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United States Department of Agriculture

Agricultural Research Service

Related Topics

Chao Qiang Lai
Boston, Massachusetts
Research Molecular Biologist

Phone: (617) 556-3206
Fax: (617) 556-3299
USDA-ARS-HNRCA
711 WASHINGTON STREET
BOSTON, MA, 02111

Projects
Genomics, Nutrition, and Health
Appropriated (D)
  Accession Number: 427832

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Dietary modulators of statin efficacy in cardiovascular disease and cognition - (Review Article) - (14-Apr-14)
Genome-wide association studies identified novel loci for non-high-density lipoprotein cholesterol and its postprandial lipemic response - (Peer Reviewed Journal)
An, P., Straka, R.J., Pollin, T.I., Feitosa, M.F., Wojczynski, M.K., Daw, E., O'Connell, J.R., Gibson, Q., Ryan, K.A., Hopkins, P.N., Tsai, M.Y., Lai, C., Province, M.A., Ordovas, J.M., Shuldiner, A.R., Arnett, D.K., Borecki, I.B. 2014. Genome-wide association studies identified novel loci for non-high-density lipoprotein cholesterol and its postprandial lipemic response. Human Genetics. DOI: 10.1007/s00439-014-1435-3.
Lipoprotein lipase variants interact with polyunsaturated fatty acids to modulate obesity traits in Puerto Ricans - (Abstract Only)
Ma, Y., Tucker, K.L., Smith, C.E., Lee, Y., Huang, T., Lai, C., Parnell, L.D., Richardson, K., Ordovas, J.M. 2014. Lipoprotein lipase variants interact with polyunsaturated fatty acids to modulate obesity traits in Puerto Ricans. Journal of Federation of American Societies for Experimental Biology. 28:1037.7.
Cry1 Circadian Gene Variant Interacts with Carbohydrate Intake for Insulin Resistance in Two Independent Populations: Mediterranean and North American - (Peer Reviewed Journal)
Dashti, H.S., Smith, C.E., Lee, Y., Parnell, L.D., Lai, C., Arnett, D.K., Ordovas, J.M., Garaulet, M. 2014. CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American. Chronobiology International. 31(5):660-668. DOI: 10.3109/07420528.2014.886587.
Integrating nutrigenomics data to identify cardiometabolic gene-environment interactions - (Proceedings)
Parnell, L.D., Lee, Y., Dashti, H., Ma, Y., Pham, L., Sloan, S., Smith, C.E., Richardson, K., Lai, C., Ordovas, J.M. 2013. Integrating nutrigenomics data to identify cardiometabolic gene-environment interactions. Meeting Abstract. p.1 Abstract #5.
Circulating 25-hydroxyvitamin D, IRS1 variant rs2943641 and insulin resistance: replication of a gene-nutrient interaction in four populations of different ancestries - (Peer Reviewed Journal) - (28-Oct-13)
Apolipoprotein A2 polymorphism interacts with intakes of dairy foods to influence body weight in 2 U.S. populations - (Peer Reviewed Journal)
Smith, C.E., Tucker, K.L., Arnett, D.K., Noel, S.E., Corella, D., Borecki, I.B., Feitosa, M.F., Aslibekyan, S., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2013. Apolipoprotein A2 polymorphism interacts with intakes of dairy foods to influence body weight in 2 U.S. populations. Journal of Nutrition. 143(12):1865-1871.
Quantifying diet for nutrigenomic studies - (Review Article)
Tucker, K.L., Smith, C.E., Lai, C., Ordovas, J.M. 2013. Quantifying diet for nutrigenomic studies. Annual Review of Nutrition. 33:349-371.
Curcumin and aging - (Review Article)
Shen, L., Parnell, L.D., Ordovas, J., Lai, C. 2013. Curcumin and aging. Biofactors. 39(1):133-140.
Genetic variants at PSMD3 interact with dietary fat and carbohydrate to modulate insulin resistance - (Peer Reviewed Journal)
Zheng, J., Arnett, D., Parnell, L.D., Lee, Y., Ma, Y., Smith, C., Richardson, K., Li, D., Ordovas, J., Tucker, K., Lai, C., Borecki, I. 2013. Genetic variants at PSMD3 interact with dietary fat and carbohydrate to modulate insulin resistance. Journal of Nutrition. 143(3):354-361.
Genetic variants associated with VLDL, LDL and HDL particle size differ with race/ethnicity - (Peer Reviewed Journal)
Frazier-Wood, A.C., Manichaikul, A., Aslibekyan, S., Borecki, I.B., Goff, D.C., Hopkins, P.N., Lai, C., Ordovas, J.M., Post, W.S., Rich, S.S., Sale, M.M., Siscovick, D., Straka, R.J., Tiwari, H.K., Tsai, M.Y., Rotter, J.I., Arnett, D.K. 2013. Genetic variants associated with VLDL, LDL and HDL particle size differ with race/ethnicity. Human Genetics. 132(4):405-413.
