, M., Brown, P.A., Draghia-Akli, R. 2003. Maternal GHRH plasmid administration changes pituitary cell lineage and improves progeny growth of pigs [abstract]. Molecular Therapy, The American Society of Gene Therapy. Part 2, 7(5):S380.

MATERNAL GHRH PLASMID ADMINISTRATION CHANGES PITUITARY CELL LINEAGE AND IMPROVES PROGENY GROWTH OF PIGS - (Peer Reviewed Journal)

Khan, A.S., Fiorotto, M.L., Cummings, K.K., Pope, M.A., Brown, P.A., Draghia-Akli, R. 2003. Maternal GHRH plasmid administration changes pituitary cell lineage and improves progeny growth of pigs. American Journal of Physiology, Endocrinology and Metabolism. 285(1):E224-E231.

MODULATION OF MUSCLE PROTEIN SYNTHESIS BY INSULIN IS MAINTAINED DURING ACUTE NEONATAL ENDOTOXEMIA - (Abstract Only)

Orellana, R.A., O'Connor, P.M., Nguyen, H.V., Bush, J.A., Thivierge, M.C., Suryawan, A., Liu, C.W., Fiorotto, M.L., Davis, T.A. 2003. Modulation of muscle protein synthesis by insulin is maintained during acute neonatal endotoxemia [abstract]. Federation of American Societies for Experimental Biology Conference. Part I, 17(4):A739.

ADMINISTRATION OF A PLASMID EXPRESSING GROWTH HORMONE-RELEASING HORMONE (GHRH) AUGMENTS LEAN MASS GAIN IN PIGS - (Abstract Only)

Fiorotto, M.L., Khan, A.S., Cummings, K.K., Draghia-Akli, R. 2003. Administration of a plasmid expressing growth hormone-releasing hormone (GHRH) augments lean mass gain in pigs [abstract]. The Federation of American Societies for Experimental Biology Conference. Part I, 17(4):A700.

HIGH-EFFICIENCY GROWTH HORMONE-RELEASING HORMONE PLASMID VECTOR ADMINISTRATION INTO SKELETAL MUSCLE MEDIATED BY ELECTROPORATION IN PIGS - (Peer Reviewed Journal)

Draghia-Akli, R., Ellis, K.J., Hill, L., Malone, P., Fiorotto, M.L. 2003. High-efficiency growth hormone-releasing hormone plasmid vector administration into skeletal muscle mediated by electroporation in pigs. Federation of American Societies for Experimental Biology Conference. 17:526-528.

HIGH-EFFICIENCY GROWTH HORMONE-RELEASING HORMONE PLASMID VECTOR ADMINISTRATION INTO SKELETAL MUSCLE MEDIATED BY ELECTROPORATION IN PIGS - (Peer Reviewed Journal)

Draghia-Akli, R., Ellis, K.M., Hill, L.A., Malone, P.B., Fiorotto, M.L. 2003. High-efficiency growth hormone-releasing hormone plasmid vector administration into skeletal muscle mediated by electroporation in pigs. Journal of The Federation of American Societies for Experimental Biology. 17(3):526-528.

BIOGRAPHICAL ARTICLE: PETER J. REEDS, FEBRUARY 22, 1945 - AUGUST 13, 2002 - (Review Article)

Davis, T.A., Burrin, D.G., Fiorotto, M.L. 2003. Biographical Article: Peter J. Reeds (February 22, 1945-August 13, 2002). Journal of Nutrition. 133(1):5-8.

PERSISTENT IGF-I OVEREXPRESSION IN SKELETAL MUSCLE TRANSIENTLY ENHANCES DNA ACCRETION AND GROWTH - (Peer Reviewed Journal)

Fiorotto, M.L., Schwartz, R.J., Delaughter, M.C. 2002. Persistent IGF-I overexpression in skeletal muscle transiently enhances DNA accretion and growth. Journal of The Federation of American Societies of Experimental Biology. Journal of Federation of American Societies for Experimental Biology. 17(1):59-60.

ACUTE IGF-1 INFUSION STIMULATES PROTEIN SYNTHESIS IN SKELETAL MUSCLE AND OTHER TISSUES OF NEONATAL PIGS - (Peer Reviewed Journal)

Davis,T.A., Fiorotto,M.L., Burrin,D.G., Vann,R.C., Reed,P.J., Nguyen,H.V., Beckett,P.R., Bush,J.A. 2002. Acute IGF-I infusion stimulates protein synthesis in skeletal muscle and other tissues of neonatal pigs. American Journal of Physiology - Endocrinology and Metabolism. 283(4):E638-E647.

STIMULATION OF PROTEIN SYNTHESIS BY BOTH INSULIN AND AMINO ACIDS IS UNIQUE TO SKELETAL MUSCLE IN NEONATAL PIGS - (Peer Reviewed Journal)

Davis,T.A., Fiorotto,M.L., Beckett,P.R., Burrin,D.G., Reeds,P.J., Vann,R., Nguyen,H.V., O'Connor,P.M.J. 2002. American Journal of Physiology - Endocrinology and Metabolism. 282(4):E880-E890.

DIFFERENTIAL EFFECTS OF INSULIN ON PERIPHERAL AND VISCERAL TISSUE PROTEIN SYNTHESIS IN NEONATAL PIGS - (Peer Reviewed Journal)

Davis, T.A., Fiorotto, M.L., Beckett, P.R., Burrin, D.G., Reeds, R.J., Wray-Cahen, D., Nguyen, H.V. 2001. Differential effects of insulin on peripheral and visceral tissue protein synthesis in neonatal pigs. American Journal of Physiology: Endocrinology and Metabolism. 280(5):E770-E779.

PERINATAL ONTOGENY OF BRAIN GROWTH IN THE DOMESTIC PIG - (Peer Reviewed Journal) - (29-Jul-99)

LOCAL INSULIN-LIKE GROWTH FACTOR I EXPRESSION INDUCES PHYSIOLOGIC, THEN PATHOLOGIC CARDIAC HYPERTROPHY IN TRANSGENIC MICE - (Peer Reviewed Journal)

Delaughter, M.C., Taffet, G.E., Fiorotto, M.L., Entman, M.L., Schwartz, R.J. 1999. Local insulin-like growth factor I expression induces physiologic, then pathologic, cardiac hypertrophy in transgenic mice. Journal of Federation of American Societies for Experimental Biology. 13(14):1923-1929.

PROTEIN KINETICS IN CALLIPYGE LAMBS - (Peer Reviewed Journal) - (26-May-99)

COLOSTRUM ENHANCES THE NUTRITIONAL STIMULATION OF VITAL ORGAN PROTEIN SYNTHESIS IN NEONATAL PIGS. - (Peer Reviewed Journal) - (04-Mar-97)