Projects

Functional Genomics and Genetic Analysis of the Innate Immune Response Required to Resist Food-Borne Bacterial Infections in Poultry Appropriated (D)   Accession Number: 410231

Development of a Disease Model for Gangrenous Dermatitis in Broilers, and An Evaluation of Cobb Chickens to the Disease Trust (T)   Accession Number: 414953

Use of Cationic Peptides As Feed Additives to Improve Innate Immunity & Reduce Gut Colonization with Salmonella and Campylobacter in Weaned Trust (T)   Accession Number: 416649

Publications

Chicken scavenger receptors and their ligand-induced cellular immune responses - (Peer Reviewed Journal)

He, H., MacKinnon, K.M., Genovese, K.J., Nerren, J.R., Swaggerty, C.L., Nisbet, D.J., Kogut, M.H. Chicken scavenger receptors and their ligand-induced cellular immune responses. Molecular Immunology. 46:2218-2225.

Selection of broilers with improved innate immune responsiveness to reduce on-farm infection by foodborne pathogens: A review - (Peer Reviewed Journal)

Swaggerty, C.L., Pevzner, I.Y., He, H., Genovese, K.J., Nisbet, D.J., Kaiser, P., Kogut, M.H. 2009. Selection of broilers with improved innate immune responsiveness to reduce on-farm infection by foodborne pathogens: A review. Foodborne Pathogens and Disease. 6:1-7.

Differential AP-1 and NF-kB expression in polymorphonuclear cells from a non-mammalian species following TLR4-mediated stimulation - (Abstract)

Swaggerty, C.L., Street, M.R., Kogut, M.H. 2009. Differential AP-1 and NF-kB expression in polymorphonuclear cells from a non-mammalian species following TLR4-mediated stimulation [abstract]. Keystone Symposia: Pattern Recognition Molecules and Immune Senors of Pathogens, March 29-April 3, 2009, Banff, Alberta. p. 127.

Expression profile of toll-like receptors within the gastrointestinal tract of 2-day-old Salmonella enteriditis-infected broiler chickens - (Peer Reviewed Journal)

MacKinnon, K.M., He, H., Nerren, J.R., Swaggerty, C.L., Genovese, K.J., Kogut, M.H. 2009. Expression profile of toll-like receptors within the gastrointestinal tract of 2-day-old Salmonella enteriditis-infected broiler chickens. Infection and Immunity. 137:313-319.

An immunologist's perspective on nutrition, immunity and infectious diseases: Introduction and overview - (Peer Reviewed Journal)

Kogut, M.H., Klasing, K. 2009. An immunologist's perspective on nutrition, immunity and infectious diseases: Introduction and overview. Journal of Applied Poultry Research. 18:103-110.

Impact of nutrition on the innate immune response to infection in poultry - (Peer Reviewed Journal)

Kogut, M.H. 2009. Impact of nutrition on the innate immune response to infection in poultry. Journal of Applied Poultry Research. 18:111-124.

Differential mRNA expression of the avian-specific toll-like receptor 15 between heterophils from Salmonella-susceptible and -resistant chickens - (Peer Reviewed Journal)

Nerren, J.R., Swaggerty, C.L., MacKinnon, K.M., Genovese, K.J., He, H., Pevzner, I., Kogut, M.H. 2009. Differential mRNA expression of the avian-specific toll-like receptor 15 between heterophils from Salmonella-susceptible and -resistant chickens. Immunogenetics. 61:71-77.

In ovo treatment with CpG oligodeoxynucleotides decreases colonization of Salmonella enteriditis - (Peer Reviewed Journal)

MacKinnon, K.M., He, H., Swaggerty, C.L., McReynolds, J.L., Genovese, K.J., Duke, S.E., Nerren, J.R., Kogut, M.H. 2009. In ovo treatment with CpG oligodeoxynucleotides decreases colonization of Salmonella enteriditis. Veterinary Immunology and Immunopathology. 127:371-375.

Genome-wide gene expression profiling of chicken spleen responding to Campylobacter jejuni infection in broilers - (Abstract)

Li, X., Swaggerty, C.L., Kogut, M.H., Chiang, H., Ying, W., Genovese, K.J., He, H., Pevzner, I., Zhou, H. 2009. Genome-wide gene expression profiling of chicken spleen responding to Campylobacter jejuni infection in broilers [abstract]. Plant & Animal Genome XVII Conference, January 10-14, 2009, San Diego, California. p. 511.

Gene expression profiling of innate immune response to Campylobacter jejuni infection in the bursa of broilers - (Abstract)

Li, X., Swaggerty, C.L., Kogut, M.H., Chiang, H., Ying, W., Genovese, K.J., He, H., Kirita, V.J., Pevzner, I., Zhou, H. 2009. Gene expression profiling of innate immune response to Campylobacter jejuni infection in the bursa of broilers [abstract]. Plant & Animal Genome XVII Conference, January 10-14, 2009, San Diego, California. p. 509.

The selective Dectin-1 agonist, curdlan, induces an oxidative burst response in chicken heterophils and peripheral blood mononuclear cells - (Peer Reviewed Journal)

Nerren, J.R., Kogut, M.H. 2009. The selective Dectin-1 agonist, curdlan, induces an oxidative burst response in chicken heterophils and peripheral blood mononuclear cells. Veterinary Immunology and Immunopathology. 127:162-166.

Gene expression profiling in chicken heterophils with Salmonella enteritidis stimulation using a chicken 44 K Agilent microarray - (Peer Reviewed Journal)

Chiang, H., Swaggerty, C.L., Kogut, M.H., Dowd, S.E., Li, X., Pevzner, I.Y., Zhou, H. 2008. Gene expression profiling in chicken heterophils with Salmonella enteritidis stimulation using a chicken 44 K Agilent microarray. Biomed Central (BMC) Genomics. 9:Article 526.

Profiling pro-inflammatory cytokine and chemokine mRNA expression levels as a novel method for selection of increased innate immune responsiveness - (Peer Reviewed Journal)

Swaggerty, C.L., Pevzner, I.Y., Kaiser, P., Kogut, M.H. 2008. Profiling pro-inflammatory cytokine and chemokine mRNA expression levels as a novel method for selection of increased innate immune responsiveness. Veterinary Immunology and Immunopathology. 126(1-2):35-42.

Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2-dependent activation of AP-1 and NF-kappaB signaling pathways - (Peer Reviewed Journal)

Kogut, M.H., Genovese, K.J., He, H., Kaiser, P. 2008. Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2-dependent activation of AP-1 and NF-kappaB signaling pathways. Innate Immunity. 14:213-222.

The paternal effect of Campylobacter jejuni colonization in ceca in broilers - (Peer Reviewed Journal)

Li, X., Swaggerty, C.L., Kogut, M.H., Chiang, H., Wang, Y., Genovese, K.J., He, H., Stern, N.J., Pevzner, I.Y., Zhou, H. 2008. The paternal effect of Campylobacter jejuni colonization in ceca in broilers. Poultry Science. 87:1742-1747.

Phospholipase C, phosphatidylinositol 3-kinase, and intracellular [Ca2+] are involved in activation of chicken HD11 macrophage by CpG oligodeoxynucleotide - (Peer Reviewed Journal)

He, H., Genovese, K.J., Nisbet, D.J., Kogut, M.H. 2008. Phospholipase C, phosphatidylinositol 3-kinase, and intracellular [Ca2+] are involved in activation of chicken HD11 macrophage by CpG oligodeoxynucleotide. Developmental and Comparative Immunology. 32(10):1111-1118.

Differential induction of nitric oxide, degranulation, and oxidative burst activities in response to microbial agonist stimulation in monocytes and heterophils from young commercial turkeys - (Peer Reviewed Journal)

He, H., Genovese, K.J., Swaggerty, C.L., Nisbet, D.J., Kogut, M.H. 2008. Differential induction of nitric oxide, degranulation, and oxidative burst activities in response to microbial agonist stimulation in monocytes and heterophils from young commercial turkeys. Veterinary Immunology and Immunopathology. 123(3-4):177-185.

Gene expression profiling of heterophils from Salmonella-resistant and -susceptible chickens using a 44K agilent microarray - (Abstract)

Swaggerty, C.L., Chiang, H.I., Zhou, H., Li, X., Pevzner, I.Y., Kogut, M.H. 2007. Gene expression profiling of heterophils from Salmonella-resistant and-susceptible chickens using a 44K agilent microarray [abstract]. In: Proceedings of the Society for Leukocyte Biology, October 11-13, 2007, Cambridge, Massachusetts. p. 20.

Salmonella induces SRC protein tyrosine kinase, c-Jun N-terminal kinase (JNK), and NF-kappaBp65 signaling pathways in commercial and wild-type turkey leukocytes - (Abstract)

Genovese, K.J., He, H., McReynolds, J.L., Swaggerty, C.L., Nisbet, D.J., Kogut, M.H. 2007. Salmonella induces SRC protein tyrosine kinase, c-Jun N-terminal kinase (JNK), and NF-kappaBp65 signaling pathways in commercial and wild-type turkey leukocytes [abstract]. In: Proceedings of the Society for Leukocyte Biology, October 11-13, 2007, Cambridge, Massachusetts. p. 58.

Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by NF-kappaB and AP-1 pathways - (Abstract)

Kogut, M.H., Genovese, K.J., He, H. 2007. Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by NF-kappaB and AP-1 pathways [abstract]. In: Proceedings of the Society for Leukocyte Biology, October 11-13, 2007, Cambridge, Massachusetts. p. 57.

Innate immune responses to microbial agonist stimulations in heterophils and monocytes from young commercial turkeys - (Abstract)

He, H., Genovese, K.J., Kogut, M.H. 2007. Innate immune responses to microbial agonist stimulations in heterophils and monocytes from young commercial turkeys [abstract]. In: Proceedings of World Veterinary Poultry Association, September 10-15, 2007, Beijing, China. p. 593.

Dynamics of the avian inflammatory response to Salmonella following administration of the toll-like receptor 5 agonist flagellin - (Peer Reviewed Journal)

Genovese, K.J., He, H., Lowry, V.K., Nisbet, D.J., Kogut, M.H. 2007. Dynamics of the avian inflammatory response to Salmonella following administration of the toll-like receptor 5 agonist flagellin. FEMS Immunology and Medical Microbiology. 51(1):112-117.

Immune stimulatory CpG oligodeoxynucleotides reduces Salmonella enterica subsp. Arizonae organ colonization and mortality in young turkeys - (Abstract)

He, H., Genovese, K.J., Swaggerty, C.L., Kogut, M.H. 2007. Immune stimulatory CpG oligodeoxynucleotides reduces Salmonella enterica subsp. Arizonae organ colonization and mortality in young turkeys [abstract]. Poultry Science. 86:300.

CpG oligodeoxynucleotide and double-stranded RNA synergize inflammatory cytokine gene expressions in chicken monocytes - (Abstract)

He, H., Genovese, K.J., Kogut, M.H. 2007. CpG oligodeoxynucleotide and double-stranded RNA synergize inflammatory cytokine gene expressions in chicken monocytes [abstract]. The Journal of Immunology. 178:90.13.

In vivo priming heterophil innate immune functions and increasing resistance to Salmonella enteritidis infection in neonatal chickens by immune stimulatory CpG-ODN - (Peer Reviewed Journal)

He, H., Genovese, K.J., Swaggerty, C.L., Nisbet, D.J., Kogut, M.H. 2007. In vivo priming heterophil innate immune functions and increasing resistance to Salmonella enteritidis infection in neonatal chickens by immune stimulatory CpG-ODN oligodeoxynucleotides. Veterinary Immunology and Immunopathology. 117:275-283.

The effects of BT/TAMUS 2032 cationic peptide on innate immunity and susceptibility of young chickens to extraintestinal Salmonella enterica serovar Enteritidis infection - (Peer Reviewed Journal)

Kogut, M.H., Genovese, K.J., He, H., Li, M.A., Jiang, Y.W. 2007. The effects of BT/TAMUS 2032 cationic peptides on innate immunity and susceptibility of young chickens to extraintestinal Salmonella enterica serovar Enteritidis infection. International Immunopharmacology. 7:912-919.

