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United States Department of Agriculture

Agricultural Research Service

Related Topics

JUAN PACHECO-TOBIN
Foreign Animal Disease Research
Research Microbiologist

Phone: (631) 323-3171
Fax: (631) 323-3006
Room MOD 5
ROUTE 25
ORIENT POINT, NY, 11957


Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Morphologic and phenotypic characteristics of myocarditis in two pigs infected by foot-and mouth disease virus strains of serotypes O or A - (Peer Reviewed Journal)
Stenfeldt, C., Pacheco Tobin, J., Borca, M.V., Rodriguez, L.L., Arzt, J. 2014. Morphologic and phenotypic characteristics of myocarditis in two pigs infected by foot-and mouth disease virus strains of serotypes O or A. Acta Veterinaria Scandinavica. 56(1):42.
Detection of Foot-and-Mouth Disease Virus RNA and capsid protein in lymphoid tissues of convalescent pigs does not indicate existence of a carrier state - (Peer Reviewed Journal)
Stenfeldt, C., Pacheco Tobin, J., Smoliga, G.R., Bishop, E.A., Pauszek, S.J., Hartwig, E.J., Rodriguez, L.L., Arzt, J. 2014. Detection of Foot-and-Mouth Disease Virus RNA and capsid protein in lymphoid tissues of convalescent pigs does not indicate existence of a carrier state. Transboundary and Emerging Diseases. DOI: 10.1111/tbed.12235.
Infection dynamics of foot-and-mouth disease virus in pigs using two novel simulated natural inoculation methods - (Peer Reviewed Journal)
Stenfeldt, C., Pacheco Tobin, J., Rodriguez, L.L., Arzt, J. 2014. Infection dynamics of foot-and-mouth disease virus in pigs using two novel simulated natural inoculation methods. Research in Veterinary Science. 96:396-405.
Foot and mouth disease virus virulence in cattle is co-determined by viral replication dynamics and route of infection - (Peer Reviewed Journal)
Arzt, J., Pacheco Tobin, J., Tucker, M.T., Smoliga, G.R., Bishop, E.A., Pauszek, S.J., Hartwig, E.J., De Los Santos, T.B., Rodriguez, L.L. 2014. Foot and mouth disease virus virulence in cattle is co-determined by viral replication dynamics and route of infection. Virology. 452-453:12-22.
Interaction of foot-and-mouth disease virus non-structural protein 3A with host protein DCTN3 is important for viral virulence in cattle - (Peer Reviewed Journal)
Gladue, D.P., O'Donnell, V., Baker-Branstetter, R., Pacheco Tobin, J., Holinka-Patterson, L.G., Arzt, J., Pauszek, S.J., Fernandez-Sainz, I., Fletcher, P., Brocchi, E., Lu, Z., Rodriguez, L.L., Borca, M.V. 2014. Interaction of foot-and-mouth disease virus non-structural protein 3A with host protein DCTN3 is important for viral virulence in cattle. Journal of Virology. 88(5):2737-2747.
Characterization of a chimeric foot-and-mouth disease virus bearing bovine rhinitis B virus leader proteinase - (Peer Reviewed Journal)
Uddowla, S., Pacheco Tobin, J., Larson, C., Bishop, E.A., Rodriguez, L.L., Rai, D., Arzt, J., Rieder, A.E. 2013. Characterization of a chimeric foot-and-mouth disease virus bearing bovine rhinitis B virus leader proteinase. Virology. 447(1-2):172-180.
A partial deletion in non-structural protein 3A can attenuate foot-and-mouth disease virus in cattle - (Peer Reviewed Journal)
Pacheco Tobin, J., Gladue, D.P., Holinka-Patterson, L.G., Arzt, J., Bishop, E.A., Smoliga, G.R., Pauszek, S.J., Bracht, A.J., O'Donnell, V., Fernandez-Sainz, I., Fletcher, P., Piccone, M.E., Rodriguez, L.L., Borca, M.V. 2013. A partial deletion in non-structural protein 3A can attenuate foot-and-mouth disease virus in cattle. Virology. 446(1-2):260-267.
