Projects

NUTRITION, AGING, IMMUNITY AND INFLAMMATION Appropriated (D)   Accession Number: 415267

NUTRITION, AGING, IMMUNE AND INFLAMMATORY RESPONSES IN HEALTH AND DISEASES Specific Cooperative Agreement (S)   Accession Number: 416750

Publications

Vitamin E reverses impaired linker for activation of T cells activation in T cells from aged C57BL/6 mice - (Peer Reviewed Journal)

Marko, M., Pang, H.E., Bunnell, S.C., Azzi, A., Huber, B.T., Meydani, S. 2009. Vitamin E reverses impaired linker for activation of T cells activation in T cells from aged C57BL/6 mice. Journal of Nutrition. 139:1192-1197.

Green tea EGCG suppresses T cell proliferation by impairing IL-2/IL-2R signaling leading to inhibition of cell cycle - (Abstract)

Pae, M., Meydani, S., Meydani, M., Shang, F., Wu, D. 2009. Green tea EGCG suppresses T cell proliferation by impairing IL-2/IL-2R signaling leading to inhibition of cell cycle. Journal of Federation of American Societies for Experimental Biology. 23:110.5.

Effect of age on proteasomal activity of T cells and macrophages - (Abstract)

Ren, Z., Shang, F., Meydani, S., Wu, D. 2009. Effect of age on proteasomal activity of T cells and macrophages. Journal of Federation of American Societies for Experimental Biology. 23:908.9.

Effect of blueberries on the immune response of obese mice induced by high fat diet - (Abstract)

Wu, D., Ren, Z., Defuria, J., Obin, M., Meydani, S. 2009. Effect of blueberries on the immune response of obese mice induced by high fat diet. Journal of Federation of American Societies for Experimental Biology. 23:908.5.

Inflammation status in adipose tissue and peritoneal macrophages of young and old mice in diet-induced obesity - (Abstract)

Wu, D., Ren, Z., Pae, M., Han, S., Meydani, S. 2009. Inflammation status in adipose tissue and peritoneal macrophages of young and old mice in diet-induced obesity. Journal of Federation of American Societies for Experimental Biology. 23:909.3.

Effect of vitamin E and SNPs at cytokine genes on cytokine production in the elderly - (Abstract)

Belisle, S.E., Leka, L.S., Delgado-Lista, J., Jacques, P., Ordovas, J.M., Meydani, S. 2009. Effect of vitamin E and SNPs at cytokine genes on cytokine production in the elderly. Journal of Federation of American Societies for Experimental Biology. 23:110.2.2.

Effect of dietary supplementation with a formulated nutrient mixture together with whey-based protein on immune response of young and old mice - (Abstract)

Wu, D., Onwulata, C., Ren, Z., Pae, M., Pang, H., Meydani, S. 2009. Effect of dietary supplementation with a formulated nutrient mixture together with whey-based protein on immune response of young and old mice. Journal of Federation of American Societies for Experimental Biology. 23:909.7.

SNPs at IL-2 and IL-10 genes are associated with respiratory infection in the elderly and may modulate the effect of vitamin E on lower respiratory infections in elderly women - (Abstract)

Belisle, S.E., Hamer, D.H., Leka, L.S., Dallal, G., Delgado-Lista, J., Fine, B.C., Jacques, P., Ordovas, J.M., Meydani, S. 2009. SNPs at IL-2 and IL-10 genes are associated with respiratory infection in the elderly and may modulate the effect of vitamin E on lower respiratory infections in elderly women. Journal of Federation of American Societies for Experimental Biology. 23:221.1.

Cytokine response to vitamin E supplementation is dependent on pre-supplementation cytokine levels - (Peer Reviewed Journal)

Belisle, S.E., Leka, L.S., Dallal, G., Jacques, P., Lista, J., Ordovas, J.M., Meydani, S. 2008. Cytokine response to vitamin E supplementation is dependent on pre-supplementation cytokine levels. Biofactors. 33:191-200.