Synergy of CpG oligodeoxynucleotide and double-stranded RNA (poly I:C) on nitric oxide induction in chicken peripheral blood monocytes - (Peer Reviewed Journal)

He, H., Genovese, K.J., Nisbet, D.J., Kogut, M.H. 2007. Synergy of CpG oligodeoxynucleotide and double-stranded RNA (poly I:C) on nitric oxide induction in chicken peripheral blood monocytes. Molecular Immunology. 44:3234-3242.

Measurement of avian cytokines with real time RT-PCR following infection with avian influenza - (Book/Chapter)

Kapczynski, D.R., Kogut, M.H. 2008. Measurement of avian cytokines with real time RT-PCR following infection with avian influenza. In: Spackman, E., editor. Avian Influenza Virus. Totowa, NJ: Humana Press, Inc. p. 122-129.

Protein tyrosine and mitogen activated kinase activities in turkey heterophils isolated from commercial and wild-type turkeys - (Peer Reviewed Journal)

Genovese, K.J., He, H., Lowry, V.K., Kogut, M.H. 2007. Comparison of MAP and tyrosine kinase signaling in heterophils from commercial and wild-type turkeys. Developmental and Comparative Immunology. 31:927-933.

Use of toll-like receptor agonists to reduce Salmonella colonization in neonatal swine - (Proceedings/Symposium)

Genovese, K.J., He, H., Nisbet, D.J., Kogut, M.H. 2007. Use of toll-like receptor agonists to reduce Salmonella colonization in neonatal swine. In: Proceedings of 7th International Safepork Symposium, May 9-11, 2007, Verona, Italy. p. 244-247.

Comparison of Erk 1/2, P38 Mapk, and Ptk Kinase Activity in Heterophils from Wild-Type Turkeys to Activity in Heterophils from a Commercial Turkey Line - (Abstract)

Genovese, K.J., Lowry, V.K., He, H., Nisbet, D.J., Kogut, M.H. 2006. Comparison of ERK1/2, p38 MAPK, and PTK activity in heterophils from wild-type turkeys to heterophils from a commercial turkey line [abstract]. Innate Immunity Keystone Symposia. p. 60.

Differential JAK response in polymorphonuclear cells from a non-mammalian species following exposure to Salmonella enteritidis - (Abstract)

Swaggerty, C.L., Pevzner, I.Y., Kogut, M.H. 2007. Differential JAK response in polymorphonuclear cells from a non-mammalian species following exposure to Salmonella enteritidis [abstract]. In: Proceedings of Keystone Symposia on Molecular and Cellular Biology - Jaks, Stats and Immunity, January 5-10, 2007, Steamboat Springs, Colorado. p. 66.

The Feathering Gene Is Linked to Degranulation and Oxidative Burst Not Cytokine/chemokine Mrna Expression Levels Or Salmonella Enteritidis Organ Invasion in Broilers - (Peer Reviewed Journal)

Swaggerty, C.L., He, H., Genovese, K.J., Kaiser, P., Pevzner, I.Y., Kogut, M.H. 2006. The feathering gene is linked to degranulation and oxidative burst not cytokine/chemokine mRNA expression levels or Salmonella enteritidis organ invasion in broilers. Avian Pathology. 35:465-470.

Flagellin and Lipopolysaccharide Stimulate the Mek-Erk Signaling Pathway in Chicken Heterophils Through Differential Activation of the Small Gtpases, Ras and Rap1 - (Peer Reviewed Journal)

Kogut, M.H., Genovese, K.J., He, H. 2006. Flagellin and lipopolysaccharide stimulate the MEK-ERK signaling pathway in chicken heterophils through differential activation of the small GTPases, Ras and Rap1. Molecular Immunology. 44:1729-1736.

Involvement of Phosphatidylinositol-Phospholipase C in Immune Response to Salmonella Lipopolysacharide in Chicken Macrophage Cells (Hd11) - (Peer Reviewed Journal)

He, H., Genovese, K.J., Nisbet, D.J., Kogut, M.H. 2006. Involvement of phosphatidylinositol-phospholipase C in immune response to Salmonella lipopolysacharide in chicken macrophage cells (HD11). International Immunopharmacology. 6:1780-1787.

Functional Analysis of Chicken Myd88 in Toll-Like Receptor Mediated Innate Immune Responses by Using Antisense Oligonucleotides - (Abstract)

He, H., Genovese, K.J., Kogut, M.H. 2006. Functional analysis of chicken MyD88 in toll-like receptor mediated innate immune responses by using antisense oligonucleotides [abstract]. In: Proceedings of 09th Avian Immunology Research Group Meeting, October 21-24, 2006, Paris, France. p. 20.

Prophylactic Application of Immune Stimulatory Cpg-Odn Reduces Salmonella Enterica Subsp. Arizonae Organ Colonization and Mortality in Young Turkeys - (Abstract)

He, H., Genovese, K.J., Swaggerty, C.L., Kogut, M.H. 2006. Prophylactic application of immune stimulatory CpG-ODN reduces Salmonella enterica subsp. Arizonae organ colonization and mortality in young turkeys [abstract]. American Society for Microbiology. p. 67.

Nitric Oxide Synthesis and Cytokine Gene Expression in Chicken Monocytes Stimulated with Cpg-Odn and Double-Stranded Rna - (Abstract)

He, H., Genovese, K.J., Kogut, M.H. 2006. Nitric oxide synthesis and cytokine gene expression in chicken monocytes stimulated with CpG-ODN and double-stranded RNA [abstract]. In: Proceedings of 09th Avian Immunology Research Group Meeting, October 21-24, 2006, Paris, France. p. 29.

Differential Heterophil Intracellular Signaling and Functions in Wild-Type and Commercial Turkeys - (Abstract)

Genovese, K.J., He, H., Swaggerty, C.L., Kogut, M.H. 2006. Differential heterophil intracellular signaling and functions in wild-type and commercial turkeys [abstract]. In: Proceedings of 09th Avian Immunology Research Group Meeting, October 21-24, 2006, Paris, France. p. 51.

In Vivo Effects of Salmonella Flagellin Administration to Day-Old Chickens - (Abstract)

Genovese, K.J., He, H., Kogut, M.H. 2006. In vivo effects of Salmonella flagellin administration to day-old chickens [abstract]. American Society for Microbiology. p. 43.

