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United States Department of Agriculture

Agricultural Research Service

Panickar's Publications
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Kiran Panickar, PhD

Research Biologist, Diet Genomics and Immunology Lab

Beltsville Human Nutrition Research Center

USDA, Agriculture Research Service

 


 

Journal articles and book chapters:

 

2010

 

Panickar, K.S & Anderson R.A. (2010) Dietary polyphenols exert neuroprotective effects by attenuating neuronal and astrocytic damage in cerebral ischemia. In, Phytochemicals and Human Heath: Pharmacological and Molecular Aspects (Ed) Farooqui, A.A. Springer, NY. (in press).

 

Panickar, K.S (2010) Corticorelin acetate, a synthetic human corticotropin-releasing factor analog for the treatment of peritumoral brain edema. Thomson Reuters' Thomson Pharma (www.thomson-pharma.com). (submitted).

 

Qin, B; Panickar, K.S & Anderson, R.A (2010) Cinnamon: The potential role in the prevention of insulin resistance, metabolic syndrome and type 2 diabetes. Journal of Diabetes Science and Technology. 4(3):685-693.

 

Panickar, K.S & Anderson R.A. (2010) Role of dietary polyphenols in attenuating brain edema and cell swelling in cerebral ischemic injury. Recent Patents on CNS Drug Discovery. 5(2): 99-108.

 

Jayakumar, A.R; Panickar, KS; Curtis, K.M; Tong, X.Y; Moriyama, M & Norenberg, M.D. (2010)  Na-K-Cl Cotransporter-1 in the Mechanism of Cell Swelling in Cultured Astrocytes after trauma. (submitted). 

 

Panickar, K.S & Anderson R.A. (2010) Mechanisms underlying the protective effects of myricetin and quercetin following oxygen-glucose deprivation-induced cell swelling and the reduction in glutamate uptake in glial cells. Experimental Neurology (Submitted).

 

 

2009

 

Krishnamurthy, R; Senut, M-C; Zemke, D; Min, J; Frenkel, M.B; Greenberg, E.J; Yu, S-W; Ahn, N; , Goudreau, J; Panickar, K.S; Majid, A (2009) Asiatic acid, a pentacyclic triterpene from Centella asiatica is neuroprotective in a mouse model of focal cerebral ischemia. Journal of Neuroscience Research. 87(11):2541-50.

 

Panickar, K.S; Polansky, M.M & Anderson R.A. (2009) Cinnamon polyphenols attenuate cell swelling and mitochondrial dysfunction following oxygen-glucose deprivation in glial cells. Experimental Neurology 216: 420-427.

 

Panickar, K.S; Polansky, M.M & Anderson R.A. (2009) Green tea polyphenols attenuate cell swelling and mitochondrial dysfunction following oxygen-glucose deprivation in glial cells. Nutritional Neuroscience 12(3):105-113.

 

 

Panickar, K.S; Jayakumar, A.R; Rama Rao, K.V & Norenberg, M.D (2009) Ammonia-induced activation of p53 in cultured astrocytes: Role in cell swelling and glutamate uptake. Neurochemistry International. 55(1-3):98-105.

 

Panickar, K.S; Cao, H.C; Qin, B & Anderson R.A. (2009) Molecular targets and therapeutic uses of cinnamon. In, Molecular targets and therapeutic uses of spices: Modern uses for ancient medicine. Monograph of Spices. Aggarwal, B.B; Kunnumakkara, A.B. (Eds), World Scientific Publishing Co., Inc. pp. 87-115.

 

Panickar, K.S & Bhathena, S.J (2009) Control of fatty acid intake and the role of essential fatty acids in cognitive function and neurological disorders. In Fat detection: Taste, texture and post-ingestive effects. Montmayeur, J-P, Coutre, J (Eds). CRC Press, Boca Raton, FL. pp. 463-484.

 

 

 

2008

 

Panickar, K.S; Nonner, D; White, M.G & Barrett, J.N (2008) Overexpression of Cdk5 or non-phosphorylatable retinoblastoma protein protects septal neurons from oxygen-glucose deprivation. Neurochemical Research 33(9):1852-1858.

