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United States Department of Agriculture

Agricultural Research Service

Jeffrey A. Fabrick

Research Entomologist

Biography

Pest Management & Biological Control Research Unit

USDA-ARS, Arid-Land Agricultural Research Center

 

   

Jeffrey A. Fabrick

Research Entomologist

Arid-Land Agricultural Research Center

21881 North Cardon Lane

Maricopa, Arizona 85138

520-316-6335

520-316-6330 (FAX)

 

jeff.fabrick@ars.usda.gov

 

Education:

B.S. Biochemistry, Kansas State University 1995

Ph.D. Biochemistry, Kansas State University 2003

 

Research Interests:

My research interests include understanding various molecular, biochemical and physiological functions in insects, including Bt mode-of-action and receptor function, insecticide/Bt resistance, digestive biochemistry and physiology, immunity, and parasitoid/host interactions.  I am interested in understanding the properties and function of Bt-binding cadherin receptor proteins from various insects, including the cotton pest insect Pectinophora gossypiella (pink bollworm) and the stored product beetle Tenebrio molitor (yellow mealworm) and how specific peptide fragments can enhance or synergize the activity of Bt toxins.  Furthermore, I am currently working to characterize an intact transposable element that disrupts a pink bollworm cadherin Bt receptor and is responsible for r3 cadherin resistance allele.  My laboratory is also currently active in understanding the digestive physiology and water transport proteins (aquaporins) in other cotton pests, including Bemisia tabaci and Lygus hesperus.

 

Pink bollworm

 

 

 

 

 

 

 

 

 


Key Publications (last 5 years)

Fabrick, J.A., Mathew, L.G., Tabashnik, B.E., Li, X. 2011. Insertion of an intact CR1 retrotransposon in a cadherin gene linked with Bt resistance in the pink bollworm, Pectinophora gossypiella. Insect Mol. Biol. In press. Accepted June 6, 2011.  doi: 10.1111/j.1365-2583.2011.01095.x. (available as Early View at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2583/earlyview).

Gao, Y., Jurat-Fuentes, J.L., Oppert, B.S., Fabrick, J.A., Lui, C.A., Gao, J., Lei, Z. 2011. Increased toxicity of Bacillus thuringiensis Cry3Aa against Crioceris quatuorodecimpunctatata, Phaedon brassicae, and Colaphellus bowringi by a Tenebrio molitor cadherin fragment. Pest Manag. Sci.  In press. Accepted Feb 1, 2011. doi: 10.1002/ps.2149. (available as Early View at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1526-4998/earlyview).

Mathew, L.G., Campbell, E.M., Yool, A.J., Fabrick, J.A. 2011. Identification and characterization of a functional aquaporin water channel protein from alimentary tract of whitefly, Bemisia tabaci. Insect Biochem. Mol. Biol. 41(3): 178-190. (pdf)

Tabashnik, B.T., Sisterson, M.S., Ellsworth, P.C., Dennehy, T.J., Antilla, L., Liesner, L., Whitlow, M., Staten, R.T., Fabrick, J.A., Unnithan, G.C., Yelich, A.J., Ellers-Kirk, C., Harpold, V.S., Li, X., Carriere, Y. 2010. Suppressing resistance to Bt cotton with sterile insect releases. Nat. Biotechnol. 28(12): 1304-1307. (pdf) (supplemental materials) (Wu commentary)

Dennehy, T.J., DeGain, B.A., Harpold, V.S., Zaborac, M., Morin, S., Fabrick, J.A., Nichols, R.L., Brown, J.K., Byrne, F.J., Li, X.-C. 2010. Extraordinary resistance to insecticides reveals exotic Q biotype of Bemisia tabaci (Gennadius) in the New World. J. Econ. Entomol. 103(6): 2174-2186. (pdf)

Fabrick, J.A. 2010. Insights into the genetics and molecular mechanisms of pink bollworm resistance to Cry toxins. Southwest. Entomol. 35(3): 431-435.

Carrière, Y., Showalter, A.M., Fabrick, J.A., Sollome, J., Ellers-Kirk, C., Tabashnik, B.E. 2009. Cadherin gene expression and effects of Bt resistance on sperm transfer in pink bollworm. J. Insect Physiol. 55: 1058-1064. (pdf) 

Morris, K.M., Lorenzen, M., Hiromasa, Y., Tomich, J.M., Oppert, C., Elpidina, E.N., Vinokurov, K., Jurat-Fuentes, J.L. , Fabrick, J.A., Oppert, B.S. 2009. Tribolium castaneum larval gut transcriptome and proteome: A resource for the study of the coleopteran gut. J. Proteome Res. 8: 3889-3898. (pdf)

Fabrick, J., Oppert, C., Lorenzen, M.D., Morris, K., Oppert, B., Jurat-Fuentes, J.L. 2009. A novel Tenebrio molitor cadherin is a functional receptor for Bacillus thuringiensis Cry3Aa toxin. J. Biol. Chem. 284(27): 18401-18410. (pdf)

Gassmann, A.J., Fabrick, J.A., Sisterson, M.S., Hannon, E.R., Stock, S.P., Carriere, Y., Tabashnik, B.E. 2009. Effects of pink bollworm resistance to Bt on phenoloxidase activity and susceptibility to entomopathogenic nematodes. J. Econ. Entomol. 102(3): 1224-1232. (pdf) 

