Projects

A SYSTEMS BIOLOGY APPROACH TO UNDERSTANDING THE SALMONELLA-HOST INTERACTOME IN POULTRY AND SWINE Appropriated (D)   Accession Number: 420971

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Obligate brood parasites show more functionally effective innate immune responses: An eco-immunological hypothesis - (Peer Reviewed Journal) - (02-Apr-13)

Enhanced innate immune responses in a brood parasitic cowbird species: Degranulation and oxidative burst - (Peer Reviewed Journal) - (17-Dec-12)

A comparative study on invasion, survival, modulation of oxidative burst, and nitric oxide responses of macrophages (HD11), and systemic infection in chickens by prevalent poultry Salmonella serovars - (Peer Reviewed Journal)

He, L.H., Genovese, K.J., Swaggerty, C.L., Nisbet, D.J., Kogut, M.H. 2012. A comparative study on invasion, survival, modulation of oxidative burst, and nitric oxide responses of macrophages (HD11), and systemic infection in chickens by prevalent poultry Salmonella serovars. Foodborne Pathogens and Disease. 9:1104-1110.

Electron-beam irradiation inactivation of Salmonella: Effects on innate immunity and induction of protection against Salmonella enterica serovar Typhimurium challenge of chickens - (Peer Reviewed Journal)

Kogut, M.H., McReynolds, J., He, L.H., Genovese, K.J., Jesudhasan, P.R., Davidson, M.A., Cepeda, M.A., Pillai, S.D. 2012. Electron-beam irradiation inactivation of Salmonella: Effects on innate immunity and induction of protection against Salmonella enterica serovar Typhimurium challenge of chickens. Procedia in Vaccinology. 6:47-63.

Loxoribine pretreatment reduces Salmonella enteritidis organ invasion in 1-day-old chickens - (Peer Reviewed Journal)

Swaggerty, C.L., He, L.H., Genovese, K.J., Duke, S.E., Kogut, M.H. 2012. Loxoribine pretreatment reduces Salmonella enteritidis organ invasion in 1-day-old chickens. Poultry Science. 91:1038-1042.

Co-stimulation with TLR3 and TLR21 ligands synergistically up-regulates Th1-cytokine IFN-gamma and regulatory cytokine IL-10 expression in chicken monocytes - (Peer Reviewed Journal)

He, L.H., Genovese, K.J., Swaggerty, C.L., MacKinnon, K.M., Kogut, M.H. 2011. Co-stimulation with TLR3 and TLR21 ligands synergistically up-regulates Th1-cytokine IFN-gamma and regulatory cytokine IL-10 expression in chicken monocytes. Developmental and Comparative Immunology. 36:756-760.

Bacterial toll-like receptor agonists induce sequential NF-kB-mediated leukotriene B4 and prostaglandin E2 production in chicken heterophils - (Peer Reviewed Journal)

Kogut, M.H., He, L.H., Genovese, K.J. 2011. Bacterial toll-like receptor agonists induce sequential NF-kB-mediated leukotriene B4 and prostaglandin E2 production in chicken heterophils. Veterinary Immunology and Immunopathology. 145:159-170.

BT cationic peptides: Small peptides that modulate innate immune responses of chicken heterophils and monocytes - (Peer Reviewed Journal)

Kogut, M.H., Genovese, K.J., He, L.H., Swaggerty, C.L., Jiang, Y. 2011. BT cationic peptides: Small peptides that modulate innate immune responses of chicken heterophils and monocytes. Veterinary Immunology and Immunopathology. 145:151-158.

Systemic response to Campylobacter jejuni infection by profiling gene transcription in the spleens of two genetic lines of chickens - (Peer Reviewed Journal)

Li, X., Swaggerty, C.L., Kogut, M.H., Chiang, H.I., Wang, Y., He, L.H., Genovese, K.J., Mccarthy, F., Burgess, S., Pevzner, I.Y., Zhou, H. 2011. Systemic response to Campylobacter jejuni infection by profiling gene transcription in the spleens of two genetic lines of chickens. Immunogenetics. 64:59-69.

Effects of avian triggering receptor expressed on myeloid cells (TREM-A1) activation on heterophil functional activites - (Peer Reviewed Journal)

Kogut, M.H., Genovese, K.J., Nerren, J., He, L.H. 2012. Effects of avian triggering receptor expressed on myeloid cells (TREM-A1) activation on heterophil functional activites. Developmental and Comparative Immunology. 36:157-165.

SRC protein tyrosine kinase, c-Jun N-terminal kinase (JNK), and NF-kappaBp65 signaling in commercial and wild-type turkey leukocytes - (Peer Reviewed Journal) - (11-Jan-11)

Modulation of chicken macrophage effector function by Th1/Th2 cytokines - (Peer Reviewed Journal)

He, H., Genovese, K.J., Kogut, M.H. 2011. Modulation of chicken macrophage effector function by Th1/Th2 cytokines. Cytokine. 53:363-369.

Protein tyrosine kinase and mitogen-activated protein kinase signalling pathways contribute to differences in heterophil-mediated innate immune responsiveness between two lines of broilers - (Peer Reviewed Journal)

Swaggerty, C.L., He, L.H., Genovese, K.J., Pevzner, I.Y., Kogut, M.H. 2011. Protein tyrosine kinase and mitogen-activated protein kinase signaling pathways contribute to differences in heterophil-mediated innate immune responsiveness between two lines of broilers. Avian Pathology. 40:289-297.

Caecal transcriptome analysis of colonized and non-colonized chickens within two genetic lines that differ in caecal colonization by Campylobacter jejuni - (Peer Reviewed Journal)

Li, X., Swaggerty, C.L., Kogut, M.H., Chiang, H., Wang, Y., Genovese, K.J., He, L.H., Pevzner, I.Y., Zhou, H. 2011. Caecal transcriptome analysis of colonized and non-colonized chickens within two genetic lines that differ in caecal colonization by Campylobacter jejuni. Animal Genetics. 42:491-500.

