Projects

Evaluation of Genetically Engineered Cattle and Refining Techniques for Producing Them Appropriated (D)   Accession Number: 412303

Evergreen Phage Conference 2009 Grant (G)   Accession Number: 418398

Triple Action Chimera: Eradication of Nasal S. Aureus by Cell Wall Hydrolases Reimbursable (R)   Accession Number: 414843

Engineering Bacteriophage Endolysins: Antimicrobials for Mastitis Pathogens That Are Refractory to Resistance Development Reimbursable (R)   Accession Number: 412123

Triple Action Chimera: Eradication of Nasal S. Aureus by Cell Wall Hydrolases Specific Cooperative Agreement (S)   Accession Number: 414971

Publications

Peptidoglycan Hydrolases for Control of Mastitis Pathogens - (Abstract)

Schmelcher, M., Becker, S.C., Foster Frey, J.A., Donovan, D.M. 2009. Peptidoglycan Hydrolases for Control of Mastitis Pathogens. Evergreen International Phage Meeting.

Engineering Antimicrobials Refractory to Resistance - (Abstract)

Becker, S.C., Pohl, C.S., Mohammadi, H., Schmelcher, M., Foster Frey, J.A., Lease, R.A., Don, S., Baker, J.R., Pritchard, D.G., Donovan, D.M. 2009. Engineering Antimicrobials Refractory to Resistance. Evergreen International Phage Meeting.

Peptidoglycan hydrolase fusion to protein transduction domains kill intracellular staphylococci. - (Abstract)

Becker, S.C., Foster Frey, J.A., Willard, R.R., Lease, R.A., Almeida, R., Marriott, I., Dong, S., Baker, J.R., Pritchard, D.G., Donovan, D.M. 2009. Peptidoglycan hydrolase fusion to protein transduction domains kill intracellular staphylococci. Evergreen International Phage Meeting.

Differentially conserved staphylococcal SH3b_5 cell wall binding domains confer increased staphylolytic and streptolytic activity to a streptococcal prophage endolysin domain. - (Peer Reviewed Journal)

Becker, S.C., Foster-Frey, J., Stodola, A.J., Anacker, D., Donovan, D.M., 2009. Differentially conserved staphylococcal SH3b_5 cell wall binding domains confer identical staphylolytic activity to a streptococcal prophage endolysin lytic domain. FEMS Immunology and Medical Microbiology. 443(1-2):32-41.

Antimicrobials for staphylococcal pathogens that are refractory to resistance development - (Abstract)

Becker, S.C., Foster Frey, J.A., Willard, R.R., Lease, R.A., Almeida, R., Marriott, I., Dong, S., Pritchard, D.G., Donovan, D.M. 2009. Antimicrobials for staphylococcal pathogens that are refractory to resistance development. International Symposium on Antimicrobial Peptides.

Expression of Two Bacteriophage Enzymes that Lyse Clostridium perfringens which Share Sequences in the Cell Binding Domain of the Molecules but are Dissimilar in their Catalytic Enzymatic Domain - (Abstract)

Simmons, I.M., Siragusa, G., Donovan, D.M., Seal, B.S. 2009. Expression of Two Bacteriophage Enzymes that Lyse Clostridium perfringens which Share Sequences in the Cell Binding Domain of the Molecules but are Dissimilar in their Catalytic Enzymatic Domain. International Symposium on Antimicrobial Peptides.

Engineering of Peptidoglycan Hydrolases for Control of Pathogenic Bacteria - (Abstract)

Schmelcher, M., Loessner, M.J., Donovan, D.M. 2009. ENGINEERING OF PEPTIDOGLYCAN HYDROLASES FOR CONTROL OF PATHOGENIC BACTERIA. BARC Poster Day.

Antimicrobials for mastitis causing pathogens that are refractory to resistance development - (Abstract)

Becker, S.C., Don, S., Baker, J.R., Foster Frey, J.A., Pritchard, D.G., Donovan, D.M. 2009. Antimicrobials for mastitis causing pathogens that are refractory to resistance development. BARC Poster Day.