Association between BDNF-rs6265 and obesity in the Boston Puerto Rican Health Study - (Peer Reviewed Journal)
Ma, X., Qiu, W., Smith, C., Parnell, L.D., Jiang, Z., Ordovas, J., Tucker, K., Lai, C. 2012. Association between BDNF-rs6265 and obesity in the Boston Puerto Rican Health Study. Journal of Obesity. DOI: 10.1155/2012102942.
Gain-of-function Lipoprotein Lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site - (Peer Reviewed Journal)
Richardson, K., Nettleton, J.A., Rotlan, N., Tanaka, T., Smith, C.E., Lai, C., Parnell, L.D., Lee, Y., Lahti, J., Lemaitre, R.N., Manichaikul, A., Keller, M., Mikkila, V., Ngwa, J., Van Rooij, F., Ballentyne, C.M., Borecki, I.B., Cupples, L., Garcia, M., Hofman, A., Ferrucci, L., Mozaffarian, D., Perala, M., Raitakari, O., Tracy, R.P., Arnett, D.K., Bandinelli, S., Boerwinkle, E., Eriksson, J.G., Franco, O.H., Kahonen, M., Nalls, M., Siscovick, D.S., Houston, D.K., Psaty, B.M., Viikari, J., Witteman, J., Goodarzi, M.O., Lehtimaki, T., Liu, Y., Zillikens, M., Chen, Y.I., Uitterlinden, A.G., Rotter, J.I., Fernandez-Hernando, C., Ordovas, J. 2013. Gain-of-function Lipoprotein Lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site. The American Journal of Human Genetics. 92(1):5-14.
Genetic analysis of 16 NMR-lipoprotein fractions in humans, the GOLDN study - (Peer Reviewed Journal)
Kraja, A.T., Borecki, I.B., Tsai, M.Y., Ordovas, J.M., Hopkins, P.N., Lai, C., Frazier-Wood, A.C., Straka, R.J., Hixson, J.E., Province, M.A. 2013. Genetic analysis of 16 NMR-lipoprotein fractions in humans, the GOLDN study. Lipids. 48(2):155-165.
Mechanism of action of recombinant Acc-royalisin from royal jelly of Chinese honeybee against gram-positive bacteria - (Peer Reviewed Journal)
Shen, L., Liu, D., Yang, X., Jin, F., Din, M., Parnell, L.D., Lai, C. 2012. Mechanism of action of recombinant Acc-royalisin from royal jelly of Chinese honeybee against gram-positive bacteria. PLoS One. 7(10):e47194 DOI: 10.1371/journal.pone.0047194.
Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate - (Peer Reviewed Journal)
Frazier-Wood, A.C., Aslibekyan, S., Borecki, I.B., Hopkins, P.N., Lai, C., Ordovas, J.M., Straka, R.J., Tiwari, H.K., Arnett, D.K. 2012. Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate. Pharmacogenetics and Genomics. 22(10):750-757.
Low density lipoprotein receptor related protein 1 variant interacts with saturated fatty acids in Puerto Ricans - (Peer Reviewed Journal)
Smith, C.E., Tucker, K.L., Lee, Y., Lai, C., Parnell, L.D., Ordovas, J.M. 2013. Low density lipoprotein receptor related protein 1 variant interacts with saturated fatty acids in Puerto Ricans. Obesity. 21:602-608.
Status of vitamin B-12 and B-6 but not of folate, homocysteine and the methylenetetrahydrofolate reductase C677T polymorphism are associated with impaired cognition and depression in adults - (Peer Reviewed Journal)
Moorthy, D., Inga, P., Scott, T.M., Parnell, L.D., Lai, C., Crott, J.W., Ordovas, J.M., Selhub, J., Griffith, J., Rosenberg, I.H., Tucker, K.L., Troen, A.M. 2012. Status of vitamin B-12 and B-6 but not of folate, homocysteine and the methylenetetrahydrofolate reductase C677T polymorphism are associated with impaired cognition and depression in adults. Journal of Nutrition. 142(8):1554-1560.
Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila - (Peer Reviewed Journal)
Shen, L., Xiao, F., Peng, Y., Chen, Y., Qi-Kang, G., Parnell, L.D., Meydani, M., Ordovas, J.M., Li, D., Lai, C. 2013. Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila. Journal of the American Aging Association (AGE). 35(4):1133-1142. DOI 10.1007/s11357-012-9438-2.
Aging is a more significant determinant of hepatic DNA methylation patterns than a western style diet - (Abstract Only)
Park, L.K., Saltzman, E., Schnitzler, G., Yoon, B., Parnell, L.D., Lai, C., Choi, S. 2012. Aging is a more significant determinant of hepatic DNA methylation patterns than a western style diet. Journal of Federation of American Societies for Experimental Biology. 2012(26):243.5.
Adaptive genetic variation and population differences - (Book / Chapter)
Lai, C. 2012. Adaptive genetic variation and population differences. In: Bouchard, C., Ordovas, J. M., editors. Recent Advances in Nutrigenetics and Nutrigenomics. Oxford, UK: Elsevier. 108:461-489. PMID.22656388.