Gene expression profiling of the local cecal response of genetic chicken lines that differ in their susceptibility to Campylobacter jejuni colonization - (Peer Reviewed Journal)

Li, X., Swaggerty, C.L., Kogut, M.H., Chiang, H., Wang, Y., Genovese, K.J., He, H., Zhou, H. 2010. Gene expression profiling of the local cecal response of genetic chicken lines that differ in their susceptibility to Campylobacter jejuni colonization. PLoS One. 5:e11827.

Expression of the avian-specific toll-like receptor 15 in chicken heterophils is mediated by Gram-negative and Gram-postive bacteria, but not TLR agonists - (Peer Reviewed Journal)

Nerren, J.R., He, H., Genovese, K.J., Kogut, M.H. 2010. Expression of the avian-specific toll-like receptor 15 in chicken heterophils is mediated by Gram-negative and Gram-postive bacteria, but not TLR agonists. Veterinary Immunology and Immunopathology. 136:151-156.

CpG oligodeoxynucleotide and double-stranded RNA synergize nitric oxide production and mRNA expression of inducible nitric oxide synthase, pro-inflammatory cytokines, and chemokines in chicken monocytes - (Peer Reviewed Journal)

He, L.H., Mackinnon, K.M., Genovese, K.J., Kogut, M.H. 2010. CpG oligodeoxynucleotide and double-stranded RNA synergize nitric oxide production and mRNA expression of inducible nitric oxide synthase, pro-inflammatory cytokines, and chemokines in chicken monocytes. Journal of Innate Immunity. 16:1-8.

Alfalfa as a nutritive modulator in maintaining the innate immune response during the molting process - (Peer Reviewed Journal)

McReynolds, J.L., Genovese, K.J., He, H., Swaggerty, C.L., Byrd II, J.A., Ricke, S.C., Nisbet, D.J., Kogut, M.H. 2009. Alfalfa as a nutritive modulator in maintaining the innate immune response during the molting process. Journal of Applied Poultry Research. 18:410-417.

Feeding the BT cationic peptides to chickens at hatch reduces cecal colonization by Salmonella enterica serovar Enteritidis and primes innate immune cell functional activity - (Peer Reviewed Journal)

Kogut, M.H., He, H., Genovese, K.J., Jiang, Y. 2010. Feeding the BT cationic peptides to chickens at hatch reduces cecal colonization by Salmonella enterica serovar Enteritidis and primes innate immune cell functional activity. Foodborne Pathogens and Disease. 7:23-30.

Chicken scavenger receptors and their ligand-induced cellular immune responses - (Peer Reviewed Journal)

He, H., MacKinnon, K.M., Genovese, K.J., Nerren, J.R., Swaggerty, C.L., Nisbet, D.J., Kogut, M.H. Chicken scavenger receptors and their ligand-induced cellular immune responses. Molecular Immunology. 46:2218-2225.

Selection of broilers with improved innate immune responsiveness to reduce on-farm infection by foodborne pathogens: A review - (Peer Reviewed Journal)

Swaggerty, C.L., Pevzner, I.Y., He, H., Genovese, K.J., Nisbet, D.J., Kaiser, P., Kogut, M.H. 2009. Selection of broilers with improved innate immune responsiveness to reduce on-farm infection by foodborne pathogens: A review. Foodborne Pathogens and Disease. 6:1-7.

Expression profile of toll-like receptors within the gastrointestinal tract of 2-day-old Salmonella enteriditis-infected broiler chickens - (Peer Reviewed Journal)

MacKinnon, K.M., He, H., Nerren, J.R., Swaggerty, C.L., Genovese, K.J., Kogut, M.H. 2009. Expression profile of toll-like receptors within the gastrointestinal tract of 2-day-old Salmonella enteriditis-infected broiler chickens. Infection and Immunity. 137:313-319.

Differential mRNA expression of the avian-specific toll-like receptor 15 between heterophils from Salmonella-susceptible and -resistant chickens - (Peer Reviewed Journal)

Nerren, J.R., Swaggerty, C.L., MacKinnon, K.M., Genovese, K.J., He, H., Pevzner, I., Kogut, M.H. 2009. Differential mRNA expression of the avian-specific toll-like receptor 15 between heterophils from Salmonella-susceptible and -resistant chickens. Immunogenetics. 61:71-77.

In ovo treatment with CpG oligodeoxynucleotides decreases colonization of Salmonella enteriditis - (Peer Reviewed Journal)

MacKinnon, K.M., He, H., Swaggerty, C.L., McReynolds, J.L., Genovese, K.J., Duke, S.E., Nerren, J.R., Kogut, M.H. 2009. In ovo treatment with CpG oligodeoxynucleotides decreases colonization of Salmonella enteriditis. Veterinary Immunology and Immunopathology. 127:371-375.

Genome-wide gene expression profiling of chicken spleen responding to Campylobacter jejuni infection in broilers - (Abstract Only)

Li, X., Swaggerty, C.L., Kogut, M.H., Chiang, H., Ying, W., Genovese, K.J., He, H., Pevzner, I., Zhou, H. 2009. Genome-wide gene expression profiling of chicken spleen responding to Campylobacter jejuni infection in broilers [abstract]. Plant & Animal Genome XVII Conference, January 10-14, 2009, San Diego, California. p. 511.

Gene expression profiling of innate immune response to Campylobacter jejuni infection in the bursa of broilers - (Abstract Only)

Li, X., Swaggerty, C.L., Kogut, M.H., Chiang, H., Ying, W., Genovese, K.J., He, H., Kirita, V.J., Pevzner, I., Zhou, H. 2009. Gene expression profiling of innate immune response to Campylobacter jejuni infection in the bursa of broilers [abstract]. Plant & Animal Genome XVII Conference, January 10-14, 2009, San Diego, California. p. 509.

A survey of Rhipicephalus microplus populations for mutations associated by pyrethroid resistance - (Peer Reviewed Journal)

Chen, A.C., He, H., Temeyer, K.B., Jones, S., Green, P., Barker, S.C. 2009. A survey of Rhipicephalus microplus populations for mutations associated by pyrethroid resistance. Journal of Economic Entomology. 120(1):373-380.

Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2-dependent activation of AP-1 and NF-kappaB signaling pathways - (Peer Reviewed Journal)

Kogut, M.H., Genovese, K.J., He, H., Kaiser, P. 2008. Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2-dependent activation of AP-1 and NF-kappaB signaling pathways. Innate Immunity. 14:213-222.

The paternal effect of Campylobacter jejuni colonization in ceca in broilers - (Peer Reviewed Journal)

Li, X., Swaggerty, C.L., Kogut, M.H., Chiang, H., Wang, Y., Genovese, K.J., He, H., Stern, N.J., Pevzner, I.Y., Zhou, H. 2008. The paternal effect of Campylobacter jejuni colonization in ceca in broilers. Poultry Science. 87:1742-1747.

Phospholipase C, phosphatidylinositol 3-kinase, and intracellular [Ca2+] are involved in activation of chicken HD11 macrophage by CpG oligodeoxynucleotide - (Peer Reviewed Journal)

He, H., Genovese, K.J., Nisbet, D.J., Kogut, M.H. 2008. Phospholipase C, phosphatidylinositol 3-kinase, and intracellular [Ca2+] are involved in activation of chicken HD11 macrophage by CpG oligodeoxynucleotide. Developmental and Comparative Immunology. 32(10):1111-1118.

Differential induction of nitric oxide, degranulation, and oxidative burst activities in response to microbial agonist stimulation in monocytes and heterophils from young commercial turkeys - (Peer Reviewed Journal)

He, H., Genovese, K.J., Swaggerty, C.L., Nisbet, D.J., Kogut, M.H. 2008. Differential induction of nitric oxide, degranulation, and oxidative burst activities in response to microbial agonist stimulation in monocytes and heterophils from young commercial turkeys. Veterinary Immunology and Immunopathology. 123(3-4):177-185.

Identification of novel attenuated Salmonella Enteritidis mutants - (Peer Reviewed Journal)

Chang, J., Pang, E., He, L.H., Kwong, J. 2008. Identification of novel attenuated Salmonella Enteritidis mutants. FEMS Immunology and Medical Microbiology. 53:26-34.

MUTATIONS IN A PUTATIVE OCTOPAMINE RECEPTOR GENE IN AMITRAZ-RESISTANT CATTLE TICKS - (Peer Reviewed Journal)

Chen, A.C., He, H., Davey, R.B. 2007. Mutations in a putative octopamine receptor gene in amitraz-resistant cattle ticks. Veterinary Parasitology. 148:379-383.

Salmonella induces SRC protein tyrosine kinase, c-Jun N-terminal kinase (JNK), and NF-kappaBp65 signaling pathways in commercial and wild-type turkey leukocytes - (Abstract Only)

Genovese, K.J., He, H., McReynolds, J.L., Swaggerty, C.L., Nisbet, D.J., Kogut, M.H. 2007. Salmonella induces SRC protein tyrosine kinase, c-Jun N-terminal kinase (JNK), and NF-kappaBp65 signaling pathways in commercial and wild-type turkey leukocytes [abstract]. In: Proceedings of the Society for Leukocyte Biology, October 11-13, 2007, Cambridge, Massachusetts. p. 58.

Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by NF-kappaB and AP-1 pathways - (Abstract Only)

Kogut, M.H., Genovese, K.J., He, H. 2007. Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by NF-kappaB and AP-1 pathways [abstract]. In: Proceedings of the Society for Leukocyte Biology, October 11-13, 2007, Cambridge, Massachusetts. p. 57.

Innate immune responses to microbial agonist stimulations in heterophils and monocytes from young commercial turkeys - (Abstract Only)

He, H., Genovese, K.J., Kogut, M.H. 2007. Innate immune responses to microbial agonist stimulations in heterophils and monocytes from young commercial turkeys [abstract]. In: Proceedings of World Veterinary Poultry Association, September 10-15, 2007, Beijing, China. p. 593.

Dynamics of the avian inflammatory response to Salmonella following administration of the toll-like receptor 5 agonist flagellin - (Peer Reviewed Journal)

Genovese, K.J., He, H., Lowry, V.K., Nisbet, D.J., Kogut, M.H. 2007. Dynamics of the avian inflammatory response to Salmonella following administration of the toll-like receptor 5 agonist flagellin. FEMS Immunology and Medical Microbiology. 51(1):112-117.

Immune stimulatory CpG oligodeoxynucleotides reduces Salmonella enterica subsp. Arizonae organ colonization and mortality in young turkeys - (Abstract Only)

He, H., Genovese, K.J., Swaggerty, C.L., Kogut, M.H. 2007. Immune stimulatory CpG oligodeoxynucleotides reduces Salmonella enterica subsp. Arizonae organ colonization and mortality in young turkeys [abstract]. Poultry Science. 86:300.

CpG oligodeoxynucleotide and double-stranded RNA synergize inflammatory cytokine gene expressions in chicken monocytes - (Abstract Only)

He, H., Genovese, K.J., Kogut, M.H. 2007. CpG oligodeoxynucleotide and double-stranded RNA synergize inflammatory cytokine gene expressions in chicken monocytes [abstract]. The Journal of Immunology. 178:90.13.

In vivo priming heterophil innate immune functions and increasing resistance to Salmonella enteritidis infection in neonatal chickens by immune stimulatory CpG-ODN - (Peer Reviewed Journal)

He, H., Genovese, K.J., Swaggerty, C.L., Nisbet, D.J., Kogut, M.H. 2007. In vivo priming heterophil innate immune functions and increasing resistance to Salmonella enteritidis infection in neonatal chickens by immune stimulatory CpG-ODN oligodeoxynucleotides. Veterinary Immunology and Immunopathology. 117:275-283.

The effects of BT/TAMUS 2032 cationic peptide on innate immunity and susceptibility of young chickens to extraintestinal Salmonella enterica serovar Enteritidis infection - (Peer Reviewed Journal)

Kogut, M.H., Genovese, K.J., He, H., Li, M.A., Jiang, Y.W. 2007. The effects of BT/TAMUS 2032 cationic peptides on innate immunity and susceptibility of young chickens to extraintestinal Salmonella enterica serovar Enteritidis infection. International Immunopharmacology. 7:912-919.

