Dr. Saebyeol Jang
Research Nutritionist, Post-doc
Performs studies that investigate the effects of flavonoids in the central nervous system, including its ability to mitigate cognitive deficits associated with neuroinflammation. A recent focus in my research is on the impact of bioactive food components on central leptin sensitivity in obesity, which is closely associated with a state of chronic low-grade inflammation.
Jang S and Johnson RW. 2010. Can Consuming Flavonoids Restore Old Microglia to their Youthful State? Nutrition Reviews. In press
Jang S, Dilger RN, and Johnson RW. 2010. Dietary luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice. J of Nutrition. 140(10): 1892-8.
Jang S, Kelley KW, Johnson RW. 2008. Luteolin reduces interleukin-6 production in microglia by inhibiting c-Jun N-terminal kinase phosphorylation and activation of AP-1. Proc Natl Acad Sci U S A. 105(21): 7534-9
Abraham J, Jang S, Godbout JP, Chen J, Kelley KW, Dantzer R, Johnson RW. 2008. Aging sensitizes mice to behavioral deficits induced by central HIV-1 gp120. Neurobiol Aging. 29(4): 614-21
Jang S, Won J, Kim H, Kim J, Lee KH, Han H, Rha HK, Choi CR. 2002. TAK1 mediates lipopolysaccharide-induced RANTES promoter activation in BV-2 microglial cells. Mol Cells 14(1):35-42
Lee WK, Jang S, Cha SH, Lee JH, Lee KH, Kim J, Jo YH, Endou H. 2002. Different sensitivity to nephrotoxic agents and osmotic stress in proximal tubular and collecting duct cell lines derived from transgenic mice. Toxicol In Vitro. 16(1):55-62.
Jang S and Lee KH. 2000. p38 MAPK and NF-kB are required for LPS-induced RANTES production in immortalized murine microglia (BV-2). Korean Journal of Physiology and Pharmacology 4:339-346.