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United States Department of Agriculture

Agricultural Research Service

Related Topics

Jonathan Arzt
Foreign Animal Disease Research
Veterinary Medical Officer

Phone: (631) 323-4421
Fax: (631) 323-3006
40550 ROUTE 25
ORIENT POINT, NY, 11957

Projects
COUNTERMEASURES TO CONTROL FOREIGN ANIMAL DISEASES OF SWINE
Appropriated (D)
  Accession Number: 422018
INTERVENTION STRATEGIES TO SUPPORT THE GLOBAL CONTROL AND ERADICATION OF FOOT-AND-MOUTH DISEASE VIRUS (FMDV)
Appropriated (D)
  Accession Number: 422203
ECOLOGY AND PATHOGENESIS OF RE-EMERGING VESICULAR STOMATITIS VIRUS (VSV) IN NORTH AMERICA
Appropriated (D)
  Accession Number: 422286
Evaluating and Mitigating the Impact of FMDV Persistence in Cattle Subsequent to AD5FMD Vaccination
Interagency Reimbursable Agreement (I)
  Accession Number: 424833
COUNTERMEASURES FOR FOOT-AND-MOUTH DISEASE UTILIZING DIAGNOSTICS, BIOTHERAPEUTICS, A NOVEL VACCINE PLATFORM AND IMPROVED CHALLENGE SYSTEMS
Reimbursable (R)
  Accession Number: 421628
MOLECULAR EPIDEMIOLOGY, SURVEILLANCE, AND PREDICTIVE TOOLS FOR FOOT-AND-MOUTH DISEASE CONTROL IN VIETNAM
Specific Cooperative Agreement (S)
  Accession Number: 419465
MOLECULAR EPIDEMIOLOGY AND PATHOGENESIS STUDIES OF EMERGING FOOT-AND-MOUTH DISEASE STRAINS IN VIETNAM
Specific Cooperative Agreement (S)
  Accession Number: 422415
IN VITRO EVALUATION OF THE CAPACITY OF FOOT-AND-MOUTH DISEASE VIRUS TO INITIATE T-INDEPENDENT HUMORAL RESPONSES IN A BOVINE MODEL
Specific Cooperative Agreement (S)
  Accession Number: 423165
UNDERSTANDING THE ECOLOGY OF FOOT-AND-MOUTH DISEASE VIRUSES CIRCULATING IN CAMEROON
Specific Cooperative Agreement (S)
  Accession Number: 423166
INVESTIGATING POTENTIAL EXISTENCE OF CHRONIC, PERSISTENT FOOT-AND-MOUTH DISEASE VIRUS INFECTION IN DOMESTIC PIGS; IMPLICATIONS .. STRATEGIES
Trust (T)
  Accession Number: 422247

