Projects

RICE AS A SOURCE AND DELIVERY SYSTEM FOR NUTRIENTS AND LIPOPHILIC BIOACTIVE COMPOUNDS Appropriated (D)   Accession Number: 418062

DEVELOPMENT OF A REAL-TIME ELECTRONIC SENSOR TO DETECT ASPERGILLUS FLAVUS GROWTH ON STORED CORN Nonfunded Cooperative Agreement (N)   Accession Number: 418344

PHYTOESTROGENIC EFFECTS OF FUNGALLY INDUCED ISOFLAVONOIDS IN LEGUMES Specific Cooperative Agreement (S)   Accession Number: 413335

DETERMINE NATURAL PRODUCT INDUCTION IN LEGUMES AND THE PHARMACOLOGIC CONSEQUENCES IN HUMAN MODEL SYSTEMS Specific Cooperative Agreement (S)   Accession Number: 413440

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Inhibition of bacterial and filamentous fungal growth in high moisture, non-sterile corn with intermittent pumping of trans-2-hexenal vapor - (Peer Reviewed Journal) - (04-Apr-13)

Phytoalexins, miRNAs and breast cancer: a review of phytochemical mediated miRNA regulation in breast cancer - (Review Article)

Tilghman, S.L., Rhodes, L.V., Bratton, M., Carriere, P., Preyan, L.C., Boue, S.M., Mclachlan, J., Burow, M.E. 2013. Phytoalexins, miRNAs and breast cancer: a review of phytochemical mediated miRNA regulation in breast cancer. Journal of Health Care for the Poor and Underserved. 24:36-46.

Screening and identification of glyceollins and their metabolites by electrospray ionization tandem mass spectrometry with precursor ion scanning - (Peer Reviewed Journal)

Quadri, S., Stratford, R., Boue, S.M., Cole, R.B. 2013. Screening and identification of glyceollins and their metabolites by electrospray ionization tandem mass spectrometry with precursor ion scanning. Analytical Chemistry. 85:1727-1733.

Porous rice powder from the precipitation of gelatinized flour or starch paste with ethanol - (Peer Reviewed Journal)

Patindol, J.A., Shih, F.F., Ingber, B.F., Champagne, E.T., Boue, S.M. 2013. Porous rice powder from the precipitation of gelatinized flour or starch paste with ethanol. Starch/Starke. 65:296-303.

Glyceollins, soy isoflavone phytoalexins, improve oral glucose disposal by stimulating glucose uptake - (Peer Reviewed Journal)

Boue, S.M., Isakova, I.A., Burow, M., Cao, H., Bhatnagar, D., Sarver, J., Shinde, K.V., Erhardt, P., Heiman, M. 2012. Glyceollins, soy isoflavone phytoalexins, improve oral glucose disposal by stimulating glucose uptake. Journal of Agricultural and Food Chemistry. 60(25):6376-6382.

Volatile profiles and aflatoxin production by toxigenic and non-toxigenic isolates of Aspergillus flavus grown on sterile and non-sterile cracked corn - (Peer Reviewed Journal)

De Lucca II, A.J., Boue, S.M., Carter Wientjes, C.H., Bhatnagar, D. 2012. Volatile profiles and aflatoxin production by toxigenic and non-toxigenic isolates of Aspergillus flavus grown on sterile and non-sterile cracked corn. Annals of Agriculture and Environmental Medicine. 19(1):91-98.

The protective effect of soybean phytochemicals on androgen responsive human prostate cancer cells LNCaP is likely mediated through modulation of hormone/cytokine-dependent pathways - (Peer Reviewed Journal)

Wang, T.T., Boue, S.M., Krishnan, H.B. 2011. The protective effect of soybean phytochemicals on androgen responsive human prostate cancer cells LNCaP is likely mediated through modulation of hormone/cytokine-dependent pathways. Functional Foods in Health and Disease. 1(11):457-471.

Glyceollin-elicited soy protein consumption induces distinct transcriptional effects as compared to standard soy protein - (Peer Reviewed Journal)

Wood, C.E., Boue, S.M., Collins-Burow, B.M., Rhodes, L.V., Register, T.C., Cline, J., Dewi, F.N., Burow, M.E. 2012. Glyceollin-elicited soy protein consumption induces distinct transcriptional effects as compared to standard soy protein. Journal of Agricultural and Food Chemistry. 60(1):81-6.

