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Jacob Selhub (Tufts University)
Human Nutrition Research Center on Aging
(This person is no longer with ARS)
Projects
THE ROLE OF B VITAMINS AND ONE CARBON METABOLISM IN AGING
Appropriated (D)
  Accession Number: 414748
ONE-CARBON METABLISM AND RISK OF COLORECTAL ADENOMAS IN THE PROSTATE, LUNG, OVARIAN AND COLORECTAL CANCER SCREENING TRIAL COHORT
Grant (G)
  Accession Number: 411868
ONE-CARBON METABOLISM AND RISK OF COLORECTAL ADENOMAS IN THE PROSTATE, LUNG, OVARIAN AND COLORECTAL CANCER SCREENING TRIAL (PLCO) COHORT
Reimbursable (R)
  Accession Number: 412488
THE ROLE OF B VITAMINS AND ONE CARBON METABOLISM IN AGING
Specific Cooperative Agreement (S)
  Accession Number: 416623
B VITAMIN METABOLISM AND AGING
Specific Cooperative Agreement (S)
  Accession Number: 411664

Publications
Not all cases of neural-tube defect can be prevented by increasing the intake of folic acid - (Peer Reviewed Journal)
Heseker, H.B., Mason, J.B., Selhub, J., Rosenberg, I., Jacques, P. 2009. Not all cases of neural-tube defect can be prevented by increasing the intake of folic acid. British Journal of Nutrition. 102:173-180.
Micronutrient deficiencies are associated with impaired immune response and higher burden of respiratory infections in elderly Ecuadorians - (Peer Reviewed Journal)
Hamer, D.H., Sempertegui, F., Estrella, B., Tucker, K., Rodriguez, A., Egas, J., Dallal, G., Selhub, J., Griffiths, J.K., Meydani, S. 2009. Micronutrient deficiencies are associated with impaired immune response and higher burden of respiratory infections in elderly Ecuadorians. Journal of Nutrition. 139:113-119.
Cognitive impairment in folate-deficient rats corresponds to depleted brain phosphatidylcholine and is prevented by methionine without lowering homocysteine - (Peer Reviewed Journal)
Troen, A.M., Chao, W., Crivello, N.A., Shukitt Hale, B., Smith, D., Selhub, J., Rosenberg, I. 2008. Cognitive impairment in folate-deficient rats corresponds to depleted brain phosphatidylcholine and is prevented by methionine without lowering homocysteine. Journal of Nutrition. 138(12):2502-2509.
High-Dose B-Vitamin Supplementation and Progression of Subclinical Atherosclerosis: A Randomized Controlled Trial - (Peer Reviewed Journal)
Hodis, H.N., Mack, W.J., Dustin, L., Mahrer, P.R., Azen, S.P., Detrano, R., Selhub, J., Alaupovic, P., Liu, C., Liu, C., Hwang, J., Wilcox, A.G., Selzer, R.H. 2009. High-Dose B-Vitamin Supplementation and Progression of Subclinical Atherosclerosis: A Randomized Controlled Trial. Stroke. 40:730-736.
Common variants of FUT2 are associated with plasma vitamin B12 levels - (Peer Reviewed Journal)
Hazra, A., Kraft, P., Selhub, J., Giovannuci, E.L., Thomas, G., Hoover, R.N., Chanock, S., Hunter, D.J. 2008. Common variants of FUT2 are associated with plasma vitamin B12 levels. Nature Genetics. 40(10):1160-1162.
B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice - (Peer Reviewed Journal)
Troen, A.M., Shea-Budgell, M., Shukitt Hale, B., Smith, D., Selhub, J., Rosenberg, I. 2008. B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice. Proceedings of the National Academy of Sciences. 105(34):12474-12479.
Folic acid fortification and cancer risk: plea for objective evaluation of the evidence - (Other)
Mason, J.B., Cole, B.F., Baron, J.A., Kim, Y., Refsum, H., Selhub, J., Smith, A. 2008. Folic acid fortification and cancer risk: plea for objective evaluation of the evidence. Lancet. 371: 1335-1336.
Plasma B vitamins, homocysteine and their relation with bone loss and hip fracture in elderly men and women - (Peer Reviewed Journal)
Mclean, R.R., Jacques, P., Selhub, J., Fredman, L., Tucker, K., Samelson, E.J., Kiel, D.P., Cupples, L.A., Hannan, M.T. 2008. Plasma B vitamins, homocysteine and their relation with bone loss and hip fracture in elderly men and women. Journal of Clinical Endocrinology and Metabolism. 93(6):2206-2212.