Synergy of CpG oligodeoxynucleotide and double-stranded RNA (poly I:C) on nitric oxide induction in chicken peripheral blood monocytes - (Peer Reviewed Journal)

He, H., Genovese, K.J., Nisbet, D.J., Kogut, M.H. 2007. Synergy of CpG oligodeoxynucleotide and double-stranded RNA (poly I:C) on nitric oxide induction in chicken peripheral blood monocytes. Molecular Immunology. 44:3234-3242.

Protein tyrosine and mitogen activated kinase activities in turkey heterophils isolated from commercial and wild-type turkeys - (Peer Reviewed Journal)

Genovese, K.J., He, H., Lowry, V.K., Kogut, M.H. 2007. Comparison of MAP and tyrosine kinase signaling in heterophils from commercial and wild-type turkeys. Developmental and Comparative Immunology. 31:927-933.

Use of toll-like receptor agonists to reduce Salmonella colonization in neonatal swine - (Proceedings)

Genovese, K.J., He, H., Nisbet, D.J., Kogut, M.H. 2007. Use of toll-like receptor agonists to reduce Salmonella colonization in neonatal swine. In: Proceedings of 7th International Safepork Symposium, May 9-11, 2007, Verona, Italy. p. 244-247.

COMPARISON OF ERK 1/2, P38 MAPK, AND PTK KINASE ACTIVITY IN HETEROPHILS FROM WILD-TYPE TURKEYS TO ACTIVITY IN HETEROPHILS FROM A COMMERCIAL TURKEY LINE - (Abstract Only)

Genovese, K.J., Lowry, V.K., He, H., Nisbet, D.J., Kogut, M.H. 2006. Comparison of ERK1/2, p38 MAPK, and PTK activity in heterophils from wild-type turkeys to heterophils from a commercial turkey line [abstract]. Innate Immunity Keystone Symposia. p. 60.

THE FEATHERING GENE IS LINKED TO DEGRANULATION AND OXIDATIVE BURST NOT CYTOKINE/CHEMOKINE MRNA EXPRESSION LEVELS OR SALMONELLA ENTERITIDIS ORGAN INVASION IN BROILERS - (Peer Reviewed Journal)

Swaggerty, C.L., He, H., Genovese, K.J., Kaiser, P., Pevzner, I.Y., Kogut, M.H. 2006. The feathering gene is linked to degranulation and oxidative burst not cytokine/chemokine mRNA expression levels or Salmonella enteritidis organ invasion in broilers. Avian Pathology. 35:465-470.

FLAGELLIN AND LIPOPOLYSACCHARIDE STIMULATE THE MEK-ERK SIGNALING PATHWAY IN CHICKEN HETEROPHILS THROUGH DIFFERENTIAL ACTIVATION OF THE SMALL GTPASES, RAS AND RAP1 - (Peer Reviewed Journal)

Kogut, M.H., Genovese, K.J., He, H. 2006. Flagellin and lipopolysaccharide stimulate the MEK-ERK signaling pathway in chicken heterophils through differential activation of the small GTPases, Ras and Rap1. Molecular Immunology. 44:1729-1736.

INVOLVEMENT OF PHOSPHATIDYLINOSITOL-PHOSPHOLIPASE C IN IMMUNE RESPONSE TO SALMONELLA LIPOPOLYSACHARIDE IN CHICKEN MACROPHAGE CELLS (HD11) - (Peer Reviewed Journal)

He, H., Genovese, K.J., Nisbet, D.J., Kogut, M.H. 2006. Involvement of phosphatidylinositol-phospholipase C in immune response to Salmonella lipopolysacharide in chicken macrophage cells (HD11). International Immunopharmacology. 6:1780-1787.

FUNCTIONAL ANALYSIS OF CHICKEN MYD88 IN TOLL-LIKE RECEPTOR MEDIATED INNATE IMMUNE RESPONSES BY USING ANTISENSE OLIGONUCLEOTIDES - (Abstract Only)

He, H., Genovese, K.J., Kogut, M.H. 2006. Functional analysis of chicken MyD88 in toll-like receptor mediated innate immune responses by using antisense oligonucleotides [abstract]. In: Proceedings of 09th Avian Immunology Research Group Meeting, October 21-24, 2006, Paris, France. p. 20.

PROPHYLACTIC APPLICATION OF IMMUNE STIMULATORY CPG-ODN REDUCES SALMONELLA ENTERICA SUBSP. ARIZONAE ORGAN COLONIZATION AND MORTALITY IN YOUNG TURKEYS - (Abstract Only)

He, H., Genovese, K.J., Swaggerty, C.L., Kogut, M.H. 2006. Prophylactic application of immune stimulatory CpG-ODN reduces Salmonella enterica subsp. Arizonae organ colonization and mortality in young turkeys [abstract]. American Society for Microbiology. p. 67.

NITRIC OXIDE SYNTHESIS AND CYTOKINE GENE EXPRESSION IN CHICKEN MONOCYTES STIMULATED WITH CPG-ODN AND DOUBLE-STRANDED RNA - (Abstract Only)

He, H., Genovese, K.J., Kogut, M.H. 2006. Nitric oxide synthesis and cytokine gene expression in chicken monocytes stimulated with CpG-ODN and double-stranded RNA [abstract]. In: Proceedings of 09th Avian Immunology Research Group Meeting, October 21-24, 2006, Paris, France. p. 29.

DIFFERENTIAL HETEROPHIL INTRACELLULAR SIGNALING AND FUNCTIONS IN WILD-TYPE AND COMMERCIAL TURKEYS - (Abstract Only)

Genovese, K.J., He, H., Swaggerty, C.L., Kogut, M.H. 2006. Differential heterophil intracellular signaling and functions in wild-type and commercial turkeys [abstract]. In: Proceedings of 09th Avian Immunology Research Group Meeting, October 21-24, 2006, Paris, France. p. 51.