The effect of CYP7A1 polymorphisms on lipid responses to fenofibrate - (Peer Reviewed Journal)
Shen, J., Arnett, D., Parnell, L.D., Lai, C., Straka, R., Hopkins, P., An, P., Feitosa, M., Ordovas, J. 2012. The effect of CYP7A1 polymorphisms on lipid responses to fenofibrate. Journal of Cardiovascular Pharmacology. 59(3):254-259.
A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWAS - (Peer Reviewed Journal)
Richardson, K., Lai, C., Parnell, L.D., Lee, Y., Ordovas, J. 2011. A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWAS. Biomed Central (BMC) Genomics. 2:504.
A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI - (Peer Reviewed Journal)
Corella, D., Arnett, D.K., Tucker, K.L., Kabagambe, E.K., Tsai, M.Y., Parnell, L.D., Lai, C., Lee, Y., Warodomwichit, D., Hopkins, P.N., Ordovas, J.M. 2011. A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI. Journal of Nutrition. 141(12):2219-2225.
A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network - (Peer Reviewed Journal)
Aslibekyan, S., Kabagambe, E.K., Irvin, M.R., Straka, R.J., Borecki, I.B., Tiwari, H.K., Tsai, M.Y., Hopkins, P.N., Shen, J., Lai, C., Ordovas, J.M., Arnett, D.K. 2012. A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network. Pharmacogenetics and Genomics. 22(3):191-197.
Apolipoprotein A1/C3/A5 haplotypes and serum lipid levels - (Peer Reviewed Journal)
Yin, R., Li, Y., Lai, C. 2011. Apolipoprotein A1/C3/A5 haplotypes and serum lipid levels. Lipids in Health and Disease. 10:140. DOI: 10.1186/1476-511X-10-140.
The PLIN4 variant rs8887 modulates obesity related phenotypes in humans through creation of a novel miR-522 seed site - (Peer Reviewed Journal)
Richardson, K., Louie-Gao, Q., Arnett, D., Parnell, L.D., Lai, C., Davalos, A., Fox, C., Demissie, S., Cupples, L., Fernandez-Hernando, C., Ordovas, J. 2011. The PLIN4 variant rs8887 modulates obesity related phenotypes in humans through creation of a novel miR-522 seed site. PLoS One. 6(4):e17944.
A database of gene-environment interactions pertaining to blood lipid traits, cardiovascular disease and type 2 diabetes - (Peer Reviewed Journal)
Lee, Y., Lai, C., Ordovas, J.M., Parnell, L.D. 2011. A database of gene-environment interactions pertaining to blood lipid traits, cardiovascular disease and type 2 diabetes. Journal of Data Mining in Genomics & Proteomics. 2:106. DOI:10.4172/2153-0602.1000106.
The folate hydrolase 1561 C>T polymorphism is associated with depressive symptoms in Puerto Rican adults - (Peer Reviewed Journal)
Ye, X., Lai, C., Crott, J., Troen, A., Ordovas, J., Tucker, K. 2011. The folate hydrolase 1561 C>T polymorphism is associated with depressive symptoms in Puerto Rican adults. Psychosomatic Medicine. 73(5):385-392.
Interactions between genetic variants of folate metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican Population - (Peer Reviewed Journal)
Huang, T., Tucker, K., Lee, Y., Crott, J., Parnell, L.D., Shen, J., Smith, C., Ordovas, J., Li, D., Lai, C. 2011. Interactions between genetic variants of methionine metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican Population. Molecular Nutrition and Food Research. DOI: 10.1017/S1368980011000140.
Modulation of gene expression by alpha-tocopherol and alpha-tocopheryl phosphate in thp-1 monocytes - (Peer Reviewed Journal)
Zingg, J., Libinaki, R., Lai, C., Meydani, M., Gianello, R., Ogru, E., Azzi, A. 2010. Modulation of gene expression by alpha-tocopherol and alpha-tocopheryl phosphate in thp-1 monocytes. Journal of Free Radical Biology and Medicine. 49:1989-2000.
Perilipin polymorphism interacts with saturated fat and carbohydrates to modulate insulin resistance - (Peer Reviewed Journal)
Smith, C.E., Arnett, D.K., Corella, D., Tsai, M.Y., Lai, C., Parnell, L.D., Lee, Y., Ordovas, J.M. 2012. Perilipin polymorphism interacts with saturated fat and carbohydrates to modulate insulin resistance. Nutrition, Metabolism and Cardiovascular Diseases. 22(5):449-455.
Gene variations of nitric oxide synthase regulate the effects of a saturated fat rich meal on endothelial function - (Peer Reviewed Journal)
Delgado-Lista, J., Fuentes, F., Jimenez-Gomez, Y., Perez-Martinez, P., Gomez-Luna, M.J., Parnell, L.D., Marin, C., Lai, C., Perez-Jimenez, F., Ordovas, J.M., Lopez-Miranda, J. 2010. Gene variations of nitric oxide synthase regulate the effects of a saturated fat rich meal on endothelial function. Clinical Nutrition. 30(2):234-238.