Will Increasing Folic Acid in Fortified Grain Products Further Reduce Neural Tube Defects without Causing Harm?: Consideration of the Evidence - (Other)
Morris, M.S., Jacques, P., Rosenberg, I., Selhub, J. 2008. Will Increasing Folic Acid in Fortified Grain Products Further Reduce Neural Tube Defects without Causing Harm?: Consideration of the Evidence. Pediatric Research. 63(4):450.
Response to Quinlivan: Post-fortification, folate intake in vitamin B12 deficiency is positively related to homocysteine and methylmalonic acid - (Other)
Morris, M.S., Jacques, P., Selhub, J. 2008. Response to Quinlivan: Post-fortification, folate intake in vitamin B12 deficiency is positively related to homocysteine and methylmalonic acid. Proceedings of the National Academy of Sciences. 105(5):E8.
Plasma Pyridoxal 5'-phosphate (PLP) in the United States population: the National Health and Nutrition Examination Survey, 2003-2004 - (Peer Reviewed Journal)
Morris, M.S., Picciano, M.F., Jacques, P., Selhub, J. 2008. Plasma Pyridoxal 5'-phosphate (PLP) in the United States population: the National Health and Nutrition Examination Survey, 2003-2004. American Journal of Clinical Nutrition. 87(5):1446-1454.
Relationship between the 19 base pair deletion polymorphism in DHFR and unmetabolized folic and in plasma and RBC folate - (Abstract)
Kalmbach, R., Choumenkovitch, S., Jacques, P., D'Agostino, R.B., Troen, A., Selhub, J. 2008. Relationship between the 19 base pair deletion polymorphism in DHFR and unmetabolized folic and in plasma and RBC folate. Federation of American Societies for Experimental Biology Journal. 22:296.4.
Nutritional and Immunological Status and Burden of Infection in Elderly Ecuadorian - (Abstract)
Hamer, D., Sempertegui, F., Estrella, B., Tucker, K., Rodriguez, A., Egas, J., Dallal, G., Selhub, J., Meydani, S. 2008. Nutritional and Immunological Status and Burden of Infection in Elderly Ecuadorian. Experimental Biology. Abstract No. 450.5.
Metabolic Syndrome in Elderly Living in Marginal Peri-Urban Communities in Quito, Ecuador - (Abstract)
Sempertegui, F., Estrella, B., Tucker, K., Hamer, D.H., Narvaez, X., Sempertegui, M., Rodriguez, A., Noel, S., Dallal, G., Selhub, J., Meydani, S. 2008. Metabolic Syndrome in Elderly Living in Marginal Peri-Urban Communities in Quito, Ecuador. Experimental Biology Annual Meeting. Abstract No. 307.6.
In vitamin B12 deficiency, higher serum folate is assoicated with increased total homocysteine (tHcy) and methlmalonic acid (MMA) concentrations - (Peer Reviewed Journal)
Selhub, J., Morris, M.S., Jacques, P. 2007. In vitamin B12 deficiency, higher serum folate is assoicated with increased total homocysteine (tHcy) and methlmalonic acid (MMA) concentrations. Proceedings of the National Academy of Sciences. 104(50):19995-20000.
Plasma Cysteinylglycine Levels and Breast Cancer Risk in Women - (Peer Reviewed Journal)
Lin, J., Manson, J.E., Selhub, J., Buring, J.E., Zhang, S.M. 2007. Plasma Cysteinylglycine Levels and Breast Cancer Risk in Women. Cancer Research. 67:11123-11127. doi:10.1158/0008-5472.
Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women - (Peer Reviewed Journal)
Lin, J., Lee, I., Cook, N.R., Selhub, J., Manson, J.E., Buring, J.E., Zhang, S.M. 2008. Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women. American Journal of Clinical Nutrition. 87(3):734-43.
A Temporal Association between Folic Acid Fortification and a Rise in Colorectal Cancer Rates May be Illuminating Important Biological Principles: a Hypothesis - (Peer Reviewed Journal)
Mason, J.B., Dickstein, A., Jacques, P., Haggarty, P., Selhub, J., Dallal, G., Rosenberg, I. 2007. A temporal association between folic acid fortification and a rise in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiology Biomarkers and Prevention. 16:1.
Associations of plasma natriuretic peptide, adrenomedullin, and homocysteine levels with alterations in arterial stiffness: The Framingham Heart Study - (Peer Reviewed Journal)
Levy, D., Hwang, S., Katalar, A., Benjamin, E.J., Vasan, R.S., Parise, H., Larson, M.G., Wang, T.J., Selhub, J., Jacques, P., Vita, J.A., Keyes, M.J., Mitchell, G.F. 2007. Associations of plasma natriuretic peptide, adrenomedullin, and homocysteine levels with alterations in arterial stiffness: The Framingham Heart Study. Circulation. 115:3069-3085.