Micronutrient deficiencies are associated with impaired immune response and higher burden of respiratory infections in elderly Ecuadorians - (Peer Reviewed Journal)

Hamer, D.H., Sempertegui, F., Estrella, B., Tucker, K., Rodriguez, A., Egas, J., Dallal, G., Selhub, J., Griffiths, J.K., Meydani, S. 2009. Micronutrient deficiencies are associated with impaired immune response and higher burden of respiratory infections in elderly Ecuadorians. Journal of Nutrition. 139:113-119.

Letter to the Editor: Reply to Leung and Yew - (Other)

Villamor, E., Bosch, R.J., Mugusi, F., Urassa, W., Saathoff, E., Matsumoto, K., Meydani, S., Fawzi, W.W. 2009. Letter to the Editor: Reply to Leung and Yew. Journal of Infectious Diseases. 199: 288.

Age-associated changes in immune and inflammatory response: role of nutritional intervention - (Review Article)

Wu, D., Meydani, S. 2008. Age-associated changes in immune and inflammatory response: role of nutritional intervention. Journal of Leukocyte Biology. 84:900-914.

Nutrition and age-associated inflammation: implications for disease prevention - (Proceedings/Symposium)

Meydani, S., Wu, D. 2008. Nutrition and age-associated inflammation: implications for disease prevention. Journal of Parenteral and Enteral Nutrition. 32:626-629.

LONG TERM CARE FACILITIES: A CORNUCOPIA OF VIRAL PATHOGENS - (Peer Reviewed Journal)

Falsey, A.R., Dallal, G., Formica, M.A., Andolina, G.G., Hamer, D.H., Leka, L.S., Meydani, S. 2008. Long term care facilities: a cornucopia of viral pathogens. Journal of the American Geriatrics Society. 56:1281-1285.

White button mushroom enhances maturation of bone marrow derived dendritic cells and their antigen presenting function in mice - (Peer Reviewed Journal)

Ren, Z., Guo, Z., Meydani, S., Wu, D. 2008. White button mushroom enhances maturation of bone marrow derived dendritic cells and their antigen presenting function in mice. Journal of Nutrition. 138:544-550.

Effect of short term supplementation with Lactobacillus acidophilus LAFTI® L10 on resistance to influenza infection in young and old mice - (Abstract)

Han, S., Thomas, A., Peters, E., Elliott, J., Meydani, S. 2008. Effect of short term supplementation with Lactobacillus acidophilus LAFTI® L10 on resistance to influenza infection in young and old mice. Experimental Biology Annual Meeting. Abstract No. 450.4.

Age Increases Susceptibility to Salmonella typhimurium Infection in C57BL/6 Mice: Role of the Immune System - (Abstract)

Ren, Z., Gay, R., Thomas, A., Pae, M., Logsdon, L., Mecsas, J., Meydani, S. 2008. Age Increases Susceptibility to Salmonella typhimurium Infection in C57BL/6 Mice: Role of the Immune System. Experimental Biology Annual Meeting. Abstract No. 675.26.

Nutritional and Immunological Status and Burden of Infection in Elderly Ecuadorian - (Abstract)

Hamer, D., Sempertegui, F., Estrella, B., Tucker, K., Rodriguez, A., Egas, J., Dallal, G., Selhub, J., Meydani, S. 2008. Nutritional and Immunological Status and Burden of Infection in Elderly Ecuadorian. Experimental Biology. Abstract No. 450.5.

Metabolic Syndrome in Elderly Living in Marginal Peri-Urban Communities in Quito, Ecuador - (Abstract)

Sempertegui, F., Estrella, B., Tucker, K., Hamer, D.H., Narvaez, X., Sempertegui, M., Rodriguez, A., Noel, S., Dallal, G., Selhub, J., Meydani, S. 2008. Metabolic Syndrome in Elderly Living in Marginal Peri-Urban Communities in Quito, Ecuador. Experimental Biology Annual Meeting. Abstract No. 307.6.

