Projects

Mitigating the Risk of Transmission and Environmental Contamination of Transmissible Spongiform Encephalopathies Appropriated (D)   Accession Number: 422167

Control of Ovine Respiratory Disease through Genetic and Immunologic Mitigation of Pathogen Transmission and Disease Appropriated (D)   Accession Number: 422169

Development of Strategies to Control Anaplasmosis Appropriated (D)   Accession Number: 422174

IDENTIFICATION OF MANNHEIMIA HAEMOLYTICA SHEDDING DYNAMICS OF DOMESTIC SHEEP UNDER RANGE CONDITIONS Specific Cooperative Agreement (S)   Accession Number: 420259

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Genome-Wide association identifies multiple genomic regions associated with susceptibility to and control of ovine lentivirus - (Peer Reviewed Journal)

White, S.N., Mousel, M.R., Herrmann-Hoesing, L.M., Reynolds, J.O., Leymaster, K.A., Neibergs, H.L., Lewis, G.S., Knowles Jr, D.P. 2012. Genome-Wide association identifies multiple genomic regions associated with susceptibility to and control of ovine lentivirus . PLoS One. 7(10):e47829.

Ovine progressive pneumonia virus is transmitted more effectively via aerosol nebulization than oral administration - (Peer Reviewed Journal)

Herrmann-Hoesing, L.M., White, S.N., Neiswanger-Broughton, L.E., Johnson, W.C., Noh, S.M., Schneider, D.A., Li, H., Taus, N.S., Reynolds, J.O., Truscott, T.C., Dassanayake, R.P., Knowles Jr, D.P. 2012. Ovine progressive pneumonia virus is transmitted more effectively via aerosol nebulization than oral administration. Open Journal of Veterinary Medicine . 2(3):113-119.

Re-emergence of the apicomplexan theileria equi in the United States: Elimination of persistent infection and transmission risk - (Peer Reviewed Journal)

Ueti, M.W., Mealey, R.H., Kappmeyer, L.S., White, S.N., Kumpula-Mcwhirter, N., Pelzel, A.M., Grause, J.F., Bunn, T.O., Schwartz, A., Traub-Dargatz, J.L. 2012. Re-emergence of the apicomplexan theileria equi in the United States: Elimination of persistent infection and transmission risk. PLoS One. PloSONE 7(9):e44713.

MHC class II DR allelic diversity in bighorn sheep - (Peer Reviewed Journal)

Subramaniam, R., White, S.N., Herrmann-Hoesing, L.M., Subramaniam, S. 2012. MHC class II DR allelic diversity in bighorn sheep. Gene. GENE2012506(1):217-222.

Ovine herpesvirus 2 infection in american bison: virus and host dynamics in the development of sheep-associated malignant catarrhal fever - (Peer Reviewed Journal)

Cunha, C.W., Gailbreath, K.L., O'Toole, D., Knowles Jr, D.P., Schneider, D.A., White, S.N., Taus, N.S., Davis, C.J., Davis, W.C., Li, H. 2012. Ovine herpesvirus 2 infection in american bison: virus and host dynamics in the development of sheep-associated malignant catarrhal fever. Veterinary Microbiology. 159:307-319.

Extended scrapie incubation time in goats singly heterozygous for PRNP S146 or K222 - (Peer Reviewed Journal)

White, S.N., Reynolds, J.O., Waldron, D.F., Schneider, D.A., Orourke, K.I. 2012. Extended scrapie incubation time in goats singly heterozygous for PRNP S146 or K222. Gene. 501(1):49-51.

A splice site mutation in a gene encoding for PDK4, a mitochondrial protein, is associated with the development of dilated cardiomyopathy in the Doberman pinscher - (Peer Reviewed Journal)

Meurs, K.M., Lahmers, S., Keene, B.W., White, S.N., Oyama, M.A., Mauceli, E., Lindblad-Toh, K. 2012. A splice site mutation in a gene encoding for PDK4, a mitochondrial protein, is associated with the development of dilated cardiomyopathy in the Doberman pinscher. Human Genetics. 131(8):1319-25.

Reduced lentivirus susceptibility in sheep with TMEM154 mutations - (Peer Reviewed Journal)

Heaton, M.P., Clawson, M.L., Chitko-Mckown, C.G., Leymaster, K.A., Smith, T.P.L., Harhay, G.P., White, S.N., Herrmann-Hoesing, L.M., Mousel, M.R., Lewis, G.S., Kalbfleisch, T.S., Keen, J.E., Laegreid, W.W. 2012. Reduced lentivirus susceptibility in sheep with TMEM154 mutations. PLoS Genetics. 8(1): e1002467. DOI: 10.1371/journal.pgen.1002467.