Apolipoprotein B genetic variants modify the response to fenofibrate: a GOLDN study - (Peer Reviewed Journal)
Wojczynski, M.K., Gao, G., Borecki, I., Hopkins, P.N., Parnell, L.D., Lai, C., Ordovas, J.M., Arnett, D.K. 2010. Apolipoprotein B genetic variants modify the response to fenofibrate: a GOLDN study. Journal of Lipid Research. 51(11):3316-3323.
Mat1a Variants Modulate the Effect of Dietary Fatty Acids on Plasma Homocysteine Concentrations and DNA Damage - (Peer Reviewed Journal)
Huang, T., Tucker, K., Lee, Y., Crott, J., Parnell, L.D., Shen, J., Smith, C.E., Ordovas, J.M., Li, D., Lai, C. 2010. MAT1A variants modulate the effect of dietary fatty acids on plasma homocysteine concentrations and DNA damage. Nutrition, Metabolism and Cardiovascular Diseases. DOI: 1016/j.numecd.2010.07.015.
Drosophila lacks C20 and C22 polyunsaturated fatty acids - (Peer Reviewed Journal)
Shen, L., Lai, C., Feng, X., Parnell, L.D., Wang, J., Li, D., Ordovas, J.M., Kang, J. 2010. Drosophila lacks C20 and C22 polyunsaturated fatty acids. Journal of Lipid Research. 51(10)2985-2992.
Urinary 8-hydroxy-2-deoxyguanosine and cognitive function in Puerto Rican adults - (Peer Reviewed Journal)
Gao, X., Lai, C., Scott, T., Shen, J., Cai, T., Ordovas, J.M., Tucker, K. 2010. Urinary 8-hydroxy-2-deoxyguanosine and cognitive function in Puerto Rican adults. American Journal of Epidemiology. 172(3):271-278.
Mat1a Variants Are Associated with Hypertension, Stroke, and DNA Damage and Are Modulated by Vlasma Vitamin B6 and Folate Concentration - (Peer Reviewed Journal)
Lai, C., Tucker, K., Parnell, L.D., Shen, J., Caouette, H., Warodomwichit, D., Lee, Y., Crott, J., Ordovas, J.M. 2010. MAT1A variants are associated with hypertension, stroke, and DNA damage and are modulated by plasma vitamin B6 and folate concentration. American Journal of Clinical Nutrition. 91(5):1377-1386.
Expression of recombinant AccMRJP1 protein from royal jelly of Chinese honeybee in Pichia pastoris and its proliferation activity in an insect cell line - (Peer Reviewed Journal)
Shen, L., Zhang, W., Jin, F., Zhang, L., Chen, Z., Liu, L., Parnell, L.D., Lai, C., Li, D. 2010. Expression of recombinant AccMRJP1 protein from royal jelly of Chinese honeybee in Pichia pastoris and its proliferation activity in an insect cell line. Journal of Agricultural and Food Chemistry. 58(4):2266-2273.
Adaptive genetic variation and heart disease risk - (Review Article)
Parnell, L.D., Lee, Y., Lai, C. 2010. Adaptive genetic variation and heart disease risk. Current Opinion in Lipidology. 21(2):116-122.
Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study - (Peer Reviewed Journal)
Shen, J., Lai, C., Mattei, J., Ordovas, J.M., Tucker, K.L. 2010. Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study. American Journal of Clinical Nutrition. 91(2):337-342.
Clock Genetic Variation and Metabolic Syndrome Risk: Modulation by Monounsaturated Fatty Acids - (Peer Reviewed Journal)
Garaulet, M., Lee, Y., Shen, J., Parnell, L.D., Arnett, D.K., Tsai, M.Y., Lai, C., Ordovas, J.M. 2009. CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids. American Journal of Clinical Nutrition. 90(6):1466-1475.
Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors - (Peer Reviewed Journal)
Garaulet, M., Lee, Y., Shen, J., Parnell, L.D., Arnett, D.K., Tsai, M.Y., Lai, C., Ordovas, J.M. 2009. Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors. Human Molecular Genetics. 18(3):364-369.
Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites - (Peer Reviewed Journal)
Mattei, J., Parnell, L.D., Lai, C., Garcia-Bailo, B., Adiconis, X., Shen, J., Arnett, D., Demissie, S., Tucker, K., Ordovas, J.M. 2009. Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites. BioMed Central (BMC) Genetics. 10:45.
Apoa2, Dietary Fat and Body Mass Index: Replication of a Gene-Diet Interaction in Three Independent Populations - (Peer Reviewed Journal)
Corella, D., Peloso, G., Arnett, D.K., Demissie, S., Cupples, L., Tucker, K., Lai, C., Parnell, L.D., Coltell, O., Lee, Y., Ordovas, J.M. 2009. APOA2, dietary fat and body mass index: replication of a gene-diet interaction in three independent populations. Archives of Internal Medicine. 169:1897-1906.