Effects of repeated administration of intradermal skin test by Mantoux method on delayed-type hypersensitivity responses in healthy young and elderly subjects - (Other)

Ahmed, T., Hamer, D.H., Meydani, S. 2007. Effects of repeated administration of intradermal skin test by Mantoux method on delayed-type hypersensitivity responses in healthy young and elderly subjects. British Journal of Nutrition. 99: 1388-1390.

Age-associated inflammatory changes: role of nutritional intervention - (Proceedings/Symposium)

Meydani, S., Wu, D. 2007. Age-associated inflammatory changes: role of nutritional intervention. Nutrition Reviews. 65(12):S1-S4.

AGING UP-REGULATES EXPRESSION OF INFLAMMATORY MEDIATORS IN MOUSE ADIPOSE TISSUE - (Peer Reviewed Journal)

Wu, D., Ren, Z., Pae, M., Guo, W., Cui, X., Merrill, A.H., Meydani, S. 2007. Aging up-regulates expression of inflammatory mediators in mouse adipose tissue. Journal of Immunology. 179:4829-4839.

Serum zinc and pneumonia in nursing home elderly - (Peer Reviewed Journal)

Meydani, S., Barnett, J.B., Dallal, G., Fine, B.C., Jacques, P., Leka, L.S., Hamer, D.H. 2007. Serum zinc and pneumonia in nursing home elderly. American Journal of Clinical Nutrition. 86:1167-73.

Dietary Supplementation with White Button Mushroom Enhances Natural Killer Cell Activity in C57BL/6 Mice - (Peer Reviewed Journal)

Wu, D., Pae, M., Ren, Z., Guo, Z., Smith, D., Meydani, S. 2007. Dietary Supplementation with White Button Mushroom Enhances Natural Killer Cell Activity in C57BL/6 Mice. Journal of Nutrition. 137(6): 1472-1477.

In vitro supplementation with white button mushroom promotes maturation of bone marrow-derived dendritic cells in mice - (Abstract)

Ren, Z., Guo, Z., Meydani, S., Wu, D. 2007. In vitro supplementation with white button mushroom promotes maturation of bone marrow-derived dendritic cells in mice. Experimental Biology/The FASEB Journal. 21(6):p. A737.

Green tea catechin EGCG suppresses T cell-mediated function through inhibiting cell division and reducing cell survival - (Abstract)

Wu, D., Guo, Z., Ren, Z., Meydani, S. 2007. Green tea catechin EGCG suppresses T cell-mediated function through inhibiting cell division and reducing cell survival. Experimental Biology/The FASEB Journal. 21(6):p. A738.

Effect of dietary supplementation with white button mushroom on immune function of C57BL mice - (Abstract)

Wu, D., Pae, M., Ren, Z., Guo, Z., Smith, D., Meydani, S. 2007. Effect of dietary supplementation with white button mushroom on immune function of C57BL mice. Experimental Biology/The FASEB Journal. 21(5):p. A47.

Effect of Bed Rest with Amino Acid Supplementation on Cell-Mediated Immune Response in Healthy Men: Indications for Immune Status of Astronauts - (Abstract)

Eksir, F., Castaneda-Sceppa, C., Cloutier, G., Dallal, G.E., Thomas, A., Roubenoff, R., Meydani, S. 2007. Effect of Bed Rest with Amino Acid Supplementation on Cell-Mediated Immune Response in Healthy Men: Indications for Immune Status of Astronauts. In: Experimental Biology Annual Meeting, April 27 - May 7, 2007, Washington D.C. 21(6):704.8.

The Effects of Dietary Changes in the Ratio of Omega-3 to Omega-6 Polyunsaturated Fatty Acids on Lung Carcinogenesis in A/J Mice - (Abstract)

Mernitz, H., Meydani, S., Smith, D., Wang, X. 2006. The Effects of Dietary Changes in the Ratio of Omega-3 to Omega-6 Polyunsaturated Fatty Acids on Lung Carcinogenesis in A/J Mice. American Association of Cancer Research: Frontiers in Cancer Prevention Research, November 12-15, 2006, Boston, MA. Abstract No. A223.

