Projects

INTERVENTION STRATEGIES TO SUPPORT THE GLOBAL CONTROL AND ERADICATION OF FOOT-AND-MOUTH DISEASE VIRUS (FMDV) Appropriated (D)   Accession Number: 422203

DEVELOPMENT OF IMPROVED MUCOSAL FOOT-AND-MOUTH DISEASE VIRUS VACCINES Nonfunded Cooperative Agreement (N)   Accession Number: 423281

COUNTERMEASURES FOR FOOT-AND-MOUTH DISEASE UTILIZING DIAGNOSTICS, BIOTHERAPEUTICS, A NOVEL VACCINE PLATFORM AND IMPROVED CHALLENGE SYSTEMS Reimbursable (R)   Accession Number: 421628

ANTIGENIC STRUCTURE OF FMDV CAPSID PROTEINS AND THE SELECTION OF APPROPRIATE CANDIDATE VACCINE STRAINS IN EMERGING FMD OUTBREAKS Specific Cooperative Agreement (S)   Accession Number: 418615

EXPLOITING THE POTENTIAL OF LEADER PROTEINASE CODING SEQUENCE OF FOOT-AND-MOUTH DISEASE VIRUS TO DERIVE ATTENUATED STRAINS...COUNTERMEASURES Trust (T)   Accession Number: 422928

Development of Novel Foot-and-Mouth Disease Virus with Multiple Mutations for Evaluation as Live Attenuated Diva Vaccine Candidate Trust (T)   Accession Number: 424159

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Use of replication-defective adenoviruses to develop vaccines and biotherapeutics against foot-and-mouth disease - (Peer Reviewed Journal)

Grubman, M.J., Diaz San Segundo, F.C., Dias, C.C., Moraes, M.P., Perez-Martin, E., De Los Santos, T.B. 2012. Use of replication-defective adenoviruses to develop vaccines and biotherapeutics against foot-and-mouth disease. Future Virology. 7(8):767-778.

Novel antiviral therapeutics to control foot-and-mouth disease - (Peer Reviewed Journal)

Dias, C.C., Moraes, M.P., Weiss, M., Diaz San Segundo, F.C., Perez-Martin, E., Salazar, A.M., De Los Santos, T.B., Grubman, M.J. 2012. Novel antiviral therapeutics to control foot-and-mouth disease. Journal of Interferon and Cytokine Research. 32(10):462-473.

Bovine type III interferon significantly delays and reduces the severity of foot-and-mouth disease in cattle - (Peer Reviewed Journal)

Perez-Martin, E., Weiss, M., Diaz San Segundo, F.C., Pacheco Tobin, J., Arzt, J., Grubman, M.J., De Los Santos, T.B. 2012. Bovine type III interferon significantly delays and reduces the severity of foot-and-mouth disease in cattle. Journal of Virology. 86(8):4477-4487.

Inoculation of swine with foot-and-mouth disease SAP-mutant virus induces early protection against disease - (Peer Reviewed Journal)

Diaz San Segundo, F.C., Weiss, M., Perez-Martin, E., Dias, C.C., Grubman, M.J., De Los Santos, T.B. 2012. Inoculation of swine with foot-and-mouth disease SAP-mutant virus induces early protection against disease. Journal of Virology. 86(3):1316-1327.

Antiviral activity of bovine type III interferon against foot-and-mouth disease virus - (Peer Reviewed Journal)

Diaz-San Segundo, F., Weiss, M., Perez-Martin, E., Koster, M.J., Zhu, J.J., Grubman, M.J., De Los Santos, T.B. 2011. Antiviral activity of bovine type III interferon against foot-and-mouth disease virus. Virology. 413(2):283-292.

Evidence of activation and suppression during the early immune response to foot-and-mouth disease virus - (Review Article)

Golde, W.T., De Los Santos, T.B., Robinson, L., Grubman, M.J., Sevilla, N., Summerfield, A. 2011. Evidence of activation and suppression during the early immune response to foot-and-mouth disease virus. Transboundary and Emerging Diseases. 58(4):283-290.

Introduction of tag epitopes in the inter-AUG region of foot and mouth disease virus: effect on the L protein - (Peer Reviewed Journal)

Piccone, M.E., Diaz-San Segundo, F., Kramer, E., Rodriguez, L.L., De Los Santos, T.B. 2011. Introduction of tag epitopes in the inter-AUG region of foot and mouth disease virus: effect on the L protein. Virus Research. 155(1):91-97.

Porcine type I interferon rapidly protects swine against challenge with multiple serotypes of foot-and-mouth disease virus - (Peer Reviewed Journal)

Dias, C.C., Moraes, M.P., Diaz-San Segundo, F., De Los Santos, T.B., Grubman, M.J. 2011. Porcine type I interferon rapidly protects swine against challenge with multiple serotypes of foot-and-mouth disease virus. Journal of Interferon and Cytokine Research. 31(2):227-236.