Glyceollins as novel targeted therapeutic for the treatment of metastatic triple-negative breast cancer - (Peer Reviewed Journal)

Rhodes, L.V., Tilghman, S.L., Boue, S.M., Wang, S., Khalili, H., Muir, S., Bratton, M.R., Zhang, Q., Wang, G., Burow, M.E., Collins-Burow, B.M. 2011. Glyceollins as novel targeted therapeutic for the treatment of metastatic triple-negative breast cancer. Oncology Reports. 3:163-171.

Volatile trans-2-hexenal a soybean aldehyde inhibits Aspergillus flavus growth and aflatoxin production in corn - (Peer Reviewed Journal)

De Lucca II, A.J., Carter Wientjes, C.H., Boue, S.M., Bhatnagar, D. 2011. Volatile trans-2-hexenal, a soybean aldehyde, inhibits Aspergillus flavus growth and aflatoxin production in corn. Journal of Food Science. 76:M381-M386.

Biomimetic synthesis and antiproliferative properties of racemic natural(-) and unnnatural(+) glyceollin I - (Peer Reviewed Journal)

Khupse, R.S., Sarver, J.G., Trendel, J.A., Ellis, N.R., Reese, M.D., Wiese, T.E., Boue, S.M., Burow, M.E., Cleveland, T.E., Bhatnagar, D., Erhardt, P.W. 2011. Biomimetic synthesis and antiproliferative properties of racemic, natural(-), and unnnatural(+) glyceollin I. Journal of Medicinal Chemistry. 54(10):3506-3523.

Estrogenic and antiestrogenic activities of phytoalexins from red kidney bean (Phaseolus vulgaris L.) - (Peer Reviewed Journal)

Boue, S.M., Burow, M.E., Wiese, T.E., Shih, B.Y., Elliott, S., Carter Wientjes, C.H., Mclachlan, J.A., Bhatnagar, D. 2011. Estrogenic and antiestrogenic activities of phytoalexins from red kidney bean (Phaseolus vulgaris L.). Journal of Agricultural and Food Chemistry. 59:112-120.

Volatile profiles of toxigenic and non-toxigenic Aspergillus flavus using SPME for solid phase extraction - (Peer Reviewed Journal)

De Lucca II, A.J., Boue, S.M., Carter-Wientjes, C.H., Bland, J.M., Bhatnagar, D., Cleveland, T.E. 2010. Volatile profiles of toxigenic and non-toxigenic Aspergillus flavus using SPME for solid phase extraction. Annals of Agriculture and Environmental Medicine. 17:301-308.

Effects of 7-O substitutions on estrogenic and anti-estrogenic activities of daidzein analogues in MCF-7 breast cancer cells - (Peer Reviewed Journal)

Jiang, Q., Payton-Stewart, F., Elliott, S., Driver, J., Rhodes, L.V., Zhang, Q., Zheng, S., Bhatnagar, D., Boue, S.M., Collins-Burow, B.M., Sridhar, J., Stevens, C., Mclachlan, J.A., Wiese, T.E., Burow, M.E., Wang, G. 2010. Effects of 7-O substitutions on estrogenic and anti-estrogenic activities of daidzein analogues in MCF-7 breast cancer cells. Journal of Medicinal Chemistry. 53(16):6153-6163.

Glyceollin I Enantiomers Distinctly Regulate ER-Mediated Gene Expression - (Peer Reviewed Journal)

Payton-Stewart, F., Khupse, R.S., Boue, S.M., Elliott, S., Zimmerman, C.M., Skripnikova, E.V., Ashe, H., Tilghman, S.L., Beckman, B.S., Cleveland, T.E., Mclachlan, J.A., Bhatnagar, D., Wiese, T.E., Erhardt, P., Burow, M.E. 2010. Glyceollin I Enantiomers Distinctly Regulate ER-Mediated Gene Expression. Steroids. 75:870-878.

Silver enhances the in vitro antifungal activity of the saponin, CAY-1 - (Peer Reviewed Journal)

De Lucca II, A.J., Boue, S.M., Sein, T., Cleveland, T.E., Walsh, T.J. 2009. Silver enhances the in vitro antifungal activity of the saponin, CAY-1. Mycoses. 54:e1-e9.