Age and vitamin E-induced changes in Gene Expression Profiles of T cells - (Peer Reviewed Journal)

Han, S., Adolfsson, O., Lee, C., Prolla, T.A., Ordovas, J.M., Meydani, S. 2006. Age and vitamin E-induced changes in Gene Expression Profiles of T cells. Journal of Immunology. 177(12): 6052-6061.

Vitamin E (E) supplementation reverses the age associated decline in phosphorylation of the adaptor protein LAT in CD4+ T cells of old mice - (Abstract)

Marko, M.G., Bunnell, S.C., Huber, B.T., Meydani, S.N. 2006. Vitamin E (E) supplementation reverses the age associated decline in phosphorylation of the adaptor protein LAT in CD4+ T cells of old mice. AGE. 28(1):12-13.

PROTEASOME ACTIVITY DECLINES IN AGED MACROPHAGES - (Abstract)

Cui, X., Shang, F., Wu, D., Meydani, S.N. 2006. Proteasome activity declines in aged macrophages. AGE. 28(1):71.

CALORIE RESTRICTION ENHANCES T CELL MEDIATED IMMUNE RESPONSE IN OVERWEIGHT MEN AND WOMEN - (Abstract)

Ahmed, T., Das, S., Roberts, S.B., Golden, J.K., Saltzman, E., Meydani, S.N. 2006. Calorie restriction enhances t cell mediated immune response in overweight men and women. AGE. 28(1):20.

SUSCEPTIBILITY TO SALMONELLA TYPHIMURIUM INFECTION INCREASES WITH AGE IN C57BL/6 MICE - (Abstract)

Ren, Z., Gay, R., Thomas, A., Logsdon, L., Mecsas, J., Meydani, S.M. 2006. Susceptibility to salmonella typhimurium infection increases with age in c57bl/6 mice. AGE. 28(1):62-63.

T cell Receptor Proximal Effects of Vitamin E (E) in old Mice: Reversal of age-associated Decrease in Effective Immune Synapse Formation and Phosphorylation of Early Signaling Proteins in T cells - (Abstract)

Meydani, S.N., Marko, M., Ahmed, T., Bunnell, S.C., Huber, B.T. 2006. T cell Receptor Proximal Effects of Vitamin E (E) in old Mice: Reversal of age-associated Decrease in Effective Immune Synapse Formation and Phosphorylation of Early Signaling Proteins in T cells. 13th Biennial Congress Society for Free Radical Research International. Aug. 15-19, 2006: Davos, Switzerland.

IMPACT OF VITAMIN E ON IMMUNE FUNCTION AND ITS CLINICAL IMPLICATIONS - (Review Article)

Han, S., Meydani, S. 2006. The impact of vitamin e on immune function and its clinical implications. Expert Review of Clinical Immunology. 2(4):561-567.

VITAMIN E (E) SUPPLEMENTATION REVERSES THE AGE ASSOCIATED DECLINE IN PHOSPHORYLATION OF THE ADAPTOR PROTEIN LAT IN CD4+ T CELLS - (Abstract)

Marko, M.G., Bunnell, S.C., Huber, B.T., Meydani, S.N. 2006. Vitamin e (e) supplementation reverses the age associated decline in phosphorylation of the adaptor protein lat in cd4+ t cells. Federation of American Societies for Experimental Biology Conference.20:A558.

CALORIE RESTRICTION (CR) ENHANCES T CELL MEDIATED IMMUNE RESPONSE IN OVERWEIGHT MEN AND WOMEN - (Abstract)

Ahmed, T., Das, S.K., Roberts, S.B., Golden, J.K., Saltzman, E., Meydani, S.N. 2006. Calorie restriction (cr) enhances t cell mediated immune response in overweight men and women. Federation of American Societies for Experimental Biology Conference.20:A988.