Differential gene expression in bovine cells infected with wild type and leaderless foot-and-mouth disease virus - (Peer Reviewed Journal)

Zhu, J.J., Weiss, M., Grubman, M.J., De Los Santos, T.B. 2010. Differential gene expression in bovine cells infected with wild type and leaderless foot-and-mouth disease virus. Virology. 404(1):32-40.

Interferon induced protection against foot-and-mouth disease virus correlates with enhanced tissue specific innate immune cell infiltration and interferon stimulated gene expression - (Peer Reviewed Journal)

Diaz-San Segundo, F., Moraes, M.P., De Los Santos, T.B., Dias, C., Grubman, M.J. 2010. Interferon induced protection against foot-and-mouth disease virus correlates with enhanced tissue specific innate immune cell infiltration and interferon stimulated gene expression. Journal of Virology. 84:2063-2077.

Foot-and-mouth disease - (Book / Chapter)

Grubman, M.J., Rodriguez, L.L., De Los Santos, T.B. 2010. Foot-and-mouth disease. In: Ehrenfeld, E., Domingo, E., Roos, R.P., editors. The Picornaviruses. Washington, DC: ASM Press. p. 397-410.

Functional genomics approach to understand the role of Lpro in FMDV virulence - (Abstract Only)

De Los Santos, T.B., Grubman, M.J., Zhu, J.J. 2009. Functional genomics approach to understand the role of Lpro in FMDV virulence. American Society for Virology Meeting. Paper No. 9-21: P.262.

Examing the mechanisms of interferon-induced protection against foot-and-mouth disease virus in swine - (Abstract Only)

Diaz-San Segundo, F., Moraes, M.P., De Los Santos, T.B., Koster, M.J., Dias, C., Grubman, M.J. 2009. Examing the mechanisms of interferon-induced protection against foot-and-mouth disease virus in swine. American Society for Virology Meeting. Paper No. W21-5: p. 133.

Exploring the role of the lab protein of Foot-and-Mouth Disease Virus (FMDV) during viral infection - (Abstract Only)

De Los Santos, T.B., Piccone, M.E., Diaz-San Segundo, F., Pauszek, S.J., Kramer, E.V., Rodriguez, L.L. 2009. Exploring the role of the lab protein of Foot-and-Mouth Disease Virus (FMDV) during viral Infection. American Society for Virology Meeting. Paper No. 32-7: p. 337.

A Conserved Domain in the Leader Proteinase of Foot-and-Mouth Disease Virus is Required for Proper Sub-Cellular Localization and Function - (Peer Reviewed Journal)

De Los Santos, T.B., Diaz-San Segundo, F., Zhu, J.J., Koster, M.J., Dias, C., Grubman, M.J. 2008. A Conserved Domain in the Leader Proteinase of Foot-and-Mouth Disease Virus is Required for Proper Sub-Cellular Localization and Function. Journal of Virology. 83(4):1800-1810.

Role of IL-10 during Foot-and-Mouth Disease Virus (FMDV) Infection and Its Potential Use as Immunomodulator - (Abstract Only) - (01-Oct-08)

Type I and II Interferons Activate the Innate Immune System to Promote Early Protection of Swine Against Foot-and-Mouth Disease Virus - (Abstract Only)

Diaz-San Segundo, F., Moraes, M., De Los Santos, T., Pacheco Tobin, J., Koster, M.J., Dawson, H., Golde, W.T., Grubman, M.J. 2008. Type I and II Interferons Activate the Innate Immune System to Promote Early Protection of Swine Against Foot-and-Mouth Disease Virus. European Study Group on the Molecular Biology of Picornaviruses. P 149

A Conserved Domain in the Leader Proteinase of Foot-and-Mouth Disease Virus is Required for Proper Subcellular Localization and Function - (Abstract Only)

De Los Santos, T., San Segundo-Diaz, F., Zhu, J., Koster, M.J., Grubman, M.J. 2008. A conserved domain in the leader proteinase of foot-and-mouth disease virus is required for proper subcellular localization and function. European Study Group on the Molecular Biology of Picornaviruses. P 86

Evading the Host Immune Response: How Foot-and-Mouth Disease Virus Has Become an Effective Pathogen - (Peer Reviewed Journal)

Grubman, M.J., Moraes, M., Diaz-San Segundo, F., Pena, L., De Los Santos, T. 2008. Evading the Host Immune Response: How Foot-and-Mouth Disease Virus Has Become an Effective Pathogen. Federation of European Microbiological Societies Microbiology Letters. 53:8-17.

Degradation of Nuclear Factor Kappa B During Foot-and-Mouth Disease Virus Infection - (Peer Reviewed Journal)

De Los Santos, T., Diaz-San Segundo, F., Grubman, M.J. 2007. Degradation of Nuclear Factor Kappa B During Foot-and-Mouth Disease Virus Infection. Journal of Virology. 81(23):12803-12815.