Genome-Wide Association Study of Entropion Eyelid in Multiple Breeds of Sheep - (Abstract Only)

Mousel, M.R., Reynolds, J.O., White, S.N. 2012. Genome-Wide Association Study of Entropion Eyelid in Multiple Breeds of Sheep. Plant and Animal Genome. No. W151.

In vitro activity of ponazuril against Theileria equi - (Peer Reviewed Journal)

Wise, L.N., Ueti, M.W., Kappmeyer, L.S., Hines, M.T., White, S.N., Davis, W., Knowles Jr, D.P. 2012. In vitro activity of ponazuril against Theileria equi. Veterinary Parasitology. 185(2-4):282-5.

Characterization of ovine herpesvirus 2-induced malignant catarrhal fever in rabbits - (Peer Reviewed Journal)

Li, H., Cunha, C.W., Gailbreath, K.L., O'Toole, D., White, S.N., Vanderplasschen, A., Dewals, B., Knowles Jr, D.P., Taus, N.S. 2011. Characterization of ovine herpesvirus 2-induced malignant catarrhal fever in rabbits. Veterinary Microbiology. 150(3-4):270-7.

Association analysis of PRNP gene region with chronic wasting disease in Rocky Mountain elk - (Peer Reviewed Journal)

White, S.N., Spraker, T.R., Reynolds, J.O., Orourke, K.I. 2010. Association analysis of PRNP gene region with chronic wasting disease in Rocky Mountain elk. BMC Research Notes. 3:314.

An insertion mutation in ABCB4 is associated with gallbladder mucocele formation in dogs - (Peer Reviewed Journal)

Mealey, K.L., Minch, J.D., White, S.N., Snekvik, K.R., Mattoon, J.S. 2010. An insertion mutation in ABCB4 is associated with gallbladder mucocele formation in dogs. Comparative Hepatology. 9:6.

Genome-wide association identifies a deletion in the 3’ untranslated region of Striatin in a canine model of arrhythmogenic right ventricular cardiomyopathy - (Peer Reviewed Journal)

Meurs, K.M., Mauceli, E., Lahmers, S., Acland, G.M., White, S.N., Lindblad-Toh, K. 2010. Genome-wide association identifies a deletion in the 3’ untranslated region of Striatin in a canine model of arrhythmogenic right ventricular cardiomyopathy. Human Genetics. 128:315-324.

Non-maternal transmission is the major mode of ovine lentivirus transmission in a ewe flock: A molecular epidemiology study - (Peer Reviewed Journal)

Broughton-Neiswanger, L.E., White, S.N., Knowles Jr, D.P., Mousel, M.R., Lewis, G.S., Herndon, D.R., Hoesing, L.M. 2010. Non-maternal transmission is the major mode of ovine lentivirus transmission in a ewe flock: A molecular epidemiology study. Infection, Genetics and Evolution. 10(7):998-1007.

Evaluation of a Caprine Arthritis-Encephalitis Virus/Maedi-Visna Virus Indirect Enzyme-Linked Immunosorbent Assay in the Serological Diagnosis of Ovine Progressive Pneumonia Virus in U.S. Sheep - (Peer Reviewed Journal)

Hoesing, L.M., Broughton-Neiswanger, .L., Gouine, K., White, S.N., Mousel, M.R., Lewis, G.S., Marshall, K.L., Knowles Jr, D.P. 2010. Evaluation of a Caprine Arthritis-Encephalitis Virus/Maedi-Visna Virus Indirect Enzyme-Linked Immunosorbent Assay in the Serological Diagnosis of Ovine Progressive Pneumonia Virus in U.S. Sheep. Clinical and Vaccine Immunology. 17(2):307-310.

Ovine Progressive Pneumonia Virus Capsid Antigen as Found in CD163- and CD172a-Positive Alveolar Macrophages of Persistently Infected Sheep - (Peer Reviewed Journal)

Hoesing, L.M., Noh, S.M., Snekvik, K.R., White, S.N., Schneider, D.A., Truscott, T.C., Knowles Jr, D.P. 2010. Ovine Progressive Pneumonia Virus Capsid Antigen as Found in CD163- and CD172a-Positive Alveolar Macrophages of Persistently Infected Sheep. Veterinary Pathology. 47(3):518-528.