Response of Nitric Oxide Production to Cpg Oligodeoxynucleotides in Turkey and Chicken Peripheral Blood Monocytes - (Peer Reviewed Journal)

He, H., Genovese, K.J., Lowry, V.K., Nisbet, D.J., Kogut, M.H. 2006. Response of nitric oxide production to CpG oligodeoxynucleotides in turkey and chicken peripheral blood monocytes. FEMS Immunology and Medical Microbiology. 48:99-106.

Tamus Cationic Peptides Decrease Susceptibility of Young Chickens to Salmonella Enterica Serovar Enteritidis Infection by Up-Regulation of the Innate Immune Response - (Abstract)

Kogut, M.H., Genovese, K.J., He, H., Jiang, Y. 2006. TAMUS cationic peptides decrease susceptibility of young chickens to Salmonella enterica serovar Enteritidis infection by up-regulation of the innate immune response [abstract]. American Society for Microbiology. p. 43.

Flagellin and Lipopolysaccharide Stimulate the Mek-Erk Signaling Pathway in Chicken Heterophils Through Differential Activation of the Small Gtpases, Ras and Rap1 - (Abstract)

Kogut, M.H., Genovese, K.J., He, H. 2006. Flagellin and lipopolysaccharide stimulate the MEK-ERK signaling pathway in chicken heterophils through differential activation of the small GTPases, Ras and Rap1 [abstract]. In: Proceedings of 09th Avian Immunology Research Group Meeting, October 21-24, 2006, Paris, France. p. 97.

The Feathering Gene Is Linked to Degranulation and Oxidative Burst Not Cytokine/chemokine Expression Or Salmonella Enteritidis Organ Invasion in Broilers - (Abstract)

Swaggerty, C.L., He, H., Genovese, K.J., Kaiser, P., Pevzner, I.Y., Kogut, M.H. 2006. The feathering gene is linked to degranulation and oxidative burst not cytokine/chemokine expression or Salmonella enteritidis organ invasion in broilers [abstract]. In: Proceedings of 09th Avian Immunology Research Group Meeting, October 21-24, 2006, Paris, France. p. 58.

Interaction of Bacterial Cpg-Odn and Viral Double-Stranded Rna (Poly I:c) on the Innate Immune Responses in Chicken Monocytes - (Abstract)

He, H., Genovese, K.J., Kogut, M.H. 2006. Interaction of bacterial CpG-ODN and viral double-stranded RNA (poly I:C) on nitric oxide synthesis and cytokine gene expression in chicken monocytes [abstract]. 10th International Congress of Developmental and Comparative Immunology. p. 122.

Flagellin and Lps Stimulate the Mek-Erk Signaling Pathway in Chicken Heterophils Through Differential Activation of the Small Gtpases, Ras, & Rap1 - (Abstract)

Kogut, M.H., Genovese, K.J., He, H. 2006. Flagellin and LPS stimulate the MEK-ERK signaling pathway in chicken heterophils through differential activation of the small GTPases, Ras, & Rap1 [abstract]. 10th International Congress of Developmental and Comparative Immunology. p. 140.

Cell Signaling and Host Innate Immune Defenses in Wild-Type and Commercial Turkeys - (Abstract)

Genovese, K.J., He, H., Lowry, V.K., Swaggerty, C.L., Nisbet, D.J., Kogut, M.H. 2006. Cell signaling and host innate immune defenses in wild-type and commercial turkeys [abstract]. 10th International Congress of Developmental and Comparative Immunology. p. 110.

The Feathering Gene Influences Degranulation and Oxidative Burst But Not Cytokine/chemokine Mrna Expression Or Salmonella Enteritidis Organ Invasion in Broilers - (Abstract)

Swaggerty, C.L., He, H., Genovese, K.J., Kaiser, P., Pevzner, I.Y., Kogut, M.H. 2006. The feathering gene influences degranulation and oxidative burst but not cytokine/chemokine mRNA expression or Salmonella enteritidis organ invasion in broilers [abstract]. In: Proceedings of 10th International Congress of Developmental and Comparative Immunology, July 1-6, 2006, Charleston, South Carolina. p. 236.

Comparison of Heterophil Functions of Modern Commercial and Wild-Type Rio Grande Turkeys - (Peer Reviewed Journal)

Genovese, K.J., He, H., Lowry, V.K., Swaggerty, C.L., Kogut, M.H. 2006. Comparison of heterophil functions of modern commercial and wild-type Rio Grande turkeys. Avian Pathology. 35:217-223.

Heterophil Cytokine Mrna Profile from Genetically Distinct Lines of Chickens with Differential Heterophil-Mediated Innate Immune Responses - (Peer Reviewed Journal)

Swaggerty, C.L., Kaiser, P., Rothwell, L., Pevzner, I., Kogut, M.H. 2006. Heterophil cytokine mRNA profiles from genetically distinct lines of chickens with differential heterophil-mediated innate immune responses. Avian Pathology. 35:102-108.

Phosphatidylinositol-Phospholipase C Modulates Tlr4-Mediated Immune Responses to Salmonella Lipopolysaccharide in Chicken Macrophage Cells (Hd11) - (Abstract)

He, H., Genovese, K.J., Kogut, M.H. 2006. Phosphatidylinositol-phospholipase C modulates TLR4-mediated immune responses to Salmonella lipopolysaccharide in chicken macrophage cells (HD11) [abstract]. Innate Immunity Keystone Symposia. p. 65.

Stimulation of Avian Heterophils by Different Tlr Agonists Induce Ras-Dependent and Ras-Independent Activation of Erk Signaling - (Abstract)

Kogut, M.H., Genovese, K.J., He, H. 2006. Stimulation of avian heterophils by different toll-like agonists induce Ras-dependent and Ras-independent activation of ERK signaling [abstract]. Innate Immunity Keystone Symposia. p. 70.

Bacterial Cpg-Dna and Viral Double-Stranded Rna Synergize Innate Immune Responses in Monocytes from Neonatal Chickens - (Abstract)

He, H., Genovese, K.J., Kogut, M.H. 2005. Bacterial CpG-DNA and viral double-stranded RNA synergize innate immune responses in monocytes from neonatal chickens [abstract]. Cell Research. 15(Suppl. 10):249.