Characterization of cytotoxic T lymphocyte function following foot-and-mouth disease virus infection and vaccination - (Peer Reviewed Journal)
Patch, J.R., Kenney, M.A., Pacheco Tobin, J., Grubman, M.J., Golde, W.T. 2013. Characterization of cytotoxic T lymphocyte function following foot-and-mouth disease virus infection and vaccination. Viral Immunology. 26(4):239-249 DOI:10.1089/vim.2013.0011.
Mechanisms of foot-and-mouth disease virus tropism inferred from differential tissue gene expression Reprint Icon - (Peer Reviewed Journal)
Zhu, J.J., Arzt, J., Puckette, M.C., Smoliga, G.R., Pacheco Tobin, J., Rodriguez, L.L. 2013. Mechanisms of foot-and-mouth disease virus tropism inferred from differential tissue gene expression. PLoS One. 8(5):e64119. DOI:10.1371/journal.pone.0064119.
Foot-and-mouth disease virus modulates cellular vimentin for virus survival Reprint Icon - (Peer Reviewed Journal)
Gladue, D.P., O'Donnell, V., Baker-Branstetter, R., Holinka-Patterson, L.G., Pacheco Tobin, J., Fernandez Sainz, I.J., Lu, Z., Brocchi, E., Piccone, M.E., Fletcher, P., Ambroggio, X., Rodriguez, L.L., Borca, M.V. 2013. Foot-and-mouth disease virus modulates cellular vimentin for virus survival. Journal of Virology. 87(12):6794-6803.
Foot-and-mouth disease virus (FMDV) with a stable FLAG epitope in the VP1 G-H loop as a new tool for studying FMDV pathogenesis Reprint Icon - (Peer Reviewed Journal)
Lawrence, P., Uddowla, S., Pacheco Tobin, J., Kotecha, A., Fry, E., Rieder, A.E. 2012. Foot-and-mouth disease virus (FMDV) with a stable FLAG epitope in the VP1 G-H loop as a new tool for studying FMDV pathogenesis. Virology. 136(1):150-161.
Foot and mouth disease virus non structural protein 2C interacts with Beclin1 modulating virus replication Reprint Icon - (Peer Reviewed Journal)
Gladue, D.P., O'Donnell, V., Baker-Branstetter, R., Pacheco Tobin, J., Holinka-Patterson, L.G., Fernandez Sainz, I.J., Lu, Z., Brocchi, E., Baxt, B., Piconne, M.E., Rodriguez, L.L., Borca, M.V. 2012. Foot and mouth disease virus non structural protein 2C interacts with Beclin1 modulating virus replication. Journal of Virology. 86(22):12080-12090. doi:10.1128/JVI.01610-12.
An alternate delivery system improves vaccine performance against foot-and-mouth disease virus (FMDV) Reprint Icon - (Peer Reviewed Journal)
Pandya, M., Pacheco Tobin, J., Bishop, E.A., Kenney, M.A., Milward, F., Doel, T., Golde, W.T. 2012. An alternate delivery system improves vaccine performance against foot-and-mouth disease virus (FMDV). Vaccine. 30(20):3106-3111.
Bovine type III interferon significantly delays and reduces the severity of foot-and-mouth disease in cattle Reprint Icon - (Peer Reviewed Journal)
Perez-Martin, E., Weiss, M., Diaz San Segundo, F.C., Pacheco Tobin, J., Arzt, J., Grubman, M.J., De Los Santos, T.B. 2012. Bovine type III interferon significantly delays and reduces the severity of foot-and-mouth disease in cattle. Journal of Virology. 86(8):4477-4487.
Direct contact transmission of three different foot-and-mouth disease virus strains in swine demonstrates important strain-specific differences Reprint Icon - (Peer Reviewed Journal)
Pacheco Tobin, J., Tucker, M.T., Hartwig, E.J., Bishop, E.A., Arzt, J., Rodriguez, L.L. 2012. Direct contact transmission of three different foot-and-mouth disease virus strains in swine demonstrates important strain-specific differences. The Veterinary Journal. 193(2):456-463.