Plasma Homocysteine and Carotid Artery Intima-Media Thickness: Site-Specific Associations in the Framingham Offspring Cohort - (Abstract)
Dietrich, M., Jacques, P., Polak, J., Pencina, M., Evans, J., Selhub, J., Vasan, R., D'Agostino, R. 2006. Plasma Homocysteine and Carotid Artery Intima-Media Thickness: Site-Specific Associations in the Framingham Offspring cohort. Federation of American Societies of Experimental Biology. Abstract no. 660.9.
Use of the affinity/HPLC method for quantitative estimation of folic acid enriched cereal grain products - (Peer Reviewed Journal)
Poo-Prieto, R., Haytowitz, D.B., Holden, J.M., Rogers, G., Choumenkovitch, S.F., Jacques, P.F., Selhub, J. 2006. Use of the affinity/HPLC method for quantitative estimation of folic acid enriched cereal grain products. Journal of Nutrition. 136:3079-3083.
Multiple Biomarkers for the Prediction of First Major Cardiovascular Events and Death - (Peer Reviewed Journal)
Wang, T.J., Gona, P., Larson, M.G., Toffler, G.H., Levy, D., Newton-Cheh, C., Jacques, P., Rifai, N., Selhub, J., Robins, S.J., Benjamin, E.J., D'Agostiono, R.B., Vasan, R.S. 2006. Multiple Biomarkers for the Prediction of First Major Cardiovascular Events and Death. New England Journal of Medicine. 355(25): 2631-9.
Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification - (Peer Reviewed Journal)
Morris, M.S., Jacques, P., Rosenberg, I., Selhub, J. 2007. Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. American Journal of Clinical Nutrition. 85(1):193-200.
Folate and Vitamin B12 Transport Systems in the Developing Infant - (Review Article)
Rosenberg, I., Selhub, J. 2006. Folate and Vitamin B12 Transport Systems in the Developing Infant. Journal of Pediatrics. 149(5):S62-S63.
The cognitive impact of nutritional homocysteinemia in apolipoprotein-E deficient mice - (Peer Reviewed Journal)
Troen, A.M., Shukitt Hale, B., Chao, W., Alburquerque, B., Smith, D.E., Selhub, J., Rosenberg, I. 2006. The cognitive impact of nutritional homocysteinemia in apolipoprotein-E deficient mice. Journal of Alzheimer's Disease. 9(4): 381-92.
Dietary Choline and Betanine Assessed by Food-Frequency Questionnaire in Relation to Plasma Total Homocysteine Concentration in the Framingham Offspring Study - (Peer Reviewed Journal)
Cho, E., Zeisel, S.H., Jacques, P.F., Selhub, J., Dougherty, L., Colditz, G.A., Willett, W.C. 2006. Dietary Choline and Betanine Assessed by Food-Frequency Questionnaire in Relation to Plasma Total Homocysteine Concentration in the Framingham Offspring Study. American Journal of Clinical Nutrition. 83(4):905-911.
The Many Facets of Hyperhomocysteinemia: Studies from the Framingham Cohorts - (Peer Reviewed Journal)
Selhub, J. 2006. The many facets of hyperhomocysteinemia: studies from the framingham cohorts. Journal of Nutrition. 136(6 Suppl):1726S-1730S.
The Nutrition, Aging, and Memory in Elders (Name) Study: Design and Methods for a Study of Micronutrients and Cognitive Function in a Homebound Elderly Population - (Peer Reviewed Journal)
Scott, T.M., Peter, I., Tucker, K.L., Arsenault, L., Bergethon, P., Bhadelia, R., Buell, J., Collinsa, L., Dashe, J.F., Griffith, J., Hibberd, P., Leins, D., Liu, T., Ordovas, J.M., Patz, S., Price, L., Qui, W., Sarnak, M., Selhub, J., Smaldone, L., Wagner, C., Wang, L., Weiner, D., Yee, J., Rosenberg, I., Folstein, M. 2006. The nutrition, aging, and memory in elders (name) study: design and methods for a study of micronutrients and cognitive function in a homebound elderly population. International Journal or Geriatric Psychiatry. 21(6):519-28.
Unmetabolized Folic Acid in Plasma Is Associated with Reduced Natural Killer Cell Cytotoxicity among Postmenopausal Women - (Peer Reviewed Journal)
Troen, A.M., Mitchell, B., Sorensen, B., Wener, M.H., Johnston, A., Wood, B., Selhub, J., Mctiernan, A., Yasui, Y., Oral, E., Potter, J.D., Ulrich, C.M. 2006. Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. Journal of Nutrition. 136(1):189-94.