IN VIVO EFFECTS OF SALMONELLA FLAGELLIN ADMINISTRATION TO DAY-OLD CHICKENS - (Abstract Only)

Genovese, K.J., He, H., Kogut, M.H. 2006. In vivo effects of Salmonella flagellin administration to day-old chickens [abstract]. American Society for Microbiology. p. 43.

RESPONSE OF NITRIC OXIDE PRODUCTION TO CPG OLIGODEOXYNUCLEOTIDES IN TURKEY AND CHICKEN PERIPHERAL BLOOD MONOCYTES - (Peer Reviewed Journal)

He, H., Genovese, K.J., Lowry, V.K., Nisbet, D.J., Kogut, M.H. 2006. Response of nitric oxide production to CpG oligodeoxynucleotides in turkey and chicken peripheral blood monocytes. FEMS Immunology and Medical Microbiology. 48:99-106.

TAMUS CATIONIC PEPTIDES DECREASE SUSCEPTIBILITY OF YOUNG CHICKENS TO SALMONELLA ENTERICA SEROVAR ENTERITIDIS INFECTION BY UP-REGULATION OF THE INNATE IMMUNE RESPONSE - (Abstract Only)

Kogut, M.H., Genovese, K.J., He, H., Jiang, Y. 2006. TAMUS cationic peptides decrease susceptibility of young chickens to Salmonella enterica serovar Enteritidis infection by up-regulation of the innate immune response [abstract]. American Society for Microbiology. p. 43.

FLAGELLIN AND LIPOPOLYSACCHARIDE STIMULATE THE MEK-ERK SIGNALING PATHWAY IN CHICKEN HETEROPHILS THROUGH DIFFERENTIAL ACTIVATION OF THE SMALL GTPASES, RAS AND RAP1 - (Abstract Only)

Kogut, M.H., Genovese, K.J., He, H. 2006. Flagellin and lipopolysaccharide stimulate the MEK-ERK signaling pathway in chicken heterophils through differential activation of the small GTPases, Ras and Rap1 [abstract]. In: Proceedings of 09th Avian Immunology Research Group Meeting, October 21-24, 2006, Paris, France. p. 97.

THE FEATHERING GENE IS LINKED TO DEGRANULATION AND OXIDATIVE BURST NOT CYTOKINE/CHEMOKINE EXPRESSION OR SALMONELLA ENTERITIDIS ORGAN INVASION IN BROILERS - (Abstract Only)

Swaggerty, C.L., He, H., Genovese, K.J., Kaiser, P., Pevzner, I.Y., Kogut, M.H. 2006. The feathering gene is linked to degranulation and oxidative burst not cytokine/chemokine expression or Salmonella enteritidis organ invasion in broilers [abstract]. In: Proceedings of 09th Avian Immunology Research Group Meeting, October 21-24, 2006, Paris, France. p. 58.

INTERACTION OF BACTERIAL CPG-ODN AND VIRAL DOUBLE-STRANDED RNA (POLY I:C) ON THE INNATE IMMUNE RESPONSES IN CHICKEN MONOCYTES - (Abstract Only)

He, H., Genovese, K.J., Kogut, M.H. 2006. Interaction of bacterial CpG-ODN and viral double-stranded RNA (poly I:C) on nitric oxide synthesis and cytokine gene expression in chicken monocytes [abstract]. 10th International Congress of Developmental and Comparative Immunology. p. 122.

CELL SIGNALING AND HOST INNATE IMMUNE DEFENSES IN WILD-TYPE AND COMMERCIAL TURKEYS - (Abstract Only)

Genovese, K.J., He, H., Lowry, V.K., Swaggerty, C.L., Nisbet, D.J., Kogut, M.H. 2006. Cell signaling and host innate immune defenses in wild-type and commercial turkeys [abstract]. 10th International Congress of Developmental and Comparative Immunology. p. 110.

FLAGELLIN AND LPS STIMULATE THE MEK-ERK SIGNALING PATHWAY IN CHICKEN HETEROPHILS THROUGH DIFFERENTIAL ACTIVATION OF THE SMALL GTPASES, RAS, & RAP1 - (Abstract Only)

Kogut, M.H., Genovese, K.J., He, H. 2006. Flagellin and LPS stimulate the MEK-ERK signaling pathway in chicken heterophils through differential activation of the small GTPases, Ras, & Rap1 [abstract]. 10th International Congress of Developmental and Comparative Immunology. p. 140.

THE FEATHERING GENE INFLUENCES DEGRANULATION AND OXIDATIVE BURST BUT NOT CYTOKINE/CHEMOKINE MRNA EXPRESSION OR SALMONELLA ENTERITIDIS ORGAN INVASION IN BROILERS - (Abstract Only)

Swaggerty, C.L., He, H., Genovese, K.J., Kaiser, P., Pevzner, I.Y., Kogut, M.H. 2006. The feathering gene influences degranulation and oxidative burst but not cytokine/chemokine mRNA expression or Salmonella enteritidis organ invasion in broilers [abstract]. In: Proceedings of 10th International Congress of Developmental and Comparative Immunology, July 1-6, 2006, Charleston, South Carolina. p. 236.

COMPARISON OF HETEROPHIL FUNCTIONS OF MODERN COMMERCIAL AND WILD-TYPE RIO GRANDE TURKEYS - (Peer Reviewed Journal)

Genovese, K.J., He, H., Lowry, V.K., Swaggerty, C.L., Kogut, M.H. 2006. Comparison of heterophil functions of modern commercial and wild-type Rio Grande turkeys. Avian Pathology. 35:217-223.

PHOSPHATIDYLINOSITOL-PHOSPHOLIPASE C MODULATES TLR4-MEDIATED IMMUNE RESPONSES TO SALMONELLA LIPOPOLYSACCHARIDE IN CHICKEN MACROPHAGE CELLS (HD11) - (Abstract Only)

He, H., Genovese, K.J., Kogut, M.H. 2006. Phosphatidylinositol-phospholipase C modulates TLR4-mediated immune responses to Salmonella lipopolysaccharide in chicken macrophage cells (HD11) [abstract]. Innate Immunity Keystone Symposia. p. 65.