Adam17_i33780a>g Polymorphism Interacts with Dietary N-6 Polyunsaturated Fatty Acids to Modulate Obesity Risk in the Genetics of Lipid Lowering Drugs and Diet Network Study - (Peer Reviewed Journal)
Junyent, M., Arnett, D.A., Tsai, M.Y., Kabagambe, E.K., Straka, R.J., Province, M., An, P., Smith, C., Borecki, I., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2010. ADAM17_i33780A>G polymorphism interacts with dietary n-6 polyunsaturated fatty acids to modulate obesity risk in the genetics of lipid lowering drugs and diet network study. Nutrition Metabolism and Cardiovascular Disease. 20(101):698-705.
Novel variants at KCTD10 and MVK/MMAB genes interact with dietary carbohydrates to modulate HDL-C concentrations in the genetics of lipid lowering drugs and diet network study - (Peer Reviewed Journal)
Junyent, M., Arnett, D.A., Tsai, M.Y., Kabagambe, E.K., Straka, R.J., Province, M., An, P., Smith, C., Borecki, I., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2009. Novel variants at KCTD10 and MVK/MMAB genes interact with dietary carbohydrates to modulate HDL-C concentrations in the genetics of lipid lowering drugs and diet network study. American Journal of Clinical Nutrition. 90(3):686-694.
Apolipoprotein A5 and lipoprotein lipase interact to modulate anthropometric measures in Hispanics of Caribbean origin - (Peer Reviewed Journal)
Smith, C.E., Tucker, K.L., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2010. Apolipoprotein A5 and lipoprotein lipase interact to modulate anthropometric measures in Hispanics of Caribbean origin. Obesity. 18(2):327-332.
The effects of ABCG5/G8 polymorphisms on HDL-cholesterol concentrations depend on ABCA1 genetic variants in the Boston Puerto Rican health study - (Peer Reviewed Journal)
Junyent, M., Tucker, K., Smith, C., Lane, J., Mattei, J., Lai, C., Parnell, L.D., Ordovas, J. 2010. The effects of ABCG5/G8 polymorphisms on HDL-cholesterol concentrations depend on ABCA1 genetic variants in the Boston Puerto Rican health study. Nutrition Metabolism and Cardiovascular Disease. 20(8):558-566.
The effect of ABCG5/G8 polymorphisms on plasma HDL cholesterol levels depends on the ABCA1 gene variation in the Boston Puerto Rican Health Study - (Peer Reviewed Journal)
Junyent, M., Tucker, K.L., Lane, J.M., Mattei, J., Smith, C., Parnell, L.D., Lai, C., Ordovas, J.M. 2009. The effect of ABCG5/G8 polymorphisms on plasma HDL cholesterol levels depends on the ABCA1 gene variation in the Boston Puerto Rican Health Study. Nutrition Metabolism and Cardiovascular Disease. 18:64-69.
Apolipoprotein C3 polymorphism is associated with cognitive function in Caribbean Hispanics - (Peer Reviewed Journal)
Smith, C.E., Tucker, K.L., Scott, T.M., Van Rompay, M., Parnell, L.D., Lai, C., Mattei, J., Junyent, M., Lee, Y., Garcia-Bailo, B., Ordovas, J.M. 2009. Apolipoprotein C3 polymorphism is associated with cognitive function in Caribbean Hispanics. PLoS One. 4(5):e5465.
A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study - (Peer Reviewed Journal)
Junyent, M., Parnell, L.D., Lai, C., Ordovas, J.M., Tucker, K.L., Shen, J., Mattei, J., Smith, C., Lee, Y. 2009. A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study. Nutrition Metabolism and Cardiovascular Disease.20(3):157-167.
A composite scoring of genotypes discriminates coronary heart disesase risk beyond conventional risk factors in the Boston Puerto Rican Health Study - (Peer Reviewed Journal)
Junyent, M., Tucker, K., Shen, J., Lee, Y., Smith, C., Mattei, J., Lai, C., Parnell, L.D., Ordovas, J. 2010. A composite scoring of genotypes discriminates coronary heart disesase risk beyond conventional risk factors in the Boston Puerto Rican Health Study. Nutrition Metabolism and Cardiovascular Disease. 20(3):157-164.
Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study - (Peer Reviewed Journal)
Smith, C.E., Arnett, D.K., Tsai, M.Y., Lai, C., Parnell, L.D., Shen, J., Laclaustra, M., Junyent, M., Ordovas, J.M. 2009. Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study. Atherosclerosis.206:500-504.
