|Bruce C. Campbell|
Dr. Campbell has a broad spectrum of research experience involving biochemistry, evolutionary biology and molecular biology. Dr. Campbell was involved in chemogenomic and chemosensitization research. His research was done in collaboration with Dr. Jong H. Kim, FTDP, Dr. Russell Molyneux, College of Pharmacy, Univ. of Hawaii, Dr. Jiujiang Yu, ARS BARC Food Quality Lab, Beltsville, and Dr. William Nierman, at the J. Craig Venter Institute. The chemogenomic research involves the use of chemical probes to elucidate the functional genomics of mycotoxin biosynthesis. This work has led to the discovery of targeting the oxidative stress response system of fungi to inhibit mycotoxin production. The chemosensitization work was also done in collaboration with Dr. Robert Cramer, Dartmouth College, Dr. David A. Stevens, MD, Santa Clara Valley Medical Center, Stanford Univ. School of Medicine, Dr. Greg May, MD Anderson Cancer Center, Univ. of Texas, Dr. Arunmozhi Balajee, Centers for Disease Control and Prevention, Natália Faria and Dr. Maria de Luz Martins, Institute of Hygiene and Tropical Medicine, New Univ. of Lisbon, Portugal and Drs. Larisa Scherbakova and Vitaly Dzhavakhiya, Russian Research Institute of Phytopathology (VNIIF), Moscow. This work uses safe, natural products to target fungal genes that control stress response. This targeting results in greatly heightened sensitivity to commercial fungicides and antifungal drugs, with implications for improving veterinarial and medical treatment as well as controlling agriculturally important pathogens. Drs. Campbell and Kim received the Thomas J. Walsh Clinical Mycology Award for their research on chemosensitization as the most innovative research on chemotherapy for human mycoses in 2008.
Earlier research in Dr. Campbell's career originated the concept of tri-trophic interactions. This concept brought to light possible negative consequences in the interaction between biological control and host-plant resistance in that the chemical bases of insect-plant interactions involves other trophic levels, namely insect parasitoids or symbiotic bacteria. Later, with Dr. David Dreyer (ARS retired), he discovered structural differences in plant matrix heteropolysaccharides (e.g., pectins) affect host-plant recognition and feeding behavior by aphids. Dr. Campbell was also in the forefront of using molecular phylogenetic tools, based on DNA and RNA secondary structure, to infer evolutionary relationships among insects; including Hemiptera, with Drs. Thierry Bourgoin and David Ouvrard at the Museum national d'Histoire naturelle (MNHN), Paris, France, and Chalcidoidea, with Dr. John Heraty, University of California, Riverside.
Dr. Campbell has supervised the research of nine post-doctoral research associates, two Ph.D. students from the University of California, Berkeley, and Univ. of Oulu, Finland, Masters students from Northeastern Univ., the New Univ. of Lisbon and Univ. of Rome "La Sapienza" and a diplôme d'études approfondies and Ph. D. student from MNHN. In his lab, he has hosted visiting scholars from the Chinese Academy of Sciences, Univ. of Oulu, ARRIP and MNHN. Dr. Campbell was Adjunct Professor to the Univ. of California, Berkeley and Scientific Officer for the Office of Scientific Quality Review in charge of peer-review of all ARS research projects. He is a Fellow of the American Association for the Advancement of Science and currently has >100 senior and co-authored publications as peer-reviewed journal papers and book chapters. He is currently an Associate Editor for Frontiers in Microbiology.