STIMULATION OF AVIAN HETEROPHILS BY DIFFERENT TLR AGONISTS INDUCE RAS-DEPENDENT AND RAS-INDEPENDENT ACTIVATION OF ERK SIGNALING - (Abstract Only)

Kogut, M.H., Genovese, K.J., He, H. 2006. Stimulation of avian heterophils by different toll-like agonists induce Ras-dependent and Ras-independent activation of ERK signaling [abstract]. Innate Immunity Keystone Symposia. p. 70.

BACTERIAL CPG-DNA AND VIRAL DOUBLE-STRANDED RNA SYNERGIZE INNATE IMMUNE RESPONSES IN MONOCYTES FROM NEONATAL CHICKENS - (Abstract Only)

He, H., Genovese, K.J., Kogut, M.H. 2005. Bacterial CpG-DNA and viral double-stranded RNA synergize innate immune responses in monocytes from neonatal chickens [abstract]. Cell Research. 15(Suppl. 10):249.

EXPRESSION OF TOLL-LIKE RECEPTORS AND DIFFERENTIAL ACTIVATION OF NITRIC OXIDE SYNTHASE BY TOLL-LIKE RECEPTOR AGONISTS ON MONOCYTES FROM NEONATAL CHICKENS - (Peer Reviewed Journal)

He, H., Genovese, K.J., Nisbet, D.J., Kogut, M.H. 2006. Profile of toll-like receptor expressions and induction of nitric oxide synthesis by toll-like receptor agonists in chicken monocytes. Molecular Immunology. 43:783-789.

EFFECT OF CPG ON SWINE NEUTROPHILS AND USE AGAINST SALMONELLA IN PIGS - (Proceedings)

Genovese, K.J., He, H., Lowry, V., Kogut, M.H. 2005. Effect of CpG on swine neutrophils and use against Salmonella in pigs. Proceedings of SafePork 2005. p. 271-273.

LIPOPOLYSACCAHRIDE-BINDING PROTEIN/CD14/TLR4-DEPENDENT RECOGNITION OF SALMONELLA LPS INDUCES THE FUNCTIONAL ACTIVATION OF CHICKEN HETEROPHILS AND UP-REGULATION OF PRO-INFLAMMATORY CYTOKINE & CHEMOKINE GENE EXPRESSION IN CELLS - (Peer Reviewed Journal)

Kogut, M.H., He, H., Kaiser, P. 2005. Lipopolysaccahride-binding protein/CD14/TLR4-dependent recognition of Salmonella LPS induces the functional activation of chicken heterophils and up-regulation of pro-inflammatory cytokine and chemokine gene expression in cells. Animal Biotechnology. 16:165-181.

USE OF ANTISENSE OLIGONUCLEOTIDES AS A FUNCTIONAL GENOMIC RESEARCH TOOL TO ELUCIDATE ROLE OF CHICKEN MYD88 IN TOLL-LIKE RECEPTOR MEDIATED INNATE IMMUNE RESPONSES IN VITRO - (Abstract Only)

He, H., Genovese, K.J., Kogut, M.H. 2005. Use of antisense oligonucleotides as a functional genomic research tool to elucidate role of chicken MyD88 in toll-like receptor mediated innate immune responses in vitro [abstract]. Chicken Genomics and Development. p. 28.

LIPOLYSACCHARIDE BINDING PROTEIN/CD14/TLR4-DEPENDENT RECOGNITION OF SALMONELLA-LPS INDUCES THE FUNCTIONAL ACTIVATION AND UP-REGULATION OF PRO-INFLAMMATORY CYTOKINE AND CHEMOKINE GENE EXPRESSION IN CHICKEN HETEROPHILS - (Abstract Only)

Kogut, M.H., He, H., Kaiser, P. 2005. Lipolysaccharide binding protein/CD14/TLR4-dependent recognition of Salmonella-LPS induces the functional activation and up-regulation of pro-inflammatory cytokine and chemokine gene expression in chicken heterophils [abstract]. Chicken Genomics and Development. p. 34.

EXPRESSION AND FUNCTION OF TOLL-LIKE RECEPTORS IN CHICKEN HETEROPHILS - (Peer Reviewed Journal)

Kogut, M.H., Iqbal, M., He, H., Philbin, V., Kaiser, P., Smith, A. 2005. Expression and function of toll-like receptors in chicken heterophils. Developmental and Comparative Immunology. 29:791-807.

EXPRESSION OF TOLL-LIKE RECEPTORS AND DIFFERENTIAL ACTIVATION OF NITRIC OXIDE SYNTHASE BY TOLL-LIKE RECEPTOR AGONISTS IN MONOCYTES FROM NEONATAL CHICKEN - (Abstract Only)

He, H., Kogut, M.H. 2005. Expression of toll-like receptors and differential activation of nitric oxide synthase by toll-like receptor agonists in monocytes from neonatal chicken [abstract]. Innate Immunity to Pathogens Keystone Symposium. p. 49.

USE OF CPG OLIGODEOXYNUCLEOTIDES TO STIMULATE PORCINE NEUTROPHILS IN VITRO AND TO REDUCE SALMONELLA CHOLERAESUIS COLONIZATION IN VIVO - (Abstract Only)

Genovese, K.J., He, H., Lowry, V.K., Kogut, M.H. 2005. Use of CpG oligodeoxynucleotides to stimulate porcine neutrophils in vitro and to reduce Salmonella choleraesuis colonization in vivo [abstract]. Innate Immunity to Pathogens Keystone Symposium. p. 48.

RECOMBINANT CHICKEN IL-6 DOES NOT ACTIVATE HETEROPHILS ISLOATED FROM DAY-OLD CHICKENS IN VITRO - (Peer Reviewed Journal)

Ferro, P.J., Swaggerty, C.L., He, H., Rothwell, L., Kaiser, P., Kogut, M.H. 2005. Recombinant chicken IL-6 does not activate heterophils isloated from day-old chickens in vitro. Developmental and Comparative Immunology. 29:375-383.

