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This is a tale of tails. The moral of
the tale: Science isn't just about combing the textbooks for the answers to
tomorrows quiz.
Sometimes science changes what textbooks
say!
Were not suggesting you mark up your
school books with red ink. But sometimes we discover that the scientists before
us were wrong.
Consider the case of
microbiologist Peter Holt.
For 60 years, the textbooks have had it wrong about a microscopic critter
called Salmonella pullorum [sal-mun-EL-uh
pull-OR-um).
The books said this germ DOESN'T have
whip-like tails called flagella [fluh-JELL-uh]. Oh
yes they do, Holt discovered. They use them, like tiny oars, to wiggle through
the bloodstream of chickens.
Holt works at the
Southeast Poultry Research
Laboratory in Athens, Ga. It's part of the USDA's Agricultural Research
Service. Some types of Salmonella he studies can make people sick. And
some types, including Pullorum, cost farmers money--by killing their
chickens.
Finding flagella is good because it makes
bacteria easier to detect in a sample of a chicken's blood. Why? Because, cells
called antibodies that attack germs REALLY gang up on those tails. And this
helps scientists make test kits to find out which Salmonella, if any,
are present.
Trouble was, most Salmonella that have
flagella have relatively thick, stubby
ones. Holt proved pullorum is different: it has fine, feathery,
hairlike flagella that were kind
of finicky about growing out.
How did Holt get the heads-up on
pullorum's tails? He borrowed a special growth medium from other
scientists.
A growth medium is a
chemical "soup"--a mix of proteins, hormones and other goodies. Some of them
are made so that bacteria will do things they dont do in a normal lab
sample. Bacteria like pullorum act differently based on where they
are--just like you probably act differently at home than at school. In this
case, the medium made pullorum feel like sprouting some tails and going
mobile.
Holt used a special microscope and camera to
be sure he was right about the tails.
The pictures show why the tails were hard to
find. As you can see, most Salmonella strains have thick, not feathery,
flagella.
Now that Dr. Holt has caught pullorum
by its tail, a company can make test kits to detect the germ faster. If they
do, it will help birds, farmers and anyone who likes fried chicken.
By Jill Lee, formerly,
Agricultural Research Service, Information Staff
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