The effect of a novel intergenic polymorphism (rs11774572) on HDL cholesterol concentrations depends on the TaqIB polymorphism in the cholesterol ester transfer protein gene - (Peer Reviewed Journal)
Junyent, M., Arnett, D.A., Tsai, M.Y., Kabagambe, E.K., Straka, R.J., Province, M., An, P., Smith, C., Shen, J., Borecki, I., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2009. The effect of a novel intergenic polymorphism (rs11774572) on HDL cholesterol concentrations depends on the TaqIB polymorphism in the cholesterol ester transfer protein gene. Nutrition Metabolism and Cardiovascular Disease.20:34-40.
Genetic Variants at the PDZ-Interacting Domain of the Scavenger Receptor Class B Type I Interact with Diet to Influence the Risk of Metabolic Syndrome in Obese Men and Women - (Peer Reviewed Journal)
Junyent, M., Arnett, D.A., Tsai, M.Y., Kabagambe, E.K., Straka, R.J., Province, M., An, P., Shen, J., Borecki, I., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2009. Genetic Variants at the PDZ-Interacting Domain of the Scavenger Receptor Class B Type I Interact with Diet to Influence the Risk of Metabolic Syndrome in Obese Men and Women. Journal of Nutrition. 139(6):842-848.
Polyunsaturated fatty acids modulate the effect of TCF7L2 gene variants on postprandial lipemia - (Peer Reviewed Journal)
Warodomwichit, D., Arnett, D.K., Kabagambe, E.K., Tsai, M.Y., Hixson, J.E., Straka, R.J., Province, M., An, P., Lai, C., Borecki, I., Ordovas, J. 2009. Polyunsaturated fatty acids modulate the effect of TCF7L2 gene variants on postprandial lipemia. Journal of Nutrition. 139:439-446.
The effects of ABCG5/G8 polymorphisms on plasma HDL cholesterol concentrations depend on smoking habit in the Boston Puerto Rican Health Study - (Peer Reviewed Journal)
Junyent, M., Tucker, K., Smith, C., Garcia-Rios, A., Mattei, J., Lai, C., Parnell, L.D., Ordovas, J.M. 2008. The effects of ABCG5/G8 polymorphisms on plasma HDL cholesterol concentrations depend on smoking habit in the Boston Puerto Rican Health Study. Journal of Lipid Research. 50:565-573.
Wdtc1, An Ortholog of Drosphilia Adipose Gene, Associates with Human Obesity - (Peer Reviewed Journal)
Lai, C., Parnell, L.D., Garcia-Bailo, B., Tucker, K., Ordovas, J.M. 2008. WDTC1, an ortholog of Drosphilia adipose gene, associates with human obesity. Obesity. 17(3):593-600.
Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states - (Peer Reviewed Journal)
Perez-Martinez, P., Corella, D., Shen, J., Arnett, D.K., Yiannakouris, N., Tai, E., Orho-Melander, M., Tucker, K.L., Tsai, M., Straka, R.J., Province, M., Kai, C., Perez-Jimenez, F., Lai, C., Lopez-Miranda, J., Guillen, M., Parnell, L.D., Borecki, I., Kathiresan, S., Ordovas, J.M. 2009. Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states. American Journal of Clinical Nutrition. 89:391-399.
Adipoq Polymorphisms, Monounsaturated Fatty Acids, and Obesity Risk: the Goldn Study - (Peer Reviewed Journal)
Warodomwichit, D., Shen, J., Arnett, D., Tsai, M., Kabagambe, E., Peacock, J., Hixson, J., Straka, R., Province, M., An, P., Lai, C., Parnell, L.D., Borecki, I., Ordovas, J.M. 2009. ADIPOQ Polymorphisms, Monounsaturated Fatty Acids, and Obesity Risk: The GOLDN Study. Obesity. 17:510-517.
Perilipin polymorphism interacts with dietary carbohydrates to modulate anthropometric traits in Hispanics of Caribbean origin - (Peer Reviewed Journal)
Smith, C., Tucker, K., Yiannakouris, N., Garcia-Bailo, B., Mattei, J., Lai, C., Parnell, L.D., Ordovas, J.M. 2008. Perilipin Polymorphism Interacts with Dietary Carbohydrates to Modulate Anthropometric Traits in Hispanics of Caribbean Origin. Journal of Nutrition. 138(10):1852-1858.
A Common Missense Variant in the Glucokinase Regulatory Protein Gene (GCKR) Is Associated with Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations - (Peer Reviewed Journal)
Orho-Melander, M., Melander, O., Guiducci, C., Perez-Martinez, P., Corella, D., Roos, C., Tewhey, R., Rieder, M.J., Hall, J., Abecasis, G., Tai, E., Welch, C., Arnett, D.K., Lyssenko, V., Lindholm, E., Saxena, R., De Bakker, P., Burtt, N., Voight, B.F., Hirschhorn, J.N., Tucker, K., Hedner, T., Tuomi, T., Isomaa, B., Eriksson, K., Taskinen, M., Wahlstrand, B., Hughes, T.E., Parnell, L.D., Lai, C., Berglund, G., Peltonen, L., Vartiainen, E., Jousilahti, P., Havulinna, A.S., Salomaa, V., Nilsson, P., Groop, L., Altshuler, D., Ordovas, J.M., Kathiresan, S. 2008. A Common Missense Variant in the Glucokinase Regulatory Protein Gene (GCKR) Is Associated with Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations. Diabetes. 57:3112-3121.