IN VITRO ACTIVATION OF CHICKEN LEUKOCYTES AND IN VIVO PROTECTION AGAINST SALMONELLA ENTERITIDIS ORGAN INVASION AND PERITONEAL S. ENTERITIDIS INFECTION-INDUCED MORTALITY IN NEONATAL CHICKENS BY IMMUNOSTIMULATORY CPG OLIGODEOXY - (Peer Reviewed Journal)

He, H., Lowry, V.K., Swaggerty, C.L., Ferro, P.J., Kogut, M.H. 2004. In vitro activation of chicken leukocytes and in vivo protection against Salmonella enteritidis organ invasion and peritoneal S. enteritidis infection-induced mortality in neonatal chickens by immunostimulatory CpG oligodeoxynucleotide. FEMS Immunology and Medical Microbiology. 43:81-89.

CPG-OLIGODEOXYNUCLEOTIDE-STIMULATED CHICKEN HETEROPHIL DEGRANULATION IS SERUM COFACTOR AND CELL SURFACE RECEPTOR DEPENDENT - (Peer Reviewed Journal)

He, H., Lowry, V.K., Ferro, P.J., Kogut, M.H. 2005. CpG-oligodeoxynucleotide-stimulated chicken heterophil degranulation is serum cofactor and cell surface receptor dependent. Developmental and Comparative Immunology. 29:255-264.

CPG-OLIGODEOXYNUCLEOTIDE-STIMULATED CHICKEN HETEROPHIL DEGRANULATION IS SERUM COFACTOR- AND CELL SURFACE RECEPTOR-DEPENDENT - (Abstract Only)

He, H., Kogut, M.H. 2004. CpG-oligodeoxynucleotide-stimulated chicken heterophil degranulation is serum cofactor- and cell surface receptor-dependent [abstract]. 8th Avian Immunology Research Group Meeting. p. 78.

UP-REGULATION OF NITRIC OXIDE SYNTHESIS BY TLR9 AGONIST CPG OLIGODEOXYNUCLEOTIDE IN CHICKEN MONOCYTES VIA ACTIVATION OF ERK, P38 MAPK, JNK, AND NF-KAPPAB SIGNAL PATHWAYS - (Abstract Only)

He, H., Kogut, M.H. 2004. Up-regulation of nitric oxide synthesis by TLR9 agonist CpG oligodeoxynucleotide in chicken monocytes via activation of ERK, p38 MAPK, JNK, and NF-kappaB signal pathways [abstract]. 8th Avian Immunology Research Group Meeting. p. 77.

HETEROPHIL TOLL-LIKE RECEPTORS: RECOGNITION, SIGNALING AND FUNCTIONAL ACTIVATION - (Abstract Only)

Kogut, M.H., Iqbal, M., He, H., Philbin, V., Kaiser, P., Smith, A. 2004. Heterophil toll-like receptors: Recognition, signaling and functional activation [abstract]. 7th International Veterinary Immunology Symposium. p. 395.

EXPRESSION AND FUNCTION OF TOLL-LIKE RECEPTORS IN CHICKEN HETEROPHILS - (Abstract Only)

Kogut, M.H., Iqbal, M., He, H., Philbin, V., Kaiser, P., Smith, A. 2004. Expression and function of toll-like receptors in chicken heterophils [abstract]. 8th Avian Immunology Research Group Meeting. p. 23.

STIMULATION OF CHICKEN LEUKOCYTES AND REDUCTION OF SALMONELLA ORGAN INVASION IN NEONATAL CHICKEN BY IMMUNOSTIMULATORY CPG-OLIGODEOXYNUCLEOTIDE - (Abstract Only)

HE, H., KOGUT, M.H. STIMULATION OF CHICKEN LEUKOCYTES AND REDUCTION OF SALMONELLA ORGAN INVASION IN NEONATAL CHICKEN BY IMMUNOSTIMULATORY CPG-OLIGODEOXYNUCLEOTIDE. ARS IMMUNOLOGY WORKSHOP. 2003. ABSTRACT P. 25.

THE INHIBITION OF NITRIC OXIDE PRODUCTION IN CHICKEN PHAGOCYTES - (Abstract Only)

CRIPPEN, T.L., HE, H., KOGUT, M.H. THE INHIBITION OF NITRIC OXIDE PRODUCTION IN CHICKEN PHAGOCYTES. ARS IMMUNOLOGY WORKSHOP. 2003. ABSTRACT P. 27.

PHARMACOLOGICAL ANALYSIS OF SIGNAL TRANSDUCTION PATHWAYS REQUIRED FOR OXIDATIVE BURST IN CHICKEN HETEROPHILS STIMULATED BY A TOLL-LIKE RECEPTOR 2 AGONIST - (Peer Reviewed Journal)

Farnell, M.B., He, H., Genovese, K.J., Kogut, M.H. 2003. Pharmacological analysis of signal transduction pathways required for oxidative burst in chicken heterophils stimulated by a toll-like receptor 2 agonist. International Immunopharmacology. 3:1677-1684.

SEQUENCE DEPENDENT INDUCTION OF NITRIC OXIDE BY CPG-ODN IS MEDIATED THROUGH CLATHRIN-DEPENDENT ENDOCYTOSIS, ENDOSOMAL MATURATION, AND ACTIVATION OF PKC,MEK1/2 AND P38 MAPK, AND NF-KAPPAB PATHWAYS IN AVIAN MACROPHAGE CELLS (HD - (Abstract Only) - (07-May-03)

DIFFERENTIAL ACTIVATION OF SIGNAL TRANSDUCTION PATHWAYS MEDIATING OXIDATIVE BURST BY CHICKEN HETEROPHILS IN RESPONSE TO STIMULATION WITH LIPOPOLYSACCHARIDE AND LIPOTEICHOIC ACID - (Peer Reviewed Journal)

FARNELL, M.B., HE, H., KOGUT, M.H. DIFFERENTIAL ACTIVATION OF SIGNAL TRANSDUCTION PATHWAYS MEDIATING OXIDATIVE BURST BY CHICKEN HETEROPHILS IN RESPONSE TO STIMULATION WITH LIPOPOLYSACCHARIDE AND LIPOTEICHOIC ACID. INFLAMMATION. 2003. V. 27. P. 225-231.