Comparison of two bacteriophage derived enzymes with lytic activity against strains of Clostridium perfringens - (Abstract)

Simmons, I.M., Siragusa, G.R., Donovan, D.M., Seal, B.S. 2009. Comparison of two bacteriophage derived enzymes with lytic activity against strains of Clostridium perfringens. American Society for Microbiology.

Peptidoglycan hydrolase enzyme fusions are uniquely suited for treating multi-drug resistant pathogens - (Review Article)

Donovan, D.M., Becker, S.C., Dong, S., Baker, J.R., Foster Frey, J.A., Pritchard, D.G. 2009. Peptidoglycan hydrolase enzyme fusions are uniquely suited for treating multi-drug resistant pathogens. Biotech International 21(2):6-10.

LysK CHAP endopeptidase domain is required for lysis of live staphylococcal cells. - (Peer Reviewed Journal)

Becker, S.C., Don, S., Baker, J.R., Foster Frey, J.A., Pritchard, D.G., Donovan, D.M. 2009. LysK CHAP endopeptidase domain is required for lysis of live staphylococcal cells. FEMS Microbiology Letter. 294(1):52-60.

Significant modulation of mitochondrial electron transport system by nicotine in various rat brain regions - (Peer Reviewed Journal)

Wang, J., Kim, J., Donovan, D.M., Becker, K.G., Li, M.D. 2009. Significant modulation of mitochondrial electron transport system by nicotine in various rat brain regions. Mitochondrion. 9:186-195.

Genome walk of an unknown upstream region of myostatin gene in Spanish goats - (Abstract)

Singh, M., Amoah, E., Kannan, G., Stice, S., Donovan, D.M. 2009. Genome walk of an unknown upstream region of myostatin gene in Spanish goats. Reproductive Biology.

A Novel Use of a Bacteriophage Lysin, PlyC, as a Disinfectant against Streptococcus equi - (Peer Reviewed Journal)

Hoopes, J.T., Stark, C.J., Kim, H.A., Sussman, D.J., Donovan, D.M., Nelson, D.C. 2009. A Novel Use of a Bacteriophage Lysin, PlyC, as a Disinfectant against Streptococcus equi. Applied and Environmental Microbiology. 75(5):1388-94.

Identification of Known Phage Endolysin Genes by Pcr - (Abstract) - (05-Aug-08)

SH3b Cell wall binding domains can enhance anti-staphylococcal activity of endolysin lytic domains. - (Abstract) - (10-Jul-08)

Engineering Antimicrobials that are Refractory to Resistance Development. - (Abstract)

Donovan, D.M., Becker, S.C. 2009. Engineering Antimicrobials that are Refractory to Resistance Development. Meeting Abstract.

Engineering MRSA antimicrobials that are refractory to resistance development - (Abstract)

Becker, S.C., Donovan, D.M., Foster Frey, J.A. 2008. Engineering MRSA antimicrobials that are refractory to resistance development. BARC Poster Day.

Use of a bacteriophage lysin for barnyard decontamination of Streptococcus equi - (Abstract) - (20-Feb-08)

Genotyping Staphylococcus aureus allows one to identify bacteriophages harboring unknow endolysins. - (Abstract)

Donovan, D.M., Abaev, I., Schischkova, N., Myakinina, V., Korobova, O., Pecherskich, E., Kopylov, P., Kiseleva, N. 2008. Genotyping Staphylococcus aureus allows one to identify bacteriophages harboring unknow endolysins. Meeting Abstract.

Chronic nicotine exposure regulates the mitochondrial electron transport system in multiple brain regions of rat - (Abstract)

Wang, J., Kim, J., Donovan, D.M., Becker, K.G., Li, M. 2007. Chronic nicotine exposure regulates the mitochondrial electron transport system in multiple brain regions of rat. Society for Neuroscience Abstracts and Proceedings.