The effect of IL6-174C/G polymorphisms on postprandial triglycerides metabolism in the GOLDN study - (Peer Reviewed Journal)
Shen, J., Arnett, D.K., Perez-Martinez, P., Parnell, L.D., Peacock, J.M., Hixson, J.E., Tsai, M.Y., Lai, C., Straka, R.J., Hopkins, P.N., Ordovas, J.M. 2008. The effect of IL6-174C/G polymorphisms on postprandial triglycerides metabolism in the GOLDN study. Journal of Lipid Research. 49:1839-1845.
Association of common C-protein (CRP) gene polymorphism with baseline plasma CRP levels and fenofibrate response: The GOLDN Study - (Peer Reviewed Journal)
Shen, J., Arnett, D.K., Parnell, L.D., Peacock, J.M., Lai, C., Hixson, J.E., Tsai, M.Y., Province, M., Straka, R.J., Ordovas, J.M. 2008. Association of common C-protein (CRP) gene polymorphism with baseline plasma CRP levels and fenofibrate response: The GOLDN Study. Diabetes Care. 31(5):910-915.
Ppargc1a Variations Associated with DNA Damage, Diabetes, and Cardiovascular Diseases: the Boston Puerto Rican Study - (Review Article)
Lai, C., Tucker, K., Parnell, L.D., Adiconis, X., Garcia-Bailo, B., Griffith, J., Meydani, M., Ordovas, J.M. 2008. PPARGC1A Variations Associated with DNA Damage, Diabetes, and Cardiovascular Diseases: The Boston Puerto Rican Study. Diabetes. 57:809-816.
The Modulation of Endothelial Cell Gene Expression by Green Tea Polyphenol-Egcg - (Peer Reviewed Journal)
Liu, L., Lai, C., Nie, L., Ordovas, J.M., Band, M., Moser, L., Meydani, M. 2008. THE MODULATION OF ENDOTHELIAL CELL GENE EXPRESSION BY GREEN TEA POLYPHENOL-EGCG. Molecular Nutrition and Food Research. 52:1182-1192.
Speed-Mapping Quantitative Trait Loci Using Microarrays - (Peer Reviewed Journal)
Lai, C., Leips, J., Zou, W., Roberts, J.F., Wollenberg, K.R., Parnell, L.D., Zeng, Z., Ordovas, J.M., Mckay, T.F. 2007. Speed-Mapping Quantitative Trait Loci Using Microarrays. Nature Methods. 4(10):839-841.
Gene expression analysis in pregnant women and their infants identifies unique fetal biomarkers that circulate in maternal blood - (Peer Reviewed Journal)
Maron, J.L., Johnson, K.L., Sionim, D., Lai, C., Ramoni, M., Alterovitz, G., Jerrah, Z., Yang, Z., Bianchi, D.W. 2007. Gene expression analysis in pregnant women and their infants identifies unique fetal biomarkers that circulate in maternal blood. Journal of Clinical Investigation. 117:3007-3019.
Interleukin 1B genetic polymorphisms interact with polyunsaturated fatty acids to affect risk of the metabolic syndrome in the GOLDN Study - (Peer Reviewed Journal)
Shen, J., Arnett, D.K., Peacock, J.M., Parnell, L.D., Aldi, K., Hixson, J.E., Tsai, M.Y., Kabagambe, E.K., Lai, C., Stratka, R.J., Ordovas, J.M. 2007. Interleukin 1B genetic polymorphisms interact with polyunsaturated fatty acids to affect risk of the metabolic syndrome in the GOLDN Study. Journal of Nutrition. 137(8):1846-1851.
The -256T>C Polymorphism in the Apolipoprotein A-II Gene Promoter Is Associated with Body Mass Index and Food Intake in the Genetics of Lipid Lowering Drugs and Diet Network Study - (Peer Reviewed Journal)
Corella, D., Arnett, D.K., Tsai, M.Y., Kabagambe, E.K., Peacock, J.M., Hixson, J.E., Straka, R.J., Province, M., Lai, C., Parnell, L.D., Borecki, I., Ordovas, J.M. 2007. The -256T>C Polymorphism in the Apolipoprotein A-II Gene Promoter Is Associated with Body Mass Index and Food Intake in the Genetics of Lipid Lowering Drugs and Diet Network Study. Clinical Chemistry.53:1144-1152.
Fenofibrate Effect on Triglyceride and Postprandial Response of Apolipoprotein A5 Variants: The GOLDN Study - (Peer Reviewed Journal)
Lai, C., Arnett, D.K., Straka, R.J., Tsai, M.Y., Peacock, J.M., Adiconis, X., Parnell, L.D., Hixson, J.E., Province, M.A., Ordovas, J.M. 2007. Fenofibrate Effect on Triglyceride and Postprandial Response of Apolipoprotein A5 Variants: The GOLDN Study. Arteriosclerosis Thrombo Vasc Biol. 27:1417-1425.
Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping - (Abstract Only)
Lai, C., Parnell, L.D., Lyman, R.F., Ordovas, J.M., Mackay, T.F. 2006. Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping. Mechanisms of Aging and Development 128:237-249.
Apoa5 Gene Variation Modulates the Effects of Dietary Fat Intake on Body Mass Index and Obesity Risk in the Framingham Heart Study - (Peer Reviewed Journal)
Corella, D., Lai, C., Demissie, S., Cupples, A., Manning, A.K., Tucker, K., Ordovas, J.M. 2007. APOA5 gene variation modulates the effects of dietary fat intake on body mass index and obesity risk in the Framingham Heart Study. Journal of Molecular Medicine.85:119-128.
Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet - (Peer Reviewed Journal)
Troen, A.M., French, E.E., Roberts, J.F., Selhub, J., Ordovas, J.M., Parnell, L.D., Lai, C. 2006. Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet. Age.29:29-39.
Dietary Intake of N-6 Fatty Acids Modulates Effect of Apolipoprotein A5 Gene on Plasma Fasting Triglycerides, Remnant Lipoprotein Concentrations, and Lipoprotein Particle Size: the Framingham Heart Study Reprint Icon - (Peer Reviewed Journal)
Lai, C., Corella, D., Demissie, S., Cupples, A., Adiconis, X., Zhu, Y., Ordovas, J.M. 2006. Dietary intake of n-6 fatty acids modulates effect of apolipoprotein a5 gene on plasma fasting triglycerides, remnant lipoprotein concentrations, and lipoprotein particle size: the framingham heart study. Circulation. 113(17):2062-70.
Variants at the Apoa5 Locus, Association with Carotid Atherosclerosis, and Modification by Obesity: the Framingham Study - (Peer Reviewed Journal)
Elosua, R., Ordovas, J.M., Cupples, L., Lai, C., Demissie, S., Fox, C., Polak, J.F., Wolf, P.A., D'Agostino, R.A., O'Donnell, C. 2006. Variants at the apoa5 locus, association with carotid atherosclerosis, and modification by obesity: the framingham study. Journal of Lipid Research. 47(5):990-6.
Genome-Wide Linkage Analyses and Candidate Gene Fine Mapping for Hdl3 Cholesterol: the Framingham Study - (Peer Reviewed Journal)
Yang, Q., Lai, C., Parnell, L.D., Cupples, L., Adiconis, X., Zhu, Y., Wilson, P.W., Housman, D.E., Sherman, A.M., D'Agostino, R.B., Ordovas, J.M. 2005. Genome-wide linkage analyses and candidate gene fine mapping for HDL3 cholesterol: the Framingham Study. Journal of Lipid Research. 46(7):1416-1425.
The Apoa1/c3/a4/a5 Gene Cluster, Lipid Metabolism and Cardiovascular Disease Risk - (Review Article)
Lai, C., Parnell, L.D., Ordovas, J.M. 2005. The apoa1/c3/a4/a5 gene cluster, lipid metabolism and cardiovascular disease risk. Current Opinion in Lipidology 2005, 16:153-166.
Global Gene Expression Analysis of the Living Human Fetus Using Cell-Free Messenger Rna in Amniotic Fluid - (Peer Reviewed Journal)
Larrabee, P.B., Johnson, K.L., Lai, C., Ordovas, J.M., Cowan, J.W., Tantravahi, U., Bianchi, D.W. 2005. Global gene expression analysis of the living human fetus using cell-free messenger RNA in amniotic fluid. Journal of the American Medical Association. 16;293(7):836-42.
Influence of the Apolipoprotein A5 Locus on Plasma Triglyceride, Remnant-Like Particles, and Lipoprotein Subfraction Concentrations -Implication for Cardiovascular Risk in the Framingham Heart Study - (Peer Reviewed Journal)
Lai, C., Demissie, S., Cupples, A., Zhu, Y., Adiconis, X., Parnell, L.D., Corella, D., Ordovas, J.M. 2004. Influence of the apolipoprotein a5 locus on plasma triglyceride, remnant-like particles, and lipoprotein subfraction concentrations -implication for cardiovascular risk in the framingham heart study. Arteriosclerosis Thrombosis and Vascular Biology. 2004; 45: 2096-2105
The Apolipoprotein A5 Locus Is a Strong Determinant of Plasma Triglyceride Concentrations Across Ethnic Groups in Singapore - (Peer Reviewed Journal)
Lai, C., Tai, E., Tan, C., Cutter, J., Chew, S., Zhu, Y., Adiconis, X., Ordvas, J. 2003. The apolipoprotein a5 locus is a strong determinant of plasma triglyceride concentrations across ethnic groups in singapore. Journal Of Lipid Research 2003;44:2365-73.
Last Modified: 12/18/2014
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