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Detection of Foot-and-Mouth Disease Virus RNA and capsid protein in lymphoid tissues of convalescent pigs does not indicate existence of a carrier state - (Peer Reviewed Journal)
Stenfeldt, C., Pacheco Tobin, J., Smoliga, G.R., Bishop, E.A., Pauszek, S.J., Hartwig, E.J., Rodriguez, L.L., Arzt, J. 2014. Detection of Foot-and-Mouth Disease Virus RNA and capsid protein in lymphoid tissues of convalescent pigs does not indicate existence of a carrier state. Transboundary and Emerging Diseases. DOI: 10.1111/tbed.12235.
Infection dynamics of foot-and-mouth disease virus in pigs using two novel simulated natural inoculation methods - (Peer Reviewed Journal)
Stenfeldt, C., Pacheco Tobin, J., Rodriguez, L.L., Arzt, J. 2014. Infection dynamics of foot-and-mouth disease virus in pigs using two novel simulated natural inoculation methods. Research in Veterinary Science. 96:396-405.
Foot and mouth disease virus virulence in cattle is co-determined by viral replication dynamics and route of infection - (Peer Reviewed Journal) - (02-Jan-14)
Interaction of foot-and-mouth disease virus non-structural protein 3A with host protein DCTN3 is important for viral virulence in cattle - (Peer Reviewed Journal)
Gladue, D.P., O'Donnell, V., Baker-Branstetter, R., Pacheco Tobin, J., Holinka-Patterson, L.G., Arzt, J., Pauszek, S.J., Fernandez-Sainz, I., Fletcher, P., Brocchi, E., Lu, Z., Rodriguez, L.L., Borca, M.V. 2014. Interaction of foot-and-mouth disease virus non-structural protein 3A with host protein DCTN3 is important for viral virulence in cattle. Journal of Virology. 88(5):2737-2747.
The pathogenesis of highly virulent African Swine Fever virus in domestic pigs exposed via intraoropharyngeal, intranasopharyngeal, and intramuscular inoculation, and by direct contact with infected pigs - (Peer Reviewed Journal)
Howey, E.B., O'Donnell, V., De Carvalho Ferreira, H.C., Borca, M.V., Arzt, J. 2013. The pathogenesis of highly virulent African Swine Fever virus in domestic pigs exposed via intraoropharyngeal, intranasopharyngeal, and intramuscular inoculation, and by direct contact with infected pigs. Virus Research. 178(2):328-339.
Characterization of a chimeric foot-and-mouth disease virus bearing bovine rhinitis B virus leader proteinase - (Peer Reviewed Journal)
Uddowla, S., Pacheco Tobin, J., Larson, C., Bishop, E.A., Rodriguez, L.L., Rai, D., Arzt, J., Rieder, A.E. 2013. Characterization of a chimeric foot-and-mouth disease virus bearing bovine rhinitis B virus leader proteinase. Virology. 447(1-2):172-180.
A partial deletion in non-structural protein 3A can attenuate foot-and-mouth disease virus in cattle - (Peer Reviewed Journal)
Pacheco Tobin, J., Gladue, D.P., Holinka-Patterson, L.G., Arzt, J., Bishop, E.A., Smoliga, G.R., Pauszek, S.J., Bracht, A.J., O'Donnell, V., Fernandez-Sainz, I., Fletcher, P., Piccone, M.E., Rodriguez, L.L., Borca, M.V. 2013. A partial deletion in non-structural protein 3A can attenuate foot-and-mouth disease virus in cattle. Virology. 446(1-2):260-267.
Mechanisms of foot-and-mouth disease virus tropism inferred from differential tissue gene expression Reprint Icon - (Peer Reviewed Journal)
Zhu, J.J., Arzt, J., Puckette, M.C., Smoliga, G.R., Pacheco Tobin, J., Rodriguez, L.L. 2013. Mechanisms of foot-and-mouth disease virus tropism inferred from differential tissue gene expression. PLoS One. 8(5):e64119. DOI:10.1371/journal.pone.0064119.
Early adaptive immune responses in the respiratory tract of foot and mouth disease-infected cattle Reprint Icon - (Peer Reviewed Journal)
Pega, J., Bucafusco, D., Di Giacomo, S., Malacari, D., Capozzo, A., Arzt, J., Perez-Beascoechea, C., Maradei, E., Rodriguez, L.L., Borca, M.V., Perez-Filgueira, M. 2012. Early adaptive immune responses in the respiratory tract of foot and mouth disease-infected cattle. Journal of Virology. 87(5):2489-2495.
Time-dependent biodistribution and transgene expression of a recombinant human adenovirus serotype 5-luciferase vector as a surrogate agent for rAd5-FMDV vaccines in cattle Reprint Icon - (Peer Reviewed Journal)
Montiel, N.A., Smoliga, G.R., Arzt, J. 2012. Time-dependent biodistribution and transgene expression of a recombinant human adenovirus serotype 5-luciferase vector as a surrogate agent for rAd5-FMDV vaccines in cattle. Veterinary Immunology and Immunopathology. 151(1-2):37-48. DOI: 110.1016/j.vetimm.2012.10.003.