Resolving the database sequence discrepancies for the Staphylococcus aureus bacteriophage phi 11 amidase. - (Peer Reviewed Journal)

Donovan D.M., Foster-Frey J., Garrett W.M., Blomberg, L. 2008. Resolving the database sequence discrepancies for the Staphylococcus aureus bacteriophage phi11 amidase. Journal of Basic Microbiology. 48(1):48-52.

Assessment of the in vitro binding of JHW 007, a dopamine transport inhibitor that blocks the effects of cocaine - (Abstract)

Kopajtic, T.A., Donovan, D.M., Newman, A.H., Katz, J.L. 2007. Assessment of the in vitro binding of JHW 007, a dopamine transport inhibitor that blocks the effects of cocaine. Society for Neuroscience Abstracts and Proceedings.

A summary of staphylococcal C-terminal SH3b_5 cell wall binding domains. - (Abstract)

Donovan, D.M., Stodola, A.J., Annacker, D. 2007. A summary of staphylococcal C-terminal SH3b_5 cell wall binding domains.. Evergreen International Phage Meeting.

Bacteriophage and peptidoglycan degrading enzymes with antimicrobial applications. - (Review Article)

Donovan, D.M. 2007. Bacteriophage and peptidoglycan degrading enzymes with antimicrobial applications. Review Article. Recent Patents on Biotechnology. 1(2):113-122.

Designer Antimicrobials: Peptidoglycan Hydrolase Module Shuffling - (Abstract) - (30-Oct-06)

Bacteriophage Phi11 Endolysin Has Antimicrobial Activity Against the Mastitis Pathogens Staphylococcus Aureus and Coagulase Negative Staphylococcus - (Peer Reviewed Journal)

Donovan, D.M., Foster Frey, J.A. 2006. Bacteriophage phi11 endolysin has antimicrobial activity against the mastitis pathogens staphylococcus aureus and coagulase negative staphylococcus. Applied and Environmental Microbiology. 265(1):133-139.

The Cell Lysis Activity of the Streptococcus Agalactiae Bacteriophage B30 Endolysin Relies on the Chap Endopeptidase DOMAIN. - (Peer Reviewed Journal)

Donovan, D.M., Foster Frey, J.A., Dong, S., Rousseau, G., Moineau, S., Pritchard, D.G. 2006. The cell lysis activity of the streptococcus agalactiae bacteriophage b30 endolysin relies on the chap endopeptidase domain. Applied Environmental Microbiology. 72:5108-5112.

Designer Antimicrobials: Peptidoglycan Hydrolase Module Shuffling - (Abstract)

Donovan, D.M., Dong, S., Garrett, W.M., Foster Frey, J.A., Rousseau, G.M., Moineau, S., Pritchard, D.G. 2006. Designer Antimicrobials: Peptidoglycan Hydrolase Module Shuffling. American Society for Microbiology.

Engineering Disease Resistant Cattle - (Review Article)

Donovan, D.M., Kerr, D.E., Wall, R.J. 2005. Engineering disease resistant cattle. Transgenic Research. 14(5):563-567.

Follicular Expression of a Human Beta-Cell Leukemia/lymphoma-2 (Bcl-2)transgene Does Not Decrease Atresia Or Increase Ovulation Rate in Swine - (Peer Reviewed Journal)

Guthrie, H.D., Wall, R.J., Pursel, V.G., Foster Frey, J.A., Donovan, D.M., Dawson, H.D., Welch, G.R., Garrett, W.M. 2005. Follicular expression of a human B-cell leukemia/lymphoma-2 (Bcl-2)transgene does not decrease atresia or increase ovulation rate in swine. Journal Of Reproduction, Fertility And Development. 17(4):457-468.

Follicular Expression of a Human Beta-Cell Leukemia/lymphoma-2 (Bcl-2)transgene Does Not Decrease Atresia Or Increase Ovulation Rate in Swine - (Abstract)

Guthrie, H.D., Wall, R.J., Pursel, V.G., Donovan, D.M., Welch, G.R., Garrett, W.M. 2004. Follicular expression of a human beta-cell leukemia/lymphoma-2 (bcl-2)transgene does not decrease atresia or increase ovulation rate in swine [abstract]. Society for the Study of Reproduction Annual Meeting. p. 275.

