Giving Broilers a Firmer Leg To Stand
An indentation of cartilage from the growth plate border into the bone (red,
dyed area)usually a smooth arcindicates a growth abnormality from
Today's broiler chickens are bred for fast growth--and their growth rate is
now almost double that of 30 years ago. Consequently, the bones do not have
enough time to mature and grow properly. Producers are plagued with lame birds,
their lameness attributed to leg deformities, broken bones, and
inflammation-causing bone infections.
Tackling this problem is Narayan Rath, a poultry physiologist in the
Agricultural Research Service Poultry
Production and Product Safety Research Unit at Fayetteville, Arkansas. He is
trying to establish methods that will reduce the incidence or severity of
bone-related problems that cost the poultry industry millions of dollars in
losses each year. Rath says reducing leg problems in poultry will save money
for the industry and eventually for consumers.
He is studying a major metabolic bone disorder known as tibial
dyschondroplasia, or TD.
"The ends of long bones are made up of cartilage, a type of connective
tissue responsible for long-bone growth in young birds. It is gradually
replaced by bone, until growth ceases," says Rath.
But TD impedes cartilage replacement by bone. This causes the tibia--the
inner, larger bone just below the knee--to be soft and fragile and prone to
deformities and breakage.
In laboratory tests, Rath found that cartilage cell death in the growth
plate near the ends of the bones prevents the cartilage tissue from being
replaced by new living cells and bone tissue. Instead, it remains as an island
of dead cartilage surrounded by living cells.
"We didn't have this knowledge before. And even though we don't know
the cause of this cell death," says Rath, "the finding at least
provides a major clue in searching for agents that cause abnormal cell death in
the tibial growth plate. It also allows us to focus on specific ways to
suppress this process."
Technician David Horlick (left) and poultry physiologist Narayan Rath prepare
to analyze collagen cross-links made of a fibrous protein.
Rath notes that certain mineral nutrients prevent cell death in lab tests,
but researchers have not tried them in animal experiments.
Rath is also looking at ways to increase bone maturity and strength during
its growth period. Bone contains both inorganic mineral and organic components.
The inorganic part is mostly calcium and phosphorus and constitutes 65 to 70
percent of bone weight; the organic part is mostly collagen--a fibrous protein.
Bone strength is related to its density and mineral content. Chemical bonds
called cross-links tie collagen fibers to each other, significantly increasing
collagen strength and eventually bone strength.
"We are now examining these collagen cross-links from birds of both
sexes and different ages," Rath says. "We want to learn more about
bone strength as related to the cross-links, bone minerals, and other
Rath says researchers don't know if the cross-links can be enhanced to
increase bone strength.
"We know that steroids such as androgen can enhance bone strength, but
we'll be looking for some cost-effective nutritional manipulations to achieve
these objectives," he says. "We may have a long way to go."--By
Tara Weaver, ARS.
Narayan Rath is in the USDA-ARS
Poultry Production and Product Safety
Research Unit, University of Arkansas, 0-303 Poultry Science Center,
Fayetteville, AR 72701; phone (501) 575-6189, fax (501) 575-4202.
"Giving Broilers a Firmer Leg To Stand On" was published in
the May 1998 issue of Agricultural Research magazine. Click here to see this
issue's table of contents.