CPG-ODN-INDUCED NITRIC OXIDE PRODUCTION IS MEDIATED THROUGH CLATHRIN-DEPENDENT ENDOCYTOSIS, ENDOSOMAL MATURATION, AND ACTIVATION OF PKC, MEK1/2 AND P38 MAPK, AND NF-KB PATHWAYS IN AVIAN MACROPHAGE CELLS (HD11) - (Peer Reviewed Journal)

HE, H., KOGUT, M.H. CPG-ODN-INDUCED NITRIC OXIDE PRODUCTION IS MEDIATED THROUGH CLATHRIN-DEPENDENT ENDOCYTOSIS, ENDOSOMAL MATURATION, AND ACTIVATION OF PKC, MEK1/2 AND P38 MAPK, AND NF-KB PATHWAYS IN AVIAN MACROPHAGE CELLS (HD11). CELLULAR SIGNALLING. 2003. V. 15. P. 911-917.

INFLAMMATORY AGONIST STIMULATION AND SIGNAL PATHWAY OF OXIDATIVE BURST IN NEONATAL CHICKEN HETEROPHILS - (Peer Reviewed Journal)

HE,H. ., FARNELL,M.B., KOGUT,M.H., INFLAMMATORY AGONIST STIMULATION AND SIGNAL PATHWAY OF OXIDATIVE BURST IN NEONATAL CHICKEN HETEROPHILS, COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY, Part A 135 (2003) 177-184.

DIFFERENTIAL NITRIC OXIDE PRODUCTION BY CHICKEN IMMUNE CELLS - (Peer Reviewed Journal)

CRIPPEN,T.L., HE,H. ., SHEFFIELD,C.L., LOWRY,V.K., KOGUT,M.H., DIFFERENTIAL NITRIC OXIDE PRODUCTION BY CHICKEN IMMUNE CELLS, INFLAMMATION, 27: 603-610, 2003.

IDENTIFICATION OF CPG OLIGODEOXYNUCLEOTIDE MOTIFS THAT STIMULATE NITRIC OXIDE AND CYTOKINE PRODUCTION IN AVIAN MACROPHAGE AND PERIPHERAL BLOOD MONONUCLEAR CELLS - (Abstract Only) - (15-Nov-02)

IDENTIFICATION OF CPG OLIGODEOXYNUCLEOTIDE MOTIFS THAT STIMULATE NITRIC OXIDE AND CYTOKINE PRODUCTION IN AVIAN MACROPHAGE AND PERIPHERAL BLOOD MONONUCLEAR CELLS - (Peer Reviewed Journal)

HE,H. ., CRIPPEN,T.L., FARNELL,M.B., KOGUT,M.H., IDENTIFICATION OF CPG OLIGODEOXYNUCLEOTIDE MOTIFS THAT STIMULATE NITRIC OXIDE AND CYTOKINE PRODUCTION IN AVIAN MACROPHAGE AND PERIPHERAL BLOOD MONONUCLEAR CELLS, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, : 27 (2003) 621-627.

DIFFERENTIAL ACTIVATION OF SIGNAL TRANSDUCTION PATHWAYS MEDIATING OXIDATIVE BURST BY CHICKEN HETEROPHILS IN RESPONSE TO STIMULATION WITH SALMONELLA ENTERITIDIS LIPOPOLYSACCHARIDE AND STAPHYLOCOCCUS AUREUS LIPOTEICHOIC ACID - (Abstract Only) - (10-Nov-02)

OXIDATIVE BURST MEDIATED BY TOLL LIKE RECEPTORS (TLR) AND CD14 ON AVIAN HETEROPHILS STIMULATED WITH BACTERIAL TOLL AGONISTS - (Peer Reviewed Journal) - (19-Sep-02)

OXIDATIVE BURST BY TOLL LIKE RECEPTORS (TLR) AND CD14 IN AVIAN HETEROPHILS STIMULATED WITH BACTERIAL COMPONENTS - (Abstract Only) - (09-Nov-01)

ACTIVATION OF CHICKEN IMMUNE CELLS BY UNMETHYLATED CPG DINUCLEOTIDE MOTIF OF BACTERIAL DNA - (Abstract Only) - (07-Nov-01)

MOLECULAR CLONING AND NUCLEOTIDE SEQUENCE OF A NEW P450 GENE, CYP319A1, FROM THE CATTLE TICK, BOOPHILUS MICROPLUS - (Peer Reviewed Journal) - (06-May-01)

CLONING AND TRANSCRIPTIONAL EXPRESSION OF A LEUCOKININ-LIKE PEPTIDE RECEPTOR FROM THE SOUTHERN CATTLE TICK, BOOPHILUS MICROPLUS (ACARI: IXODIDAE) - (Peer Reviewed Journal) - (30-May-00)

IDENTIFICATION OF A POINT MUTATION IN THE PARA-TYPE SODIUM CHANNEL GENE FROM A PYRETHROID-RESISTANT CATTLE TICK - (Peer Reviewed Journal) - (06-Jul-99)

CLONING AND SEQUENCING OF A PUTATIVE ACETYLCHOLINESTERASE CDNA FROM BOOPHILUS MICROPLUS (ACARI: IXODIDAE) - (Peer Reviewed Journal) - (02-Jun-99)

CHARACTERIZATION AND MOLECULAR CLONING OF A GLUTATHIONE S-TRANSFERASE GENE FROM THE TICK, BOOPHILUS MICROPLUS (ACARI:IXODIDAE) - (Peer Reviewed Journal) - (05-May-99)

SEQUENCING AND ANALYSIS OF THE KDR-HOMOLOGOUS REGION OF THE PARA-TYPE SODIUM CHANNEL GENE FROM PYRETHROID-RESISTANT BOOPHILUS MICROPLUS (ACARI: IXODIDAE) - (Peer Reviewed Journal) - (23-Mar-99)