AGING INCREASES EXPRESSION OF INFLAMMATORY MEDIATORS IN MOUSE ADIPOSE TISSUE (AT) - (Abstract)

Wu, D., Pae, M., Ren, Z., Guo, W., Cui, X., Meydani, S.N. 2006. Aging increases expression of inflammatory mediators in mouse adipose tissue (at). Federation of American Societies for Experimental Biology Conference.20:A140.

Nutritional, immunological and health status of the elderly population living in poor neighbourhoods of Quito, Ecuador - (Peer Reviewed Journal)

Sempertegui, F., Estrella, B., Elmieh, N., Jordan, M., Ahmed, T., Rodriguez, A., Tucker, K.L., Hamer, D.H., Reeves, P.G., Meydani, S.N. 2006. Nutritional, immunological, and health status of the elderly population living in poor neighborhoods of quito, ecuador: a preliminary report. British Journal of Nutrition. 96:845-853.

AGING UP-REGULATES EXPRESSION OF INFLAMMATORY MEDIATORS IN MOUSE ADIPOSE TISSUE (AT) - (Abstract)

Wu, D., Pae, M., Ren, Z., Guo, W., Cui, X., Meydani, S.N. 2006. Aging up-regulates expression of inflammatory mediators in mouse adipose tissue (at). Oxygen Club of California Annual Meeting. p. 119.

Age-associated decline in effective immune synapse formation of CD4+ T cells is reversed by vitamin E supplementation - (Peer Reviewed Journal)

Marko, M.G., Ahmed, T., Bunnell, S.C., Wu, D., Chung, H., Huber, B.T., Meydani, S. 2007. Age-associated decline in effective immune synapse formation of CD4+ T cells is reversed by vitamin E supplementation. Journal of Immunology. 178:1443-1449.

PROTEASOME ACTIVITY DECLINES IN AGED MACROPHAGES - (Abstract)

Cui, X., Shang, F., Wu, D., Meydani, S.N. 2006. Proteasome activity declines in aged macrophages. Federation of American Societies for Experimental Biology Conference.20:A983.

IMPACT OF SOYBEAN OILS VARYING IN FATTY ACID PROFILE ON T CELL PROLIFERATION OF MODERATELY HYPERLIPIDEMIC SUBJECTS - (Abstract)

Han, S., Lichtenstein, A.H., Wu, D., Ausman, L.M., Meydani, S.N. 2005. Impact of soybean oils varying in fatty acid profile on t cell proliferation of moderately hyperlipidemic subjects. Federation of American Societies for Experimental Biology Conference.20:A123.

VITAMIN E AND RESPIRATORY INFECTION IN THE ELDERLY: LETTER IN REPLY TO EDITOR - (Other)

Hamer, D.H., Meydani, S. 2004. Vitamin e and respiratory infection in the elderly: letter in reply to editor. Journal of the American Medical Association. 292(23):2834.

OPTIMIZATION OF IMMUNE FUNCTION IN MILITARY PERSONNEL - (Proceedings/Symposium)

Meydani, S., Eksir, F. 2006. Optimization of immune function in military personnel. In: Nutrient Composition of Rations for Short-Term, High-Intensity Combat Operations. Eds. Institute of Medicine of the National Academies. The National Academies Press, Washington, DC: 330-36.

VITAMIN E AND RESPIRATORY INFECTION IN THE ELDERLY - (Review Article)

Meydani, S., Han, S., Hamer, D.H. 2004. Vitamin E and respiratory infection in the elderly. In: Annals Of The New York Academy Of Sciences. Vitamin E and Health Symposium, May 22-24, 2004, Boston, Massachusetts, USA. p. 1031:214-222.

VITAMIN E AND GENE EXPRESSION IN IMMUNE CELLS - (Proceedings/Symposium)

Han, S., Adolfsson, O., Lee, C., Prolla, T.A., Ordovas, J.M., Meydani, S. 2004. Vitamin E and gene expression in immune cells. In: Annals Of The New York Academy Of Sciences. Vitamin E and Health Symposium, May 22-24, 2004, Boston, Massachusetts, USA. p.96-101.