Public health significance of elevated homocysteine - (Proceedings/Symposium)
Selhub, J. 2008. Public health significance of elevated homocysteine. Food and Nutrition Bulletin. 29(2)(Suppl):S116-S125.
The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B12 status - (Proceedings/Symposium)
Selhub, J., Jacques, P., Dallal, G., Choumenkovitch, S., Rogers, G. 2008. The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B12 status. Food and Nutrition Bulletin. 29(2)(Suppl):S67-S73.
Public health significance of supplementation or fortification of grain products with folic acid - (Proceedings/Symposium)
Selhub, J., Rosenberg, I. 2008. Public health significance of supplementation or fortification of grain products with folic acid. Food and Nutrition Bulletin. 29(2)(Suppl):S173-S176.
Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis - (Peer Reviewed Journal)
Chiang, E.I., Selhub, J., Bagley, P.J., Dallal, G., Roubenoff, R. 2005. Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis. Arthritis Research & Therapy. 133(4):1056-1059.
Total plasma homocysteine and arteriosclerotic outcomes in type 2 diabetes with nephropathy - (Peer Reviewed Journal)
Friedman, A.N., Hunsicker, L.G., Selhub, J., Bostom, A.G. 2005. Total plasma homocysteine and arteriosclerotic outcomes in type 2 diabetes with nephropathy. Journal of the American Society of Nephrology. 16:3397-3402.
Polymorphisms in Cytoplasmic Serine Hydroxymethyltransferase and Methylenetetrahydrofolate Reductase Affect the Risk of Cardiovascular Disease in Men - (Peer Reviewed Journal)
Lim, U., Peng, K., Shane, B., Stover, P.J., Litonjua, A.A., Weiss, S.T., Gaziano, J.M., Strawderman, R.L., Raiszadeh, F., Selhub, J., Tucker, K.L., Cassano, P.A. 2005. Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in men. Journal of Nutrition. 135(8):1989-1994.
Polymorphisms in Cytoplasmic Serine Hydroxymethyltransferase and Methylenetetrahydrofolate Reductase Affect the Risk of Cardiovascular Disease in Men - (Peer Reviewed Journal)
Lim, U., Peng, K., Shane, B., Stover, P.J., Litonjua, A.A., Weiss, S.T., Gaziano, M.J., Strawderman, R.L., Raiszadeh, F., Selhub, J., Tucker, K.L., Cassano, P.A. 2005. Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in men. Journal of Nutrition. 135(8):1989-94.
Homocysteine & Cognitive Performance in the Framingham Offspring Study: Age Is Important - (Peer Reviewed Journal)
Elias, M.F., Sullivan, L.M., D'Agostino, R.B., Elias, P.K., Jacques, P.F., Selhub, J., Seshadri, S., Au, R., Beiser, A., Wolf, P.A. 2005. Homocysteine & Cognitive Performance in the Framingham Offspring Study: Age is Important. American Journal of Epidemiology. 162(7):644-653.
Developmental consequences of in utero sodium arsenate exposure in mice with folate transport deficiencies - (Peer Reviewed Journal)
Spiegelstein, O., Gould, A., Wlodarczyk, B., Tsie, M., Lu, X., Troen, A., Selhub, J., Piedrahita, J.A., Salbaum, M.J., Kappen, C., Melny, S., James, J., Finnell, R.H. 2005. Developmental consequences of in utero sodium arsenate exposure in mice with folate transport deficiencies. Journal of Toxicology and Applied Pharmacology. 203(1): 18-26.
Homocysteine As a Risk Factor for Coronary Heart Diseases and Its Association with Inflammatory Biomarkers, Lipids and Dietary Factors - (Peer Reviewed Journal)
Shai, I., Stampfer, M.J., Ma, J., Manson, J.E., Hankinson, S.E., Cannuscio, C., Selhub, J., Curthan, G., Rimm, E.B. 2004. Homocysteine as a risk factor for coronary heart diseases and its association with inflammatory biomarkers, lipids and dietary factors. Atherosclerosis. 177:375-381.
A Common Polymorphism in the Methylenetetrahydrofolate Reductase (Mthfr) Gene Is Associated with Quantitative Ultrasound in Those with Low Plasma Folate - (Peer Reviewed Journal)
Mclean, R.R., Karasik, D., Selhub, J., Tucker, K., Ordovas, J.M., Russo, G.T., Cupples, A., Jacques, P., Kiel, D.P. 2004. A common polymorphism in the methylenetetrahydrofolate reductase (mthfr) gene is associated with quantitative ultrasound in those with low plasma folate. Journal of Bone and Mineral Research. 19:410-418.
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