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United States Department of Agriculture

Agricultural Research Service

Deployed War-Fighter Protection (DWFP) Program
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1 - What is DWFP?
2 - Projected studies
3 - Insectary
4 - Cooperative activities
5 - Toxicology research to discover new insecticides
6 - Spatial repellents for military tents in deployment situations
7 - Biological validation for effectiveness of impregnated military uniforms
8 - Spatial repellent delivery field kits
Toxicology research to discover new insecticides

Screen Chemicals

Different bioassay methods are used to test various activities of candidate insecticides.

Topical applications
Topical application
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Results from a screening test
Contact bioassays
Contact bioassay
Contact test apparatus
Novel testing systems
Pesticidal chemistries have been tested against adult mosquitoes in order to select new active ingredients that can be registered and used in the control of public health pests. Several products have been determined to be better than the standard treatment in laboratory tests. Filed tests with different formulations will determine which products best fit the needs of the Armed Forces.

Determine modes of action

In order to determine the mode of action of new chemical insecticides, these compounds will be added to a suspension of ground mosquitoes which contains all possible proteins that the insecticide may target. The insecticide and the target protein will bind, allowing the isolation of this protein-insecticide complex. Once that complex is separated from the mixture, the target protein can be identified. Toxicants that target new proteins found only in the pest insects are ideal for use as insecticides because they should be very safe to humans and the environment.

Click to enlarge
Diagram for determining the mode of action

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Last Modified: 11/30/2009
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