Expression of Toll-Like Receptors and Differential Activation of Nitric Oxide Synthase by Toll-Like Receptor Agonists on Monocytes from Neonatal Chickens - (Peer Reviewed Journal)

He, H., Genovese, K.J., Nisbet, D.J., Kogut, M.H. 2006. Profile of toll-like receptor expressions and induction of nitric oxide synthesis by toll-like receptor agonists in chicken monocytes. Molecular Immunology. 43:783-789.

Avian Polymorphonuclear Cells Contribute to a Differential Innate Immune Response in Genetically Defined Chickens - (Abstract)

Swaggerty, C.L., Lowry, V.K., Pevzner, I.Y., Kogut, M.H. 2005. Avian polymorphonuclear cells contribute to a differential innate immune response in genetically defined chickens [abstract]. Journal of Leukocyte Biology. (Suppl. 2005):38.

Effect of Cpg on Swine Neutrophils and Use Against Salmonella in Pigs - (Proceedings/Symposium)

Genovese, K.J., He, H., Lowry, V., Kogut, M.H. 2005. Effect of CpG on swine neutrophils and use against Salmonella in pigs. Proceedings of SafePork 2005. p. 271-273.

Lipopolysaccahride-Binding Protein/cd14/tlr4-Dependent Recognition of Salmonella Lps Induces the Functional Activation of Chicken Heterophils and Up-Regulation of Pro-Inflammatory Cytokine & Chemokine Gene Expression in Cells - (Peer Reviewed Journal)

Kogut, M.H., He, H., Kaiser, P. 2005. Lipopolysaccahride-binding protein/CD14/TLR4-dependent recognition of Salmonella LPS induces the functional activation of chicken heterophils and up-regulation of pro-inflammatory cytokine and chemokine gene expression in cells. Animal Biotechnology. 16:165-181.

Lipolysaccharide Binding Protein/cd14/tlr4-Dependent Recognition of Salmonella-Lps Induces the Functional Activation and Up-Regulation of Pro-Inflammatory Cytokine and Chemokine Gene Expression in Chicken Heterophils - (Abstract)

Kogut, M.H., He, H., Kaiser, P. 2005. Lipolysaccharide binding protein/CD14/TLR4-dependent recognition of Salmonella-LPS induces the functional activation and up-regulation of pro-inflammatory cytokine and chemokine gene expression in chicken heterophils [abstract]. Chicken Genomics and Development. p. 34.

Differential Cytokine Mrna Expression by Heterophils Isolated from Chickens That Vary in Susceptibility to Diverse Pathogens - (Abstract)

Swaggerty, C.L., Kogut, M.H., Pevzner, I.Y., Kaiser, P. 2005. Differential cytokine mRNA expression by heterophils isolated from chickens that vary in susceptibility to diverse pathogens [abstract]. Chicken Genomics and Development. p. 44.

Use of Antisense Oligonucleotides As a Functional Genomic Research Tool to Elucidate Role of Chicken Myd88 in Toll-Like Receptor Mediated Innate Immune Responses in Vitro - (Abstract)

He, H., Genovese, K.J., Kogut, M.H. 2005. Use of antisense oligonucleotides as a functional genomic research tool to elucidate role of chicken MyD88 in toll-like receptor mediated innate immune responses in vitro [abstract]. Chicken Genomics and Development. p. 28.

The Impact of Innate Immunity on Disease Resistance and Susceptibility in Poultry - (Proceedings/Symposium)

Kogut, M.H. 2005. The impact of innate immunity on disease resistance and susceptibility in poultry. XXX Convencion Anual de ANECA, April 27-30, 2005, Puerto Vallarta, Mexico. 2005 CDROM.

Expression and Function of Toll-Like Receptors in Chicken Heterophils - (Peer Reviewed Journal)

Kogut, M.H., Iqbal, M., He, H., Philbin, V., Kaiser, P., Smith, A. 2005. Expression and function of toll-like receptors in chicken heterophils. Developmental and Comparative Immunology. 29:791-807.

Disparity in Susceptibility to Vancomycin-Resistant Enterococcus Organ Invasion in Commercial Broiler Chickens That Differ in Innate Immune Responsiveness - (Peer Reviewed Journal)

Swaggerty, C.L., Lowry, V.K., Ferro, P.J., Pevzner, I.Y., Kogut, M.H. 2005. Disparity in susceptibility to vancomycin-resistant Enterococcus organ invasion in commercial broiler chickens that differ in innate immune responsiveness. Food and Agricultural Immunology. 16:1-15.

Interferon-Gamma Upregulates the Expression of Proinflammatory and Th1 Cytokine Mrna in Chicken Heteropils During Receptor-Mediated Phagocytosis of Opsonized and Nonopsonized Salmonella Enterica Serovar Enteritidis - (Peer Reviewed Journal)

Kogut, M.H., Rothwell, L., Kaiser, P. 2005. IFN-y priming of chicken heterophils upregulates the expression of proinflammatory and TH1 cytokine mRNA following receptor-mediated phagocytosis of Salmonella enterica serovar enteritidis. Journal of Interferon and Cytokine Research. 25:73-81.

Expression of Toll-Like Receptors and Differential Activation of Nitric Oxide Synthase by Toll-Like Receptor Agonists in Monocytes from Neonatal Chicken - (Abstract)

He, H., Kogut, M.H. 2005. Expression of toll-like receptors and differential activation of nitric oxide synthase by toll-like receptor agonists in monocytes from neonatal chicken [abstract]. Innate Immunity to Pathogens Keystone Symposium. p. 49.

Use of Cpg Oligodeoxynucleotides to Stimulate Porcine Neutrophils in Vitro and to Reduce Salmonella Choleraesuis Colonization in Vivo - (Abstract)

Genovese, K.J., He, H., Lowry, V.K., Kogut, M.H. 2005. Use of CpG oligodeoxynucleotides to stimulate porcine neutrophils in vitro and to reduce Salmonella choleraesuis colonization in vivo [abstract]. Innate Immunity to Pathogens Keystone Symposium. p. 48.

Heterophils Are Associated with Resistance to Systemic Salmonella Enteritidis Infections in Genetically Distinct Chicken Lines - (Peer Reviewed Journal)

Swaggerty, C.L., Ferro, P.J., Pevzner, I.Y., Kogut, M.H. 2005. Heterophils are associated with resistance to systemic Salmonella enteritidis infections in genetically distinct chicken lines. FEMS Immunology and Medical Microbiology. 43:149-154.