Glyceollin I, A Novel Antiestrogenic Phytoalexin Isolated from Activated Soy - (Peer Reviewed Journal)

Zimmermann, M., Tilghman, S.L., Boue, S.M., Salvo, V.A., Elliott, S., Williams, K., Skripnikova, E.V., Ashe, H., Payton-Stewart, F., Vanhoy-Rhodes, L., Fonseca, J., Corbitt, C., Collins-Burow, B.M., Howell, M.H., Lacey, M., Shih, B.Y., Carter Wientjes, C.H., Cleveland, T.E., Mclachlan, J.A., Wiese, T.E., Beckman, B.S., Burow, M.E. 2010. Glyceollin I, A Novel Antiestrogenic Phytoalexin Isolated from Activated Soy. Journal of Pharmacology and Experimental Therapeutics. 332(1):35-45.

Greenhouse and Field Evaluation of the Natural Saponin CAY-1, for Control of Several Strawberry Diseases - (Peer Reviewed Journal)

Abril, M., Curry, K.J., Smith, B.J., De Lucca Ii, A.J., Boue, S.M., Wedge, D.E. 2009. Greenhouse and Field Evaluation of the Natural Saponin CAY-1, for Control of Several Strawberry Diseases. International Journal of Fruit Science. 9:3,211-220.

Phytoalexin-Enriched Functional Foods - (Review Article)

Boue, S.M., Cleveland, T.E., Carter Wientjes, C.H., Shih, B.Y., Bhatnagar, D., Mclachlan, J.M., Burow, M. 2009. Phytoalexin-Enriched Functional Foods. Journal of Agricultural and Food Chemistry. 57(7):2614-2622.

Identification of the Potent Phytoestrogen Glycinol in Elicited Soybean (Glycine max) - (Peer Reviewed Journal)

Boue, S.M., Tilghman, S.L., Elliott, S., Zimmerman, M., Williams, K.Y., Payton-Stewart, F., Miraflor, A.P., Howell, M.H., Shih, B.Y., Carter Wientjes, C.H., Segar, C., Beckman, B.S., Wiese, T.E., Cleveland, T.E., Mclachlan, J.A., Burow, M.E. 2009. Identification of the Potent Phytoestrogen Glycinol in Elicited Soybean (Glycine max). Endocrinology. 150(5):2446-2453.

Cyclodextrins as Carriers of Monterpenes into the Hemolymph of the Honey Bee (Apis mellifera) for Integrated Pest Management - (Peer Reviewed Journal)

Le Blanc, B.W., Boue, S.M., Hoffman, G.D., Deeby, T.A., Mccready, H.D., Loeffelmann, K.L. 2008. Cyclodextrins as Carriers of Monterpenes into the Hemolymph of the Honey Bee (Apis mellifera) for Integrated Pest Management. Journal of Agricultural and Food Chemistry 56(18), 8565-8573.

Evaluation of CAY-1, an Experimental, Natural Fungicide for Control of Strawberry Pathogens - (Proceedings)

Abril, M., Curry, K.J., Smith, B.J., De Lucca Ii, A.J., Boue, S.M., Wedge, D.E. 2009. Evaluation of CAY-1, an Experimental, Natural Fungicide for Control of Strawberry Pathogens. Acta Horticulturae. 842:295-298.

In vitro activity of CAY-1, a saponin from Capsicum frutescens, against microsporum and trichophyton species - (Peer Reviewed Journal)

Stergiopoulou, T., De Lucca II, A.J., Meletiadis, J., Sein, T., Boue, S.M., Schaufele, R., Roilides, E., Ghannoum, M., Walsh, T.J. 2008. In vitro activity of CAY-1, a saponin from Capsicum frutescens, against microsporum and trichophyton species. Medical Mycology. 46(8):805-810.

Effect of Biotic Elicitors on Enrichment of Antioxidant Properties and Induced Isoflavones in Soybean - (Peer Reviewed Journal)

Boue, S.M., Shih, F.F., Shih, B.Y., Daigle, K.W., Carter Wientjes, C.H., Cleveland, T.E. 2008. Effect of Biotic Elicitors on Enrichment of Antioxidant Properties and Induced Isoflavones in Soybean. Journal of Food Science. 73:H43-H49.

