Projects

GENOMIC AND IMMUNOLOGICAL ANALYSIS OF SPIROCHETE DISEASES Appropriated (D)   Accession Number: 411434

Publications

Bovine Immune Response to Papillomatous Digital Dermatitis (PDD)-associated Spirochetes is Skewed in Isolate Reactivity and Subclass Elicitation - (Peer Reviewed Journal)

Elliott, M.K., Alt, D.P. 2009. Bovine Immune Response to Papillomatous Digital Dermatitis (PDD)-associated Spirochetes is Skewed in Isolate Reactivity and Subclass Elicitation. Veterinary Immunology and Immunopathology. Available: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TD5-4VNH3P6-1-5&_cdi=5189&_user=4250360&_orig=search&_coverDate=02%2F20%2F2009&_sk=999999999&view=c&wchp=dGLbVzz-zSkzk&md5=771143ed20313a4ee6d2259f33ebd596&ie=/sdarticle.pdf.

Variable Nucleotide Tandem-Repeat Analysis Revealing a Unique Group of Leptospira interrogans Serovar Pomona Isolates Associated with California Sea Lions - (Peer Reviewed Journal)

Zuerner, R.L., Alt, D.P. 2009. Variable Nucleotide Tandem-Repeat Analysis Revealing a Unique Group of Leptospira interrogans Serovar Pomona Isolates Associated with California Sea Lions. Journal of Clinical Microbiology. 47(4):1202-1205.

Geographical Dissemination of Leptospira interrogans serovar Pomona During Seasonal Migration of California Sea Lions - (Peer Reviewed Journal)

Zuerner, R.L., Cameron, C.E., Raverty, S., Robinson, J., Colegrove, K., Norman, S.A., Lambourn, D., Jeffries, S., Alt, D.P., Gulland, F. 2009. Geographical Dissemination of Leptospira interrogans serovar Pomona During Seasonal Migration of California Sea Lions. Veterinary Microbiology. 137(1-2):105-110.

Western-blot detection of PrP**sc in archived paraffin-embedded brainstem from scrapie-affected sheep - (Peer Reviewed Journal)

Kunkle, R.A., Nicholson, E.M., Lebepe-Mazur, S., Orcutt, D.L., Srinivas, M.L., Greenlee, J.J., Alt, D.P., Hamir, A.N. 2008. Western blot detection of PrP**sc in archived paraffin-embedded brainstem from scrapie-affected sheep. Journal of Veterinary Diagnostic Investigation. 20(4):522-526.

Antigenic Targets of the Bovine Humoral Response to PDD-associated Spirochetes Change with Subsequent Exposure - (Abstract) - (14-Sep-07)

Lesion Formation and Antibody Response Induced by Papillomatous Digital Dermatitis-Associated Spirochetes in a Murine Abscess Model - (Peer Reviewed Journal)

Elliott, M.K., Alt, D.P., Zuerner, R.L. 2007. Lesion Formation and Antibody Response Induced by Papillomatous Digital Dermatitis (PDD)-associated spirochetes in a Murine Abscess Model. Infection and Immunity. 75(9):4400-4408.

Papillomatous Digital Dermatitis Spirochetes Suppress the Bovine Macrophage Innate Immune Response - (Peer Reviewed Journal)

Zuerner, R.L., Heidari, M., Elliott, M.K., Alt, D.P., Neill, J.D. 2007. Papillomatous Digital Dermatitis Spirochetes Suppress the Bovine Macrophage Innate Immune Response. Veterinary Microbiology. 125(2007):256-264.

Diagnostic Characterization of a Feral Swine Herd Enzootically Infected with Brucella - (Peer Reviewed Journal)

Stoffregen, W.C., Olsen, S.C., Wheeler, C.J., Bricker, B.J., Palmer, M.V., Jensen, A.E., Halling, S.M., Alt, D.P. 2007. Diagnostic Characterization of a Feral Swine Herd Enzootically Infected with Brucella. Journal of Veterinary Diagnostic Investigation. 19(3):227-237.

Identification and characterization of two bovine spongiform encephalopathy cases diagnosed in the United States - (Peer Reviewed Journal)

Richt, J.A., Kunkle, R.A., Alt, D., Nicholson, E.M., Hamir, A.N., Czub, S., Kluge, J., Davis, A.J., Hall, S.M. 2007. Identification and characterization of two bovine spongiform encephalopathy cases diagnosed in the United States. Journal of Veterinary Diagnostic Investigation. 19(2):142-154.

Genome reduction in Leptospira borgpetersenii reflects limited transmission potential - (Peer Reviewed Journal)

Bulach, D., Zuerner, R.L., Wilson, P., Seemann, T., Mcgrath, A., Cullen, P., Davies, J., Kuczek, E., Alt, D.P., Peterson-Burch, B. 2006. Genome reduction in Leptospira borgpetersenii reflects limited transmission potential. Proceedings of the National Academy of Sciences. 103(39):14560-14565.