 

Sinke, A; Jayakumar, A.R; Panickar, K.S; Moriyama, M; Reddy, P.V.B & Norenberg, M.D. (2008) NFκB in the mechanism of ammonia-induced astrocyte swelling in culture. Journal of Neurochemistry. 106(6):2302-2311.

 

Jayakumar, A.R; Rama Rao, K.V; Panickar,K.S; Moriyama, M; Reddy, P.V.B & Norenberg, M.D (2008) Trauma-induced cell swelling in cultured astrocytes. Journal of Neuropathology and Experimental Neurology. 67(5):417-427.

 

Cao, H.C; Qin, B; Panickar, K.S & Anderson, R.A. (2008) Tea and cinnamon polyphenols improve the metabolic syndrome. Agro Food Industry High Tech. 19(6): 16-19.

 

 

2007

 

 

Panickar, K.S; Jayakumar, A.R; Rama Rao K.V & Norenberg, M.D (2007) Downregulation of the 18 kDA translocator protein (TSPO): Effects on the ammonia-induced mitochondrial permeability transition and cell swelling in cultured astrocytes. Glia. 55(16):1720-1727.

 

Norenberg, M.D; Jayakumar, A.R; Rama Rao, K.V & Panickar, K.S. (2007) New concepts in the mechanism of ammonia-induced astrocyte swelling. Metabolic Brain Disease. 22(3-4):219-234.

 

 

2006

 

 

Jayakumar, A.R; Panickar, K.S. Murthy, C.R & Norenberg, M.D (2006) Oxidative stress and MAPK phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes. Journal of Neuroscience. 26(18):4774-4784.

 

 

Norenberg, M.D; Jayakumar, A.R; Rama Rao, K.V & Panickar, K.S (2006) The peripheral benzodiazepine receptor and neurosteroids in the pathogenesis of Hepatic Encephalopathy and ammonia neurotoxicity. In, Hepatic Encephalopathy and nitrogen metabolism. Haussinger D, Kircheis G, Schliess F (Eds). Springer Dordrecht, The Netherlands. pp143-159.

 

 

2005

 

Panickar, K.S; Nonner, D & Barrett, J.N (2005) Overexpression of Bcl-xl protects septal neurons from prolonged hypoglycemia and from acute ischemia-like stress. Neuroscience. 135(1):73-80.

 

Panickar, K.S & Norenberg, M.D (2005) Astrocytes in cerebral ischemic injury: General & morphological considerations. Glia. 50(4):287-98.

 

Rama Rao, K.V; Panickar, K.S; Jayakumar, A.R & Norenberg, M.D (2005)  Astrocytes protect neurons from ammonia toxicity. Neurochemical Research. 30(10):1311-1318.

 

 

2004

 

 

Nonner, D; Panickar, K.S; Barrett, E.F & Barrett, J.N (2004) Bone morphogenetic proteins (BMPs) and neurotrophins provide complementary protection of septal cholinergic function during phosphatase inhibitior-induced stress. Journal of Neurochemistry. 91:77-87.

 

Fass, U; Panickar, K.S.; Williams, K; Nevels, K; Personett, D & McKinney, M (2004) The role of glutathione in nitric oxide donor toxicity to SN56 cholinergic neuron-like cells. Brain Research. 1005: 90-100.

 

 

 

2000-2003

 

 

Panickar, K.S; Jayakumar, A.R & Norenberg, M.D. (2002) Differential response of neural cells to trauma-induced free radical production in vitro. Neurochemical Research. 27(1-2):161-166.

 

Jayakumar, A.R; Panickar, K.S & Norenberg, M.D. (2002) Effects on free radical generation by ligands of the peripheral benzodiazepine receptor in cultured neural cells. Journal of Neurochemistry. 83:1226-1234.