Fungicidal activity of the plant saponin, CAY-1, for fungi isolated from diseased Vitis fruit and stems - (Peer Reviewed Journal)

De Lucca Ii, A.J., Klich, M.A., Sien, T., Boue, S.M., Cleveland, T.E., Walsh, T.J. 2008. Fungicidal activity of the plant saponin, CAY-1, for fungi isolated from diseased Vitis fruit and stems. American Journal of Enology and Viticulture.59:67-72.

EFFECTS OF SOYBEAN GLYCEOLLINS AND ESTRADIOL IN POSTMENOPAUSAL FEMALE MONKEYS - (Peer Reviewed Journal)

Wood, C.E., Clarkson, T.B., Appt, S.E., Franke, A.A., Boue, S.M., Burow, M.E., Mccoy, T., Cline, J.M. 2006. Effects of soybean glyceollins and estradiol in postmenopausal female monkeys. Nutrition and Cancer. 56(1):74-81.

ANTIESTROGENIC GLYCEOLLINS SUPPRESS HUMAN BREAST AND OVARIAN CARCINOMA TUMORIGENESIS - (Peer Reviewed Journal)

Salvo, V.A., Boue, S.M., Fonseca, J.P., Elliott, S., Corbitt, C., Collins-Burow, B.M., Curiel, T.J., Srivastav, S.K., Shih, B.Y., Carter-Wientjes, C.H., Wood, C.E., Erhardt, P.W., Beckman, B.S., Mclachlan, J.A., Cleveland, T.E., Burow, M.E. 2006. Antiestrogenic glyceollins suppress human breast and ovarian carcinoma tumorigenesis. Clinical Cancer Research. 12(23):7159-7164.

FUNGICIDAL PROPERTIES OF TWO SAPONINS FROM CAPSICUM FRUTESCENS AND THE RELATIONSHIP OF STRUCTURE AND FUNGICIDAL ACTIVITY - (Peer Reviewed Journal)

De Lucca II, A.J., Boue, S.M., Palmgren, M.S., Maskos, K., Cleveland, T.E. 2006. Fungicidal properties of two saponins from Capsicum frutescens and the relationship of structure and fungicidal activity. Canadian Journal of Microbiology. 52:336-342.

SYNERGISM OF CAY-1 WITH AMPHOTERICIN B AND ITRACONAZOLE - (Peer Reviewed Journal)

De Lucca II, A.J., Bland, J.M., Boue, S.M., Vigo, C.B., Cleveland, T.E., Walsh, T.J. 2006. Synergism of Cay-1 with amphotericin B and itraconazole. Chemotherapy. 52:285-287.

THE AFLATOXIN BIOSYNTHESIS CLUSTER GENE HYPA IS REQUIRED FOR CONVERSION OF VERSICOLORIN A TO STERIGMATOCYSTIN - (Peer Reviewed Journal)

Ehrlich, K., Montalbano, B.G., Boue, S.M., Bhatnagar, D. 2005. An aflatoxin biosynthesis cluster gene encodes a novel oxidase required for conversion of versicolorin a to sterigmatocystin. Applied and Environmental Microbiology. 71:8963-8965.

RESPONSE OF SOYBEAN CELL CULTURES TO BIOLOGICAL ELICITORS FOR THE PRODUCTION OF ANTIESTROGENIC PHYTOALEXINS - (Abstract Only)

Boue, S.M., Kale-Ireland, S., Khan, S., Rajasekaran, K., Shih, B.Y., Carter-Wientjes, C.H., McLachlan, J., Cleveland, T.E. 2005. Response of soybean cell cultures to biological elicitors for the production of antiestrogenic phytoalexins. Society for In Vitro Biology Meeting, June 2005, Baltimore, MD. 40:19-A.

EFFECT OF SOYBEAN LIPOXYGENASE ON VOLATILE GENERATION AND INHIBITION OF ASPERGILLUS FLAVUS MYCELIAL GROWTH - (Peer Reviewed Journal)

Boue, S.M., Shih, B.Y., Carter Wientjes, C.H., Cleveland, T.E. 2005. Effect of soybean lipoxygenase on volatile generation and inhibition of Aspergillus flavus mycelial growth. Journal of Agricultural and Food Chemistry. 53(12):4778-4783.