Association analysis of a CCR5 variant with ewe lifetime production. - (Abstract Only)

Mousel, M.R., White, S.N., Hoesing, L.M. 2010. Association analysis of a CCR5 variant with ewe lifetime production. Plant and Animal Genome Conference Proceedings. P571.

Association analysis of a CCR5 variant with ewe lifetime production in 3 breeds of sheep. - (Peer Reviewed Journal)

Mousel, M.R., White, S.N., Hoesing, L.M. 2010. Association analysis of a CCR5 variant with ewe lifetime production in 3 breeds of sheep. Animal Genetics. 41(2):222-223.

Babesia bovis: Transcriptional analysis of rRNA gene unit expression - (Peer Reviewed Journal)

Laughery, J.M., Lau, A.O., White, S.N., Howell, J.M., Suarez, C.E. 2009. Babesia bovis: Transcriptional analysis of rRNA gene unit expression. Experimental Parasitology. 123(1):45-50.

The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution - (Peer Reviewed Journal)

Elsik, C.G., Gibbs, R., Skow, L., Tellam, R., Weinstock, G., Worley, K., Kappes, S.M., Green, R.D., Alexander, L.J., Bennett, G.L., Carroll, J.A., Chitko Mckown, C.G., Hamernik, D.L., Harhay, G.P., Keele, J.W., Liu, G., Macneil, M.D., Matukumalli, L.K., Rijnkels, M., Roberts, A.J., Smith, T.P., Snelling, W.M., Stone, R.T., Waterman, R.C., White, S.N. 2009. The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution. Science. 324:522-528.

Peripheral Ovine Progressive Pneumonia Provirus Levels Correlate with and Predict Histological Tissue Lesion Severity in Naturally Infected Sheep - (Peer Reviewed Journal)

Hoesing, L.M., Noh, S.M., White, S.N., Snekvik, K.R., Truscott, T.C., Knowles Jr, D.P. 2009. Peripheral Ovine Progressive Pneumonia Provirus Levels Correlate with and Predict Histological Tissue Lesion Severity in Naturally Infected Sheep. Clinical and Vaccine Immunology. 16(4):551-557.

Ovine progressive pneumonia provirus levels are unaffected by the prion 171R allele in an Idaho sheep flock - (Peer Reviewed Journal)

Harrington, R.D., Hoesing, L.M., White, S.N., Orourke, K.I., Knowles Jr, D.P. 2009. Ovine progressive pneumonia provirus levels are unaffected by the prion 171R allele in an Idaho sheep flock. Genetics Selection Evolution. 41(1):17

Common promoter deletion is associated with 3.9-fold differential transcription of ovine CCR5 and reduced proviral level of ovine progressive pneumonia virus - (Peer Reviewed Journal)

White, S.N., Mousel, M.R., Reynolds, J.O., Lewis, G.S., Hoesing, L.M. 2009. Common promoter deletion is associated with 3.9-fold differential transcription of ovine CCR5 and reduced proviral level of ovine progressive pneumonia virus. Animal Genetics. 40(5):583-589.

Increased risk of chronic wasting disease in Rocky Mountain elk associated with decreased magnesium and increased manganese in brain tissue - (Peer Reviewed Journal)

White, S.N., Orourke, K.I., Gidlewski, T.L., Vercauteren, K.C., Mousel, M.R., Phillips, G.E., Spraker, T.R. 2010. Increased risk of chronic wasting disease in Rocky Mountain elk associated with decreased magnesium and increased manganese in brain tissue. Canadian Journal of Veterinary Research. 74:50-53.

Ovine progressive pneumonia provirus levels associate with breed and Ovar-DRB1 - (Peer Reviewed Journal)

Hoesing, L.M., White, S.N., Mousel, M.R., Lewis, G.S., Knowles Jr, D.P. 2008. Ovine progressive pneumonia provirus levels associate with breed and Ovar-DRB1. Immunogenetics. 60(12):749-758.

Prion gene (PRNP) haplotype variation in United States goat breeds - (Peer Reviewed Journal)

White, S.N., Hoesing, L.M., O'Rourke, K.I., Waldron, D., Rowe, J., Alverson, J. 2008. Prion gene (PRNP) haplotype variation in United States goat breeds. Genetics Selection Evolution. 40(5):553-561.

Myenteric neurons of the ileum that express somatostatin are a target of prion neuroinvasion in an alimentary model of sheep scrapie - (Peer Reviewed Journal)

Schneider, D.A., Yan, H., Fry, L.M., Alverson, J., White, S.N., Orourke, K.I. 2008. Myenteric neurons of the ileum that express somatostatin are a target of prion neuroinvasion in an alimentary model of sheep scrapie. Acta Neuropathologica. 115(6):651-661.