Recombinant Chicken Il-6 Does Not Activate Heterophils Isloated from Day-Old Chickens in Vitro - (Peer Reviewed Journal)

Ferro, P.J., Swaggerty, C.L., He, H., Rothwell, L., Kaiser, P., Kogut, M.H. 2005. Recombinant chicken IL-6 does not activate heterophils isloated from day-old chickens in vitro. Developmental and Comparative Immunology. 29:375-383.

In Vitro Activation of Chicken Leukocytes and in Vivo Protection Against Salmonella Enteritidis Organ Invasion and Peritoneal S. Enteritidis Infection-Induced Mortality in Neonatal Chickens by Immunostimulatory Cpg Oligodeoxy - (Peer Reviewed Journal)

He, H., Lowry, V.K., Swaggerty, C.L., Ferro, P.J., Kogut, M.H. 2004. In vitro activation of chicken leukocytes and in vivo protection against Salmonella enteritidis organ invasion and peritoneal S. enteritidis infection-induced mortality in neonatal chickens by immunostimulatory CpG oligodeoxynucleotide. FEMS Immunology and Medical Microbiology. 43:81-89.

Cpg-Oligodeoxynucleotide-Stimulated Chicken Heterophil Degranulation Is Serum Cofactor and Cell Surface Receptor Dependent - (Peer Reviewed Journal)

He, H., Lowry, V.K., Ferro, P.J., Kogut, M.H. 2005. CpG-oligodeoxynucleotide-stimulated chicken heterophil degranulation is serum cofactor and cell surface receptor dependent. Developmental and Comparative Immunology. 29:255-264.

Purified Beta-Glucan As An Abiotic Feed Additive Up-Regulates the Innate Immune Response in Immature Chickens Against Salmonella Enterica Serovar Enteritidis - (Peer Reviewed Journal)

Lowry, V.K., Farnell, M.B., Ferro, P.J., Swaggerty, C.L., Bahl, A., Kogut, M.H. 2005. Purified beta-glucan as an abiotic feed additive up-regulates the innate immune response in immature chickens against Salmonella enterica serovar enteritidis. International Journal of Food Microbiology. 98:309-318.

Differential Cytokine Mrna Expression in Heterophils Isolated from Salmonella-Resistant and -Susceptible Chickens - (Peer Reviewed Journal)

Swaggerty, C.L., Kogut, M.H., Ferro, P.J., Rothwell, L., Pevzner, I.Y., Kaiser, P. 2004. Differential cytokine mRNA expression in heterophils isolated from Salmonella-resistant and -susceptible chickens. Immunology. 113:139-148.

Cpg-Oligodeoxynucleotide-Stimulated Chicken Heterophil Degranulation Is Serum Cofactor and Cell Surface Receptor-Dependent - (Abstract)

He, H., Kogut, M.H. 2004. CpG-oligodeoxynucleotide-stimulated chicken heterophil degranulation is serum cofactor- and cell surface receptor-dependent [abstract]. 8th Avian Immunology Research Group Meeting. p. 78.

Up-Regulation of Nitric Oxide Synthesis by Tlr9 Agonist Cpg Oligodeoxynucleotide in Chicken Monocytes Via Activation of Erk, P38 Mapk, Jnk, and Nf-Kappab Signal Pathways - (Abstract)

He, H., Kogut, M.H. 2004. Up-regulation of nitric oxide synthesis by TLR9 agonist CpG oligodeoxynucleotide in chicken monocytes via activation of ERK, p38 MAPK, JNK, and NF-kappaB signal pathways [abstract]. 8th Avian Immunology Research Group Meeting. p. 77.

Heterophil Toll-Like Receptors: Recognition, Signaling and Functional Activation - (Abstract)

Kogut, M.H., Iqbal, M., He, H., Philbin, V., Kaiser, P., Smith, A. 2004. Heterophil toll-like receptors: Recognition, signaling and functional activation [abstract]. 7th International Veterinary Immunology Symposium. p. 395.

Heterophils Isolated from Chickens Resistant to Extraintestinal Salmonella Enteritidis Infection Express Higher Levels of Pro-Inflammatory Cytokine Mrna Following Infection Than Heterophils from Susceptible Chickens - (Peer Reviewed Journal)

Ferro, P.J., Swaggerty, C.L., Kaiser, P., Pevzner, I.Y., Kogut, M.H. 2004. Heterophils isolated from chickens resistant to extra-intestinal Salmonella enteritidis infection express higher levels of pro-inflammatory cytokine mRNA following infection than heterophils from susceptible chickens. Epidemiology and Infection. 132:1029-1037.

Differential Cytokine Mrna Expression by Heterophils Isolated from Chickens That Vary in Their Susceptibility to Diverse Pathogens - (Abstract)

Swaggerty, C.L., Kogut, M.H., Ferro, P., Rothwell, L., Pevzner, I.Y., Kaiser, P. 2004. Differential cytokine mRNA expression by heterophils isolated from chickens that vary in their susceptibility to diverse pathogens [abstract]. 8th Avian Immunology Research Group Meeting. p. 22.

Expression and Function of Toll-Like Receptors in Chicken Heterophils - (Abstract)

Kogut, M.H., Iqbal, M., He, H., Philbin, V., Kaiser, P., Smith, A. 2004. Expression and function of toll-like receptors in chicken heterophils [abstract]. 8th Avian Immunology Research Group Meeting. p. 23.

Characterization of the Heterophil, the Avian Neutrophil Equivalent - (Abstract)

Kaiser, P., Rothwell, L., Swaggerty, C.L., Ferro, P., Kogut, M.H. 2004. Characterization of the heterophil, the avian neutrophil equivalent [abstract]. Research in Veterinary Science. 76(Suppl. A):47.

Interferon-Gamma Upregulates the Expression of Pro-Inflammatory and Th1 Cytokine Mrna in Chicken Heterophils During Receptor Mediated Phagocytosis of Opsonized and Nonopsonized Salmonella Enteterica Serovar Enteritidis - (Abstract)

KOGUT, M.H., ROTHWELL, L., KAISER, P. INTERFERON-GAMMA UPREGULATES THE EXPRESSION OF PRO-INFLAMMATORY AND TH1 CYTOKINE MRNA IN CHICKEN HETEROPHILS DURING RECEPTOR MEDIATED PHAGOCYTOSIS OF OPSONIZED AND NONOPSONIZED SALMONELLA ENTETERICA SEROVAR ENTERITIDIS. ARS IMMUNOLOGY WORKSHOP. 2003. ABSTRACT P. 29.