GAS CHROMATOGRAPHY-ELECTRON IONIZATION MASS SPECTROMETRY AND LIQUID CHROMATOGRAPHY-ELECTROSPRAY TANDEM MASS SPECTROMETRY FOR DETERMINATION OF IMPURITIES IN THE ANTI-CANCER DRUG ISOPHOSPHORAMIDE MUSTARD - (Peer Reviewed Journal)

Cole, R.B., Chou, C., Boue, S.M., Leblanc, B.W., Rodgers, A.H., Struck, R.F., Morgan, L.R. 2004. Gas chromatography-electron ionization mass spectrometry and liquid chromatography-electrospray tandem mass spectrometry for determination of impurities in the anti-cancer drug isophosphoramide mustard. International Journal of Mass Spectrometry. 231:147-155.

REDUCED FUNGICIDAL PROPERTIES OF CAY-1 PRECURSORS - (Abstract Only)

De Lucca II, A.J., Boue, S.M., Palmgren, M.S., Maskos, K., Cleveland, T.E. 2004. Reduced fungicidal properties of CAY-1 precursors. Interscience Conference on Antimicrobial Agents & Chemotherapy Proceedings. Abstract F-845. p. 208.

CAY-1, A PLANT-PRODUCED SAPONIN ACTIVE AGAINST PHYTOPATHOGENIC AND MEDICAL PATHOGENIC FUNGI - (Abstract Only)

De Lucca II, A.J., Boue, S.M., Bland, J.M., Wartelle, L.H., Selitrennikoff, C., Renault, S., Cushion, M., Cleveland, T.E., Walsh, T. 2004. CAY-1, a plant-produced saponin active against phytopathogenic and medical pathogenic fungi. In: Proceedings of World Conference on Magic Bullets (Celebrating Paul Ehrlich's 150th Birthday). Abstract 119. p. 19.

EFFECTS OF FLOUR SOURCES ON ACRYLAMIDE FORMATION AND OIL UPTAKE IN FRIED BATTERS - (Peer Reviewed Journal)

Shih, F.F., Boue, S.M., Daigle, K.W., Shih, B.Y. 2004. Effects of flour sources on acrylamide formation and oil uptake in fried batters. Journal of American Oil Chemists Society. 81:265-268.

CAY-1, A NOVEL ANTIFUNGAL COMPOUND FROM CAYENNE PEPPER - (Peer Reviewed Journal)

Renault, S., De Lucca II, A.J., Boue, S.M., Bland, J.M., Vigo, C.B., Selitrennikoff, C. 2003. Cay-1, a novel antifungal compound from cayenne pepper. Medical Mycology. 41(1):75-82.

EFFECTS OF PLANT FLAVONOIDS ON FECUNDITY, SURVIVAL, AND FEEDING OF THE FORMOSAN SUBTERRANEAN TERMITE - (Peer Reviewed Journal)

Boue, S.M., Raina, A.K. 2003. Effects of plant flavonoids on fecundity, survival, and feeding of the formosan subterranean termite. Journal of Chemical Ecology. 29(11):2575-2584.

ANTIHORMONAL EFFECTS OF THE SOYBEAN PHYTOALEXIN GLYCEOLLIN - (Abstract Only)

Boue, S.M., Wiese, T.E., Burow, M.E., Carter-Wientjes, C.H., Shih, B.Y., Morlaes, V.S., Cleveland, T.E. Antihormonal effects of the soybean phytoalexin glyceollin. 5th International Symposium on the Role of Soy in Preventing and Treating Chronic Disease, September 21-24, 2003, Orlando, FL.

IDENTIFICATION OF VOLATILE COMPOUNDS IN SOYBEAN AT VARIOUS DEVELOPMENTAL STAGES USING SOLID PHASE MICROEXTRACTION - (Peer Reviewed Journal)

Boue, S.M., Shih, B.Y., Carter Wientjes, C.H., Cleveland, T.E. 2003. Identification of volatile compounds in soybean at various developmental stages using solid phase microextraction. Journal of Agricultural and Food Chemistry. 51:4873-4876.