Technical Note: Comparison of traditional needle vaccination to pneumatic, needle-free vaccination in sheep - (Peer Reviewed Journal)

Mousel, M.R., Leeds, T.D., White, S.N., Hoesing, L.M. 2008. Technical Note: Comparison of traditional needle vaccination to pneumatic, needle-free vaccination in sheep. Journal of Animal Science. 86:1468-1471.

Genomic analysis of Ovis aries (Ovar)MHC Class IIa loci - (Peer Reviewed Journal)

Hoesing, L.M., White, S.N., Kappmeyer, L.S., Herndon, D.R., Knowles Jr, D.P. 2008. Genomic analysis of Ovis aries (Ovar)MHC Class IIa loci. Immunogenetics. 60(3):167-176.

Development and Validation of an Ovine Progressive Pneumonia Virus Quantitative PCR - (Peer Reviewed Journal)

Hoesing, L.M., White, S.N., Lewis, G.S., Mousel, M.R., Knowles Jr, D.P. 2007. Development and Validation of an Ovine Progressive Pneumonia Virus Quantitative PCR. Clinical and Vaccine Immunology. 14(10):1274-1278

Assessing the association of single nucleotide polymorphisms at the thyroglobulin gene with carcass traits in beef cattle - (Peer Reviewed Journal)

Casas, E., White, S.N., Shackelford, S.D., Wheeler, T.L., Koohmaraie, M., Bennett, G.L., Smith, T.P.L. 2007. Assessing the association of single nucleotide polymorphisms at the thyroglobulin gene with carcass traits in beef cattle. Journal of Animal Science. 85:2807-2814.

Presence of specific MHC Class II expressed alleles associates with clinical disease in ovine progressive pneumonia virus (OPPV) infected sheep - (Abstract Only) - (18-Jun-07)

Localization of a TNF-activated transcription site and interactions with the gamma activated site within the CAEV U3 70 base pair repeat - (Peer Reviewed Journal)

Murphy, B., Jasmer, D., White, S.N., Knowles Jr, D.P. 2007. Localization of a TNF-activated transcription site and interactions with the gamma activated site within the CAEV U3 70 base pair repeat. Virology. 364:196-207

ASSOCIATION OF A SINGLE NUCLEOTIDE POLYMORPHISM IN SPP1 WITH GROWTH TRAITS AND TWINNING IN A CATTLE POPULATION SELECTED FOR TWINNING RATE - (Peer Reviewed Journal)

Allan, M.F., Thallman, R.M., Cushman, R.A., Echternkamp, S.E., White, S.N., Kuehn, L.A., Casas, E., Smith, T.P. 2007. Association of a single nucleotide polymorphism in spp1 with growth traits and twinning in a cattle population selected for twinning rate. Journal of Animal Science. 85(2):341-347.

Evaluation in beef cattle of six deoxyribonucleic acid markers developed for dairy traits reveals an osteopontin polymorphism associated with postweaning growth. - (Peer Reviewed Journal)

White, S.N., Casas, E., Allan, M.F., Keele, J.W., Snelling, W.M., Wheeler, T.L., Shackelford, S.D., Koohmaraie, M., Smith, T.P. 2007. Evaluation in beef cattle of six deoxyribonucleic acid markers developed for dairy traits reveals an osteopontin polymorphism associated with post-weaning growth. Journal of Animal Science. 85:1-10.

Identification of genetic variation and putative regulatory regions in bovine CARD15 - (Peer Reviewed Journal)

Taylor, K.H., Taylor, J.F., White, S.N., Womack, J.E. 2006. Identification of genetic variation and putative regulatory regions in bovine CARD15. Mammalian Genome. 17(8):892-901.

TESTING FOR INTERACTIONS BETWEEN CALPASTATIN AND U-CALPAIN MARKERS IN BEEF CATTLE ON TENDERNESS TRAITS - (Peer Reviewed Journal)

Casas, E., White, S.N., Wheeler, T.L., Shackelford, S.D., Koohmaraie, M., Riley, D.G., Chase, C.C. Jr., Johnson, D.D., Smith, T.P. 2006. Effects of calpastatin and u-calpain markers in beef cattle on tenderness traits. Journal of Animal Science. 84:520-525.