Expression of a Group B Streptococcus Bacteriophage Lysin in Mammalian Cells. - (Abstract)

Donovan, D.M., Wall, R.J., Pritchard, D., Talbot, N.C. 2004. Expression of a group b streptococcus bacteriophage lysin in mammalian cells. [abstract]. American Society for Microbiology. No. M-035.

Identification and Characterization of Metallothionein-1 and 2 Gene Expression in the Context of (±)3,4-Methylenedioxymethamphetamine (Mdma)-Induced Toxicity to Brain Dopaminergic Neurons. - (Abstract)

Xie, T., Tong, L., Mccann, U., Yuan, J., Becker, K., Mechan, A., Cheadle, C., Donovan, D.M., Ricaurte, G. 2004. Identification and characterization of metallothionein-1 and 2 gene expression in the context of (±)3,4-methylenedioxymethamphetamine (mdma)-induced toxicity to brain dopaminergic neurons. Society for Neuroscience Abstracts and Proceedings. 24(32):7043-7050.

Identification and Annotation of 11,363 Clones from a Murine Dopamine Neuron-Specific Cdna Library Using Sequencing and Various Bioinformatics Approaches - (Abstract)

Li, M.D., Zhang, D., Taylor, W., Donovan, D.M., Becker, K.G. 2004. Identification and annotation of 11,363 clones from a murine dopamine neuron-specific cdna library using sequencing and various bioinformatics approaches. [abstract]. Society for Neuroscience Abstracts and Proceedings. 809.10.

Identification and Characterization of Metallothionein-1 and 2 Gene Expression in the Context of (±)3,4-Methylenedioxymethamphetamine (Mdma)-Induced Toxicity to Brain Dopaminergic Neurons - (Peer Reviewed Journal)

Xie, T., Tong, L., Mccann, U., Yuan, J., Becker, K., Mechan, A., Cheadle, C., Donovan, D.M., Ricaurte, A. 2004. Identification and characterization of metallothionein-1 and 2 gene expression in the context of (±)3,4-methylenedioxymethamphetamine (mdma)-induced toxicity to brain dopaminergic neurons. Journal of Neuroscience. 24(32):7043-7050.

Follicular Expression of a Human Beta-Cell Leukemia/lymphoma-2 (Bcl-2)transgene Does Not Decrease Atresia Or Increase Ovulation Rate in Swine. - (Abstract)

Guthrie, H.D., Wall, R.J., Pursel, V.G., Foster Frey, J.A., Donovan, D.M., Welch, G.R., Garrett, W.M. 2004. Follicular expression of a human beta-cell leukemia/lymphoma-2 (bcl-2)transgene does not decrease atresia or increase ovulation rate in swine. Society for the Study of Reproduction Annual Meeting. Abstract. p275.

Microsoft Excel Spread-Sheet Based Animal Colony Management for Genetically Altered Mouse Strains. - (Peer Reviewed Journal)

Donovan, D.M., Rowley, D.L., Williams, N.G. 2004. Microsoft excel spread-sheet based animal colony management for genetically altered mouse strains. Biotechniques. 37(1):50-56.

Role of U-Opioid Receptors in Formalin-Induced Pain Behavior in Mice - (Peer Reviewed Journal)

Zhao, C., Tao, Y., Tall, J.M., Donovan, D.M., Meyer, R.A., Raja, S.N. Role of u-opioid receptors in formalin-induced pain behavior in mice. Journal of Experimental Neurology. 2003. 184(2):839-45.

Microarray Analysis Reveals Interleukin-6 As a Novel Secretory Product of the Hypothalamo-Neurohypophyseal. - (Peer Reviewed Journal)

Ghorbel, M.T., Sharman, G., Leroux, M., Barrett, T., Donovan, D.M., Becker, K.G., Murphy, D. Microarray analysis reveals interleukin-6 as a novel secretory product of the hypothalamo-neurohypophyseal.. Journal of Biological Chemistry.2003 MAY 23; 278(21):19280-5. EPUB 2003 MARCH 14