Role of the Arg56 of the structural protein VP3 of foot-and-mouth disease virus (FMDV) 01 campos in virus virulence Reprint Icon - (Peer Reviewed Journal)
Borca, M.V., Pacheco Tobin, J., Holinka-Patterson, L.G., Hartwig, E.J., Carrillo, C., Garriga, D., Kramer, E., Rodriguez, L.L., Piccone, M.E. 2012. Role of the Arg56 of the structural protein VP3 of foot-and-mouth disease virus (FMDV) 01 campos in virus virulence. Virology. (422):37-45.
Foot-and-mouth disease virus utilizes an autophagic pathway during viral replication - (Peer Reviewed Journal)
O'Donnell, V., Pacheco Tobin, J., Larocco, M.A., Burrage, T., Jackson, W., Rodriguez, L.L., Borca, M.V., Baxt, B. 2010. Foot-and-mouth disease virus utilizes an autophagic pathway during viral replication. Virology. 410:142-150.
Domain disruptions of individual 3B proteins for foot-and-mouth disease virus do not alter growth in cell culture nor virulence in cattle - (Peer Reviewed Journal)
Pacheco Tobin, J., Piccone, M.E., Rieder, A.E., Pauszek, S.J., Borca, M.V., Rodriguez, L.L. 2010. Domain disruptions of individual 3B proteins for foot-and-mouth disease virus do not alter growth in cell culture nor virulence in cattle. Virology. DOI: 10.1016/j.virol.2010.05.036.
The early pathogenesis of foot-and-mouth disease in cattle after aerosol innoculation: identification of the nasopharynx as the primary site of infection - (Peer Reviewed Journal)
Arzt, J., Pacheco Tobin, J., Rodriguez, L.L. 2010. The early pathogenesis of foot-and-mouth disease in cattle after aerosol innoculation: identification of the nasopharynx as the primary site of infection. Veterinary Pathology. 47(6):1048-1063.
IgA antibody response of swine to foot-and-mouth disease virus infection and vaccination Reprint Icon - (Review Article)
Pacheco Tobin, J., Butler, J.E., Jew, J., Ferman, G., Zhu, J.J., Golde, W.T. 2010. IgA antibody response of swine to foot-and-mouth disease virus infection and vaccination. Clinical and Vaccine Immunology. p. 550-558.
IgA antibody response of swine to foot-and-mouth disease virus (FMDV) infection and vaccination - (Peer Reviewed Journal)
Pacheco Tobin, J., Butler, J.E., Jew, J., Ferman, G.S., Zhu, J.J., Golde, W.T. 2010. IgA antibody response of swine to foot-and-mouth disease virus (FMDV) infection and vaccination. Clinical and Vaccine Immunology. 17(4):550-558.
Loss of plasmacytoid dendritic cell function coincides with lymphopenia and viremia during foot-and-mouth disease infection - (Peer Reviewed Journal)
Nfon, C.K., Toka, F.N., Kenney, M.A., Pacheco Tobin, J., Golde, W.T. 2010. Loss of plasmacytoid dendritic cell function coincides with lymphopenia and viremia during foot-and-mouth disease infection. Viral Immunology. 23(1):29-41.
The region between the two polyprotein initiation codons of foot-and-mouth disease virus is critical for virulence in cattle - (Peer Reviewed Journal)
Piccone, M.E., Pacheco Tobin, J., Pauszek, S.J., Borca, M.V., Rieder, A.E., Kramer Jr, E.V., Zhu, J.J., Rodriguez, L.L. 2010. The region between the two polyprotein initiation codons of foot-and-mouth disease virus is critical for virulence in cattle. Virology. 396:152-159.