TESTING FOR INTERACTIONS BETWEEN CALPASTATIN AND U-CALPAIN MARKERS IN BEEF CATTLE ON TENDERNESS TRAITS - (Abstract Only)

Casas, E., White, S.N., Wheeler, T.L., Shackelford, S.D., Koohmaraie, M., Riley, D.G., Chase, C.C., Johnson, D.D., Smith, T.P. 2006. Testing for interactions between Calpastatin and u-Calpain markers in beef cattle on tenderness traits [abstract]. Midwestern Section of the American Society of Animal Science. 84(Suppl. 2):135. Paper No. 329.

A NEW SNP IN CAPN1 EXTENDS THE CURRENT TENDERNESS MARKER TEST TO INCLUDE CATTLE OF BOS INDICUS, BOS TAURUS, AND CROSSBRED DESCENT - (Peer Reviewed Journal)

White, S.N., Casas, E., Wheeler, T.L., Shackelford, S.D., Koohmaraie, M., Riley, D.G., Chase, C.C., Johnson, D.D., Keele, J.W., Smith, T.P. 2005. A new snp in capn1 extends the current tenderness marker test to include cattle of bos indicus, bos taurus, and crossbred descent. Journal of Animal Science. 83:2001-2008.

A NEW SNP MARKER IN CAPN1 IS ASSOCIATED WITH TENDERNESS IN CATTLE OF INDICINE, TAURINE, AND ADMIXED DESCENT - (Abstract Only)

White, S.N., Casas, E., Wheeler, T.L., Shackelford, S.D., Koohmaraie, M., Riley, D.G., Chase, C.C., Johnson, D.D., Keele, J.W., Smith, T.P. 2005. A new snp marker in capn1 is associated with tenderness in cattle of indicine, taurine, and admixed descent. Proc., Plant & Animal Genome XIII, San Diego, CA. P528. p. 203. 2005.

ASSESSMENT OF SINGLE NUCLEOTIDE POLYMORPHISMS IN GENES RESIDING ON CHROMOSOMES 14 AND 29 FOR ASSOCIATION WITH CARCASS COMPOSITION TRAITS IN BOS INDICUS CATTLE - (Abstract Only)

Chase, C.C. Jr., Casas, E., White, S.N., Riley, D.G., Smith, T.P., Brenneman, R.A., Olson, T.A., Johnson, D.D., Coleman, S.W., Bennett, G.L. 2005. Assessment of single nucleotide polymorphisms in genes residing on chromosomes 14 and 29 for association with carcass composition traits in Bos indicus cattle [Abstract]. Plant and Animal Genome XIII, January 15-19, 2005, San Diego, CA. p. 203.

ASSESSMENT OF SINGLE NUCLEOTIDE POLYMORPHISMS IN GENES RESIDING ON CHROMOSOMES 14 AND 29 FOR ASSOCIATION WITH CARCASS COMPOSITION TRAITS IN BOS INDICUS CATTLE - (Peer Reviewed Journal)

Casas, E., White, S.N., Riley, D.G., Smith, T.P., Brenneman, R.A., Olson, T.A., Johnson, D.D., Coleman, S.W., Bennett, G.L., Chase, C.C. 2005. Assessment of single nucleotide polymorphisms in genes residing on chromosomes 14 and 29 for association with carcass composition traits in bos indicus cattle. Journal of Animal Science. 83:13-19.

ASSOCIATION OF MARKERS IN THE BOVINE CAPN1 GENE WITH MEAT TENDERNESS IN LARGE CROSSBRED POPULATIONS THAT SAMPLE INFLUENTIAL INDUSTRY SIRES - (Peer Reviewed Journal)

Page, B.T., Casas, E., Quaas, R.L., Thallman, R.M., Wheeler, T.L., Shackelford, S.D., Koohmaraie, M., White, S.N., Bennett, G.L., Keele, J.W., Dikeman, M.E., Smith, T.P. Association of markers in the bovine capn1 gene with meat tenderness in large crossbred populations that sample influential industry sires. Journal of Animal Science. 82:3474-3481. 2004.

ASSOCIATION OF CAPN1 MARKERS WITH BEEF TENDERNESS IN CROSSBRED, MULTIBREED POPULATIONS - (Abstract Only)

White, S.N., Page, B.T., Casas, E., Koohmaraie, M., Wheeler, T.L., Shackelford, S.D., Keele, J.W., Smith, T.P. 2004. Association of CAPN1 markers with beef tenderness in crossbred, multibreed populations. Proc.,Plant and Animal Genome Abstracts. P644. p. 232.