Fabrick, J., Jech-Forlow, L., Henneberry, T.J. 2009. Novel pink bollworm resistance to the Bt toxin Cry1Ac: Effects on mating, oviposition, larval development, and survival. J. Insect. Sci. 9:24, available online: insectscience.org/9.24. (pdf)

Fabrick, J.A. and Tabashnik, B.E. 2007. Binding of Bacillus thuringiensis toxin Cry1Ac to multiple sites of cadherin in pink bollworm. Insect Biochem. Mol. Biol. 37: 97-106. (pdf) 

Dennehy, T.J., DeGain, B.A., Harpold, V.S., Brown, J.K., Morin, S., Fabrick, J.A., Byrne, F.J., Nichols, R.L. 2006. New challenges to management of whitefly resistance to insecticides in Arizona. The University of Arizona, College of Agriculture Vegetable Report, Series P-144. Available online: http://cals.arizona.edu/pubs/crops/az1382/.

Tabashnik, B.E., Biggs, R.W., Fabrick, J.A., Gassmann, A.J., Dennehy, T.J., Carriere, Y., Morin, S. 2006. High-level resistance to Bt toxin Cry1Ac and cadherin genotype in pink bollworm. J. Econ. Entomol. 99(6): 2125-2131. (pdf)

Tabashnik, B.E., Fabrick, J.A., Henderson, S., Biggs, R.W., Yafuso, C.M., Nyboer, M.E., Manhardt, N.M., Coughlin, L.A., Sollome, J., Carriere, Y., Dennehy, T.J., Morin, S. 2006. DNA screening reveals pink bollworm resistance to Bt cotton remains rare after a decade of exposure. J. Econ. Entomol. 99(5): 1525-1530. (pdf)


More Publications (beyond 5 years)

Morin, S., Henderson, S., Fabrick, J.A., Carrière, Y., Dennehy, T.J., Brown, J.K., Tabashnik, B.E. 2004. DNA-based detection of Bt resistance alleles in pink bollworm. Insect Biochem. Mol. Biol. 34: 1225-1233. (pdf)

Fabrick, J.A., Baker, J.E., and Kanost, M.R. 2004. Innate immunity in a Pyralid moth: Functional evaluation of domains from a beta-1,3-glucan recognition protein. J. Biol. Chem. 279(25): 26605-26611. (pdf)

Fabrick, J.A., Kanost, M.R., and Baker, J.E. 2004. RNAi-induced silencing of embryonic tryptophan oxygenase in the Pyralid moth, Plodia interpunctella. 9pp. J. Insect Sci., 4:15, Available online: http://www.insectscience.org/4.15/.

Fabrick, J.A., Baker, J.E., and Kanost, M.R. 2003. cDNA cloning, purification, properties, and function of a beta-1,3-glucan recognition protein from a pyralid moth, Plodia interpunctella. Insect Biochem. Mol. Biol. 33: 579-594. (pdf)

Yu, X.Q., Zhu, Y., Ma, C., Fabrick, J.A., and Kanost, M.R. 2002. Pattern recognition proteins in Manduca sexta plasma. Insect Biochem. Mol. Biol. 32(10): 1287-1293. (pdf)

Baker, J.E. and Fabrick, J.A. 2002. Unusual responses of Indianmeal moth larvae to envenomation and parasitization by a braconid ectoparasitoid. J. Entomol. Sci. 37(4): 370-374. (please contact me to request pdf) 

Perez-Mendoza, J., Dowell, F.E., Broce, A.B., Throne, J.E., Wirtz, R.A., Xie, F., Fabrick, J.A., and Baker, J.E. 2002. Chronological age-grading of house flies by using near-infared spectroscopy. J. Med. Entomol. 39(3): 499-508. (pdf)

Fabrick, J.A., Behnke, C., Czapla, T., Bala, K., Rao, A.G., Kramer, K.J., and Reeck, G.R. 2002. Effects of a potato cysteine proteinase inhibitor on midgut proteolytic enzyme activity and growth of the southern corn rootworm, Diabrotica undecimpunctata howardi(Coleoptera: Chrysomelidae). Insect Biochem. Mol. Biol. 32(4): 405-415. (pdf)

Baker, J.E. and Fabrick, J.A. 2000. Host hemolymph proteins and protein digestion in larval Habrobracon hebetor (Hymenoptera: Braconidae). Insect Biochem. Mol. Biol. 30(10): 937-946. (pdf)

Perez-Mendoza, J., Fabrick, J.A., Zhu, K.Y., and Baker, J.A. 2000. Alterations in esterases are associated with malathion resistance in Habrobracon hebetor(Hymenoptera: Braconidae). J. Econ. Entomol. 93(1): 31-37. (pdf)

Baker, J.E., Fabrick, J.A., and Zhu, K.Y. 1998. Characterization of esterases in malathion-resistant and susceptible strains of the pteromalid parasitoid Anisopteromalus calandrae. Insect. Biochem. Mol. Biol. 28: 1039-1050. (pdf) 

Reeck, G.R., Kramer, K.J., Baker J.E., Kanost, M.R., Fabrick, J.A., and Behnke, C.A.1997. Proteinase inhibitors and resistance of transgenic plants to insects. In Advances in Insect Control: The Role of Transgenic Plants. Eds. Carozzi, N., and Koziel, M., pp. 157-184.


Current Lab Members

 


Last Modified: 6/11/2014