 

 

Bai, G; Rama Rao, K.V; Murthy, Ch. R.K ; Panickar, K.S; Jayakumar, A.R. & Norenberg, M.D (2001) Ammonia induces the mitochondrial permeability transition in primary cultures of rat astrocytes. Journal of Neuroscience Research. 66:981-991

 

 

Personett, D; Fass, U; Panickar, K & McKinney, M. (2000) Retinoic acid enhancement of the cholinergic phenotype of SN56 neuroblastoma cells: differentiation establishes a nitric oxide-sensitive proapoptotic state. Journal of Neurochemistry. 74(6):2412- 2424.

 

Fass, U; Panickar, K; Personett, D; Bryan, D; Williams, K; Gonzalez, J & McKinney, M (2000) Differential vulnerability of cholinergic neurons in primary cultures to nitric oxide excess. Neuroreport. 11(57):931-936

 

 

 

1995-1999

 

 

Panickar, K.S; Purushotham, K.R; King, M.A; Rajakumar, G & Simpkins, J.W. (1998) Hypoglycemia-induced seizures reduce CREB levels in the rat hippocampus. Neuroscience. 83(4):1155-1160.

 

Shi, J; Panickar, K.S; Yang, S.H; Rabbani, O; Day, A.L & Simpkins, J.W. (1998) Estrogen attenuates overexpression of β-amyloid precursor protein mRNA in an animal model of focal ischemia. Brain Research. 810:87-92.

 

Simpkins, J.W; Rabbani, O; Shi, J; Panickar, K.S; Green, P.S and Day, A.L. (1998) A system for the brain-enhanced delivery of estradiol: As assessment of its potential for the treatment of Alzheimer’s disease and stroke. Die Pharmazie. 53(8) 505-511.

 

Rabbani, O; Panickar, K.S; Rajakumar, G; King, M.A; Meyer, E.M., and Simpkins, J.W. (1997) 17 β-estradiol attenuates fimbrial lesion-induced decline of ChAT-immunoreactive neurons in the rat medial septum. Experimental Neurology.146:179 186.

 

Panickar, K.S; Guan, G; King, M.A; Rajakumar, G, & Simpkins, J.W. (1997) 17 β- estradiol attenuates CREB decline in the rat hippocampus following seizure. Journal of Neurobiology. 33:961-967.

 

McNaughton, N; Panickar, K.S & Logan, B. (1996) The pituitary-adrenal axis and the different behavioral effects of buspirone and chlordiazepoxide. Pharmacology Biochemistry & Behavior. 54(1): 51-56.

 

McNaughton, N; Logan, B; Panickar, K. S; Kirk, I; Pan, W-X; Brown, N & Heenan, A (1995) The contribution of synapses in the medial supramammillary nucleus to the frequency of hippocampal theta rhythm in freely-moving rats. Hippocampus. 5(6): 534-545.

 

 

 

1991-1994

 

 

Eileen J. Martin; Kiran S. Panickar; Michael A. King; Malgorzata Deyrup; Bruce E. Hunter & Edwin M. Meyer (1994) Cytoprotective actions of 2,4- dimethoxybenzylidene anabeseine in differentiated PC 12 cells and septal cholinergic neurons. Drug Development Research. 31(2): 135-141.

 

Panickar, Kiran S. (1994) Role of nicotine and nicotinic compounds in the treatment of neurodegenerative diseases and neuropsychiatric disorders. Italian Journal of Addictions. 82-83.

 

Panickar, Kiran S & McNaughton, N (1992) Comparison of the effects of chlordiazepoxide and buspirone on differential reinforcement of low rates of response. European Journal of Pharmacology. 210, 307-313.

 

Panickar, Kiran S & McNaughton, N (1991) Dose-response analysis of the effects of buspirone on rearing in rats. Journal of Psychopharmacology. 5(1), 72-76.

 

Panickar, Kiran S & McNaughton, N (1991) Comparison of the effects of chlordiazepoxide and buspirone on successive discrimination. Pharmacology Biochemistry & Behavior. 39(2), 275-278.

 

Panickar, Kiran S & McNaughton, N (1991) Effects of buspirone on fixed interval responding in rats. Journal of Psychopharmacology. 5(4), 408-415

 

 


Last Modified: 10/20/2010