Enhanced Antiviral Activity against Foot-and-Mouth Disease Virus by a Combination of Type 1 and 2 Porcine Interfereons - (Peer Reviewed Journal)

Moraes, M., De Los Santos, T., Koster, M.J., Turecek, T.E., Wang, H., Andreyev, V.G., Grubman, M.J. 2007. Enhanced Antiviral Activity against Foot-and-Mouth Disease Virus by a Combination of Type 1 and 2 Porcine Interfereons. Journal of Virology. Vol 81. No.13: P7124-7135

Degradation of Nuclear Factor Kappa B During Foot-and-Mouth Disease Virus Infection - (Abstract Only)

De Los Santos, T., Diaz San-Segundo, F., Grubman, M.J., 2007, Degradation of Nuclear Factor Kappa B During Foot-and-Mouth Disease Virus Infection. American Society for Virology Meeting. W1-3, p.71

Porcine Interferon Gamma Promotes a Protective Innate Immune Response Against Foot-and-Mouth Disease in Swine - (Abstract Only)

Diaz-San Segundo, F., Moraes, M., De Los Santos, T., Pacheco Tobin, J., Koster, M.J., Turecek, T.E., Dawson, H., Golde, W.T., Grubman, M.J. 2007 Porcine Interferon Gamma Promotes a Protective Innate Immune Response Against Foot-and-Mouth Disease in Swine. American Society for Virology Meeting. W20-3, P. 30

THE LEADER PROTEINASE OF FOOT-AND-MOUTH DISEASE VIRUS REDUCES THE EXPRESSION OF INTERFERON BY SUPPRESSING THE ACTIVITY OF THE NUCLEAR FACTOR KAPPA B - (Abstract Only)

De Los Santos, T., Brum, M., Grubman, M.J. 2006. The leader proteinase of foot-and-mouth disease virus reduces the expression of interferon by suppressing the activity of the nuclear factor kappa b. American Society of Virology Annual Meeting. 2006. P. 67.

ENHANCED ANTIVIRAL ACTIVITY AGAINST FOOT-AND-MOUTH DISEASE VIRUS BY A COMBINATION OF TYPE 1 AND 2 PORCINE INTERFERONS - (Abstract Only)

Grubman, M.J., De Los Santos, T., Koster, M.J., Turecek, T.E., Wang, H., Andryev, V., Moraes, M.P. 2006. Enhanced antiviral activity against foot-and-mouth disease virus by a combination of type 1 and 2 porcine interferons. American Society of Virology Annual Meeting. 2006. P. 150.

THE LEADER PROTEINASE OF FOOT-AND-MOUTH DISEASE VIRUS INHIBITS THE INDUCTION OF INTERFERON BETA MRNA AND BLOCKS THE HOST INNATE IMMUNE RESPONSE - (Peer Reviewed Journal)

De Los Santos, T., Botton, S.D., Weiblen, R., Grubman, M.J. 2005. The Leader Proteinase of Foot-and-Mouth Disease Virus Inhibits the Induction of Interferon Beta mRNA and Blocks the Host Innate Immune Response. Journal of Virology.(2006) 80.4.1906-1914

THE LEADER PROTEINASE OF FOOT-AND-MOUTH DISEASE VIRUS INHIBITS THE INDUCTION OF INTERFERON BETA MRNA AND BLOCKS THE HOST INNATE IMMUNE RESPONSE - (Abstract Only)

De Los Santos, T., Botton, S.D., Grubman, M.J. 2005. The Leader Proteinase of Foot-and-Mouth Disease Virus Inhibits the Induction of Interferon Beta mRNA and Blocks the Host Innate Immune Response. American Society for Virology 24th Annual Meeting. P. W3-2.

THE LEADER PROTEINASE OF FOOT-AND-MOUTH DISEASE VIRUS INHIBITS THE INDUCTION OF INTERFERON BETA MRNA AND BLOCKS THE HOST INNATE IMMUNE RESPONSE - (Abstract Only)

De Los Santos, T., De Avila Botton, S., Grubman, M.J. 2005. The Leader Proteinase of Foot-and-Mouth Disease Virus Inhibits the Induction of Interferon Beta mRNA and Blocks the Host Innate Immune Response. European Study Grop on the Molecular Biology of Picornaviruses (ERUOPIC)2005. P. G06.

SHORT HAIRPIN RNA TARGETED TO THE HIGHLY CONSERVED 2B NONSTRUCTURAL PROTEIN CODING REGION INHIBITS REPLICATION OF MULTIPLE SEROTYPES OF FOOT-AND-MOUTH DISEASE VIRUS - (Peer Reviewed Journal)

De Los Santos, T., Wu, Q., Botton, S., Grubman, M.J. 2005. Short Hairpin RNA Targeted to the Highly Conserved 2B Nonstructural Protein Coding Region Inhibits Replication of Multiple Serotypes of Foot-and-Mouth Disease Virus. Virology. 335: P222-231.

RAPID CONTROL OF FOOT-AND-MOUTH DISEASE: IS RNAI A POSSIBLE SOLUTION? - (Review Article)

De Los Santos, T., Grubman, M.J. 2005. Rapid Control of Foot-and-Mouth Disease: Is RNAi a Possible Solution?. Trends in Immunology 26 (2)P 65-68.