Analysis of foot-and-mouth disease virus integrin receptor expression in tissues from naive and infected cattle - (Peer Reviewed Journal) - (22-Sep-09)
Cytokine mRNA expression in foot-and-mouth disease virus (FMDV) persistently infected bovine pharynx cultures: effect of IFNgamma on replication of persistent virus - (Abstract Only)
O'Donnell, V., Smoliga, G.R., Pacheco Tobin, J., Baxt, B., Rodriguez, L.L. 2009. Cytokine mRNA expression in foot-and-mouth disease virus (FMDV) persistently infected bovine pharynx cultures: effect of IFNgamma on replication of persistent virus. American Society for Virology Meeting. Paper No. W36-9: P. 178.
Early Events in the Pathogenesis of Foot-and-Mouth Disease in Cattle After Controlled Aerosol Exposure - (Peer Reviewed Journal)
Pacheco Tobin, J., Arzt, J., Rodriguez, L.L. 2008. Early Events in the Pathogenesis of Foot-and-Mouth Disease in Cattle After Controlled Aerosol Exposure. The Veterinary Journal. 183(1):46-53.
Delivery of a Foot-and-Mouth Disease Virus Empty Capsid Subunit Antigen with Nonstructural Protein 2B Improves Protection of Swine - (Peer Reviewed Journal)
Pena, L., Moraes, M., Koster, M.J., Burrage, T., Pacheco Tobin, J., Diaz San-Segundo, F., Grubman, M.J. 2008. Delivery of a Foot-and-Mouth Disease Virus Empty Capsid Subunit Antigen with Nonstructural Protein 2B Improves Protection of Swine. Vaccine. 26:5689-5699.
Type I and II Interferons Activate the Innate Immune System to Promote Early Protection of Swine Against Foot-and-Mouth Disease Virus - (Abstract Only)
Diaz-San Segundo, F., Moraes, M., De Los Santos, T., Pacheco Tobin, J., Koster, M.J., Dawson, H., Golde, W.T., Grubman, M.J. 2008. Type I and II Interferons Activate the Innate Immune System to Promote Early Protection of Swine Against Foot-and-Mouth Disease Virus. European Study Group on the Molecular Biology of Picornaviruses. P 149
Role of the Region Located Between the Two AUG Initiation Codons in the Pathogenesis of Foot-and-Mouth Disease Virus (FMDV) - (Abstract Only)
Piccone, M.E., Pacheco Tobin, J., Pauszek, S.J., Borca, M.V., Rieder, A.E., Rodriguez, L.L. 2008. Role of the Region Located Between the Two AUG Initiation Codons in the Pathogenesis of Foot-and-Mouth Disease Virus (FMDV). European Study Group on the Molecular Biology of Picornaviruses. p. 199.
Molecular Characterization of a Foot-and-Mouth Disease Virus (FMDV) Containing a 57-Nucleotide Insertion in the 3' Untranslated Region (3'UTR) - (Peer Reviewed Journal)
Piccone, M.E., Pauszek, S.J., Pacheco Tobin, J., Rieder, A.E., Kramer, E., Rodriguez, L.L. 2009. Molecular Characterization of a Foot-and-Mouth Disease Virus (FMDV) Containing a 57-Nucleotide Insertion in the 3' Untranslated Region (3'UTR). Archives of Virology. 154:671-676.
Detection of Foot-and-Mouth Disease Virus Infected Cattle Using Infrared Thermography - (Peer Reviewed Journal)
Rainwater-Lovett, K., Pacheco Tobin, J., Packer, C., Rodriguez, L.L. 2009. Detection of Foot-and-Mouth Disease Virus Infected Cattle Using Infrared Thermography. The Veterinary Journal. 180:317-324.
Porcine Interferon Gamma Promotes a Protective Innate Immune Response Against Foot-and-Mouth Disease in Swine - (Abstract Only)
Diaz-San Segundo, F., Moraes, M., De Los Santos, T., Pacheco Tobin, J., Koster, M.J., Turecek, T.E., Dawson, H., Golde, W.T., Grubman, M.J. 2007 Porcine Interferon Gamma Promotes a Protective Innate Immune Response Against Foot-and-Mouth Disease in Swine. American Society for Virology Meeting. W20-3, P. 30
ARS News Articles
Last Modified: 9/10/2014
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