Stimulation of Chicken Leukocytes and Reduction of Salmonella Organ Invasion in Neonatal Chicken by Immunostimulatory Cpg-Oligodeoxynucleotide - (Abstract)

HE, H., KOGUT, M.H. STIMULATION OF CHICKEN LEUKOCYTES AND REDUCTION OF SALMONELLA ORGAN INVASION IN NEONATAL CHICKEN BY IMMUNOSTIMULATORY CPG-OLIGODEOXYNUCLEOTIDE. ARS IMMUNOLOGY WORKSHOP. 2003. ABSTRACT P. 25.

The Inhibition of Nitric Oxide Production in Chicken Phagocytes - (Abstract)

CRIPPEN, T.L., HE, H., KOGUT, M.H. THE INHIBITION OF NITRIC OXIDE PRODUCTION IN CHICKEN PHAGOCYTES. ARS IMMUNOLOGY WORKSHOP. 2003. ABSTRACT P. 27.

Differential Pro-Inflammatory Cytokine Mrna Expression in Heterophils Isolated from Salmonella-Resistant and -Susceptible Chickens - (Abstract)

SWAGGERTY, C.L., FERRO, P.J., ROTHWELL, L., PEVZNER, I.Y., KOGUT, M.H., KAISER, P. DIFFERENTIAL PRO-INFLAMMATORY CYTOKINE MRNA EXPRESSION IN HETEROPHILS ISOLATED FROM SALMONELLA-RESISTANT AND -SUSCEPTIBLE CHICKENS. ARS IMMUNOLOGY WORKSHOP. 2003. ABSTRACT P. 57.

Heterophils Isolated from Chickens Resistant to Extraintestinal Salmonella Enteritidis Infection Express Higher Levels of Pro-Inflammatory Cytokine Mrna Following Infection Than Heterophils from Susceptible Chickens - (Abstract)

FERRO, P.J., SWAGGERTY, C.L., KAISER, P., PEVZNER, I.Y., KOGUT, M.H. HETEROPHILS ISOLATED FROM CHICKENS RESISTANT TO EXTRAINTESTINAL SALMONELLA ENTERITIDIS INFECTION EXPRESS HIGHER LEVELS OF PRO-INFLAMMATORY CYTOKINE MRNA FOLLOWING INFECTION THAN HETEROPHILS FROM SUSCEPTIBLE CHICKENS. ARS IMMUNOLOGY WORKSHOP. 2003. ABSTRACT P. 21.

Purified B-Glucan As An Abiotic Feed Additive Up-Regulates Heterophil Function in Immature Chickens - (Abstract)

LOWRY, V.K., FARNELL, M.B., FERRO, P.J., BAHL, A., KOGUT, M.H. PURIFIED B-GLUCAN AS AN ABIOTIC FEED ADDITIVE UP-REGULATES HETEROPHIL FUNCTION IN IMMATURE CHICKENS. ARS IMMUNOLOGY WORKSHOP. 2003. ABSTRACT P. 51.

Interferon-Gamma Upregulates the Expression of Proinflammatory and Th1 Cytokines Mrna in Chicken Heterophils During Receptor-Mediated Phagocytosis - (Abstract) - (23-Sep-03)

Priming by Recombinant Chicken Interleukin-2 Induces Selective Expression of Il-8 and Il-18 Mrna in Chicken Heterophils During Receptor-Mediated Phagocytosis of Opsonized and Nonopsonized Salmonella Enterica Serovar Enteritid - (Peer Reviewed Journal)

Kogut, M.H., Rothwell, L., Kaiser, P. 2003. Priming by recombinant chicken interleukin-2 induces selective expression of IL-8 and IL-18 MRNA in chicken heterophils during receptor-mediated phagocytosis of opsonized and nonopsonized Salmonella enterica serovar enteritidis. Molecular Immunology. 40:603-610.

Pharmacological Analysis of Signal Transduction Pathways Required for Oxidative Burst in Chicken Heterophils Stimulated by a Toll-Like Receptor 2 Agonist - (Peer Reviewed Journal)

Farnell, M.B., He, H., Genovese, K.J., Kogut, M.H. 2003. Pharmacological analysis of signal transduction pathways required for oxidative burst in chicken heterophils stimulated by a toll-like receptor 2 agonist. International Immunopharmacology. 3:1677-1684.

Beta-Glucan Supplemented Feed Decreases Salmonella Enteritidis Organ Invasion in Immature Chicks - (Abstract) - (21-Jul-03)

Effects of Recombinanat Il-6 on the Functional Activities of Day-Old Chicken Heterophils - (Abstract) - (21-Jul-03)

Innate Immunoprofiling of Commercial Broiler Chicken Lines - (Peer Reviewed Journal)

Crippen, T.L., Pevzner, I.Y., Lowry, V.K., Farnell, M.B., Kogut, M.H. 2003. Innate immunoprofiling of commercial broiler chicken lines. Online Journal of Veterinary Research. 7:78-90. Available: http://www.cpb.uokhsc.edu/ojvr/crippen2003/immunoprofilingbroilers/immunobroilers200.html.

Differential Regulation of Cytokine Gene Expression by Chicken Heterophils During Receptor-Mediated Phagocytosis of Opsonized and Non-Opsonized Salmonella Enteritidis - (Abstract) - (01-Jul-03)

Syk Tyrosine Kinase Involvement in Complement Receptor-Mediated Signaling Leading to An Oxidative Burst in Chicken Heterophils - (Abstract) - (30-Jun-03)

Association Between in Vitro Heterophil Function and the Feathering Gene in Commercial Broiler Chickens - (Peer Reviewed Journal)

Swaggerty, C.L., Pevzner, I.Y., Ferro, P.J., Crippen, T.L., Kogut, M.H. 2003. Association between in vitro heterophil function and the feathering gene in commercial broiler chickens. Avian Pathology. 32:483-488.