Determination of Sheep Prion Gene Polymorphisms from Paraffin-Embedded Tissue - (Peer Reviewed Journal)

Kunkle, R.A., Miller, J.M., Alt, D.P., Cutlip, R.C., Cockett, N.E., Wang, S., Richt, J.A., Thomsen, B.V., Hall, S.M. 2006. Determination of sheep prion gene polymorphisms from paraffin-embedded tissue. Journal of Veterinary Diagnostic Investigation. 18(5):443-447.

Identification of a Haemomycoplasma Species in Anemic Reindeer (Rangifer Tarandus) - (Peer Reviewed Journal)

Stoffregen, W.C., Alt, D.P., Palmer, M.V., Olsen, S.C., Waters, W.R., Stasko, J.A., Peterson Burch, B.D. 2006. Identification of a Haemomycoplasma Species in Anemic Reindeer (Rangifer Tarandus). Journal of Wildlife Diseases. 42(2):249-258.

Status of the Rb51 Genome Sequencing Project - (Abstract)

Bricker, B.J., Peterson Burch, B.D., Alt, D.P., Halling, S.M., Stoffregen, W.C., Olsen, S.C. 2005. Status of the RB51 Genome Sequencing Project [abstract]. 58th Brucellosis Research Conference. p. 92.

The Complete Genome Sequence of Mycobacterium Avium Subsp. Paratuberculosis - (Peer Reviewed Journal)

Li, L., Bannantine, J.P., Zhang, Q., Amonsin, A., May, B.J., Alt, D.P., Banerji, N., Kanjilal, S., Kapur, V. 2005. The Complete Genome Sequence of Mycobacterium avium subsp. paratuberculosis. Proceedings of the National Academy of Sciences. 102:12344-12349.

The Genome of Leptospira Biflexa - (Abstract)

Bulach, D.M., Seemann, T., Mcgrath, A., Kuczek, E., Coppel, R.L., Davies, J.K., Rood, J.I., Alt, D.P., Zuerner, R.L., Adler, B. 2005. The genome of Leptospira biflexa [abstract]. International Leptospirosis Society Meeting Abstracts and Proceedings. p. 136.

Completion of the Genome Sequence of Brucella Abortus and Comparison to the Highly Similar Genomes of B. Melitensis and B. Suis - (Peer Reviewed Journal)

Halling, S.M., Peterson Burch, B.D., Bricker, B.J., Zuerner, R.L., Qing, Z., Li, L., Kapur, V., Alt, D.P., Olsen, S.C. 2005. Completion of the genome sequence of brucella abortus and comparison to the highly similar genomes of b. melitensis and b. suis. Journal of Bacteriology. 187(8):2715-26.

Experimental Canine Leptospirosis Caused by Leptospira Interrogans Serovars Pomona and Bratislava - (Peer Reviewed Journal)

Greenlee, J.J., Alt, D.P., Bolin, C.A., Zuerner, R.L., Andreasen, C.B. 2005. Experimental canine Leptospirosis caused by Leptospira interrogans serovars Pomona and Bratislava. American Journal of Veterinary Research. 66(10):1816-1822.

Characterization of the Recent U.S. Bse Case and Methods for Surveillance - (Proceedings/Symposium)

Richt, J.A., Kluge, J.P., Alt, D.P., Kunkle, R.A., Hamir, A.N., Czub, S., Davis, A.J., Hall, S.M. 2004. Characterization of the recent U.S. BSE case and methods for surveillance. In: Proceedings of the 108th Annual Meeting of the United States Animal Health Association, October 22-27, 2004, Greensboro, North Carolina. p. 91-92.

Influence of the Spirovac(r) Leptospirosis Vaccine on Immunologic Responses of Bison to Brucella Abortus Strain Rb51 Vaccine - (Abstract)

Olsen, S.C., Stoffregen, W.C., Zuerner, R.L., Alt, D.P. 2004. Influence of the spirovac(r) leptospirosis vaccine on immunologic responses of bison to brucella abortus strain rb51 vaccine [abstract]. Research Workers in Animal Diseases Conference Proceedings. p.98.

Identification and Characterization of the U.S. Bovine Spongiform Encephalopathy Case - (Abstract)

Richt, J.A., Kluge, J.P., Alt, D.P., Kunkle, R.A., Hamir, A.N., Czub, S., Davis, A.J., Hall, S.M. 2004. Identification and characterization of the U.S. bovine spongiform encephalopathy case [abstract]. Animal Prion Diseases and the Americas. p. 38.