Bovine type III interferon significantly delays and reduces the severity of foot-and-mouth disease in cattle Reprint Icon - (Peer Reviewed Journal)
Perez-Martin, E., Weiss, M., Diaz San Segundo, F.C., Pacheco Tobin, J., Arzt, J., Grubman, M.J., De Los Santos, T.B. 2012. Bovine type III interferon significantly delays and reduces the severity of foot-and-mouth disease in cattle. Journal of Virology. 86(8):4477-4487.
Foot-and-mouth disease: global status and Indian perspective Reprint Icon - (Peer Reviewed Journal)
Biswal, J.K., Sanyal, A., Rodriguez, L.L., Subramaniam, S., Arzt, J., Sharma, G.K., Hammond, J.M., Parida, S., Mohapatra, J.K., Mathapati, B.S., Dash, B.B., Ranjan, R., Rout, M., Venketaramanan, R., Misri, J., Krishna, L., Prasad, G., Pathak, K.M., Pattnaik, B. 2012. Foot-and-mouth disease: global status and Indian perspective. Indian Journal of Animal Sciences. 82(2):109-131.
Direct contact transmission of three different foot-and-mouth disease virus strains in swine demonstrates important strain-specific differences Reprint Icon - (Peer Reviewed Journal)
Pacheco Tobin, J., Tucker, M.T., Hartwig, E.J., Bishop, E.A., Arzt, J., Rodriguez, L.L. 2012. Direct contact transmission of three different foot-and-mouth disease virus strains in swine demonstrates important strain-specific differences. The Veterinary Journal. 193(2):456-463.
Early detection and visualization of human adenovirus serotype 5-viral vectors carrying foot-and-mouth disease virus or luciferase transgenes in cell lines and bovine tissues Reprint Icon - (Peer Reviewed Journal)
Montiel, N., Smoliga, G.R., Arzt, J. 2012. Early detection and visualization of human adenovirus serotype 5-viral vectors carrying foot-and-mouth disease virus or luciferase transgenes in cell lines and bovine tissues. Vaccine. 30(9):1690-1701.
The pathogenesis of foot-and-mouth disease II; viral pathways in swine, small ruminants, and wildlife, myotropism, chronic syndromes, and molecular virus-host interactions - (Review Article)
Arzt, J., Baxt, B., Grubman, M.J., Jackson, T., Juleff, N., Rhyan, J., Rieder, A.E., Waters, R., Rodriguez, L.L. 2011. The pathogenesis of foot-and-mouth disease II; viral pathways in swine, small ruminants, and wildlife, myotropism, chronic syndromes, and molecular virus-host interactions. Transboundary and Emerging Diseases. 58(4):305-326.
The pathogenesis of foot-and-mouth disease I; viral pathways in cattle - (Review Article)
Arzt, J., Juleff, N., Zhang, Z., Rodriguez, L.L. 2011. The pathogenesis of foot-and-mouth disease I; viral pathways in cattle. Transboundary and Emerging Diseases. 58(4):291-304.
The early pathogenesis of foot-and-mouth disease in cattle after aerosol inoculation - (Other)
Arzt, J. 2010. The early pathogenesis of foot-and-mouth disease in cattle after aerosol inoculation [Ph.D. Dissertation]. Ft. Collins, CO: Colorado State University: The Graduate School at Colorado State University. 155 p.
The early pathogenesis of foot-and-mouth disease in cattle after aerosol innoculation: identification of the nasopharynx as the primary site of infection - (Peer Reviewed Journal)
Arzt, J., Pacheco Tobin, J., Rodriguez, L.L. 2010. The early pathogenesis of foot-and-mouth disease in cattle after aerosol innoculation: identification of the nasopharynx as the primary site of infection. Veterinary Pathology. 47(6):1048-1063.
Agricultural diseases on the move early in the third millennium - (Review Article)
Arzt, J., White, W.R., Thomsen, B.V., Brown, C.C. 2010. Agricultural diseases on the move early in the third millennium. Veterinary Pathology. 47(1):15-27.
Optimization of immunohistochemical and fluorescent antibody techniques for localization of foot-and-mouth disease virus in animal tissues - (Peer Reviewed Journal)
Arzt, J., Gregg, D.A., Clavijo, A., Rodriguez, L.L. 2009. Optimization of immunohistochemical and fluorescent antibody techniques for localization of foot-and-mouth disease virus in animal tissues. Journal of Veterinary Diagnostic Investigation. 21(6):779-792.
Early Events in the Pathogenesis of Foot-and-Mouth Disease in Cattle After Controlled Aerosol Exposure - (Peer Reviewed Journal)
Pacheco Tobin, J., Arzt, J., Rodriguez, L.L. 2008. Early Events in the Pathogenesis of Foot-and-Mouth Disease in Cattle After Controlled Aerosol Exposure. The Veterinary Journal. 183(1):46-53.
ARS News Articles
Last Modified: 7/23/2014
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