Sequence Dependent Induction of Nitric Oxide by Cpg-Odn Is Mediated Through Clathrin-Dependent Endocytosis, Endosomal Maturation, and Activation of Pkc,mek1/2 and P38 Mapk, and Nf-Kappab Pathways in Avian Macrophage Cells (Hd - (Abstract) - (07-May-03)

Differential Activation of Signal Transduction Pathways Mediating Oxidative Burst by Chicken Heterophils in Response to Stimulation with Lipopolysaccharide and Lipoteichoic Acid - (Peer Reviewed Journal)

FARNELL, M.B., HE, H., KOGUT, M.H. DIFFERENTIAL ACTIVATION OF SIGNAL TRANSDUCTION PATHWAYS MEDIATING OXIDATIVE BURST BY CHICKEN HETEROPHILS IN RESPONSE TO STIMULATION WITH LIPOPOLYSACCHARIDE AND LIPOTEICHOIC ACID. INFLAMMATION. 2003. V. 27. P. 225-231.

Differential Regulation of Cytokine Gene Expression by Avian Heterophils During Receptor-Mediated Phagocytosis of Opsonized and Non-Opsonized Salmonella Enteritidis - (Peer Reviewed Journal)

KOGUT, M.H., ROTHWELL, L., KAISER, P. DIFFERENTIAL REGULATION OF CYTOKINE GENE EXPRESSION BY AVIAN HETEROPHILS DURING RECEPTOR-MEDIATED PHAGOCYTOSIS OF OPSONIZED AND NON-OPSONIZED SALMONELLA ENTERITIDIS. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 2003. v. 23. p. 319-327.

Cpg-Odn-Induced Nitric Oxide Production Is Mediated Through Clathrin-Dependent Endocytosis, Endosomal Maturation, and Activation of Pkc, Mek1/2 and P38 Mapk, and Nf-Kb Pathways in Avian Macrophage Cells (Hd11) - (Peer Reviewed Journal)

HE, H., KOGUT, M.H. CPG-ODN-INDUCED NITRIC OXIDE PRODUCTION IS MEDIATED THROUGH CLATHRIN-DEPENDENT ENDOCYTOSIS, ENDOSOMAL MATURATION, AND ACTIVATION OF PKC, MEK1/2 AND P38 MAPK, AND NF-KB PATHWAYS IN AVIAN MACROPHAGE CELLS (HD11). CELLULAR SIGNALLING. 2003. V. 15. P. 911-917.

The Use of Selective Pharmacological Inhibitors to Delineate Signal Transduction Pathways Activated During Complement Receptor-Mediated Degranulation in Chicken Heterophils - (Peer Reviewed Journal)

KOGUT, M.H., LOWRY, V.K., FARNELL, M. THE USE OF SELECTIVE PHARMACOLOGICAL INHIBITORS TO DELINEATE SIGNAL TRANSDUCTION PATHWAYS ACTIVATED DURING COMPLEMENT RECEPTOR-MEDIATED DEGRANULATION IN CHICKEN HETEROPHILS. IMMUNOPHARMACOLOGY. 2003. v. 3 p. 693-706.

Inflammatory Agonist Stimulation and Signal Pathway of Oxidative Burst in Neonatal Chicken Heterophils - (Peer Reviewed Journal)

HE,H. ., FARNELL,M.B., KOGUT,M.H., INFLAMMATORY AGONIST STIMULATION AND SIGNAL PATHWAY OF OXIDATIVE BURST IN NEONATAL CHICKEN HETEROPHILS, COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY, Part A 135 (2003) 177-184.

Differential Nitric Oxide Production by Chicken Immune Cells - (Peer Reviewed Journal)

CRIPPEN,T.L., HE,H. ., SHEFFIELD,C.L., LOWRY,V.K., KOGUT,M.H., DIFFERENTIAL NITRIC OXIDE PRODUCTION BY CHICKEN IMMUNE CELLS, INFLAMMATION, 27: 603-610, 2003.

Rp33 Activates Bacterial Killing by Chicken Peripheral Blood Heterophils - (Peer Reviewed Journal)

CRIPPEN,T.L., BISCHOFF,K.M., LOWRY,V.K., KOGUT,M.H., RP33 ACTIVATES BACTERIAL KILLING BY CHICKEN PERIPHERAL BLOOD HETEROPHILS, JOURNAL OF FOOD PROTECTION, 66(5):787-792, 2003.

Identification of Cpg Oligodeoxynucleotide Motifs That Stimulate Nitric Oxide and Cytokine Production in Avian Macrophage and Peripheral Blood Mononuclear Cells - (Abstract) - (15-Nov-02)

Identification of Cpg Oligodeoxynucleotide Motifs That Stimulate Nitric Oxide and Cytokine Production in Avian Macrophage and Peripheral Blood Mononuclear Cells - (Peer Reviewed Journal)

HE,H. ., CRIPPEN,T.L., FARNELL,M.B., KOGUT,M.H., IDENTIFICATION OF CPG OLIGODEOXYNUCLEOTIDE MOTIFS THAT STIMULATE NITRIC OXIDE AND CYTOKINE PRODUCTION IN AVIAN MACROPHAGE AND PERIPHERAL BLOOD MONONUCLEAR CELLS, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, : 27 (2003) 621-627.

Functional Comparison of Heterophils Isolated from Commercial Broiler Chickens - (Abstract) - (11-Nov-02)

Differential Activation of Signal Transduction Pathways Mediating Oxidative Burst by Chicken Heterophils in Response to Stimulation with Salmonella Enteritidis Lipopolysaccharide and Staphylococcus Aureus Lipoteichoic Acid - (Abstract) - (10-Nov-02)

Oxidative Burst Mediated by Toll Like Receptors (Tlr) and Cd14 on Avian Heterophils Stimulated with Bacterial Toll Agonists - (Peer Reviewed Journal) - (19-Sep-02)

Functional Comparison of Heterophils Isolated from Commercial Broiler Chickens - (Peer Reviewed Journal) - (06-Aug-02)

Cytokine Responses: What Do We Know and Their Affect on Future Vaccine Development - (Proceedings/Symposium) - (16-Jul-02)

Scavenger Receptors Found on Chicken Heterophils Contribute to the Phagocytosis of Salmonella Enteritidis - (Abstract) - (30-Jan-02)