Clinical and Pathologic Comparison of Acute Canane Leptospirosis Caused by Two Strains of Leptospira Kirschner Serval Grippotyphosa - (Peer Reviewed Journal)

Greenlee, J., Bolin, C., Alt, D.P., Cheville, N., Andreasen, C. 2004. Clinical and pathologic comparison of acute canane leptospirosis caused by two strains of leptospira kirschner serval grippotyphosa. American Journal of Veterinary Research. 65(8):1100-7.

Identification of Haemomycoplasma Species in Anemic Reindeer (Rangifer Tarandus) - (Abstract)

Stoffregen, W.C., Alt, D.P., Palmer, M.V., Olsen, S.C., Waters, W.R. 2004. Identification of haemomycoplasma species in anemic reindeer (rangifer tarandus) [abstract]. American College of Veterinary Pathologists Meeting. 41:550.

Molecular Evolution and Mosaicism of Leptospira Outer Membrane Proteins Involves Horizontal DNA Transfer - (Peer Reviewed Journal)

Haake, D.A., Suchard, M.A., Kelley, M.M., Dundoo, M., Alt, D.P., Zuerner, R.L. 2004. Molecular evolution and mosaicism of leptospira outer membrane proteins involves horizontal dna transfer. Journal of Bacteriology. 186(9):2818-2828.

Sage Analysis of Bovine Macrophages: Identification of Genes Targeted for Immune Suppression by Digital Dermatitis Spirochetes - (Proceedings/Symposium)

Heidari, M., Zuerner, R.L., Alt, D.P., Neill, J.D. 2004. Sage analysis of bovine macrophages: identification of genes targeted for immune suppression by digital dermatitis spirochetes. Gordon Research Conference Proceedings. p. 20.

Identification and Characterization of the First U.S. Bovine Spongiform Encephalopathy Case - (Abstract)

Richt, J.A., Kluge, J.P., Alt, D.P., Kunkle, R.A., Hamir, A.N., Czub, S., Davis, A.J., Hall, S. 2004. Identification and characterization of the first U.S. bovine spongiform encephalopathy case. Poster created for use by the USDA at a meeting with the Office of International Epizootics.

Identification and Cloning of the Gene Encoding Bmpc: An Outer Membrane Lipoprotein Associated with Brachyspira Pilosicoli Membrane Vesicles - (Peer Reviewed Journal)

Trott, D.J., Alt, D.P., Zuerner, R.L., Bulach, D.M., Wannemuehler, M.J., Stasko, J.A., Townsend, K.M., Stanton, T.B. 2004. Identification and cloning of the gene encoding BmpC: an outer membrane lipoprotein associated with Brachyspira pilosicoli membrane vesicles. Microbiology. 150 (Pt 4):1041-1053.

The Genome Sequence of Mycobacterium Avium Subsp Paratuberculosis - (Abstract) - (28-Sep-03)

Characterization of Sphingomyelinase-Like Genes in Leptospira Borgpetersenii Serovar Hardjo - (Abstract) - (18-Sep-03)

Brucella 'hoof-Prints': Strain Typing by Multi-Locus Analysis of Variable Number Tandem Repeats (Vntrs) - (Peer Reviewed Journal)

Bricker, B.J., Alt, D.P., Ewalt, D.R., Halling, S.M. 2003. Brucella 'hoof-prints': strain typing by multi-locus analysis of variable number tandem repeats (vntrs). Journal of Clinical Microbiology.

Characterization of Treponema-Phagedenis-Like Spirochetes Isolated from Papillomatous Digital Dermatitis Lesions in Dairy Cattle - (Peer Reviewed Journal)

Trott, D.J., Moeller, M.R., Zuerner, R.L., Goff, J.P., Waters, W.R., Alt, D.P., Walker, R.L., Wannemuehler, M.J. 2003. Characterization of treponema-phagedenis-like spirochetes isolated from papillomatous digital dermatitis lesions in dairy cattle. Infection and Immunity.

Genomic Sequence Analysis of Leptospira Borgpetersenii Serovar Hardjo - (Abstract)

Zuerner, R.L., Alt, D.P., Bulach, D., Adler, B., Cullen, P., Haake, D. 2002. Genomic sequence analysis of leptospira borgpetersenii serovar hardjo [abstract]. International Leptospirosis Society Meeting Abstracts and Proceedings. pg. 32.

Evaluation of Type 1 Immune Response in Naive and Vaccinated Animals Following Challenge with Leptospira Borgpetersenii Serovar Hardjo: Involvement of Wc1**+ Gamma Delta and Cd4 T Cells - (Peer Reviewed Journal)

Naiman, B., Blumerman, S., Alt, D.P., Bolin, C., Brown, R., Zuerner, R.L., Baldwin, C. 2002. Evaluation of type 1 immune response in naive and vaccinated animals following challenge with leptospira borgpetersenii serovar hardjo: involvement of wc1**+ gamma delta and cd4 t cells. Infection and Immunity. 70(11)6147-57.