Projects

DETECTION OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY AGENTS IN LIVESTOCK, WILDLIFE, AGRICULTURAL PRODUCTS, AND THE ENVIRONMENT Appropriated (D)   Accession Number: 413072

Immunodiagnostics to Detect Prions and Other Important Animal Pathogens Appropriated (D)   Accession Number: 424354

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Development and characterization of six monoclonal antibodies to hemagglutinin-70 (HA70) of Clostridium botulinum and their application in a sandwich ELISA - (Peer Reviewed Journal)

Scotcher, M.C., Cheng, L.W., Ching, K.H., Mcgarvey, J.A., Hnasko, R.M., Stanker, L.H. 2013. Development and characterization of six monoclonal antibodies to hemagglutinin-70 (HA70) of Clostridium botulinum and their application in a sandwich ELISA. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 32(1):6-15. doi: 10.1089/mab.2012.0071.

Rapid multiplex immunoassay to distinguish botulinum neurotoxin serotypes on a single lateral flow device(Abstract) - (Abstract Only) - (04-Aug-12)

Novel epitopes identified by Anti-PrP monoclonal antibodies produced following immunization of Prnp0/0 Balb/cJ mice with purified scrapie prions - (Peer Reviewed Journal)

Stanker, L.H., Scotcher, M.C., Lin, A.V., Mcgarvey, J.A., Prusiner, S., Hnasko, R.M. 2012. Novel epitopes identified by Anti-PrP monoclonal antibodies produced following immunization of Prnp0/0 Balb/cJ mice with purified scrapie prions. Hybridoma. 31(5):312-324. doi:10.1089/hyb.2012.0022.

Rapid and selective detection of botulinum neurotoxin serotypes-A and –B with a single immunochromatographic test strip - (Peer Reviewed Journal)

Ching, K.H., Lin, A.V., Mcgarvey, J.A., Stanker, L.H., Hnasko, R.M. 2012. Rapid and selective detection of botulinum neurotoxin serotypes-A and –B with a single immunochromatographic test strip. Journal of Immunological Methods. 380:23-29.

A rapid method to improve protein detection by indirect ELISA - (Peer Reviewed Journal)

Hnasko, R.M., Lin, A.V., Mcgarvey, J.A., Stanker, L.H. 2011. A rapid method to improve protein detection by indirect ELISA. Biochemical and Biophysical Research Communications. 410(4):726-731. doi: 10.1016/j.bbrc.2011.06.005.

Inoculation of Scrapie with the Self-Assembling RADA-Peptide Disrupts Prion Accumulation and Extends Hamster Survival - (Peer Reviewed Journal)

Hnasko, R.M., Bruederle, C.E. 2009. Inoculation of Scrapie with the Self-Assembling RADA-Peptide Disrupts Prion Accumulation and Extends Hamster Survival. PLoS ONE. 4(2): http://www.plosone.org/article/info:doi/10.1371/journal.pone.0004440

Prion infected Meat-and-Bone Meal is still infectious after biodiesel production - (Peer Reviewed Journal)

Bruederle, C.E., Hnasko, R.M., Kraemer, T., Garcia, R.A., Haas, M.J., Marmer, W.N., Carter, J.M. 2008. Prion infected Meat-and-Bone Meal is still Infectious After Biodiesel Production. PLoS One 3(8): e2969. doi:10.1371/journal.pone.0002969.

Sensitive, Preclinical Detection of Prions in Brain by nanospray liquid chromatography/tandem mass spectrometry - (Peer Reviewed Journal)

Onisko, B.C., Silva, C.J., Dynin, I.A., Erickson, M.L., Vensel, W.H., Hnasko, R.M., Requena, J.R., Carter, J.M. 2007. Sensitive, Preclinical Detection of Prions in Brain by nanospray liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry. 21(24):4023-4026.

Genetic disruption of dopamine production results in pituitary adenomas and severe prolactinemia - (Peer Reviewed Journal)

Hnasko, T.S., Hnasko, R.M., Sotak, B.N., Kapur, R.P. 2007. Genetic disruption of dopamine production results in pituitary adenomas and severe prolactinemia. Neuroendocrinology Journal. 86(1): 48-57

Loss of Nkx2.8 deregulates progenitor cells in the large airways and leads to dysplasia - (Peer Reviewed Journal)

Tian, J., Radma, M., Hnasko, R.M., Locker, J. 2006. Loss of Nkx2.8 deregulates progenitor cells in the large airways and leads to dysplasia. Cancer Research. 1:66(21):10399-407.

PV-1 LABELS TRANS-CELLULAR OPENINGS IN MOUSE ENDOTHELIAL CELLS AND IS NEGATIVELY REGULATED BY VEGF - (Peer Reviewed Journal)

Hnasko, R.M., Carter, J.M., Medina, F., Lisanti, M. 2006. Pv-1 labels trans-cellular openings in mouse endothelial cells and is negatively regulated by vegf. Cell Cycle. 5(17):2021-28.

PV-1 IS NEGATIVELY REGULATED BY VEGF IN THE LUNG OF CAV-1, BUT NOT CAV-2, NULL MICE - (Peer Reviewed Journal)

Hnasko, R.M., Philippe, F.G., Ben-Jonathan, N., Lisanti, M.P. 2006. Pv-1 is negatively regulated by vegf in the lung of cav-1, but not cav-2, null mice. Cell Cycle 5(17):2012-20.