ESTROGENIC AND ANTIESTROGENIC EFFECTS OF LEGUME EXTRACTS ON THE GROWTH OF ESTROGEN-DEPENDENT HUMAN BREAST CANCER (MCF-7) CELLS - (Peer Reviewed Journal)

Boue, S.M., Wiese, T.E., Nehls, S., Burow, M.E., Elliott, S., Carter-Wientjes, C.H., Shih, B.Y., McLachlan, J.A., Cleveland, T.E. 2003. Evaluation of the estrogenic effects of legume extracts containing phytoestrogens. Journal of Agricultural and Food Chemistry. 51:4873-4876.

IDENTIFICATION OF FLAVONE AGLYCONES AND GLYCOSIDES IN SOYBEAN PODS BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY - (Peer Reviewed Journal)

Boue, S.M., Carter Wientjes, C.H., Shih, B.Y., Cleveland, T.E. 2003. Identification of flavone aglycones and glycosides in soybean pods by liquid chromatography-tandem mass spectrometry. Journal of Chromatography A. 991:61-68.

Synergy of CAY-1, a Fungicidal Saponin, With Amphotericin B and Itreconazole Against Aspergillus spp and Candida albicans - (Proceedings)

De Lucca II, A.J., Bland, J.M., Boue, S.M., Vigo, C.B., Cleveland, T.E., Walsh, T.J. 2002. Synergy of CAY-1, a Fungicidal Saponin, With Amphotericin B and Itreconazole Against Aspergillus spp and Candida albicans. In: Proceedings of 42nd Interscience Conference on Antimicrobial Agents & Chemotherapy. Abstract F-826. p. 205.

Variants of Microcystin in Southeastern USA Channel Catfish (Ictalurus puntctatus ralfinesque) Production Ponds - (Peer Reviewed Journal)

Zimba, P.V., Boue, S.M., Chatham, M.A., Nonneman, D.J. 2002. Variants of Microcystin in Southeastern USA Channel Catfish (Ictalurus puntctatus ralfinesque) Production Ponds. International Society Of Limnology 28:1163-1166.

PHYTOCHEMICAL GLYCEOLLINS, ISOLATED FROM SOY, MEDIATE ANTI-HORMONAL EFFECTSTHROUGH ESTROGEN RECEPTOR ALPHA AND BETA - (Peer Reviewed Journal)

Burow, M.E., Boue, S.M., Collins-Burow, B.M., Melnik, L.I., Duong, B.N., Carter Wientjes, C.H., Li, S., Wiese, T.E., Cleveland, T.E., Mclachlan, J.A. 2001. Phytochemical glyceollins, isolated from soy, mediate anti-hormonal effectsthrough estrogen receptor alpha and beta. Journal of Clinical Endocrinology and Metabolism. 86(4):1750-1758.

THE AFLATOXIN BIOSYNTHETIC GENE ADHA IN ASPERGILLUS PARASITICUS IS INVOLVED IN CONVERSION OF 5'-HYDROXYAVERANTIN TO AVERUFIN - (Peer Reviewed Journal) - (12-Aug-00)

INTERACTIONS OF DIETARY ESTROGENS WITH HUMAN ESTROGEN RECEPTORS AND THE EFFECT ON ESTROGEN RECEPTOR-ESTROGEN RESPONSE ELEMENT COMPLEX FORMATION - (Peer Reviewed Journal)

Nikov, G.N., Hopkins, N.E., Boue, S.M., Alworth, W.L. 2000. Interactions of dietary estrogens with human estrogen receptors and the effect on estrogen receptor-estrogen response element complex formation. Environmental Health Perspectives. 108(9):867-872.

INDUCTION OF THE SOYBEAN PHYTOALEXINS COUMESTROL AND GLYCEOLLIN BY ASPERGILLUS - (Peer Reviewed Journal) - (09-Mar-00)

POLARIZABILITY AND INDUCTIVE EFFECT CONTRIBUTIONS TO SOLVENT-CATION BINDING OBSERVED IN ELECTROSPRAY IONIZATION MASS SPECTROMETRY - (Peer Reviewed Journal) - (19-Oct-98)